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List of works by Jonas Demeulemeester

2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance

scientific article

4-Substituted 2-Hydroxyisoquinoline-1,3(2H,4H)-diones as a Novel Class of HIV-1 Integrase Inhibitors

scientific article

A pan-cancer landscape of somatic mutations in non-unique regions of the human genome

scientific article published on 19 July 2021

A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication

scientific article

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

scientific article published on 25 November 2021

Affinity switching of the LEDGF/p75 IBD interactome is governed by kinase-dependent phosphorylation

article published in the Proceedings of the National Academy of Sciences of the United States of America

Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

scientific article published in Nature Communications

Author Correction: Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors

scholarly article published in Nature Communications

BET-independent MLV-based Vectors Target Away From Promoters and Regulatory Elements

scientific article published on 29 July 2014

Biallelic mutations in cancer genomes reveal local mutational determinants

scientific article published on 10 February 2022

Bromodomain and extra-terminal (BET) proteins target Moloney murine leukemia virus integration to transcription start sites.

scientific article published on 19 September 2013

Cellular cofactors of lentiviral integrase: from target validation to drug discovery

scientific article published on 7 August 2012

Characterization of rare lens epithelium-derived growth factor/p75 genetic variants identified in HIV-1 long-term nonprogressors

scientific article

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

scientific article published on 15 April 2021

Development of an AlphaScreen-based HIV-1 integrase dimerization assay for discovery of novel allosteric inhibitors

scientific article published on 14 February 2012

Discovery of small molecule HIV-1 integrase dimerization inhibitors

scientific article published on 21 March 2012

Drivers underpinning the malignant transformation of giant cell tumour of bone

scientific article published on 31 August 2020

HIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.

scientific article

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

scientific article

HIV-1 integrase variants retarget viral integration and are associated with disease progression in a chronic infection cohort

scientific article published on 12 November 2014

Identification of a small molecule that modulates platelet glycoprotein Ib-von Willebrand factor interaction

scientific article

Impairing MLL-fusion gene-mediated transformation by dissecting critical interactions with the lens epithelium-derived growth factor (LEDGF/p75).

scientific article

Inhibitors of the integrase-transportin-SR2 interaction block HIV nuclear import

scientific article published on 12 January 2018

Interaction of transportin-SR2 with Ras-related nuclear protein (Ran) GTPase

scientific article published on 22 July 2013

Interpretation of allele-specific chromatin accessibility using cell state–aware deep learning

scientific article published on 08 April 2021

LEDGF/p75 is dispensable for hematopoiesis but essential for MLL-rearranged leukemogenesis

scientific article published on 30 October 2017

LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs

scientific article

LEDGINs, non-catalytic site inhibitors of HIV-1 integrase: a patent review (2006 - 2014).

scientific article published on 25 March 2014

Multiple cellular proteins interact with LEDGF/p75 through a conserved unstructured consensus motif

scientific article

Neoantigen-directed immune escape in lung cancer evolution

scientific article published on 20 March 2019

Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.

scientific article published on 31 October 2017

Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition

scientific article published on 05 February 2020

Pervasive chromosomal instability and karyotype order in tumour evolution

scientific article published on 02 September 2020

Rational design of LEDGINs as first allosteric integrase inhibitors for the treatment of HIV infection

scientific article published on December 2013

Recurrent rearrangements of FOS and FOSB define osteoblastoma.

scientific article

Structure, mechanics, and binding mode heterogeneity of LEDGF/p75–DNA nucleoprotein complexes revealed by scanning force microscopy

scientific article published on 01 May 2014

The BET family of proteins targets moloney murine leukemia virus integration near transcription start sites

scientific article

The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import

scientific article

The evolutionary history of 2,658 cancers

Towards a Safer, More Randomized Lentiviral Vector Integration Profile Exploring Artificial LEDGF Chimeras

scientific article

Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing

scientific article

Transcriptional Profiling of STAT1 Gain-of-Function Reveals Common and Mutation-Specific Fingerprints

scientific article published on 17 February 2021

Validation and structural characterization of the LEDGF/p75-MLL interface as a new target for the treatment of MLL-dependent leukemia

scientific article

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