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List of works by Vern Carruthers

A Thiazole Derivative of Artemisinin Moderately Reduces Toxoplasma gondii Cyst Burden in Infected Mice

scientific article published on 13 February 2014

A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex

scientific article

A conserved apicomplexan microneme protein contributes to Toxoplasma gondii invasion and virulence ⬇️

scientific article published on 4 August 2014

A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii

scientific article published on 19 September 2001

A dynamin is required for the biogenesis of secretory organelles in Toxoplasma gondii

scientific article

A new release on life: emerging concepts in proteolysis and parasite invasion

scientific article

A novel family of Toxoplasma IMC proteins displays a hierarchical organization and functions in coordinating parasite division

scientific article

A novel high throughput invasion screen identifies host actin regulators required for efficient cell entry by Toxoplasma gondii ⬇️

scientific article

A possible role for the 3'-untranslated region in developmental regulation in Trypanosoma brucei

scientific article published in September 1993

A transient forward-targeting element for microneme-regulated secretion in Toxoplasma gondii

scientific article published on April 2008

Acidification Activates Toxoplasma gondii Motility and Egress by Enhancing Protein Secretion and Cytolytic Activity

scientific article

Active cell invasion by Toxoplasma gondii leads to avoidance of phagocytic processing

Analysis of the Sarcocystis neurona microneme protein SnMIC10: protein characteristics and expression during intracellular development.

scientific article published in July 2003

Armed and dangerous: Toxoplasma gondii uses an arsenal of secretory proteins to infect host cells

scientific article

Biochemical and molecular characterization of the pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase from Toxoplasma gondii

scientific article published on 08 May 2012

Cathepsin L occupies a vacuolar compartment and is a protein maturase within the endo/exocytic system of Toxoplasma gondii

scientific article

Cathepsin proteases in Toxoplasma gondii

scientific article published on January 2011

Cell cycle-dependent, intercellular transmission of Toxoplasma gondii is accompanied by marked changes in parasite gene expression

scientific article

Characterization of the chloroquine resistance transporter homologue in Toxoplasma gondii

scientific article

Cysteine protease inhibitors block Toxoplasma gondii microneme secretion and cell invasion ⬇️

scientific article published on 4 December 2006

Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens

scientific article published in September 2005

Ectopic expression of a Neospora caninum Kazal type inhibitor triggers developmental defects in Toxoplasma and Plasmodium

scientific article

Effects of Toxoplasma gondii infection on the brain

scientific article

Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis

scientific article

Erratum to “Kinetic modeling of Toxoplasma gondii invasion” [J. Theor. Biol. 249 (2007) 817–825]

scholarly article published in Journal of Theoretical Biology

Forward targeting of Toxoplasma gondii proproteins to the micronemes involves conserved aliphatic amino acids

scientific article

Functional analysis of Toxoplasma gondii protease inhibitor 1.

scientific article published on 11 September 2002

Functional dissection of Toxoplasma gondii perforin-like protein 1 reveals a dual domain mode of membrane binding for cytolysis and parasite egress

scientific article published on 2 February 2013

Host cell invasion by the opportunistic pathogen Toxoplasma gondii

scientific article

Host cell manipulation by the human pathogen Toxoplasma gondii

scientific article

Identification and partial characterization of a second Kazal inhibitor in Toxoplasma gondii

scientific article published in April 2003

Intersection of Endocytic and Exocytic Systems in Toxoplasma gondii.

scientific article published on 13 February 2018

Is Toxoplasma egress the first step in invasion?

scientific article

Kinetic modeling of Toxoplasma gondii invasion ⬇️

scientific article published on 14 September 2007

MARveling at parasite invasion ⬇️

scientific article published on 18 January 2008

Manipulation of the vsg co-transposed region increases expression-site switching in Trypanosoma brucei.

scientific article published in June 1997

Microbial pathogenesis: mechanisms of infectious disease

scientific article

Microneme Protein 5 Regulates the Activity of Toxoplasma Subtilisin 1 by Mimicking a Subtilisin Prodomain

scientific article

Microneme proteins in apicomplexans

scientific article published on January 2008

Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondii

scientific article published on 01 January 1999

Molecular characterisation of an expressed sequence tag locus of Toxoplasma gondii encoding the micronemal protein MIC2.

scientific article published in February 1997

Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes of Toxoplasma gondii

scientific article

Molecular mimicry of a CCR5 binding-domain in the microbial activation of dendritic cells

scientific article

Multimerization of the Toxoplasma gondii MIC2 integrin-like A-domain is required for binding to heparin and human cells

scientific article published in April 2004

Mutation of an unusual mitochondrial targeting sequence of SODB2 produces multiple targeting fates in Toxoplasma gondii

scientific article published on 01 November 2003

Neospora caninum expresses an unusual single-domain Kazal protease inhibitor that is discharged into the parasitophorous vacuole

scientific article published in May 2004

New roles for perforins and proteases in apicomplexan egress

scientific article published on 13 July 2009

Non-canonical maturation of two papain-family proteases in Toxoplasma gondii

scientific article published on 18 December 2012

POFUT2-mediated O-glycosylation of MIC2 is dispensable for Toxoplasma gondii tachyzoites

Preparing for an invasion: charting the pathway of adhesion proteins to Toxoplasma micronemes

scientific article

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion

scientific article

Proteolysis and Toxoplasma invasion

scientific article

Proteomic analysis of cleavage events reveals a dynamic two-step mechanism for proteolysis of a key parasite adhesive complex

scientific article

Pulling together: an integrated model of Toxoplasma cell invasion

scientific article published on 11 July 2006

Rapid invasion of host cells by Toxoplasma requires secretion of the MIC2-M2AP adhesive protein complex

scientific article

Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells.

scientific article

Recent insights into apicomplexan parasite egress provide new views to a kill

scientific article

Structural Features of Apicomplexan Pore-Forming Proteins and Their Roles in Parasite Cell Traversal and Egress

scientific article published on 29 August 2017

Structural basis of Toxoplasma gondii MIC2-associated protein interaction with MIC2

scientific article

Structural basis of Toxoplasma gondii Perforin-Like Protein 1 membrane interaction and activity during egress

Synchronous invasion of host cells by Toxoplasma gondii

scientific article published on 01 August 2004

Tagging of endogenous genes in a Toxoplasma gondii strain lacking Ku80

scientific article (publication date: April 2009)

Targeted deletion of MIC5 enhances trimming proteolysis of Toxoplasma invasion proteins

scientific article published on 15 September 2006

Targeted disruption of Toxoplasma gondii serine protease inhibitor 1 increases bradyzoite cyst formation in vitro and parasite tissue burden in mice

scientific article published on 27 December 2011

Targeted disruption of expression site-associated gene-1 in bloodstream-form Trypanosoma brucei

scientific article

TgM2AP participates in Toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2

scientific article published on 01 August 2001

The Toxoplasma homolog of Plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels.

scientific article

The novel coccidian micronemal protein MIC11 undergoes proteolytic maturation by sequential cleavage to remove an internal propeptide.

scientific article

The opportunistic pathogen Toxoplasma gondii deploys a diverse legion of invasion and survival proteins

scientific article published on 7 July 2005

Toxoplasma MIC2 is a major determinant of invasion and virulence

scientific article

Toxoplasma Secretory Proteins and Their Roles in Cell Invasion and Intracellular Survival

article

Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection

scientific article published on 19 June 2017

Toxoplasma gondii Cathepsin L Is the Primary Target of the Invasion-inhibitory Compound Morpholinurea-leucyl-homophenyl-vinyl Sulfone Phenyl ⬇️

scientific article

Toxoplasma gondii Cathepsin L-like Protease, TgCPL

Toxoplasma gondii excretion of glycolytic products is associated with acidification of the parasitophorous vacuole during parasite egress

scientific article published on 05 May 2022

Toxoplasma gondii exploits the host ESCRT machinery for parasite uptake of host cytosolic proteins

scientific article published on 13 December 2021

Toxoplasma gondii ingests and digests host cytosolic proteins

scientific article

Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites

scientific article

Toxoplasma gondii toxolysin 4 is an extensively processed putative metalloproteinase secreted from micronemes

scientific article

Toxoplasma gondii uses sulfated proteoglycans for substrate and host cell attachment

scientific article

Toxoplasma gondii-induced activation of EGFR prevents autophagy protein-mediated killing of the parasite.

scientific article

Toxoplasma gondii: molecular cloning and characterization of a novel 18-kDa secretory antigen, TgMIC10.

scientific article published in February 2001

Toxoplasma sortilin-like receptor regulates protein transport and is essential for apical secretory organelle biogenesis and host infection

scientific article published in May 2012

Trans-genera reconstitution and complementation of an adhesion complex in Toxoplasma gondii

scientific article published in August 2004

Translocation of ribosomal protein P0 onto the Toxoplasma gondii tachyzoite surface

scientific article

Two Separate, Conserved Acidic Amino Acid Domains within the Toxoplasma gondii MIC2 Cytoplasmic Tail Are Required for Parasite Survival

scientific article published on 21 August 2006

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