Search filters

List of works by Jim Iley

4-Oxo-beta-lactams (azetidine-2,4-diones) are potent and selective inhibitors of human leukocyte elastase.

scientific article published in January 2010

A carbamate-based approach to primaquine prodrugs: antimalarial activity, chemical stability and enzymatic activation

scientific article published on 3 December 2011

Acyloxymethyl as a drug protecting group. Part 3. Tertiary O-amidomethyl esters of penicillin G: chemical hydrolysis and anti-bacterial activity.

scientific article

Acyloxymethyl as a drug protecting group. Part 6

scientific article published on 01 April 2000

Acyloxymethyl as a drug protecting group: Part 4. The hydrolysis of tertiary amidomethyl ester prodrugs of carboxylic acid agents

scientific article published on 01 November 1997

Aminocarbonyloxymethyl ester prodrugs of flufenamic acid and diclofenac: suppressing the rearrangement pathway in aqueous media

scientific article published on 01 January 2007

Azetidine-2,4-diones (4-oxo-beta-lactams) as scaffolds for designing elastase inhibitors

scientific article

Cleavage of tertiary amidomethyl ester prodrugs of carboxylic acids by rat liver homogenates.

scientific article

Crystallization and Preliminary Diffraction Studies of Porcine Pancreatic Elastase in Complex with a Novel Inhibitor

scientific article published on 01 January 2007

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors

scientific article published in April 2001

Design, synthesis, and enzymatic evaluation of N1-acyloxyalkyl- and N1-oxazolidin-2,4-dion-5-yl-substituted beta-lactams as novel inhibitors of human leukocyte elastase

scientific article published in July 2005

Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates

scientific article published in June 1999

Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum

scientific article published on 12 May 2006

Dopamine- and tyramine-based derivatives of triazenes: activation by tyrosinase and implications for prodrug design.

scientific article published on 27 March 2009

Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials

scientific article published in February 2005

Imidazolium ylides from a conjugate addition–proton transfer route and their cycloaddition reactions

scientific article published on 13 June 2011

Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and N,N-dimethylacetamide

scientific article published in October 2001

Intramolecular 1,3-dipolar cycloadditions of dihydroimidazolium ylides: synthesis of pyrrolo[1,2,3-de]quinoxalines and imidazo[1,2-a]indoles

scientific article published on 18 July 2006

Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one

scientific article

Mechanism of the microsomal demethylation of 1-aryl-3,3-dimethyltriazenes

scientific article published on 01 November 1990

Microsomal metabolism of N,N-diethyl-m-toluamide (DEET, DET): the extended network of metabolites

scientific article published in April 1999

Monofluorinated di- and tetrahydropyrans via Prins-type cyclisations

scientific article published on 14 June 2006

N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases

scientific article published on 28 April 2012

Oxidation of tertiary benzamides by 5,10,15,20-tetraphenylporphyrinatoironIII chloride-tert-butylhydroperoxide

scientific article

Phthalimidomethyl as a drug pro-moiety. Probing its reactivity

scientific article published on 01 April 1998

Pyrrolo[1,2,3-de]quinoxalines: unexpected products from 1,3-dipolar cycloaddition of dihydroimidazolium ylides

Rational design, synthesis, biophysical and antiproliferative evaluation of fluorenone derivatives with DNA G-quadruplex binding properties.

scientific article

Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho[2,3-d]isoxazole-4,9-diones.

scientific article published on 4 November 2009

Synthesis of the pyoverdin chromophore by a biomimetic oxidative cyclization.

scientific article published in April 2009

Synthesis, stability and in vitro dermal evaluation of aminocarbonyloxymethyl esters as prodrugs of carboxylic acid agents.

scientific article published in March 2002

Synthesis, stability, biochemical and pharmacokinetic properties of a new potent and selective 4-oxo-β-lactam inhibitor of human leukocyte elastase

scientific article published on 14 June 2010

Tetraplex DNA specific ligands based on the fluorenone-carboxamide scaffold

scientific article published on 09 February 2007

The 1,4-naphthoquinone scaffold in the design of cysteine protease inhibitors

scientific article published on 06 May 2007

The Bsmoc group as a novel scaffold for the design of irreversible inhibitors of cysteine proteases

scientific article published on 28 February 2006

The efficiency of C-4 substituents in activating the beta-lactam scaffold towards serine proteases and hydroxide ion

scientific article

The microsomal demethylation of N,N-dimethylbenzamides. Substituent and kinetic deuterium isotope effects

scientific article published in August 1992

Towards an efficient prodrug of the alkylating metabolite monomethyltriazene: synthesis and stability of N-acylamino acid derivatives of triazenes.

scientific article published on 28 June 2008

Triazene drug metabolites. Part 17: Synthesis and plasma hydrolysis of acyloxymethyl carbamate derivatives of antitumour triazenes

scientific article published on 01 July 2000

Triazene drug metabolites: part 15. Synthesis and plasma hydrolysis of anticancer triazenes containing amino acid carriers

scientific article published on 01 June 1998

Unanticipated acyloxymethylation of sumatriptan indole nitrogen atom and its implications in prodrug design

scientific article published in June 2008

Paulina is supported by:

About Paulina

Help