List of works - Yoshihisa Hagihara

A Photo‐Thermal‐Electrical Converter Based On Carbon Nanotubes for Bioelectronic Applications ⬇️

scientific article published on October 26, 2011

A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity

scientific journal article

Acid-induced unfolding and refolding transitions of cytochrome c: a three-state mechanism in H2O and D2O.

scientific article published in November 1993

Aggregation of beta(2)-glycoprotein I induced by sodium lauryl sulfate and lysophospholipids

scientific article published in January 2002

Amyloid fibril formation by the CAD domain of caspase-activated DNase.

scientific article

Amyloid fibril formation in the context of full-length protein: effects of proline mutations on the amyloid fibril formation of beta2-microglobulin

scientific article published on 4 September 2003

An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid.

scientific article

Analysis of the putative substrate binding region of hyperthermophilic endoglucanase from Pyrococcus horikoshii

scientific article published on 7 October 2007

Anti-survivin single-domain antibodies derived from an artificial library including three synthetic random regions by in vitro selection using cDNA display

scientific article published on 14 August 2018

Ascorbic acid attenuates acute pulmonary oxidative stress and inflammation caused by zinc oxide nanoparticles

scientific article published on 10 January 2015

Ascorbic acid prevents zinc oxide nanoparticle-induced intracellular oxidative stress and inflammatory responses.

scientific article

Assessment of antioxidant capacity for scavenging free radicals in vitro: a rational basis and practical application

scientific article published on 28 January 2012

Association of the physical and chemical properties and the cytotoxicity of metal oxide nanoparticles: metal ion release, adsorption ability and specific surface area.

scientific article

Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung.

scientific article published on 26 May 2012

Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols.

scientific article published on 30 January 2013

Capacity of fucoxanthin for scavenging peroxyl radicals and inhibition of lipid peroxidation in model systems

scientific article published on 10 September 2012

Capacity of peroxyl radical scavenging and inhibition of lipid peroxidation by β-carotene, lycopene, and commercial tomato juice

scientific article published on 01 November 2012

Carbon nanotube–liposome supramolecular nanotrains for intelligent molecular-transport systems ⬇️

scientific article published on January 1, 2012

Cellular effects of industrial metal nanoparticles and hydrophilic carbon black dispersion.

scientific article

Cellular quality control screening to identify amino acid pairs for substituting the disulfide bonds in immunoglobulin fold domains.

scientific article published on 3 May 2005

Cellular responses induced by cerium oxide nanoparticles: induction of intracellular calcium level and oxidative stress on culture cells

scientific article published on 21 June 2011

Chain-like conformation of heat-denatured ribonuclease A and cytochrome c as evidenced by solution X-ray scattering

scientific article published on 01 January 1998

Changes in Cell Adhesiveness and Physicochemical Properties of Cross-Linked Albumin Films after Ultraviolet Irradiation.

scientific article published on 11 December 2015

Charge repulsion in the conformational stability of melittin

scientific article published in December 1992

Comparison of acute oxidative stress on rat lung induced by nano and fine-scale, soluble and insoluble metal oxide particles: NiO and TiO2.

scientific article published on June 2012

Comparison of the conformational stability of the molten globule and native states of horse cytochrome c. Effects of acetylation, heat, urea and guanidine-hydrochloride

scientific article published on 01 April 1994

Crystal structure of thioredoxin peroxidase from aerobic hyperthermophilic archaeon Aeropyrum pernix K1

scientific article published on 01 March 2006

Crystallization and preliminary X-ray diffraction analysis of thioredoxin peroxidase from the aerobic hyperthermophilic archaeon Aeropyrum pernix K1.

scientific article

Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells

scientific article published on 27 July 2015

Design and assessment of an active anti-epidermal growth factor receptor (EGFR) single chain variable fragment (ScFv) with improved solubility

scientific article published on 11 December 2018

Desorption/Ionization Efficiency of Peptides Containing Disulfide Bonds in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry ⬇️

scientific article published on January 1, 2012

Development of an on-site rapid real-time polymerase chain reaction system and the characterization of suitable DNA polymerases for TaqMan probe technology

scientific article published on 7 June 2016

Early diagnosis of type 2 diabetes based on multiple biomarkers and non-invasive indices.

scientific article

Effect of phospholipids on conformational structure of bovine pancreatic trypsin inhibitor (BPTI) and its thermolabile mutants.

scientific article

Engineering disulfide bonds within an antibody

scientific article published on 17 July 2014

Enhanced in-cell folding of reversibly cationized transcription factor using amphipathic peptide.

scientific article published on 16 January 2017

Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene

scientific article

Enzyme hyperactivation system based on a complementary charged pair of polyelectrolytes and substrates

scientific article published on 26 March 2014

Evaluation of biological activities of a groundnut (Apios americana Medik) extract containing a novel isoflavone.

scientific article published on 12 November 2012

Evaluation of cellular effects of silicon dioxide nanoparticles.

scientific article published on 27 January 2014

Evaluation of cellular influences caused by calcium carbonate nanoparticles

scientific article published on 8 January 2014

Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion.

scientific article

Facile immunostaining and labeling of nonadherent cells using a microfluidic device to entrap the cells

scientific article published on 10 September 2013

Fatty liver induced by free radicals and lipid peroxidation

scientific article published on 27 April 2012

Flexible loop of beta 2-glycoprotein I domain V specifically interacts with hydrophobic ligands

scientific article published in July 2001

Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells.

scientific article published on 11 December 2015

Guanidine hydrochloride-induced folding of proteins

scientific article published on 01 May 1993

Heat denaturation of the antibody, a multi-domain protein

scientific article published on 18 December 2017

Heat-Induced Aggregation of Hen Ovalbumin Suggests a Key Factor Responsible for Serpin Polymerization

scientific article published on 06 September 2018

Heat-induced irreversible denaturation of the camelid single domain VHH antibody is governed by chemical modifications.

scientific article

Highly efficient production of VHH antibody fragments in Brevibacillus choshinensis expression system

scientific article

Identification of novel peptides from amphibian (Xenopus tropicalis) skin by direct tissue MALDI-MS analysis

scientific article

Identification of the region responsible for fibril formation in the CAD domain of caspase-activated DNase.

scientific article published in December 2005

Improvement of single domain antibody stability by disulfide bond introduction

scientific article

In vitro evaluation of cellular influences induced by stable fullerene C₇₀ medium dispersion: induction of cellular oxidative stress

scientific article

Investigation of a peptide responsible for amyloid fibril formation of beta 2-microglobulin by achromobacter protease I.

scientific article published on 30 October 2001

Ionization efficiency of alpha-helical peptides in laser desorption/ionization mass spectrometry

scientific article published in July 2009

Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high-throughput sequencing.

scientific article published on 17 April 2015

Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins

scientific article

Mapping the core of the beta(2)-microglobulin amyloid fibril by H/D exchange

scientific article published in May 2002

Mechanism of the conformational transition of melittin

scientific article

Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion

scientific article

Molten globule of cytochrome c studied by small angle X-ray scattering.

scientific article

Multicomponent Coculture System of Cancer Cells and Two Types of Stromal Cells for In Vitro Evaluation of Anticancer Drugs.

scientific article published on 30 September 2015

NMR assignment of the chitin-binding domain of a hyperthermophilic chitinase from Pyrococcus furiosus

scientific article published on 03 October 2006

On-site identification of meat species in processed foods by a rapid real-time polymerase chain reaction system.

scientific article

Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice

scientific article

Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients

scientific article published on 29 July 2016

Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate

scientific article

Oxidative stress is involved in fatigue induced by overnight deskwork as assessed by increase in plasma tocopherylhydroqinone and hydroxycholesterol

scientific article

Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns.

scientific article

Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin.

scientific article published on 22 January 2016

Probucol induces the generation of lipid peroxidation products in erythrocytes and plasma of male cynomolgus macaques

scientific article published on 28 November 2018

Probucol-Induced α-Tocopherol Deficiency Protects Mice against Malaria Infection

scientific article

Rapid Enzyme-linked Immunosorbent Assays for Diagnosis of Diabetes in a Compact Disc-shaped Microfluidic Device

scientific article published in January 2018

Reactivity toward oxygen radicals and antioxidant action of thiol compounds

scientific article published on 5 April 2012

Recent advances in antibody engineering

scientific article published on 01 November 2014

Rotatable reagent cartridge for high-performance microvalve system on a centrifugal microfluidic device

scientific article published on 26 June 2013

Screening for stable mutants with amino acid pairs substituted for the disulfide bond between residues 14 and 38 of bovine pancreatic trypsin inhibitor (BPTI).

scientific article

Singlet oxygen induced products of linoleates, 10- and 12-(Z,E)-hydroxyoctadecadienoic acids (HODE), can be potential biomarkers for early detection of type 2 diabetes.

scientific article

Singlet-oxygen-derived products from linoleate activate Nrf2 signaling in skin cells

scientific article

Stabilization of an immunoglobulin fold domain by an engineered disulfide bond at the buried hydrophobic region

scientific article published on 11 October 2007

Structural basis of α-catenin recognition by EspB from enterohaemorrhagic E. coli based on hybrid strategy using low-resolution structural and protein dissection

scientific article

Structural studies reveal that the diverse morphology of beta(2)-microglobulin aggregates is a reflection of different molecular architectures.

scientific article published on 9 September 2005

Structure of the catalytic domain of the hyperthermophilic chitinase from Pyrococcus furiosus

scientific article

The amyloid fibrils of the constant domain of immunoglobulin light chain

scientific article published on 18 June 2010

The induction of lipid peroxidation during the acute oxidative stress response induced by intratracheal instillation of fine crystalline silica particles in rats.

scientific article published on 31 December 2014

The role of intra-domain disulfide bonds in heat-induced irreversible denaturation of camelid single domain VHH antibodies

scientific article (publication date: 2016)

Thioflavin T-Silent Denaturation Intermediates Support the Main-Chain-Dominated Architecture of Amyloid Fibrils.

scientific article published on 25 June 2016

Toward development of a screen to identify randomly encoded, foldable sequences.

scientific article

Trifluoroethanol-induced conformational transition of hen egg-white lysozyme studied by small-angle X-ray scattering

scientific article published on 01 October 1997

Ultrasonication-dependent formation and degradation of α-synuclein amyloid fibrils

scientific article published on 18 December 2014

α-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome

scientific article published on 27 March 2011

α-Tocopheryl phosphate: uptake, hydrolysis, and antioxidant action in cultured cells and mouse.

scientific article published on 26 March 2011

List of works by Yoshihisa Hagihara

A Photo‐Thermal‐Electrical Converter Based On Carbon Nanotubes for Bioelectronic Applications ⬇️

A novel role for α-tocopherol transfer protein (α-TTP) in protecting against chloroquine toxicity

Acid-induced unfolding and refolding transitions of cytochrome c: a three-state mechanism in H2O and D2O.

Aggregation of beta(2)-glycoprotein I induced by sodium lauryl sulfate and lysophospholipids

Amyloid fibril formation by the CAD domain of caspase-activated DNase.

Amyloid fibril formation in the context of full-length protein: effects of proline mutations on the amyloid fibril formation of beta2-microglobulin

An open sandwich immunoassay for detection of 13(R,S)-hydroxy-9(E),11(E)-octadecadienoic acid.

Analysis of the putative substrate binding region of hyperthermophilic endoglucanase from Pyrococcus horikoshii

Anti-survivin single-domain antibodies derived from an artificial library including three synthetic random regions by in vitro selection using cDNA display

Ascorbic acid attenuates acute pulmonary oxidative stress and inflammation caused by zinc oxide nanoparticles

Ascorbic acid prevents zinc oxide nanoparticle-induced intracellular oxidative stress and inflammatory responses.

Assessment of antioxidant capacity for scavenging free radicals in vitro: a rational basis and practical application

Association of the physical and chemical properties and the cytotoxicity of metal oxide nanoparticles: metal ion release, adsorption ability and specific surface area.

Association of zinc ion release and oxidative stress induced by intratracheal instillation of ZnO nanoparticles to rat lung.

Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols.

Capacity of fucoxanthin for scavenging peroxyl radicals and inhibition of lipid peroxidation in model systems

Capacity of peroxyl radical scavenging and inhibition of lipid peroxidation by β-carotene, lycopene, and commercial tomato juice

Carbon nanotube–liposome supramolecular nanotrains for intelligent molecular-transport systems ⬇️

Cellular effects of industrial metal nanoparticles and hydrophilic carbon black dispersion.

Cellular quality control screening to identify amino acid pairs for substituting the disulfide bonds in immunoglobulin fold domains.

Cellular responses induced by cerium oxide nanoparticles: induction of intracellular calcium level and oxidative stress on culture cells

Chain-like conformation of heat-denatured ribonuclease A and cytochrome c as evidenced by solution X-ray scattering

Changes in Cell Adhesiveness and Physicochemical Properties of Cross-Linked Albumin Films after Ultraviolet Irradiation.

Charge repulsion in the conformational stability of melittin

Comparison of acute oxidative stress on rat lung induced by nano and fine-scale, soluble and insoluble metal oxide particles: NiO and TiO2.

Comparison of the conformational stability of the molten globule and native states of horse cytochrome c. Effects of acetylation, heat, urea and guanidine-hydrochloride

Crystal structure of thioredoxin peroxidase from aerobic hyperthermophilic archaeon Aeropyrum pernix K1

Crystallization and preliminary X-ray diffraction analysis of thioredoxin peroxidase from the aerobic hyperthermophilic archaeon Aeropyrum pernix K1.

Cytotoxicity of CdSe-based quantum dots incorporated in glass nanoparticles evaluated using human keratinocyte HaCaT cells

Design and assessment of an active anti-epidermal growth factor receptor (EGFR) single chain variable fragment (ScFv) with improved solubility

Desorption/Ionization Efficiency of Peptides Containing Disulfide Bonds in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry ⬇️

Development of an on-site rapid real-time polymerase chain reaction system and the characterization of suitable DNA polymerases for TaqMan probe technology

Early diagnosis of type 2 diabetes based on multiple biomarkers and non-invasive indices.

Effect of phospholipids on conformational structure of bovine pancreatic trypsin inhibitor (BPTI) and its thermolabile mutants.

Engineering disulfide bonds within an antibody

Enhanced in-cell folding of reversibly cationized transcription factor using amphipathic peptide.

Enhancement of lipid peroxidation and its amelioration by vitamin E in a subject with mutations in the SBP2 gene

Enzyme hyperactivation system based on a complementary charged pair of polyelectrolytes and substrates

Evaluation of biological activities of a groundnut (Apios americana Medik) extract containing a novel isoflavone.

Evaluation of cellular effects of silicon dioxide nanoparticles.

Evaluation of cellular influences caused by calcium carbonate nanoparticles

Evaluation of cellular influences of platinum nanoparticles by stable medium dispersion.

Facile immunostaining and labeling of nonadherent cells using a microfluidic device to entrap the cells

Fatty liver induced by free radicals and lipid peroxidation

Flexible loop of beta 2-glycoprotein I domain V specifically interacts with hydrophobic ligands

Generation of a patterned co-culture system composed of adherent cells and immobilized nonadherent cells.

Guanidine hydrochloride-induced folding of proteins

Heat denaturation of the antibody, a multi-domain protein

Heat-Induced Aggregation of Hen Ovalbumin Suggests a Key Factor Responsible for Serpin Polymerization

Heat-induced irreversible denaturation of the camelid single domain VHH antibody is governed by chemical modifications.

Highly efficient production of VHH antibody fragments in Brevibacillus choshinensis expression system

Identification of novel peptides from amphibian (Xenopus tropicalis) skin by direct tissue MALDI-MS analysis

Identification of the region responsible for fibril formation in the CAD domain of caspase-activated DNase.

Improvement of single domain antibody stability by disulfide bond introduction

In vitro evaluation of cellular influences induced by stable fullerene C₇₀ medium dispersion: induction of cellular oxidative stress

Investigation of a peptide responsible for amyloid fibril formation of beta 2-microglobulin by achromobacter protease I.

Ionization efficiency of alpha-helical peptides in laser desorption/ionization mass spectrometry

Isolation and characterization of antigen-specific alpaca (Lama pacos) VHH antibodies by biopanning followed by high-throughput sequencing.

Lysine pyrrolation is a naturally-occurring covalent modification involved in the production of DNA mimic proteins

Mapping the core of the beta(2)-microglobulin amyloid fibril by H/D exchange

Mechanism of the conformational transition of melittin

Molecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion

Molten globule of cytochrome c studied by small angle X-ray scattering.

Multicomponent Coculture System of Cancer Cells and Two Types of Stromal Cells for In Vitro Evaluation of Anticancer Drugs.

NMR assignment of the chitin-binding domain of a hyperthermophilic chitinase from Pyrococcus furiosus

On-site identification of meat species in processed foods by a rapid real-time polymerase chain reaction system.

Oocyte-triggered dimerization of sperm IZUMO1 promotes sperm-egg fusion in mice

Oxidation and interaction of DJ-1 with 20S proteasome in the erythrocytes of early stage Parkinson's disease patients

Oxidation of archaeal peroxiredoxin involves a hypervalent sulfur intermediate

Oxidative stress is involved in fatigue induced by overnight deskwork as assessed by increase in plasma tocopherylhydroqinone and hydroxycholesterol

Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns.

Physicochemical and biological characterizations of Pxt peptides from amphibian (Xenopus tropicalis) skin.

Probucol induces the generation of lipid peroxidation products in erythrocytes and plasma of male cynomolgus macaques

Probucol-Induced α-Tocopherol Deficiency Protects Mice against Malaria Infection

Rapid Enzyme-linked Immunosorbent Assays for Diagnosis of Diabetes in a Compact Disc-shaped Microfluidic Device

Reactivity toward oxygen radicals and antioxidant action of thiol compounds

Recent advances in antibody engineering

Rotatable reagent cartridge for high-performance microvalve system on a centrifugal microfluidic device

Screening for stable mutants with amino acid pairs substituted for the disulfide bond between residues 14 and 38 of bovine pancreatic trypsin inhibitor (BPTI).