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List of works by Nick Plant

A PXR-Mediated Negative Feedback Loop Attenuates the Expression of CYP3A in Response to the PXR Agonist Pregnenalone-16α-Carbonitrile ⬇️

scientific article published on February 2, 2011

Acrylamide-mediated subacute testicular and genotoxicity, is it reversible?

article

Activation of the Farnesoid X-receptor in breast cancer cell lines results in cytotoxicity but not increased migration potential ⬇️

scientific article published on 3 November 2015

Can a systems approach produce a better understanding of mood disorders? ⬇️

scientific article published on 24 August 2016

Can systems toxicology identify common biomarkers of non-genotoxic carcinogenesis?

scientific article published on 10 July 2008

Chapter 2. Enabling Dynamic Response to Chemical Challenge: Nuclear Receptor-mediated Control of Transporter Expression

article

Characterization of rhodamine-123 as a tracer dye for use in in vitro drug transport assays

scientific article

Characterization of the temporal induction of hepatic xenobiotic-metabolizing enzymes by glucosinolates and isothiocyanates: requirement for at least a 6 h exposure to elicit complete induction profile

scientific article published on 24 May 2012

Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds.

scientific article published on 14 October 2011

Control and statistical analysis of in vitro reporter gene assays.

scientific article

Design principles of nuclear receptor signaling: how complex networking improves signal transduction.

scientific article

Developmental modulation of cysteine conjugate beta-lyase/glutamine transaminase K/kynurenine aminotransferase mRNA in rat brain

scientific article published in October 1997

Differential gene expression in rats following subacute exposure to the anticonvulsant sodium valproate

scientific journal article

Differential response of human and rat epoxide hydrolase to polycyclic aromatic hydrocarbon exposure: studies using precision-cut tissue slices

scientific article published on 12 February 2008

Drug-regulated expression of Plasmodium falciparum P-glycoprotein homologue 1: a putative role for nuclear receptors.

scientific article published on 14 January 2008

EGF mediates monocyte chemotaxis and macrophage proliferation and EGF receptor is expressed in atherosclerotic plaques

article

Editorial overview

article

Emergence of the silicon human and network targeting drugs

article

Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities.

scientific article

Evaluation of the toxicological relevance of CYP3A4 induction.

scientific article

Fatty acid binding proteins: tissue-specific functions in health and disease

scientific article published on March 2014

Gene expression changes in rat liver following exposure to liver growth agents: role of Kupffer cells in xenobiotic-mediated liver growth

scientific article

Generation of 2,000 breast cancer metabolic landscapes reveals a poor prognosis group with active serotonin production ⬇️

scientific article published on 27 January 2016

Glucocorticoid-mediated induction of CYP3A4 is decreased by disruption of a protein: DNA interaction distinct from the pregnane X receptor response element

scientific article published in September 2002

Impact of transcription factor profile and chromatin conformation on human hepatocyte CYP3A gene expression

scientific article

In silico and in vitro modeling of hepatocyte drug transport processes: importance of ABCC2 expression levels in the disposition of carboxydichlorofluroscein

scientific article published on 20 November 2008

Inhibition of prenyltransferase activity by statins in both liver and muscle cell lines is not causative of cytotoxicity ⬇️

scientific article

Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics ⬇️

scientific article published on 7 August 2017

Interaction networks: coordinating responses to xenobiotic exposure

article

Langaside, a novel secoiridolactone glycoside derivative from Tachiadenus longiflorus Griseb. (Gentianaceae) formed by a [2+2] cycloaddition reaction

article

Lansoprazole increases testosterone metabolism and clearance in male Sprague-Dawley rats: implications for Leydig cell carcinogenesis

scientific article published in October 2003

Linking physiologically-based pharmacokinetic and genome-scale metabolic networks to understand estradiol biology ⬇️

scientific article published on 15 December 2017

MUFINS: multi-formalism interaction network simulator. ⬇️

scientific article

Mixed chelate copper complex, Casiopeina IIgly®, binds and degrades nucleic acids: A mechanism of cytotoxicity

article

Modeling Transport Processes and Their Implications for Chemical Disposition and Action

article

Molecular Biology and Biotechnology ⬇️

scientific article published on December 1, 2001

Molecular biology I: transcriptional regulation

scholarly article by Nick Plant published in March 2015

Molecular biology I: transcriptional regulation

scholarly article by Nick Plant published in April 2012

Molecular biology I: transcriptional regulation

scholarly article by Nick Plant published in April 2009

Molecular biology II: protein function ⬇️

scholarly article by Nick Plant published in March 2015

Molecular biology II: protein function

scholarly article by Nick Plant published in April 2012

Molecular biology II: protein function

scholarly article by Nick Plant published in April 2009

Multi-scale, whole-system models of liver metabolic adaptation to fat and sugar in non-alcoholic fatty liver disease ⬇️

article

Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner

scientific article

Non-toxic melanin production inhibitors from Garcinia livingstonei (Clusiaceae). ⬇️

scientific article published on 23 July 2013

Nuclear receptors: the controlling force in drug metabolism of the liver?

scientific article published on August 2009

Optimization of stress response through the nuclear receptor-mediated cortisol signalling network

scientific article

Peroxisome Proliferators Induce High Levels of DNA Synthesis in Primary Cultures of Rat Hepatocytes

article

Peroxisome Proliferators: Species Differences in Response of Primary Hepatocyte Cultures

article

Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor ⬇️

scientific article published on December 16, 2011

Primary liver cells cultured on carbon nanotube substrates for liver tissue engineering and drug discovery applications

scientific article published on 16 June 2014

Probabilistic orthology analysis of the ATP-binding cassette transporters: implications for the development of multiple drug resistance phenotype

scientific article published on 16 April 2012

QSSPN: dynamic simulation of molecular interaction networks describing gene regulation, signalling and whole-cell metabolism in human cells ⬇️

scientific article published on 23 September 2013

Receptor-dependent regulation of the CYP3A4 gene

scientific article

Regulation of the CYP3A4 gene by hydrocortisone and xenobiotics: role of the glucocorticoid and pregnane X receptors.

scientific article

Relative receptor expression is a determinant in xenobiotic-mediated CYP3A induction in rat and human cells

scientific article published in July 2003

Role of Sp1, C/EBP alpha, HNF3, and PXR in the basal- and xenobiotic-mediated regulation of the CYP3A4 gene

scientific article published on May 2004

Seizure control by ketogenic diet-associated medium chain fatty acids

scientific article (publication date: June 2013)

Site-specific, covalent incorporation of Tus, a DNA-binding protein, on ionic-complementary self-assembling peptide hydrogels using transpeptidase Sortase A as a conjugation tool†Dedicated to the memory of Joachim H. G. Steinke.‡Electronic supplemen

scientific article

Sodium valproate induces apoptosis in the rat hepatoma cell line, FaO.

scientific article published on November 2003

Strategies for using in vitro screens in drug metabolism

scientific article published on April 2004

Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices ⬇️

scientific article published on 20 April 2016

Systems biology approaches for studying the pathogenesis of non-alcoholic fatty liver disease

scientific article

The coordinate regulation of DNA synthesis and suppression of apoptosis is differentially regulated by the liver growth agents, phenobarbital and methylclofenapate

scientific article published in September 1998

The human cytochrome P450 sub-family: transcriptional regulation, inter-individual variation and interaction networks

scientific article published on 14 October 2006

The naturally occurring aliphatic isothiocyanates sulforaphane and erucin are weak agonists but potent non-competitive antagonists of the aryl hydrocarbon receptor ⬇️

scientific article published on May 30, 2012

The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1.

scientific article

The peroxisome proliferators are hepatocyte mitogens in chemically-defined media: glucocorticoid-induced PPAR alpha is linked to peroxisome proliferator mitogenesis

scientific article published in May 1998

The statin class of HMG-CoA reductase inhibitors demonstrate differential activation of the nuclear receptors PXR, CAR and FXR, as well as their downstream target genes

scientific article published on 9 April 2011

Transcriptional regulation of cytochrome P4503A4 gene expression: effects of inherited mutations in the 5′-flanking region, 33, pp. 1085–1095

Transcriptional regulation of the PXR gene: identification and characterization of a functional peroxisome proliferator-activated receptor alpha binding site within the proximal promoter of PXR.

scientific article published on 21 October 2005

Transcriptional regulation of the human pregnane-X receptor

scientific article

Transcriptomic and phylogenetic analysis of Kpna genes: a family of nuclear import factors modulated in xenobiotic-mediated liver growth

scientific article published in September 2006

Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

scientific article published in September 2007

Up-regulation of the glutathione S-transferase system in human liver by polycyclic aromatic hydrocarbons; comparison with rat liver and lung

scientific article published on 3 April 2008

Use of Reporter Genes to Measure Xenobiotic-Mediated Activation of CYP Gene Transcription

scientific article published on 01 January 2006

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