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List of works by Hendrik G. Kruger

(1R,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

scientific article

(1R,3S)-Methyl 6,7-dimeth-oxy-1-(4-meth-oxy-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate

scientific article

(1R,3S)-N-Benzhydryl-2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carbothio-amide

scientific article published on 25 November 2011

(1R,4S)-(−)-3,3-Ethylenedioxy-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one

(1S,3S)-Methyl 2-benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate.

scientific article

(1S,3S)-Methyl 6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxyl-ate

scientific article

(2-(Benzo[d]thia-zol-2yl-meth-oxy)-5-chloro-phen-yl)(phen-yl)methanone.

scientific article

(3S)-2-Benzyl-3-carb-oxy-1,2,3,4-tetra-hydro-isoquinolinium chloride monohydrate.

scientific article

(4-Hydr-oxy-3-nitro-benz-yl)methyl-ammonium chloride.

scientific article

(4R,5R)-Bis(hydroxydimethylmethyl)-2,2-dimethyl-1,3-dioxolane

(R)-4-Phenyl-2-[(S)-1,2,3,4-tetra-hydro-isoquinolin-3-yl]-4,5-dihydro-1,3-oxazole

scientific article

(S)-(+)-2-Formamido-4-methylpentanoic acid

(S)-(+)-2-Formylamino-3-methylbutanoic acid

(S)-2-Benzyl-N-(2,6-diisopropyl-phen-yl)-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide.

scientific article

(S)-4-Phenyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole

scientific article published on 21 December 2011

(S)-4-tert-Butyl-2-(1,2,3,4-tetra-hydro-isoquinolin-3-yl)-1,3-thia-zole

scientific article

(S)-Benzyl 3-phenyl-carbamoyl-1,2,3,4-tetra-hydro-isoquinoline-2-carboxyl-ate.

scientific article published on 29 February 2012

(S)-Methyl 2-benzamido-3-(3,4-dimeth-oxy-phen-yl)propano-ate.

scientific article published on 21 December 2011

(S)-Methyl 3-(3,4-dimethoxyphenyl)-2-[2-(diphenylphosphanyl)benzamido]propanoate ⬇️

scientific article published on November 12, 2011

(S)-N-Benzyl-2-methyl-1,2,3,4-tetra-hydro-isoquinoline-3-carboxamide

scientific article

1,2-Bis(2-aminophenoxy)ethane

1,7-Dimethyl-penta-cyclo-[5.4.0.0.0.0]undecane-8,11-dione.

scientific article

2-(3,5-Dimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoic acid.

scientific article

2-(4-Chloro-3-nitro-phen-yl)-4-(4-chloro-phen-yl)-1,3-thia-zole.

scientific article

2-(Tricyclo[3.3.1.1]dec-2-ylamino)ethanol hemihydrate.

scientific article

2-Methyltetrahydrofuran and cyclopentyl methyl ether for green solid-phase peptide synthesis

scientific article published on 24 September 2015

2-[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]-4-phenyl-1,3-thia-zole.

scientific article

3,5-Bis(2-hydroxyethyl)-4-oxahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecane

3-(2-Amino-1,3-thia-zol-4-yl)-6-bromo-2H-chromen-2-one

scientific article

3-(2-Amino-1,3-thia-zol-4-yl)-6-chloro-2H-chromen-2-one

scientific article

3-Benzyl-5,7-dimeth-oxy-chroman-4-ol

scientific article

6,7-Dimeth-oxy-3-meth-oxy-carbonyl-1-(2-meth-oxy-phen-yl)-3,4-dihydro-isoquinoline 2-oxide.

scientific article

6-(Bromomaleimido)hexanoic acid as a connector for the construction of multiple branched peptide platforms

scientific article

8,11-Dihydroxypentacycloundecane-8,11-lactam

8-(Biphenyl-4-yl)-8-hydroxy-penta-cyclo-[5.4.0.0.0.0]undecan-11-one ethyl-ene ketal

scientific article

8-Amino-11-hydroxypentacycloundecane-8,11-lactam

A 2018-2019 patent review of metallo beta-lactamase inhibitors

scientific article published on 12 May 2020

A Facile Synthesis of NODASA-Functionalized Peptide

A Review of Cyanoacetyl Indoles (CAIs): Versatile Starting Materials in Organic Synthesis

A Synthesis of "Dual Warhead" β-Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β-Sultams.

scientific article

A comparative modeling and molecular docking study on Mycobacterium tuberculosis targets involved in peptidoglycan biosynthesis.

scientific article

A critical survey of average distances between catalytic carboxyl groups in glycoside hydrolases.

scientific article published on 20 February 2014

A new and facile access to the 2-(indol-3-yl)-3-nitriloquinolines based on Friedländer annulations

A novel and more efficient biosynthesis approach for human insulin production in Escherichia coli (E. coli)

scientific article published on 10 March 2020

A pentacycloundecane dimer

A sensitive WST-8-based bioassay for PEGylated granulocyte colony stimulating factor using the NFS-60 cell line

scientific article

A structural investigation of 1,2 (bis-phenoxy)ethane and its derivatives

A theoretical study of pentacyclo-undecane cage peptides of the type [Ac-X-Y-NHMe].

scientific article published in February 2006

An Efficient Protecting-Group-Free Synthesis of Vinylic Sulfoximines via Horner–Wadsworth–Emmons Reaction

An efficient solid-phase strategy for total synthesis of naturally occurring amphiphilic marine siderophores: amphibactin-T and moanachelin ala-B.

scientific article

An improved and efficient strategy for the total synthesis of a colistin-like peptide

article published in 2016

An insight to the molecular interactions of the FDA approved HIV PR drugs against L38L↑N↑L PR mutant

scientific article

An unexpected re-arrangement of the antibiotic carbapenem core to new 1,4-diazepin-5-one scaffolds

scholarly article in RSC Advances, vol. 8 no. 1, 2018

Analysis of the conformational profile of trishomocubane amino acid dipeptide

scientific article published in April 2006

Anti-inflammatory activities of selected synthetic homoisoflavanones.

scientific article published on 27 September 2011

Anticancer activity of ruthenium(II) arene complexes bearing 1,2,3,4-tetrahydroisoquinoline amino alcohol ligands

scientific article published on 12 June 2013

Antimicrobial peptides: their role as infection-selective tracers for molecular imaging

scientific article

Applied Enantioselective Aminocatalysis: α-Heteroatom Functionalization Reactions on the Carbapenem (β-Lactam Antibiotic) Core

Artificial Intelligence vs. Statistical Modeling and Optimization of Continuous Bead Milling Process for Bacterial Cell Lysis

scientific article published on 22 November 2016

Asymmetric conjugate addition of thioglycolate to a range of chalcones using tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands

article

Bedaquiline has potential for targeting tuberculosis reservoirs in the central nervous system

scholarly article in RSC Advances, vol. 8 no. 22, 2018

Benzyl 5-hy-droxy-4-oxapenta-cyclo-[5.4.1.0.0.0]dodecane-3-carboxyl-ate ⬇️

scientific article

Binding Free Energy Calculations of Nine FDA-approved Protease Inhibitors Against HIV-1 Subtype C I36T↑T Containing 100 Amino Acids Per Monomer

scientific article

Bis- and trisindolylmethanes (BIMs and TIMs).

scientific article published on April 2010

Brain penetration of ketamine: Intranasal delivery VS parenteral routes of administraion

scientific article published on 20 February 2019

Catalytic asymmetric carbon–carbon bond forming reactions catalyzed by tetrahydroisoquinoline (TIQ) N,N′-dioxide ligands

Chapter 15. Cyclic Peptides as Privileged Structures

Chemical Platforms for Peptide Vaccine Constructs

scientific article published on 27 April 2015

Chemical speciation of copper(II) diaminediamide derivative of pentacycloundecane--a potential anti-inflammatory agent

scientific article published on 8 February 2007

Clofazimine protects against mycobacterium tuberculosis dissemination in the CNS following an aerosol challenge in a murine model.

scientific article

Comparison of the molecular dynamics and calculated binding free energies for nine FDA-approved HIV-1 PR drugs against subtype B and C-SA HIV PR.

scientific article published on 19 November 2012

Complete NMR Elucidation of Two N-Protected Trishomocubane Hydantoins and the Ethyl Ester of the Corresponding Amino Acid

Complete NMR elucidation of a novel trishomocubane hydantoin and its mono- and bis-t-Boc protected derivatives

scientific article

Computational study of the conformational preferences of the (R)-8-amino-pentacyclo[5.4.0.0(2,6).0(3,10).0(5,9)]undecane-8-carboxylic acid monopeptide

scientific article

Concerted hydrolysis mechanism of HIV-1 natural substrate against subtypes B and C-SA PR: insight through molecular dynamics and hybrid QM/MM studies

scientific article published on 16 January 2020

Correction to "Improved Synthesis and Isolation of Bedaquiline"

scientific article published on 09 September 2020

Crystal structure of (S)-N-benzyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, C17H20N2O2

Crystal structure of (S)-benzyl 3-(benzylcarba-moyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate, C25H24N2O3

Crystal structure of (S)-benzyl-3-{(4-bromophenyl)carbamoyl}-3,4-dihydroisoquinoline-2(1H)-carboxylate, C24H21BrN2O3

Crystal structure of (S)-tert-butyl 3-carbamothioyl-3,4-dihydroisoquinoline- 2(1H)-carboxylate, C63H86N8O9S4

Crystal structure of 2-(2,4-dioxopentan-3-yl)benzoic acid, C12H12O4

Crystal structure of 2-(bis(3,5-dimethylphenyl) ((methyldiphenylsilyl)oxy)methyl) pyrrolidine, C34H39NOSi

Crystal structure of 2-ethyl-1-tert-butyl 3-oxo-2-[phenyl(tert-butoxycarbonylamino)methyl]-1,2-pyrrolidinedicarboxylate, C24H34N2O7

Crystal structure of 2-isopropyl-(3,5-dimethyl-1,1-dioxo-2H-1,2,6- thiadiazine-4-yl)-benzoate, C15H18N2O4S

Crystal structure of 2-methyl-(2,4-dioxopentan-3-yl)benzoate, C13H14O4

Crystal structure of 4,10,16,22-tetrahydroxy-6,12,18,24-tetramethoxy-2,8,14,20-tetraethylphenylresorcin[4]arene – ethyl acetate (1/1), C68H72O10

Crystal structure of 5,11,17,23-tetra(tert-butyl)-25,26,27,28-tetrahexoxycalix[4]arene, C68H104O4

Crystal structure of 5-acetyl-3-(3-fluoro-4-morpholinophenyl)oxazolidin-2-one, C15H17FN2O4

Crystal structure of N-(2,6-diisopropylphenyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, C22H28N2O

Crystal structure of N-butyl-2-(3,5-dimethyl-1,1-dioxido-2H-1,2,6- thiadiazin-4-yl)benzamide, C16H21N3O3S

Crystal structure of bis(dicyclohexylammonium) 4-(2-carboxylatophenyl)- 3,5-dimethyl-1,2,6-thiadiazin-2-ide 1,1-dioxide methanol monosolvate, C37H62N4O5S

Crystal structure of bis(tert.-butylaminium) 4-(2-carboxylatophenyl)-3,5-dimethyl-4H-1,2,6-thiadiazin-4-ide 1,1-dioxide , C20H34N4O4S

Crystal structure of butyl 2-(3,5-dimethyl-1,1-dioxido-2H-1,2,6-thiadiazin-4-yl)benzoate, C16H20N2O4S

Crystal structure of methyl 1-(2-(fluorosulfonyl)ethyl)-2-oxocyclopentanecarboxylate, C9H13FO5S

Crystal structure of potassium 4-(2-carboxyphenyl)-3,5-dimethyl-1,2,6- thiadiazin-2-ide 1,1-dioxide monohydrate, C12H13KN2O5S

Cu(OAc)2 promoted Chan–Evans–Lam C–N cross coupling reactions on the N- and N′-nitrogen atoms of sulfonimidamides with aryl boronic acids

Design and study of peptide-based inhibitors of amylin cytotoxicity

scientific article published on 11 January 2010

Design of Ionic Liquid 3-Methyl-1-sulfonic Acid Imidazolium Nitrate as Reagent for the Nitration of Aromatic Compounds by in Situ Generation of NO2 in Acidic Media

scientific article published on 22 March 2012

Determination of the antitubercular drug PA-824 in rat plasma, lung and brain tissues by liquid chromatography tandem mass spectrometry: application to a pharmacokinetic study.

scientific article published on 9 March 2015

Development and Evaluation of Peptide-Functionalized Gold Nanoparticles for HIV Integrase Inhibition

article

Development and validation of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of tigecycline in rat brain tissues.

scientific article published on 17 September 2015

Differential flap dynamics in l,d-transpeptidase2 from mycobacterium tuberculosis revealed by molecular dynamics.

scientific article published on 8 May 2017

Diverse supramolecular arrangement of substituted oxopyrrolidine analogues influenced by weak intermolecular interactions (CH⋯O/CH⋯π/H⋯H)

Dynamics of the thumb-finger regions in a GH11 xylanase Bacillus circulans: comparison between the Michaelis and covalent intermediate

scholarly article in RSC Advances, vol. 5 no. 100, 2015

EDC·HCl and Potassium Salts of Oxyma and Oxyma-B as Superior Coupling Cocktails for Peptide Synthesis

Efficient Purification of rhG-CSF and its PEGylated Forms and Evaluation for In Vitro Activities

scientific article published in January 2015

Enantioselective Organocatalyzed Transformations of β-Ketoesters.

scientific article

Enhanced brain penetration of pretomanid by intranasal administration of an oil-in-water nanoemulsion

scientific article published on 23 May 2018

Enzymatic activation of a peptide functionalised gold nanoparticle system for prodrug delivery

scientific article

Erratum: Tetra-kis-μ-l-alanine-κO:O'-bis-[tetra-aqua-terbium(III)] hexa-perchlorate. Corrigendum.

scientific article published on 17 July 2010

Ethyl 2-(3,5-dimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoate

scientific article

Ethyl 4-(1,3-benzodioxol-5-yl)-6-methyl-2-sulfanylidene-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate

scientific article published on 29 October 2011

Ethyl 4-(4-chloro-phen-yl)-6-methyl-2-thioxo-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate

scientific article

Ethyl 4-(4-hydroxy-phen-yl)-6-methyl-2-oxo-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate monohydrate

scientific article

Ethyl 6-methyl-2-sulfanyl-idene-4-[4-(trifluoro-meth-yl)phen-yl]-1,2,3,4-tetra-hydro-pyrimidine-5-carboxyl-ate.

scientific article

Evaluating the Performance of a Non-Bonded Cu2+ Model Including Jahn-Teller Effect into the Binding of Tyrosinase Inhibitors ⬇️

scientific article published on 06 July 2020

Evaluation of MALDI Biotyping for Rapid Subspecies Identification of Carbapenemase-Producing Bacteria via Protein Profiling

Evaluation of a Flexible NOTA-RGD Kit Solution Using Gallium-68 from Different 68Ge/68Ga-Generators: Pharmacokinetics and Biodistribution in Nonhuman Primates and Demonstration of Solitary Pulmonary Nodule Imaging in Humans.

scientific article published on 14 October 2016

Evidence for the presence of clofazimine and its distribution in the healthy mouse brain.

scientific article published on 25 July 2015

Experimental and computational studies of the regioselective protection of hydantoins using anhydride

Exploring the concerted mechanistic pathway for HIV-1 PR-substrate revealed by umbrella sampling simulation

scientific article published on 19 October 2020

Exploring the flap dynamics of the South African HIV subtype C protease in presence of FDA-approved inhibitors: MD study

scientific article published on 24 September 2018

Fast and efficient detection of tuberculosis antigens using liposome encapsulated secretory proteins of Mycobacterium tuberculosis.

scientific article published on 8 July 2015

Friedländer Annulation in the Synthesis of Azaheterocyclic Compounds

From recognition to reaction mechanism: an overview on the interactions between HIV-1 protease and its natural targets

article

Green Solid-Phase Peptide Synthesis (GSPPS) 3. Green Solvents for Fmoc Removal in Peptide Chemistry

Green Solid-Phase Peptide Synthesis 2. 2-Methyltetrahydrofuran and Ethyl Acetate for Solid-Phase Peptide Synthesis under Green Conditions

article

Highly chemoselective ligation of thiol- and amino-peptides on a bromomaleimide core

scientific article

I36T↑T mutation in South African subtype C (C-SA) HIV-1 protease significantly alters protease-drug interactions

scientific article published on 19 May 2017

Identification of potent L,D-transpeptidase 5 inhibitors for Mycobacterium tuberculosis as potential anti-TB leads: virtual screening and molecular dynamics simulations

scientific article published on 28 October 2019

Immobilized coupling reagents: synthesis of amides/peptides.

scientific article

Improved Synthesis and Isolation of Bedaquiline

scientific article published on 17 February 2020

In silico modelling in the development of novel radiolabelled peptide probes

scientific article published on 03 May 2020

In vitro ADMET and physicochemical investigations of poly-N-methylated peptides designed to inhibit Abeta aggregation

scientific article published on July 2010

In vitro antifungal and antibacterial activities of pentacycloundecane tetra-amines.

scientific article published on 22 February 2011

In vitro evaluation of metal chelators as potential metallo- β -lactamase inhibitors

scientific article published on 5 February 2016

In vitro investigation of the antimicrobial activity of a series of lipophilic phenols and naphthols

Inhibition mechanism of L,D-transpeptidase 5 in presence of the β-lactams using ONIOM method

scientific article published on 28 November 2018

Integrated approach to structure-based enzymatic drug design: molecular modeling, spectroscopy, and experimental bioactivity

scientific article published on 11 September 2013

Interaction of beta-amyloid interactions with peptide functionalized gold nanoparticles.

scientific article

Interconvertions between delta-lactam and delta-lactone derivatives initiated by unique transannular interactions of the rigid cyclohexane boat structure in pentacycloundecane

scientific article

Intracellular localization of gold nanoparticles with targeted delivery in MT-4 lymphocytes

article published in 2016

Investigating time dependent brain distribution of nevirapine via mass spectrometric imaging

scientific article published on 04 November 2019

Investigation and folding pattern of l-ido and d-gluco peptides by EASY ROESY NMR and X-ray

article by Sachin A. Pawar et al published 2013 in RSC Advances

Investigation of the binding free energies of FDA approved drugs against subtype B and C-SA HIV PR: ONIOM approach.

scientific article

Iridium-catalyzed asymmetric hydrogenation of olefins using TIQ phosphine–oxazoline ligands

scholarly article by Sai Kumar Chakka et al published September 2010 in Tetrahedron: Asymmetry

Kinetic and thermodynamic characterisation of HIV-protease inhibitors against E35D↑G↑S mutant in the South African HIV-1 subtype C protease

scientific article published on 01 December 2019

Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent.

scientific article

Linear and cyclic glycopeptide as HIV protease inhibitors

scientific article published on 29 November 2012

Lysine Scanning of Arg-Teixobactin: Deciphering the Role of Hydrophobic and Hydrophilic Residues

scientific article published on 19 December 2016

MALDI MSI and LC-MS/MS: Towards preclinical determination of the neurotoxic potential of fluoroquinolones.

scientific article published on 18 September 2015

Mass Spectrometric Imaging of the Brain Demonstrates the Regional Displacement of 6-Monoacetylmorphine by Naloxone

scientific article published on 27 May 2020

Mass Spectrometry Imaging Demonstrates the Regional Brain Distribution Patterns of Three First-Line Antiretroviral Drugs

scientific article published on 05 December 2019

Mass spectrometric investigations into the brain delivery of abacavir, stavudine and didanosine in a rodent model

scientific article published on 29 August 2019

Mechanistic investigation of the uncatalyzed esterification reaction of acetic acid and acid halides with methanol: a DFT study.

scientific article published on 7 September 2016

Metabolic Imaging of Infection.

scientific article published on 17 August 2017

Methyl 1-cyclo-hexyl-6,7-dimeth-oxy-3,4-dihydro-isoquinoline-3-carboxyl-ate. ⬇️

scientific article

Methyl 2-(2,3,5-trimethyl-1,1-dioxo-2H-1λ(6),2,6-thia-diazin-4-yl)benzoate

scientific article published on 17 November 2012

Microreactors for peptide synthesis: looking through the eyes of twenty first century !!!

scientific article published on 25 June 2014

Microwave assisted SPPS of amylin and its toxicity of the pure product to RIN-5F cells

scientific article

Microwave-Assisted Synthesis of Antimicrobial Peptides.

scientific article

Microwave-Assisted Synthesis of Guanidine Organocatalysts Bearing a Tetrahydroisoquinoline Framework and Their Evaluation in Michael Addition Reactions

article

Microwave-assisted synthesis of meso-carboxyalkyl-BODIPYs and an application to fluorescence imaging

scientific article published on 28 September 2020

Molecular Modeling of T. rangeli, T. brucei gambiense, and T. evansi Sialidases in Complex with the DANA Inhibitor

scientific article published on 13 April 2012

Molecular insight on the non-covalent interactions between carbapenems and l,d-transpeptidase 2 from Mycobacterium tuberculosis: ONIOM study

scientific article published on 29 May 2018

N,N'-[(8-endo,11-endo-Dihy-droxy-penta-cyclo-[5.4.0.0.0.0]undecane-8,11-di-yl)bis-(methyl-enecarbon-yl)]di-l-phenyl-alanine

scientific article

N-(2-Hydroxy-ethyl)-N-(tricyclo-[3.3.1.1]dec-2-yl)benzamide.

scientific article

N-(Adamantan-1-yl)-2-chloro-acetamide

scientific article

N-Benzyl-5-(dimethyl-amino)-naphthalene-1-sulfonamide

scientific article

N-Trifluoromethylthiolated Sulfonimidamides and Sulfoximines: Anti-microbial, Anti-mycobacterial, and Cytotoxic Activity

scientific article published on 11 September 2019

NMR assignments of a di-pentacyclo-undecane cyclic ether

scientific article

NMR elucidation of a novel (S)-pentacyclo-undecane bis-(4-phenyloxazoline) ligand and related derivatives

scientific article

NMR elucidation of novel SQ109 derivatives

NMR elucidation of novel ligands derived from (R)-(+)-camphor

NMR elucidation of some ligands derived from the pentacycloundecane skeleton

NMR elucidation of some pentacycloundecane derived ligands

NOTA: a potent metallo-β-lactamase inhibitor.

scientific article published on 6 January 2015

Nanotechnology and the treatment of HIV infection.

scientific article

Neuroprotective potential of Linezolid: a quantitative and distribution study via mass spectrometry.

scientific article published on 21 June 2016

Novel PCU cage diol peptides as potential targets against wild-type CSA HIV-1 protease: synthesis, biological screening and molecular modelling studies

article

Novel approach to sodium hydroxide separation: synergistic pseudo-hydroxide extraction by a fluorinated alcohol and cage-functionalized crown ethers

scientific article published in December 2001

Novel linear diamine disubstituted polycyclic 'cage' derivatives as potential antimycobacterial candidates.

scientific article published on 24 October 2011

Novel polycyclic 'cage'-1,2-diamines as potential anti-tuberculosis agents.

scientific article published on 4 April 2012

Novel tetrahydroisoquinoline based organocatalysts for asymmetric Diels–Alder reactions: insight into the catalytic mode using ROESY NMR and DFT studies

On-Water Synthesis of Biaryl Sulfonyl Fluorides

scientific article published on 29 February 2016

Optically active diaryl tetrahydroisoquinoline derivatives

scientific article published on 08 February 2011

Optimized Microwave Assisted Synthesis of LL37, a Cathelicidin Human Antimicrobial Peptide

Optimized Procedure for Recovering HIV-1 Protease (C-SA) from Inclusion Bodies

article

Organocatalytic Mannich Reactions on a Carbapenem Core - Synthesis of Mannich Bases and Bicyclic Diazanonanes

Organocatalyzed Mannich reactions on minocycline: Towards novel tetracycline antibiotics

Organocatalyzed stereospecific C-C bond formation of β-lactams

scientific article published on 11 November 2013

Oxyma-B, an excellent racemization suppressor for peptide synthesis

scientific article published in November 2014

Oxyma-T, expanding the arsenal of coupling reagents

Pentacyclo-undecane derived cyclic tetra-amines: synthesis and evaluation as potent anti-tuberculosis agents

scientific article

Pentacyclo[5.4.0.02,6.03,10.05,9]undecane-8,11-dione ethylene acetal

Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease inhibitors

scientific article published on 16 August 2011

Pentacycloundecane lactam vs lactone norstatine type protease HIV inhibitors: binding energy calculations and DFT study

scientific article

Pentacycloundecane-based inhibitors of wild-type C-South African HIV-protease

scientific article published on March 2011

Pentacycloundecane-diol-based HIV-1 protease inhibitors: biological screening, 2D NMR, and molecular simulation studies

scientific article published on 27 April 2012

Peptide Functionalised Gold Nanoparticles: Effect of Loading on Aggregation and Proteolysis

scholarly article by Lauren K. Pietersen et al published 10 August 2010 in International Journal of Peptide Research and Therapeutics

Peptide synthesis beyond DMF: THF and ACN as excellent and friendlier alternatives

scientific article published in February 2015

Peptide synthesis, characterization and ⁶⁸Ga-radiolabeling of NOTA-conjugated ubiquicidin fragments for prospective infection imaging with PET/CT.

scientific article

Polycyclic Cage Structures as Lipophilic Scaffolds for Neuroactive Drugs ⬇️

scientific article published on 03 February 2012

Pore formation in phospholipid bilayers by amphiphilic cavitands

scientific article published on 20 April 2011

Post heroin dose tissue distribution of 6-monoacetylmorphine (6-MAM) with MALDI imaging

scientific article

Potential inhibition of HIV-1 encapsidation by oligoribonucleotide-dendrimer nanoparticle complexes.

scientific article published on 04 January 2017

Preclinical Assessment of a 68Ga-DOTA-Functionalized Depsipeptide as a Radiodiagnostic Infection Imaging Agent.

scientific article published on 24 August 2017

Preclinical evaluation of 68Ga-labeled 1,4,7-triazacyclononane-1,4,7-triacetic acid-ubiquicidin as a radioligand for PET infection imaging

scientific article published on 16 January 2014

Proline N-oxides: modulators of the 3D conformation of linear peptides through "NO-turns".

scientific article

Purification and characterization of naturally occurring HIV-1 (South African subtype C) protease mutants from inclusion bodies.

scientific article

Rapid and widespread distribution of doxycycline in rat brain: a mass spectrometric imaging study.

scientific article

Re-evaluation of the N-terminal substitution and the D-residues of teixobactin

scholarly article in RSC Advances, vol. 6 no. 77, 2016

Rilpivirine as a potential candidate for the treatment of HIV-associated neurocognitive disorders (HAND)

scientific article published on 22 April 2019

SQ109 analogues as potential antimicrobial candidates

Serendipitous discovery of new pentacycloundecane molecules ⬇️

scholarly article

Short AntiMicrobial Peptides (SAMPs) as a class of extraordinary promising therapeutic agents.

scientific article published on July 2016

Simulating the inhibition reaction of Mycobacterium tuberculosis L,D-transpeptidase 2 by carbapenems.

scientific article

Small molecule distribution in rat lung: a comparison of various cryoprotectants as inflation media and their applicability to MSI.

scientific article published on 13 January 2016

Solid-phase peptide synthesis (SPPS), C-terminal vs. side-chain anchoring: a reality or a myth.

scientific article published on 26 April 2014

Spatial distribution of elvitegravir and tenofovir in rat brain tissue: Application of matrix-assisted laser desorption/ionization mass spectrometry imaging and liquid chromatography/tandem mass spectrometry

scientific article published on 01 November 2019

Structural and functional features of enzymes of Mycobacterium tuberculosis peptidoglycan biosynthesis as targets for drug development.

scientific article

Structure and function of L,D- and D,D-transpeptidase family enzymes from Mycobacterium tuberculosis

scientific article published on 3 December 2018

Structure elucidation of 11-amino-8-hydroxypentacyclo[5.4.0.0(2, 6).0(3, 10).0(5, 9)]undecane-8,11-lactam through selective acetylation and complete 1H and 13C NMR spectral assignment of the mono-, di- and triacetates

scientific article published in April 2004

Sulfonimidamide in medizinischer Chemie und Agrochemie

Sulfonimidamides in Medicinal and Agricultural Chemistry

scientific article published on 13 December 2016

Synthesis and Biological Evaluation of a Teixobactin Analogue

scientific article published on 10 December 2015

Synthesis and NMR assignment of pentacycloundecane precursors of potential pharmaceutical agents

scientific article published on 01 March 2010

Synthesis and NMR elucidation of homoisoflavanone analogues

Synthesis and NMR elucidation of novel amino acid cavitand derivatives

Synthesis and NMR elucidation of novel octa-amino acid resorcin[4]arenes derivatives

Synthesis and NMR elucidation of novel penta-cycloundecane amine derivatives as potential antituberculosis agents

scientific article

Synthesis and NMR elucidation of novel pentacyclo-undecane diamine ligands

Synthesis and NMR elucidation of novel pentacycloundecane-based peptides

scientific article published in June 2010

Synthesis and NMR elucidation of novel tetrapeptides

scientific article published on 11 November 2011

Synthesis and NMR elucidation of pentacyclo-undecane diamine derivatives as potential anti-tuberculosis drugs

scholarly article by Thavendran Govender et al published 31 July 2008 in Structural Chemistry

Synthesis and NMR elucidation of pentacycloundecane-derived hydroxy acid peptides as potential anti-HIV-1 agents

article

Synthesis and Screening of C1-Substituted Tetrahydroisoquinoline Derivatives for Asymmetric Transfer Hydrogenation Reactions

Synthesis and evaluation of SQ109 analogues as potential anti-tuberculosis candidates

scientific article published on 28 January 2010

Synthesis and molecular modelling studies of novel carbapeptide analogs for inhibition of HIV-1 protease.

scientific article published on 4 April 2012

Synthesis and structural studies of pentacycloundecane-based HIV-1 PR inhibitors: a hybrid 2D NMR and docking/QM/MM/MD approach

scientific article published on 7 June 2011

Synthesis and transport studies of a new class of cage-annulated chiral macrocycles

Synthesis of arylidenepyruvic amide derivatives via Ugi-four component condensation

Synthesis of chiral pentacyclo-undecane ligands and their use in the enantioselective alkylation of benzaldehyde with diethylzinc

Synthesis of chiral pentacyclo-undecane macrocycles and their use in enantioselective Michael addition reactions

article

Synthesis of novel 1,2,4-thiadiazinane 1,1-dioxides via three component SuFEx type reaction

scholarly article in RSC Advances, vol. 8 no. 65, 2018

Synthesis of novel N-alkyl-2-(3,5-dimethyl-1,1-dioxido-2H-1,2,6-thiadiazin-4-yl)benzamides as potential antimicrobial agents

Synthesis of tetrahydroisoquinoline (TIQ)–oxazoline ligands and their application in enantioselective Henry reactions

Synthesis of tetrahydroisoquinoline-diamine ligands and their application in asymmetric transfer hydrogenation

Synthesis, 2D-NMR and molecular modelling studies of pentacycloundecane lactam-peptides and peptoids as potential HIV-1 wild type C-SA protease inhibitors

scientific article

Synthesis, 68Ga-radiolabeling, and preliminary in vivo assessment of a depsipeptide-derived compound as a potential PET/CT infection imaging agent

scientific article

Synthesis, Characterization and Biocompatibility of a Multifunctional Gold Nanoparticle System for the Delivery of Single-Stranded RNA to Lymphocytes

Synthesis, Crystal Structure and DFT Studies of 1,3-Dimethyl-5-propionylpyrimidine-2,4,6(1H,3H,5H)-trione

Synthesis, in vitro evaluation, and 68 Ga-radiolabeling of CDP1 toward PET/CT imaging of bacterial infection.

scientific article published on 22 March 2017

Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors

article

Synthetic approaches to radiochemical probes for imaging of bacterial infections.

scientific article published on 29 March 2017

TOMBU and COMBU as Novel Uronium-type peptide coupling reagents derived from Oxyma-B.

scientific article published on 18 November 2014

Targeting the cell wall of Mycobacterium tuberculosis: a molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2.

scientific article published on 12 March 2015

Tetra-kis-μ-l-alanine-κO:O'-bis-[tetra-aqua-terbium(III)] hexa-perchlorate.

scientific article

Tetrahydroisoquinoline-Based N-Oxides as Chiral Organocatalysts for the Asymmetric Allylation of Aldehydes

The Driving Force for the Acylation of β-Lactam Antibiotics by L,D-Transpeptidase 2: Quantum Mechanics/Molecular Mechanics (QM/MM) Study

scientific article published on 10 April 2019

The catalytic role of water in the binding site of l,d-transpeptidase 2 within acylation mechanism: A QM/MM (ONIOM) modelling

scientific article published on 19 October 2018

The downfall of TBA-354 - a possible explanation for its neurotoxicity via mass spectrometric imaging.

scientific article published in September 2017

The effect of N-methylation of amino acids (Ac-X-OMe) on solubility and conformation: a DFT study.

scientific article published on 20 August 2015

The impact of active site mutations of South African HIV PR on drug resistance: Insight from molecular dynamics simulations, binding free energy and per-residue footprints

scientific article published on April 2014

The role of nanotechnology in the treatment of viral infections.

scientific article

Theoretical Model for HIV-1 PR That Accounts for Substrate Recognition and Preferential Cleavage of Natural Substrates

scientific article published on 22 July 2019

Therapeutic Peptides ⬇️

scientific article published on August 1, 2012

Time-dependent regional brain distribution of methadone and naltrexone in the treatment of opioid addiction.

scientific article published on 14 February 2018

Tissue distribution of pretomanid in rat brain via mass spectrometry imaging

scientific article published on 24 July 2015

Total synthesis of a depsidomycin analogue by convergent solid-phase peptide synthesis and macrolactonization strategy for antitubercular activity.

scientific article published on 18 July 2011

Towards a stereoselective synthesis of α,α-disubstituted proline analogues

Trishomocubane Amino Acid as a β-turn scaffold

Visualization of Time-Dependent Distribution of Rifampicin in Rat Brain Using MALDI MSI and Quantitative LCMS/MS.

scientific article published on 12 June 2015

Zidovudine and Lamivudine as Potential Agents to Combat HIV-Associated Neurocognitive Disorder

scientific article published on 01 October 2019

[(1R,3S)-6,7-Dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl]methanol 2.33-hydrate

scientific article

[2-(1,3-Benzothia-zol-2-ylmeth-oxy)-5-bromo-phen-yl](4-chloro-phen-yl)methanone

scientific article published on 12 December 2012

endo-11-(Dibenzyl-amino)-tetra-cyclo-[5.4.0.0.0]undecane-8-one.

scientific article

exo-8,exo-11-Diallylpentacyclo[5.4.0.02,6.03,10.05,9]undecane-endo-8,endo-11-diol

exo-8,exo-11-Divinylpentacyclo[5.4.0.02,6.03,10.05,6]undecane-endo-8,endo-11-diol

l-Proline organocatalyzed Michael synthesis of monobactam and carbapenem β-lactam cores

tert-Butyl N-[(11-exo-benzyl-oxy-carbonyl-8-oxopenta-cyclo-[5.4.0.0.0.0]undecane-11-endo-yloxy)carbon-yl-methyl]carbamate

scientific article

{(1R,3S)-2-Benzyl-6,7-dimeth-oxy-1-phenyl-1,2,3,4-tetra-hydro-isoquinolin-3-yl}diphenyl-methanol.

scientific article

{2-[(1,3-Benzo-thia-zol-2-yl)meth-oxy]-5-fluoro-phen-yl}(4-chloro-phen-yl)methanone

scientific article published on 08 June 2013

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