List of works - Luke W. Guddat

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs

scientific article published on January 2011

A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.

scientific article

Acetohydroxyacid synthase: a target for antimicrobial drug discovery

scientific article published in January 2014

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity

scientific article

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents

scientific article

Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle

scientific article

Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction.

scientific article published on 14 June 2012

Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse

scientific article published on 15 June 2020

Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom.

scientific article published on 30 December 2015

Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives

scientific article published on 25 August 2011

Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase

scientific article

Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF

scientific article published on 25 August 2020

Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity.

scientific article published on 4 October 2017

Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)

scientific article

Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors

scientific article

Crystal structures of Trypanosoma brucei hypoxanthine - guanine - xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP

scientific article published on 24 July 2019

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle

scientific article

Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase

scientific article

Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis

scientific article published on 10 June 2006

Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase

scientific article published on 01 August 1999

Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE).

scientific article published on 23 August 2001

Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl.

scientific article published on 18 December 2003

Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae

scientific article

Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroxyacid synthase

scientific article published on 23 August 2001

Crystallographic Analysis of Antigen-Antibody Complexes: End-on Insertion of Ligands in Antibodies-CDR3 Loops as Arbiters

scientific article published on 01 June 1996

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.

scientific article published on 21 November 2017

Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry

scientific article published on 12 January 2014

Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor

scientific article published on 21 March 2020

Editorial [Hot Topic:Drug Targets for the Treatment of Protozoan Parasitic Diseases (Guest Editor: Luke Guddat)]

scientific article published on 01 January 2011

Facile crystallization of Escherichia coli ketol-acid reductoisomerase

scientific article

Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase

scientific article

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase.

scientific article published on 5 April 2006

Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?

scientific article

Identification of mammalian-like purple acid phosphatases in a wide range of plants.

scientific article published in May 2000

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics

scientific article

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

scientific article

Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids

scientific article published on 05 November 2008

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents

scientific article

International Year of Crystallography

scientific article

Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases

scientific article published on 01 December 2006

Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase

scientific article

Penicillin inhibitors of purple acid phosphatase

scientific article published on 04 February 2012

Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase.

scientific article

Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter

scientific article

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

scientific article published in April 2004

Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger

scientific article published on 24 August 2007

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy

scientific article published in June 2010

Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site

scientific article published in January 2005

Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics

scientific article published on 03 August 2018

Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase

scientific article published on 19 September 2018

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir)

scientific article

Structural aspects of conformational changes in ligand binding by antibody fragments.

scientific article published on January 1994

Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria

scientific article published on 29 June 2020

Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC

scientific article published on 30 October 2020

Structure and mechanism of inhibition of plant acetohydroxyacid synthase.

scientific article

Structure of CcmG/DsbE at 1.14 A resolution: high-fidelity reducing activity in an indiscriminately oxidizing environment

scientific article

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

scientific article

Structure-activity relationships for a new family of sulfonylurea herbicides

scientific article published in November 2005

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol

scientific article

Structures of fungal and plant acetohydroxyacid synthases

scientific article published on 08 July 2020

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes

scientific article

Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.

scientific article published on 4 September 2019

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.

scientific article

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

scientific article published on December 2011

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

scientific article published on 25 July 2009

Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases

scientific article published on 22 June 2012

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

scientific article published on 30 December 2011

Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis

scientific article published on 13 August 2019

Systematic characterization of mutations in yeast acetohydroxyacid synthase. Interpretation of herbicide-resistance data

scientific article

The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-β-lactamases and arginases.

scientific article published on 08 February 2014

The catalytic mechanisms of binuclear metallohydrolases.

scientific article published on August 2006

The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. ⬇️

scientific article

The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle

scientific article

The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate

scientific article

The effect of fast protein liquid chromatography (FPLC) cationic exchange purification on the crystallization of a monoclonal Fab fragment

scientific article published on 01 May 1988

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

scientific article published on 22 June 2013

The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis

scientific article

The structure of Human Microplasmin in Complex with Textilinin-1, an Aprotinin-like Inhibitor from the Australian Brown Snake ⬇️

scientific article published on January 15, 2013

The structure-activity relationship in herbicidal monosubstituted sulfonylureas

scientific article published on 02 November 2011

Three-dimensional structure of a human Fab with high affinity for tetanus toxoid

scientific article

Three-dimensional structure of an Fv from a human IgM immunoglobulin

scientific article published on November 5, 1992

Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties

scientific article

Three-dimensional structure of the alpha-conotoxin GI at 1.2 A resolution

scientific article

List of works by Luke W. Guddat

6-oxopurine phosphoribosyltransferase: a target for the development of antimalarial drugs

A focused sulfated glycoconjugate Ugi library for probing heparan sulfate-binding angiogenic growth factors.

Acetohydroxyacid synthase: a target for antimicrobial drug discovery

Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity

Aza-acyclic nucleoside phosphonates containing a second phosphonate group as inhibitors of the human, Plasmodium falciparum and vivax 6-oxopurine phosphoribosyltransferases and their prodrugs as antimalarial agents

Bacterial and plant ketol-acid reductoisomerases have different mechanisms of induced fit during the catalytic cycle

Binuclear metallohydrolases: complex mechanistic strategies for a simple chemical reaction.

Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse

Characterization and structural analysis of a potent anticoagulant phospholipase A2 from Pseudechis australis snake venom.

Chemical synthesis, in vitro acetohydroxyacid synthase (AHAS) inhibition, herbicidal activity, and computational studies of isatin derivatives

Commercial Herbicides Can Trigger the Oxidative Inactivation of Acetohydroxyacid Synthase

Cryo-EM structure of trimeric Mycobacterium smegmatis succinate dehydrogenase with a membrane-anchor SdhF

Crystal Structures of Staphylococcus aureus Ketol-Acid Reductoisomerase in Complex with Two Transition State Analogues that Have Biocidal Activity.

Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the venom of the Australian common brown snake (Pseudonaja textilis)

Crystal structure of yeast acetohydroxyacid synthase: a target for herbicidal inhibitors

Crystal structures of Trypanosoma brucei hypoxanthine - guanine - xanthine phosphoribosyltransferase in complex with IMP, GMP and XMP

Crystal structures of a purple acid phosphatase, representing different steps of this enzyme's catalytic cycle

Crystal structures of two novel sulfonylurea herbicides in complex with Arabidopsis thaliana acetohydroxyacid synthase

Crystallization and preliminary X-ray analysis of a Kunitz-type inhibitor, textilinin-1 from Pseudonaja textilis textilis

Crystallization and preliminary X-ray diffraction studies of mammalian purple acid phosphatase

Crystallization and preliminary diffraction studies of native and selenomethionine CcmG (CycY, DsbE).

Crystallization of Arabidopsis thaliana acetohydroxyacid synthase in complex with the sulfonylurea herbicide chlorimuron ethyl.

Crystallization of the FAD-independent acetolactate synthase of Klebsiella pneumoniae

Crystallization of the catalytic subunit of Saccharomyces cerevisiae acetohydroxyacid synthase

Crystallographic Analysis of Antigen-Antibody Complexes: End-on Insertion of Ligands in Antibodies-CDR3 Loops as Arbiters

Design of Plasmodium vivax Hypoxanthine-Guanine Phosphoribosyltransferase Inhibitors as Potential Antimalarial Therapeutics.

Determination of the catalytic activity of binuclear metallohydrolases using isothermal titration calorimetry

Discovery, synthesis and evaluation of a novel ketol-acid reductoisomerase inhibitor

Editorial [Hot Topic:Drug Targets for the Treatment of Protozoan Parasitic Diseases (Guest Editor: Luke Guddat)]

Facile crystallization of Escherichia coli ketol-acid reductoisomerase

Herbicide-binding sites revealed in the structure of plant acetohydroxyacid synthase

Identification and molecular modeling of a novel, plant-like, human purple acid phosphatase.

Identification of a non-purple tartrate-resistant acid phosphatase: an evolutionary link to Ser/Thr protein phosphatases?

Identification of mammalian-like purple acid phosphatases in a wide range of plants.

Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics

Inhibition of hypoxanthine-guanine phosphoribosyltransferase by acyclic nucleoside phosphonates: a new class of antimalarial therapeutics

Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids

Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents

International Year of Crystallography

Lead compounds for antimalarial chemotherapy: purine base analogs discriminate between human and P. falciparum 6-oxopurine phosphoribosyltransferases

Molecular basis of sulfonylurea herbicide inhibition of acetohydroxyacid synthase

Penicillin inhibitors of purple acid phosphatase

Phosphate forms an unusual tripodal complex with the Fe-Mn center of sweet potato purple acid phosphatase.

Phosphate-bound structure of an organophosphate-degrading enzyme from Agrobacterium radiobacter

Phosphotyrosyl peptides and analogues as substrates and inhibitors of purple acid phosphatases

Plant collagenase: unique collagenolytic activity of cysteine proteases from ginger

Plasmodium vivax hypoxanthine-guanine phosphoribosyltransferase: a target for anti-malarial chemotherapy

Probing the mechanism of the bifunctional enzyme ketol-acid reductoisomerase by site-directed mutagenesis of the active site

Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics

Pyrrolidine nucleoside bisphosphonates as antituberculosis agents targeting hypoxanthine-guanine phosphoribosyltransferase

Role of human hypoxanthine guanine phosphoribosyltransferase in activation of the antiviral agent T-705 (favipiravir)

Structural aspects of conformational changes in ligand binding by antibody fragments.

Structural basis for the broad substrate specificity of two acyl-CoA dehydrogenases FadE5 from mycobacteria

Structural basis of trehalose recycling by the ABC transporter LpqY-SugABC

Structure and mechanism of inhibition of plant acetohydroxyacid synthase.

Structure of CcmG/DsbE at 1.14 A resolution: high-fidelity reducing activity in an indiscriminately oxidizing environment

Structure of the RNA-dependent RNA polymerase from COVID-19 virus

Structure-activity relationships for a new family of sulfonylurea herbicides

Structures of cell wall arabinosyltransferases with the anti-tuberculosis drug ethambutol

Structures of fungal and plant acetohydroxyacid synthases

Substrate-Promoted Formation of a Catalytically Competent Binuclear Center and Regulation of Reactivity in a Glycerophosphodiesterase from Enterobacter aerogenes

Sulfide, sulfoxide and sulfone bridged acyclic nucleoside phosphonates as inhibitors of the Plasmodium falciparum and human 6-oxopurine phosphoribosyltransferases: Synthesis and evaluation.

Sulfonylureas have antifungal activity and are potent inhibitors of Candida albicans acetohydroxyacid synthase.

Synthesis of 9-phosphonoalkyl and 9-phosphonoalkoxyalkyl purines: evaluation of their ability to act as inhibitors of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

Synthesis of branched 9-[2-(2-phosphonoethoxy)ethyl]purines as a new class of acyclic nucleoside phosphonates which inhibit Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

Synthesis of novel N-branched acyclic nucleoside phosphonates as potent and selective inhibitors of human, Plasmodium falciparum and Plasmodium vivax 6-oxopurine phosphoribosyltransferases

Synthesis of purine N9-[2-hydroxy-3-O-(phosphonomethoxy)propyl] derivatives and their side-chain modified analogs as potential antimalarial agents

Synthesis, evaluation and structural investigations of potent purple acid phosphatase inhibitors as drug leads for osteoporosis

Systematic characterization of mutations in yeast acetohydroxyacid synthase. Interpretation of herbicide-resistance data

The applications of binuclear metallohydrolases in medicine: recent advances in the design and development of novel drug leads for purple acid phosphatases, metallo-β-lactamases and arginases.

The catalytic mechanisms of binuclear metallohydrolases.

The crystal structure of a bacterial class II ketol-acid reductoisomerase: domain conservation and evolution. ⬇️

The crystal structure of free human hypoxanthine-guanine phosphoribosyltransferase reveals extensive conformational plasticity throughout the catalytic cycle

The crystal structures of Klebsiella pneumoniae acetolactate synthase with enzyme-bound cofactor and with an unusual intermediate

The effect of fast protein liquid chromatography (FPLC) cationic exchange purification on the crystallization of a monoclonal Fab fragment

The effect of novel [3-fluoro-(2-phosphonoethoxy)propyl]purines on the inhibition of Plasmodium falciparum, Plasmodium vivax and human hypoxanthine-guanine-(xanthine) phosphoribosyltransferases.

The organophosphate-degrading enzyme from Agrobacterium radiobacter displays mechanistic flexibility for catalysis

The structure of Human Microplasmin in Complex with Textilinin-1, an Aprotinin-like Inhibitor from the Australian Brown Snake ⬇️

The structure-activity relationship in herbicidal monosubstituted sulfonylureas