List of works - Rosaria Gitto

1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice

scientific article

1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

scientific article published in April 1997

3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists

scientific article published in August 1998

3D Pharmacophore Models for 1,2,3,4-Tetrahydroisoquinoline Derivatives Acting as Anticonvulsant Agents

scientific article published on 01 July 2006

4,5-Dihydro-7,8-dimethoxy-1-phenyl-3H-2,3-benzodiazepin-4-one

scientific article

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

scientific article

5-phenyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8(7H)-one.

scientific article published on 11 February 2003

7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists

scientific article published on 01 April 1998

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

scientific article published on 20 February 2014

AMPA receptor antagonists as potential anticonvulsant drugs

scientific article

Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats.

scientific article published in August 1999

Binding modes of noncompetitive AMPA antagonists: a computational approach

scientific article

Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms

scientific article

Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors

scientific article published on 18 October 2016

Closing in on the AMPA receptor: synthesis and evaluation of 2-acetyl-1-(4'-chlorophenyl)-6-methoxy-7-[11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer

scientific article

Combined strategies for the discovery of ionotropic glutamate receptor antagonists

scientific article

Comparative anticonvulsant activity of N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives in rodents

scientific article

Comparative anticonvulsant activity of some 2,3-benzodiazepine derivatives in rodents

scientific article published in February 2003

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

scientific article published on 03 August 2016

Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile

scientific article published in October 2008

Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists

scientific article published in February 2002

Determination of 2,3-benzodiazepine derivatives in rat plasma by high-performance liquid chromatography

scientific article published on 01 June 1999

Determination of a potent non-competitive AMPA receptor antagonist in rat brain

scientific article published on 5 December 2006

Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists

scientific article published on 31 December 2008

Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist

scientific article

Discovery of benzimidazole-based L. mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis.

scientific article published on 4 May 2018

Effects of non-competitive AMPA receptor antagonists injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy.

scientific article published on 9 August 2006

Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy

scientific article published on 2 June 2008

Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile

scientific article published on 06 June 2019

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety

scientific article published on 01 December 2018

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

scientific article

From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands

scientific article published on 15 November 2013

GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice

scientific article published on 01 December 1995

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation

scientific article

High-performance liquid chromatographic determination of new 2,3-benzodiazepines ⬇️

scientific article published on January 23, 1998

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies

scientific article

Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening

scientific article published on 27 July 2018

Identification of potent and selective human carbonic anhydrase VII (hCA VII) inhibitors

scientific article published in June 2010

Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with beta-cyclodextrin

scientific article published on 5 August 2008

Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.

scientific article published on 2 June 2013

Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases

scientific article published on 23 November 2017

In Vivo Evaluation of Selective Carbonic Anhydrase Inhibitors as Potential Anticonvulsant Agents

scientific article published on 24 February 2016

Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms

scientific article published on 04 March 2020

Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors.

scientific article

N-substituted isoquinoline derivatives as potential AChE inhibitors

New AMPA antagonists in epilepsy.

scientific article published on 13 July 2012

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays

scientific article published on 9 August 2013

New trends in the development of AMPA receptor antagonists

article

Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton

scientific article published in September 2006

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors

scientific article published on 2 May 2015

Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists

scientific article published on March 2003

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

scientific article published in August 2009

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.

scientific article published on 28 April 2017

QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor

scientific article published in March 2004

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors

scientific article published on 25 July 2016

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease

scientific article published on 01 December 2020

Relationship Between Anticonvulsant Activity and Plasma Level of Some 2,3-Benzodiazepines in Genetically Epilepsy-Prone Rats

scientific article published on 01 November 1998

SPE-HPLC determination of new tetrahydroisoquinoline derivatives in rat plasma

scientific article published in July 2005

Searching for indole derivatives as potential mushroom tyrosinase inhibitors

scientific article published on 31 March 2015

Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives

scientific article published on 01 December 2019

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

scientific article published on 17 September 2010

Solution-phase parallel synthesis and evaluation of anticonvulsant activity of N-substituted-3,4-dihydroisoquinoline-2(1H)-carboxamides

scientific article published on 7 March 2008

Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents

scientific article

Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors

scientific article

Structure-guided design of new indoles as negative allosteric modulators (NAMs) of N-methyl-D-aspartate receptor (NMDAR) containing GluN2B subunit

scientific article

Synthesis and Biological Characterization of 3-Substituted 1H-Indoles as Ligands of GluN2B-Containing N-Methyl-d-aspartate Receptors. Part 2

scientific article published on 19 November 2012

Synthesis and Evaluation of Pharmacological and Pharmacokinetic Properties of 11H-[1,2,4]Triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones

scientific article published on 01 December 2000

Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists

scientific article published on 01 March 1999

Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

scientific article published on 29 November 2007

Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives

scientific article published in January 2004

Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors

scientific article published on 16 November 2011

Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors

scientific article published on 16 July 2013

Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors

scientific article published on 12 October 2011

Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.

scientific article published on 7 April 2009

Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives

scientific article published in August 2003

Synthesis and pharmacological properties of new 3-ethoxycarbonyl-11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepines

scientific article published on 01 September 2002

Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants

scientific article published on December 2010

Synthesis of new pyridazine derivatives as potential anti-HIV-1 agents

article

Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII

scientific article published on 01 December 2020

Synthesis, modelling and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-d-aspartate receptors

scientific article

Synthesis, resolution, stereochemistry, and molecular modeling of (R)- and (S)-2-acetyl-1-(4′-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline AMPAR antagonists

scientific article published on 31 May 2007

Synthesis, structure-activity relationship studies, and X-ray crystallographic analysis of arylsulfonamides as potent carbonic anhydrase inhibitors

scientific article

Targeting GluN2B-containing N-Methyl-D-aspartate receptors: design, synthesis, and binding affinity evaluation of novel 3-substituted indoles

scientific article published on 23 May 2014

Targeting Tyrosinase: Development and Structural Insights of Novel Inhibitors Bearing Arylpiperidine and Arylpiperazine Fragments

scientific article published on 10 April 2018

The link between the AMPK/SIRT1 axis and a flavonoid-rich extract of Citrus bergamia juice: A cell-free, in silico, and in vitro study

scientific article published on 15 May 2019

List of works by Rosaria Gitto

1,4-Benzodiazepine derivatives as anticonvulsant agents in DBA/2 mice

1-Aryl-3,5-dihydro-4H-2,3-benzodiazepin-4-ones: novel AMPA receptor antagonists.

3,5-Dihydro-4H-2,3-benzodiazepine-4-thiones: a new class of AMPA receptor antagonists

3D Pharmacophore Models for 1,2,3,4-Tetrahydroisoquinoline Derivatives Acting as Anticonvulsant Agents

4,5-Dihydro-7,8-dimethoxy-1-phenyl-3H-2,3-benzodiazepin-4-one

4-[1-(4-Fluorobenzyl)-4-hydroxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid as a prototype to develop dual inhibitors of HIV-1 integration process

5-phenyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-8(7H)-one.

7,8-Methylenedioxy-4H-2,3-benzodiazepin-4-ones as novel AMPA receptor antagonists

A new potential approach to block HIV-1 replication via protein-protein interaction and strand-transfer inhibition

AMPA receptor antagonists as potential anticonvulsant drugs

Anticonvulsant activity and plasma level of 2,3-benzodiazepin-4-ones (CFMs) in genetically epilepsy-prone rats.

Binding modes of noncompetitive AMPA antagonists: a computational approach

Carbonic anhydrase inhibitors: Design, synthesis and structural characterization of new heteroaryl-N-carbonylbenzenesulfonamides targeting druggable human carbonic anhydrase isoforms

Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors

Closing in on the AMPA receptor: synthesis and evaluation of 2-acetyl-1-(4'-chlorophenyl)-6-methoxy-7-[11C]methoxy-1,2,3,4-tetrahydroisoquinoline as a potential PET tracer

Combined strategies for the discovery of ionotropic glutamate receptor antagonists

Comparative anticonvulsant activity of N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives in rodents

Comparative anticonvulsant activity of some 2,3-benzodiazepine derivatives in rodents

Computational and synthetic approaches for developing Lavendustin B derivatives as allosteric inhibitors of HIV-1 integrase

Computational studies to discover a new NR2B/NMDA receptor antagonist and evaluation of pharmacological profile

Design and development of 2,3-benzodiazepine (CFM) noncompetitive AMPA receptor antagonists

Determination of 2,3-benzodiazepine derivatives in rat plasma by high-performance liquid chromatography

Determination of a potent non-competitive AMPA receptor antagonist in rat brain

Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists

Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist

Discovery of benzimidazole-based L. mexicana cysteine protease CPB2.8ΔCTE inhibitors as potential therapeutics for leishmaniasis.

Effects of non-competitive AMPA receptor antagonists injected into some brain areas of WAG/Rij rats, an animal model of generalized absence epilepsy.

Enhancement of anti-absence effects of ethosuximide by low doses of a noncompetitive alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist in a genetic animal model of absence epilepsy

Exploiting the 1-(4-fluorobenzyl)piperazine fragment for the development of novel tyrosinase inhibitors as anti-melanogenic agents: Design, synthesis, structural insights and biological profile

Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety

Fragment hopping approach directed at design of HIV IN-LEDGF/p75 interaction inhibitors

From NMDA receptor antagonists to discovery of selective σ₂ receptor ligands

GYKI 52466 and related 2,3-benzodiazepines as anticonvulsant agents in DBA/2 mice

HIV-1 integrase strand-transfer inhibitors: design, synthesis and molecular modeling investigation

High-performance liquid chromatographic determination of new 2,3-benzodiazepines ⬇️

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies

Identification of influenza PA-Nter endonuclease inhibitors using pharmacophore- and docking-based virtual screening

Identification of potent and selective human carbonic anhydrase VII (hCA VII) inhibitors

Improvement of water solubility of non-competitive AMPA receptor antagonists by complexation with beta-cyclodextrin

Indole derivatives as dual-effective agents for the treatment of neurodegenerative diseases: synthesis, biological evaluation, and molecular modeling studies.

Inhibitory effects and structural insights for a novel series of coumarin-based compounds that selectively target human CA IX and CA XII carbonic anhydrases

In Vivo Evaluation of Selective Carbonic Anhydrase Inhibitors as Potential Anticonvulsant Agents

Looking toward the Rim of the Active Site Cavity of Druggable Human Carbonic Anhydrase Isoforms

Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integrase inhibitors.

N-substituted isoquinoline derivatives as potential AChE inhibitors

New AMPA antagonists in epilepsy.

New scaffolds of natural origin as Integrase-LEDGF/p75 interaction inhibitors: virtual screening and activity assays

New trends in the development of AMPA receptor antagonists

Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton

Optimization of rhodanine scaffold for the development of protein-protein interaction inhibitors

Pharmacophore modeling as an efficient tool in the discovery of novel noncompetitive AMPA receptor antagonists

Pharmacophore-based discovery of small-molecule inhibitors of protein-protein interactions between HIV-1 integrase and cellular cofactor LEDGF/p75.

Probing Molecular Interactions between Human Carbonic Anhydrases (hCAs) and a Novel Class of Benzenesulfonamides.

QSAR study of anticonvulsant negative allosteric modulators of the AMPA receptor

Rational Design, Synthesis and Evaluation of Coumarin Derivatives as Protein-protein Interaction Inhibitors

Rational design of small molecules able to inhibit α-synuclein amyloid aggregation for the treatment of Parkinson's disease

Relationship Between Anticonvulsant Activity and Plasma Level of Some 2,3-Benzodiazepines in Genetically Epilepsy-Prone Rats

SPE-HPLC determination of new tetrahydroisoquinoline derivatives in rat plasma

Searching for indole derivatives as potential mushroom tyrosinase inhibitors

Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives

Small molecules targeting the interaction between HIV-1 integrase and LEDGF/p75 cofactor

Solution-phase parallel synthesis and evaluation of anticonvulsant activity of N-substituted-3,4-dihydroisoquinoline-2(1H)-carboxamides

Solution-phase parallel synthesis of novel 1,2,3,4-tetrahydroisoquinoline-1-ones as anticonvulsant agents

Structure-based screening for the discovery of new carbonic anhydrase VII inhibitors

Structure-guided design of new indoles as negative allosteric modulators (NAMs) of N-methyl-D-aspartate receptor (NMDAR) containing GluN2B subunit

Synthesis and Biological Characterization of 3-Substituted 1H-Indoles as Ligands of GluN2B-Containing N-Methyl-d-aspartate Receptors. Part 2

Synthesis and Evaluation of Pharmacological and Pharmacokinetic Properties of 11H-[1,2,4]Triazolo[4,5-c][2,3]benzodiazepin-3(2H)-ones

Synthesis and anticonvulsant activity of new 2,3-benzodiazepines as AMPA receptor antagonists

Synthesis and anticonvulsant evaluation of N-substituted isoquinoline AMPA receptor antagonists

Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives

Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors

Synthesis and biological evaluation of novel antiviral agents as protein-protein interaction inhibitors

Synthesis and biological profile of new 1,2,3,4-tetrahydroisoquinolines as selective carbonic anhydrase inhibitors

Synthesis and evaluation of pharmacological profile of 1-aryl-6,7-dimethoxy-3,4-dihydroisoquinoline-2(1H)-sulfonamides.

Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives

Synthesis and pharmacological properties of new 3-ethoxycarbonyl-11H-[1,2,4]triazolo[4,5-c][2,3]benzodiazepines

Synthesis and structure-active relationship of 1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline anticonvulsants

Synthesis of new pyridazine derivatives as potential anti-HIV-1 agents

Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII