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List of works by Philip Meuleman

101 HUMAN MONOCLONAL ANTIBODIES TARGETING SR-BI PREVENT HCV ENTRY AND VIRAL SPREAD IN VIVO

827 EXPERIMENTAL HCV VACCINE COMBINING ADENOVIRUS AND PROTEIN ELICITS POTENT T-CELL RESPONSES AND NEUTRALIZING ANTIBODIES IN RODENTS

article

861 THE LECTIN GRIFFITHSIN HAS ANTIVIRAL ACTIVITY AGAINST HEPATITIS C VIRUS IN VITRO AND IN VIVO

A central hydrophobic E1 region controls the pH range of hepatitis C virus membrane fusion and susceptibility to fusion inhibitors

scientific article published on 13 February 2019

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites

scientific article

A human monoclonal antibody targeting scavenger receptor class B type I precludes hepatitis C virus infection and viral spread in vitro and in vivo

scientific article published on 16 December 2011

A novel neutralizing human monoclonal antibody broadly abrogates hepatitis C virus infection in vitro and in vivo

scientific article published on 23 October 2017

A simple and rapid method to determine the zygosity of uPA-transgenic SCID mice

scientific article published in August 2003

Absence of zoonotic hepatitis E virus infection in Flemish dairy cows

scientific article published on 09 May 2018

Animal Models for Hepatitis E virus

scientific article published on 18 June 2019

Animal Models to Study Hepatitis C Virus Infection.

scientific article

Animal models for the study of HCV

scientific article (publication date: August 2015)

Anti-CD81 but not anti-SR-BI blocks Plasmodium falciparum liver infection in a humanized mouse model

scientific article published on 4 February 2015

Apolipoprotein E Mediates Evasion From Hepatitis C Virus Neutralizing Antibodies

scientific article published on 21 September 2015

Artemisinin analogues as potent inhibitors of in vitro hepatitis C virus replication

scientific article (publication date: 2013)

Assessment of Parasite Liver-Stage Burden in Human-Liver Chimeric Mice

scientific article published on January 2015

Blocking HCV entry as potential antiviral therapy

Blocking entry of hepatitis B and D viruses to hepatocytes as a novel immunotherapy for treating chronic infections

scientific article published on 29 January 2020

Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant

scientific article (publication date: December 2007)

Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro

scientific article

Challenge pools of hepatitis C virus genotypes 1-6 prototype strains: replication fitness and pathogenicity in chimpanzees and human liver-chimeric mouse models

scientific article

Characterization of a hepatitis C virus-like particle vaccine produced in a human hepatocyte-derived cell line

scientific article published on 4 May 2016

Clearance of persistent hepatitis C virus infection in humanized mice using a claudin-1-targeting monoclonal antibody

scientific article published on 23 March 2015

Combination of liquid-chromatography tandem mass spectrometry in different scan modes with human and chimeric mouse urine for the study of steroid metabolism

scientific article published in November 2009

Combined adenovirus vector and hepatitis C virus envelope protein prime-boost regimen elicits T cell and neutralizing antibody immune responses

scientific article

Detection and characterization of a new metabolite of 17alpha-methyltestosterone

scientific article published on 24 August 2009

Detection and structural investigation of metabolites of stanozolol in human urine by liquid chromatography tandem mass spectrometry

scientific article

Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A.

scientific article

Development and characterization of a human monoclonal antibody targeting the N-terminal region of hepatitis C virus envelope glycoprotein E1.

scientific article published on 9 November 2017

Development and validation of a quantitative gas chromatography-mass spectrometry method for the detection of endogenous androgens in mouse urine

scientific article

Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase

scientific article

Elucidating the differences in pathogenicity between hepatitis E virus genotypes: The quest continues.

scientific article

Erratum: Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture

scientific article published on 23 January 2017

Expanding the Host Range of Hepatitis C Virus through Viral Adaptation

scientific article

Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes

scientific article published on 08 January 2020

Factors determining successful engraftment of hepatocytes and susceptibility to hepatitis B and C virus infection in uPA-SCID mice

scientific article published on 31 May 2010

Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1.

scientific article published on 6 August 2015

Functional Study of the C-Terminal Part of the Hepatitis C Virus E1 Ectodomain

scientific article published on 26 September 2018

G09 : Targeting a host-cell entry factor barricades antiviral resistant HCV variants from on-therapy breakthrough in human-liver mice

Generation and characterization of small single domain antibodies inhibiting human tumor necrosis factor receptor 1.

scientific article

Griffithsin has antiviral activity against hepatitis C virus

scientific article

HCV animal models and liver disease

scientific article

HCV animal models: a journey of more than 30 years

scientific article published on 02 September 2009

HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice.

scientific article

Hepatitis C virus infection and related liver disease: the quest for the best animal model

scientific article published on 26 July 2013

Hepatitis E Virus (HEV) Open Reading Frame 2 Antigen Kinetics in Human-Liver Chimeric Mice and Its Impact on HEV Diagnosis

scientific article published on 01 July 2019

Hepatitis E Virus Lifecycle and Identification of 3 Forms of the ORF2 Capsid Protein

scientific article published on 25 September 2017

Hepatitis E virus in acute liver failure: An unusual suspect?

scientific article published on 6 August 2016

Hepatitis E virus prevalence in Flemish blood donors

scientific article published on 24 July 2019

Host cell mTORC1 is required for HCV RNA replication

scientific article published on 14 August 2015

Human but not mouse hepatocytes respond to interferon-lambda in vivo

scientific article published on 31 January 2014

Human hepatocytes secrete soluble CD14, a process not directly influenced by HBV and HCV infection

scientific article

Human skin-derived precursor cells are poorly immunogenic and modulate the allogeneic immune response

scientific article published on August 2014

Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization

scientific article

Identification of a New Benzimidazole Derivative as an Antiviral against Hepatitis C Virus

scientific article published on 13 July 2016

Immune suppression uncovers endogenous cytopathic effects of the hepatitis B virus

scientific article

Immunological responses following administration of a genotype 1a/1b/2/3a quadrivalent HCV VLP vaccine.

scientific article

Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization

scientific article

In vitro and in vivo metabolisms of 1-pentyl-3-(4-methyl-1-naphthoyl)indole (JWH-122)

In vivo and in vitro metabolism of the synthetic cannabinoid JWH-200.

scientific article published in September 2013

In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus

scientific article

In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model

scientific article

Infectivity and stability of hepatitis C virus in different perfusion solutions

scientific article published on 12 July 2019

Is hepatitis E virus an emerging problem in industrialized countries?

scientific article published on 14 July 2015

Lipoprotein lipase inhibits hepatitis C virus (HCV) infection by blocking virus cell entry

scientific article

Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice

scientific article published on 04 November 2020

Metabolic studies of prostanozol with the uPA-SCID chimeric mouse model and human liver microsomes

scientific article

Metabolic studies with promagnon, methylclostebol and methasterone in the uPA+/+-SCID chimeric mice

scientific article published on 5 July 2011

Metabolism of methylstenbolone studied with human liver microsomes and the uPA⁺/⁺-SCID chimeric mouse model

scientific article

Methylene Blue Treatment of Grafts During Cold Ischemia Time Reduces the Risk of Hepatitis C Virus Transmission

scholarly article by Fabian A Helfritz et al published 20 October 2018 in Journal of Infectious Diseases

Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice

scientific article published on 24 November 2013

Monoclonal anti-envelope antibody AP33 protects humanized mice against a patient-derived hepatitis C virus challenge

scientific article published on 28 December 2015

Mouse Systems to Model Hepatitis C Virus Treatment and Associated Resistance

scientific article (publication date: 22 June 2016)

Murine IL-2 receptor beta chain blockade improves human leukocyte engraftment in SCID mice

scientific article published in October 1998

Murine tissues of human liver chimeric mice are not susceptible to HEV of genotype 1 and 3.

scientific article published on 18 August 2017

New insights into the ORF2 capsid protein, a key player of the hepatitis E virus lifecycle

scientific article published on 18 April 2019

Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice.

scientific article

Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections

scientific article published in 2022

O.053 The human liver uPA-SCID mouse, a preclinical model to test anti-hepatitis C compounds

article

O.055 The human liver-uPA-SCID mouse: a chimeric rodent model for the study of viral hepatitis

P0674 : Clinically approved T-type calcium channel inhibitors prevent hepatitis C virus (HCV) membrane fusion in a genotype-dependent manner

P0676 : Clearance of persistent hepatitis c virus infection using a monoclonal antibody specific for tight junction protein claudin-1

P131 STAT transcriptional activity is controlled by regulated deacetylation

Pentagalloylglucose, a highly bioavailable polyphenolic compound present in Cortex moutan, efficiently blocks hepatitis C virus entry

scientific article published on 15 September 2017

Polyclonal immunoglobulins from a chronic hepatitis C virus patient protect human liver-chimeric mice from infection with a homologous hepatitis C virus strain

scientific article published on June 2008

Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action

scientific article published on 22 July 2015

Prevention of hepatitis B infections: vaccination and its limitations

scientific article

Production of Infectious Genotype 1b Virus Particles in Cell Culture and Impairment by Replication Enhancing Mutations

scientific article

Robust hepatitis E virus infection and transcriptional response in human hepatocytes

scientific article published on 02 January 2020

Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication

scientific article (publication date: December 2008)

Scavenger receptor BI and BII expression levels modulate hepatitis C virus infectivity

scientific article

Sporozoite immunization of human volunteers under chemoprophylaxis induces functional antibodies against pre-erythrocytic stages of Plasmodium falciparum

scientific article

Steroid metabolism in chimeric mice with humanized liver

scientific article

Study of hepatitis E virus infection of genotype 1 and 3 in mice with humanised liver

scientific article published on 22 March 2016

Successful Engraftment of Human Hepatocytes in uPA-SCID and FRG(®) KO Mice.

scientific article

Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents

scientific article

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice

scientific article published on 25 August 2015

The Sin3a repressor complex is a master regulator of STAT transcriptional activity

scientific article

The emergence of hepatitis E virus in Europe

The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry

scientific article

The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV.

scientific article published on 14 August 2008

The interferon gamma secretion assay: a reliable tool to study interferon gamma production at the single cell level

scientific article published in March 2004

The natural compound silvestrol inhibits hepatitis E virus (HEV) replication in vitro and in vivo

scholarly article by Daniel Todt published in September 2018

Thermostability of seven hepatitis C virus genotypes in vitro and in vivo

scientific article published on 17 January 2013

Tracking HCV protease population diversity during transmission and susceptibility of founder populations to antiviral therapy.

scientific article published on 3 January 2017

Transmission of hepatitis E virus infection to human-liver chimeric FRG mice using patient plasma

scientific article

Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture.

scientific article published on 19 December 2016

Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells

scientific article published on July 2014

Ultra-rapid cardiotoxicity of the hepatitis C virus protease inhibitor BILN 2061 in the urokinase-type plasminogen activator mouse

scientific article published on 10 July 2007

Updates in Hepatitis E virus (HEV) field; lessons learned from human liver chimeric mice

scientific article published on 13 December 2019

Vaccine-induced monoclonal antibodies targeting circumsporozoite protein prevent Plasmodium falciparum infection

scientific article

Viral entry and escape from antibody-mediated neutralization influence hepatitis C virus reinfection in liver transplantation

scientific article

uPA+/+-SCID mouse with humanized liver as a model for in vivo metabolism of exogenous steroids: methandienone as a case study.

scientific article published on 30 July 2009

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