List of works - Daniel P Poole

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

scientific article published on 28 January 2021

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

scientific article published on 04 November 2019

Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity

scientific article published on 17 October 2019

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

scientific article published on 02 August 2013

Agonist-dependent development of delta opioid receptor tolerance in the colon

scientific article published on 23 March 2019

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.

scientific article published on 16 July 2016

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

scientific article published on 16 September 2019

Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease.

scientific article published on February 2013

Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity

scientific article

CO-EXPRESSION OF μ AND ∂ OPIOID RECEPTORS BY MOUSE COLONIC NOCICEPTORS.

scientific article published on 26 March 2018

Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.

scientific article

Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon

scientific article published on 15 May 2019

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

scientific article published on 24 August 2015

Dendritic cell acquisition of epitope cargo mediated by simple cationic peptide structures

scientific article published on 10 March 2008

Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging.

scientific article published in January 2015

Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig.

scientific article

Effects and mechanisms of action of the ergopeptides ergotamine and ergovaline and the effects of peramine on reticulum motility of sheep

scientific article published in February 2009

Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine.

scientific article

Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.

scientific article published on 16 June 2009

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

scientific article published on 16 June 2020

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

scientific article published on 30 October 2017

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

scientific article

Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones

scientific journal article

Evidence that two forms of choline acetyltransferase are differentially expressed in subclasses of enteric neurons.

scientific article published on 22 November 2002

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.

scientific article published on 12 March 2010

Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system.

scientific article

G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future

scientific article

G protein-coupled receptor trafficking and signaling: new insights into the enteric nervous system

scientific article published on 31 January 2019

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.

scientific article

Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain

scientific article published on 04 February 2020

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells.

scientific article published in April 2018

Identification of neurons that express 5-hydroxytryptamine4 receptors in intestine

scientific article published on 21 April 2006

Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons

scientific article published on 10 July 2007

Inflammation without pain: Immune-derived opioids hold the key

scientific article published on 01 February 2020

Inflammation-associated changes in DOR expression and function in the mouse colon

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

scientific article published on 2 July 2015

Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain

scientific article published on 12 November 2019

Investigation of PKC isoform-specific translocation and targeting of the current of the late afterhyperpolarizing potential of myenteric AH neurons

scientific article published in February 2005

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon.

scientific article

Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon

scientific article published on 20 November 2019

N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.

scientific article

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

scientific article published on May 2017

New small molecule fluorescent probes for G protein-coupled receptors: valuable tools for drug discovery

scientific article published on 15 December 2020

Nonruminant Nutrition Symposium: Involvement of gut neural and endocrine systems in pathological disorders of the digestive tract

scientific article

P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.

scientific article

PKC δ-isoform translocation and enhancement of tonic contractions of gastrointestinal smooth muscle

scientific article published on 07 December 2006

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

scientific article

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

scientific article published on 3 January 2013

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

article published in the Proceedings of the National Academy of Sciences of the United States of America

Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane

scientific article

Protein kinase C isoforms in the enteric nervous system

scientific article

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

scientific article published on 29 May 2019

Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.

scientific article published on September 2009

Protein kinases expressed by interstitial cells of Cajal

scientific article published on 05 December 2003

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

scientific article published on 22 April 2015

Role of Nonneuronal TRPV4 Signaling in Inflammatory Processes.

scientific article published on 24 April 2017

Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

scientific article

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.

scientific article published on January 2015

The TGR5 receptor mediates bile acid-induced itch and analgesia

scientific article published on 25 March 2013

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.

scientific article

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

scientific article published on July 2013

The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system.

scientific article published in October 2002

The distribution of PKC isoforms in enteric neurons, muscle and interstitial cells of the human intestine

scientific article published on 30 May 2006

The distribution of purine P2X(2) receptors in the guinea-pig enteric nervous system

scientific article published on 26 April 2002

The involvement of nitric oxide synthase neurons in enteric neuropathies.

scientific article published on 04 September 2011

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites.

scientific article published in January 2018

The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice

scientific article

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

scientific article published on 27 April 2020

Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine

scientific article published on 4 May 2011

Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice

scientific article

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

scientific article

List of works by Daniel P Poole

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity

Agonist-biased trafficking of somatostatin receptor 2A in enteric neurons

Agonist-dependent development of delta opioid receptor tolerance in the colon

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease.

Biological redundancy of endogenous GPCR ligands in the gut and the potential for endogenous functional selectivity

CO-EXPRESSION OF μ AND ∂ OPIOID RECEPTORS BY MOUSE COLONIC NOCICEPTORS.

Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents.

Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

Dendritic cell acquisition of epitope cargo mediated by simple cationic peptide structures

Detection and Quantification of Intracellular Signaling Using FRET-Based Biosensors and High Content Imaging.

Distribution and trafficking of the μ-opioid receptor in enteric neurons of the guinea pig.

Effects and mechanisms of action of the ergopeptides ergotamine and ergovaline and the effects of peramine on reticulum motility of sheep

Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine.

Endosomal endothelin-converting enzyme-1: a regulator of beta-arrestin-dependent ERK signaling.

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Endothelin-converting enzyme 1 and β-arrestins exert spatiotemporal control of substance P-induced inflammatory signals

Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones

Evidence that two forms of choline acetyltransferase are differentially expressed in subclasses of enteric neurons.

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system.

Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system.

G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future

G protein-coupled receptor trafficking and signaling: new insights into the enteric nervous system

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.

Granulocyte-Macrophage Colony Stimulating Factor As an Indirect Mediator of Nociceptor Activation and Pain

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells.

Identification of neurons that express 5-hydroxytryptamine4 receptors in intestine

Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons

Inflammation without pain: Immune-derived opioids hold the key

Inflammation-associated changes in DOR expression and function in the mouse colon

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain

Investigation of PKC isoform-specific translocation and targeting of the current of the late afterhyperpolarizing potential of myenteric AH neurons

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon.

Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon

N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor.

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

New small molecule fluorescent probes for G protein-coupled receptors: valuable tools for drug discovery

Nonruminant Nutrition Symposium: Involvement of gut neural and endocrine systems in pathological disorders of the digestive tract

P2Y1 Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells.

PKC δ-isoform translocation and enhancement of tonic contractions of gastrointestinal smooth muscle

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling

Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling.

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Protein Kinase D and Gβγ Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane

Protein kinase C isoforms in the enteric nervous system

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2.

Protein kinases expressed by interstitial cells of Cajal

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

Role of Nonneuronal TRPV4 Signaling in Inflammatory Processes.

Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea

The G protein-coupled receptor-transient receptor potential channel axis: molecular insights for targeting disorders of sensation and inflammation.

The TGR5 receptor mediates bile acid-induced itch and analgesia

The bile acid receptor TGR5 activates the TRPA1 channel to induce itch in mice.

The bile acid receptor TGR5 does not interact with β-arrestins or traffic to endosomes but transmits sustained signals from plasma membrane rafts.

The distribution of P2X3 purine receptor subunits in the guinea pig enteric nervous system.

The distribution of PKC isoforms in enteric neurons, muscle and interstitial cells of the human intestine

The distribution of purine P2X(2) receptors in the guinea-pig enteric nervous system

The involvement of nitric oxide synthase neurons in enteric neuropathies.

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites.

The receptor TGR5 mediates the prokinetic actions of intestinal bile acids and is required for normal defecation in mice

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine

Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission