List of works - Jan Wehkamp

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon

scientific article

A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts

scientific article published on 22 September 2005

A new look at Crohn's disease: breakdown of the mucosal antibacterial defense

scientific article published on August 2006

A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.

scientific article published on 7 October 2009

A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation

scientific article

Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3.

scientific article published on 14 January 2009

Antimicrobial activity of high-mobility-group box 2: a new function to a well-known protein

scientific article

Antimicrobial host defense in the upper gastrointestinal tract.

scientific article

Antimicrobial peptides and gut microbiota in homeostasis and pathology.

scientific article

Antimicrobial peptides in the skin

scientific article published on 01 January 2003

Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease

scientific article

Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease

scientific article

Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo

scientific article published on 13 February 2013

Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease

scientific article

Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses

scientific article published on 9 February 2012

Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin

scientific article published on 10 April 2013

Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins

scientific article published on 28 June 2012

Crohn's disease--defect in innate defence.

scientific article published on September 2008

Defective antibacterial barrier in inflammatory bowel disease

scientific article

Defective paneth cell-mediated host defense in pediatric ileal Crohn's disease

scientific article published on 10 November 2009

Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease

scientific article

Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.

scientific article published on May 2003

Defensins and cathelicidins in gastrointestinal infections

scientific article published on January 2007

Defensins and other antimicrobial peptides in inflammatory bowel disease

scientific article published on July 2007

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis

scientific article published on 22 October 2008

Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation

scientific article published on 2 October 2008

Elevated human beta-defensin-2 levels indicate an activation of the innate immune system in patients with irritable bowel syndrome

scientific article published on 20 January 2009

Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch

scientific article

From intestinal stem cells to inflammatory bowel diseases

scientific article published on July 2011

Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease

scientific article

Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue

scientific article published in Scientific Reports

Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.

scientific article published on December 2007

Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease

scientific article published on 01 July 2002

Human colonic mucus is a reservoir for antimicrobial peptides

scientific article

Human -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

scientific article

In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues

scientific article

Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin.

scientific article published on 5 February 2007

Inflammatory bowel disease: an impaired barrier disease

scientific article

Infliximab as rescue medication for patients with severe ulcerative/indeterminate colitis refractory to tacrolimus

scientific article published on 18 February 2010

Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease.

scientific article published on 22 June 2009

Innate antimicrobial host defense in small intestinal Crohn's disease

scientific article published on 21 October 2009

Innate antimicrobial immunity in inflammatory bowel diseases

scientific article published on September 2010

Innate immune dysfunction in inflammatory bowel disease

scientific article published on 13 February 2012

Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.

scientific article

Intestinal barrier in inflammatory bowel disease

scientific article

Mechanisms of disease: defensins in gastrointestinal diseases

scientific article

More than a marine propeller--the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus.

scientific article published on 4 November 2012

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

scientific article published on November 2004

NOD2 mutation and mice: no Crohn's disease but many lessons to learn.

scientific article

NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease

scientific article published on 26 March 2008

Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD.

scientific article published on 15 November 2011

Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues.

scientific article published on 12 September 2006

Paneth cell function--implications in pediatric Crohn disease

scientific article published on January 2011

Paneth cells and the innate immune response

scientific article published on November 2006

Paneth's disease.

scientific article published on 6 July 2010

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

scientific article

Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans.

scientific article

Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2.

scientific article

Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide

scientific article published on 06 March 2019

Reduced Paneth cell alpha-defensins in ileal Crohn's disease

scientific article

Reduced mucosal antimicrobial activity in Crohn's disease of the colon

scientific article

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

scientific article published in Nature

Results of the 2nd scientific workshop of the ECCO (III): basic mechanisms of intestinal healing.

scientific article published on 11 December 2011

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

scientific article

Serum procalcitonin differentiates inflammatory bowel disease and self-limited colitis

scientific article published in May 2004

TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease

scientific article published on 03 July 2014

[Chronic inflammatory bowel diseases (IBD): novel pathophysiological concepts and their clinical relevance]

scientific article published on 01 September 2005

[Defensins: endogenous antibiotics as a central part of innate immunity]

scientific article published on 01 September 2006

[Human beta-defensin 1: from defence to offence]

scientific article published on 13 November 2012

[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease]

scientific article published on 01 April 2004

List of works by Jan Wehkamp

A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon

A flow cytometric assay to monitor antimicrobial activity of defensins and cationic tissue extracts

A new look at Crohn's disease: breakdown of the mucosal antibacterial defense

A novel role for constitutively expressed epithelial-derived chemokines as antibacterial peptides in the intestinal mucosa.

A peptide derived from the highly conserved protein GAPDH is involved in tissue protection by different antifungal strategies and epithelial immunomodulation

Antibacterial activity of human defensins on anaerobic intestinal bacterial species: a major role of HBD-3.

Antimicrobial activity of high-mobility-group box 2: a new function to a well-known protein

Antimicrobial host defense in the upper gastrointestinal tract.

Antimicrobial peptides and gut microbiota in homeostasis and pathology.

Antimicrobial peptides in the skin

Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease

Attenuated induction of epithelial and leukocyte serine antiproteases elafin and secretory leukocyte protease inhibitor in Crohn's disease

Bacteria regulate intestinal epithelial cell differentiation factors both in vitro and in vivo

Barrier dysfunction due to distinct defensin deficiencies in small intestinal and colonic Crohn's disease

Bifidobacterium bifidum in a rat model of necrotizing enterocolitis: antimicrobial peptide and protein responses

Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin

Construction of recombinant E. coli Nissle 1917 (EcN) strains for the expression and secretion of defensins

Crohn's disease--defect in innate defence.

Defective antibacterial barrier in inflammatory bowel disease

Defective paneth cell-mediated host defense in pediatric ileal Crohn's disease

Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease

Defensin pattern in chronic gastritis: HBD-2 is differentially expressed with respect to Helicobacter pylori status.

Defensins and cathelicidins in gastrointestinal infections

Defensins and other antimicrobial peptides in inflammatory bowel disease

Differences in goblet cell differentiation between Crohn's disease and ulcerative colitis

Diminished expression of apical sodium-dependent bile acid transporter in gallstone disease is independent of ileal inflammation

Elevated human beta-defensin-2 levels indicate an activation of the innate immune system in patients with irritable bowel syndrome

Family history of Crohn's disease is associated with an increased risk for Crohn's disease of the pouch

From intestinal stem cells to inflammatory bowel diseases

Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn's disease

Histone deacetylase-mediated regulation of the antimicrobial peptide hBD2 differs in intestinal cell lines and cultured tissue

Host-microbe interaction: mechanisms of defensin deficiency in Crohn's disease.

Human beta-defensin 2 but not beta-defensin 1 is expressed preferentially in colonic mucosa of inflammatory bowel disease

Human colonic mucus is a reservoir for antimicrobial peptides

Human -Defensin 6 Promotes Mucosal Innate Immunity Through Self-Assembled Peptide Nanonets

In vivo gene expression profiling of human intestinal epithelial cells: analysis by laser microdissection of formalin fixed tissues

Induction of human beta-defensin 2 by the probiotic Escherichia coli Nissle 1917 is mediated through flagellin.

Inflammatory bowel disease: an impaired barrier disease

Infliximab as rescue medication for patients with severe ulcerative/indeterminate colitis refractory to tacrolimus

Influence of standard treatment on ileal and colonic antimicrobial defensin expression in active Crohn's disease.

Innate antimicrobial host defense in small intestinal Crohn's disease

Innate antimicrobial immunity in inflammatory bowel diseases

Innate immune dysfunction in inflammatory bowel disease

Intestinal bacterial translocation in rats with cirrhosis is related to compromised Paneth cell antimicrobial host defense.

Intestinal barrier in inflammatory bowel disease

Mechanisms of disease: defensins in gastrointestinal diseases

More than a marine propeller--the flagellum of the probiotic Escherichia coli strain Nissle 1917 is the major adhesin mediating binding to human mucus.

NOD2 (CARD15) mutations in Crohn's disease are associated with diminished mucosal alpha-defensin expression

NOD2 mutation and mice: no Crohn's disease but many lessons to learn.

NOD2/CARD15 gene variants are linked to failure of antibiotic treatment in perianal fistulating Crohn's disease

Olfactomedin-4 is a glycoprotein secreted into mucus in active IBD.

Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues.

Paneth cell function--implications in pediatric Crohn disease

Paneth cells and the innate immune response

Paneth's disease.

Peroxisome proliferator-activated receptor gamma activation is required for maintenance of innate antimicrobial immunity in the colon

Probiotic E. coli treatment mediates antimicrobial human beta-defensin synthesis and fecal excretion in humans.

Probiotic lactobacilli and VSL#3 induce enterocyte beta-defensin 2.

Proteolytic Degradation of reduced Human Beta Defensin 1 generates a Novel Antibiotic Octapeptide

Reduced Paneth cell alpha-defensins in ileal Crohn's disease

Reduced mucosal antimicrobial activity in Crohn's disease of the colon

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

Results of the 2nd scientific workshop of the ECCO (III): basic mechanisms of intestinal healing.

Secukinumab, a human anti-IL-17A monoclonal antibody, for moderate to severe Crohn's disease: unexpected results of a randomised, double-blind placebo-controlled trial

Serum procalcitonin differentiates inflammatory bowel disease and self-limited colitis

TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease

[Chronic inflammatory bowel diseases (IBD): novel pathophysiological concepts and their clinical relevance]

[Defensins: endogenous antibiotics as a central part of innate immunity]

[Human beta-defensin 1: from defence to offence]

[The role of defensins in the pathogenesis of chronic-inflammatory bowel disease]