List of works - Doriano Lamba

"Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase

scientific article

A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor

scientific article published on 11 December 2014

A conformational study of the Smith degradation product of the Klebsiella K40 capsular polysaccharide by 1D NOESY and molecular mechanics calculations

scientific article published on 01 December 1994

Accurate prediction of the bound conformation of galanthamine in the active site of Torpedo californica acetylcholinesterase using molecular docking

scientific article published in January 2001

Assignment of disulphide bridges in Par j 2.0101, a major allergen of Parietaria judaica pollen

scientific article published in August 2003

Census of solo LuxR genes in prokaryotic genomes

scientific article published on 12 March 2015

Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor

scientific article published on 26 December 2016

Conformational plasticity of proNGF

scientific article

Corrigendum to “Crystal Structure of Wild-type Chaperonin GroEL” [J. Mol. Biol. (2005) 354, 940–951]

scholarly article published in Journal of Molecular Biology

Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its biological function

Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier

scientific article

Crystal structure of wild-type chaperonin GroEL.

scientific article

Crystallization, X-ray diffraction analysis and phasing of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus.

scientific article published on 5 November 2005

Crystallization, X-ray diffraction analysis and phasing of carboxylesterase PA3859 from Pseudomonas aeruginosa.

scientific article

Direct intracellular selection and biochemical characterization of a recombinant anti-proNGF single chain antibody fragment

scientific article

Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody

scientific article

Efficient folding of the FcepsilonRI alpha-chain membrane-proximal domain D2 depends on the presence of the N-terminal domain D1.

scientific article

Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model

scientific article

Evidence for a boat-chair equilibrium in the glucuronate residue of chondrosine

article

Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a "Painless" Lead Investigational Candidate for Therapeutic Applications

scientific article

Functional and structural study of the dimeric inner membrane protein SbmA.

scientific article published on 27 September 2013

Heterologous expression, purification, crystallization, X-ray analysis and phasing of the acetyl xylan esterase from Bacillus pumilus

scientific article

Identification of a hydrophobic exosite on tissue type plasminogen activator that modulates specificity for plasminogen.

scientific article

In vitro characterization of Arabidopsis CP12 isoforms reveals common biochemical and molecular properties

scientific article published in August 2010

In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V.

scientific article

Inhibition of human leukocyte elastase by chemically and naturally oversulfated galactosaminoglycans

scientific article published on 01 October 1995

Insight into the structure of an endopolygalacturonase from the phytopathogen Burkholderia cepacia: a biochemical and computational study

scientific article published on 15 July 2010

Insights into stereochemical features of sulphated carbohydrates: X-ray crystallographic and modelling investigations

article

Insights into subtle conformational differences in the substrate-binding loop of fungal 17β-hydroxysteroid dehydrogenase: a combined structural and kinetic approach

scientific article

Insights into the fatty acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas aeruginosa: A combined structural, biochemical and computational study

scientific article

Intrinsic structural disorder of mouse proNGF.

scientific article published in June 2009

Isolation, characterization, and heterologous expression of a carboxylesterase of Pseudomonas aeruginosa PAO1

scientific journal article

Isolation, heterologous expression and characterization of an endo-polygalacturonase produced by the phytopathogen Burkholderia cepacia.

scientific article published on 10 April 2007

Kinetic and structural studies on the inhibition of acetylcholinesterase and butyrylcholinesterase by a series of multitarget-directed galantamine-peptide derivatives

scientific article published in 2022

Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues.

scientific article published in December 2018

Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group

scientific article

Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase

scientific article published in November 1997

Metabolites of microorganisms. 229. Absolute configuration of naphthomycin A determined by X-ray analysis and chemical degradation

scientific article published on 01 November 1984

Molecular structure of 3-O-(3,6-anhydro-alpha-D-galactopyranosyl)-beta-D-galactopyranose (neocarrabiose) in the solid state and in solution: an investigation by X-ray crystallography, n.m.r. spectroscopy, and molecular mechanics calculations

scientific article published in December 1990

Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects

scientific article

NADH interactions with WT- and S94A-acyl carrier protein reductase from Mycobacterium tuberculosis: an ab initio study

scientific article published in April 2002

Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight.

scientific article

Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

scientific article published on 3 December 2015

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

scientific article published on 27 February 2019

Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives

scientific article

Proof of the Structure of the Stemodia chilensis Tetracyclic Diterpenoid (+)-19-Acetoxystemodan-12-ol by Synthesis from (+)-Podocarpic Acid: X-ray Structure Determination of a Key Intermediate

Purification, crystallization and preliminary X-ray analysis of an acetylxylan esterase from Bacillus pumilus

scientific article published on 21 November 2001

Purification, crystallization and preliminary X-ray analysis of an acetylxylan esterase fromBacillus pumilus. Erratum

article

Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti-tyrosine kinase A receptor monoclonal antibody

scientific article published on 23 August 2001

Purification, crystallization, X-ray diffraction analysis and phasing of a Fab fragment of monoclonal neuroantibody alphaD11 against nerve growth factor.

scientific article

Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue

scientific article published on 20 January 2006

Refolding of the Cupressus arizonica major pollen allergen Cup a1.02 overexpressed in Escherichia coli

scientific article published in October 2004

Regio- and Diastereoselective Synthesis and X-ray Structure Determination of (+)-2-Deoxyoryzalexin S from (+)-Podocarpic Acid. Structural Nonidentity with Its Nominal Natural Isolated Enantiomer

scientific article published on 23 October 2012

Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase.

scientific article

Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody

scientific article (publication date: 2012)

Solution conformation of a pectic acid fragment by 1H-NMR and molecular dynamics

scientific article published on April 1994

Status of the crystallography beamlines at Elettra

scholarly article by A. Lausi et al published March 2015 in European physical journal plus

Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis

scientific journal article

Structural and functional properties of mouse proNGF.

scientific article

Structural basis for inhibition of 17β-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17β-HSDcl.

scientific article published on March 2017

Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).

scientific article published in August 2006

Structural insights into a novel interkingdom signaling circuit by cartography of the ligand-binding sites of the homologous quorum sensing LuxR-family

scientific article published on 15 October 2013

Structural studies of O-sulfated D-glucosamines. The crystal and molecular structures of 2-amino-2-deoxy-α/ β-D-glucopyranose 3-sulfate (free acid) and 2-amino-2-deoxy-β-D-glucopyranose 6-sulfate (free base)

article

Structure of (+)-(S)-1,3-dimethyl-6-oxiranyl-2,4-pyrimidinedione showing anti-ASFV activity ⬇️

scientific article published on January 15, 1992

Structure of 2-C-(hydroxymethyl)-D-ribose (hamamelose) in the solid-state analyzed by CP MAS NMR and X-ray crystallography

scientific article

Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases

scientific article

Studies on synthetic LuxR solo hybrids

scientific article published on 18 June 2015

Synthesis and X-ray crystallographic structure determination of methyl α-d-galactopyranoside 2,6-bis(sodium sulfate) · 2H2O

Synthesis of dimeric and tetrameric macrolactams with cytotoxic activity 1

scholarly article by Gabriella Gentile et al published 2000 in Canadian Journal of Chemistry

The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator

scientific article

The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy

scientific article

The conundrum of the high-affinity NGF binding site formation unveiled?

scientific article published on February 2015

The crystal and molecular structure of 2-sulfamino-2-deoxy-alpha-D-glucopyranose sodium salt.2H2O (glucosamine 2-sulfate).

scientific article published in June 1995

The crystal and molecular structure of the ?-helical nonapeptide antibiotic leucinostatin A

scientific article published on 01 January 1989

The kiwifruit emerging pathogen Pseudomonas syringae pv. actinidiae does not produce AHLs but possesses three luxR solos.

scientific article published on 31 January 2014

The structure of the N-terminal region of murine skeletal muscle alpha-dystroglycan discloses a modular architecture.

scientific article

Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs

scientific article

List of works by Doriano Lamba

"Back door" opening implied by the crystal structure of a carbamoylated acetylcholinesterase

A comparative analysis of the structural, functional and biological differences between Mouse and Human Nerve Growth Factor

A conformational study of the Smith degradation product of the Klebsiella K40 capsular polysaccharide by 1D NOESY and molecular mechanics calculations

Accurate prediction of the bound conformation of galanthamine in the active site of Torpedo californica acetylcholinesterase using molecular docking

Assignment of disulphide bridges in Par j 2.0101, a major allergen of Parietaria judaica pollen

Census of solo LuxR genes in prokaryotic genomes

Conformational Rigidity within Plasticity Promotes Differential Target Recognition of Nerve Growth Factor

Conformational plasticity of proNGF

Corrigendum to “Crystal Structure of Wild-type Chaperonin GroEL” [J. Mol. Biol. (2005) 354, 940–951]

Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its biological function

Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier

Crystal structure of wild-type chaperonin GroEL.

Crystallization, X-ray diffraction analysis and phasing of 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus.

Crystallization, X-ray diffraction analysis and phasing of carboxylesterase PA3859 from Pseudomonas aeruginosa.

Direct intracellular selection and biochemical characterization of a recombinant anti-proNGF single chain antibody fragment

Dissecting NGF interactions with TrkA and p75 receptors by structural and functional studies of an anti-NGF neutralizing antibody

Efficient folding of the FcepsilonRI alpha-chain membrane-proximal domain D2 depends on the presence of the N-terminal domain D1.

Evaluation and computational characterization of the facilitated transport of Glc carbon C-1 oxime reactivators across a blood brain barrier model

Evidence for a boat-chair equilibrium in the glucuronate residue of chondrosine

Functional Characterization of Human ProNGF and NGF Mutants: Identification of NGF P61SR100E as a "Painless" Lead Investigational Candidate for Therapeutic Applications

Functional and structural study of the dimeric inner membrane protein SbmA.

Heterologous expression, purification, crystallization, X-ray analysis and phasing of the acetyl xylan esterase from Bacillus pumilus

Identification of a hydrophobic exosite on tissue type plasminogen activator that modulates specificity for plasminogen.

In vitro characterization of Arabidopsis CP12 isoforms reveals common biochemical and molecular properties

In vitro receptor binding properties of a "painless" NGF mutein, linked to hereditary sensory autonomic neuropathy type V.

Inhibition of human leukocyte elastase by chemically and naturally oversulfated galactosaminoglycans

Insight into the structure of an endopolygalacturonase from the phytopathogen Burkholderia cepacia: a biochemical and computational study

Insights into stereochemical features of sulphated carbohydrates: X-ray crystallographic and modelling investigations

Insights into subtle conformational differences in the substrate-binding loop of fungal 17β-hydroxysteroid dehydrogenase: a combined structural and kinetic approach

Insights into the fatty acid chain length specificity of the carboxylesterase PA3859 from Pseudomonas aeruginosa: A combined structural, biochemical and computational study

Intrinsic structural disorder of mouse proNGF.

Isolation, characterization, and heterologous expression of a carboxylesterase of Pseudomonas aeruginosa PAO1

Isolation, heterologous expression and characterization of an endo-polygalacturonase produced by the phytopathogen Burkholderia cepacia.

Kinetic and structural studies on the inhibition of acetylcholinesterase and butyrylcholinesterase by a series of multitarget-directed galantamine-peptide derivatives

Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues.

Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group

Long chain analogs of physostigmine as potential drugs for Alzheimer's disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase

Metabolites of microorganisms. 229. Absolute configuration of naphthomycin A determined by X-ray analysis and chemical degradation

Molecular structure of 3-O-(3,6-anhydro-alpha-D-galactopyranosyl)-beta-D-galactopyranose (neocarrabiose) in the solid state and in solution: an investigation by X-ray crystallography, n.m.r. spectroscopy, and molecular mechanics calculations

Multitarget drug design strategy: quinone-tacrine hybrids designed to block amyloid-β aggregation and to exert anticholinesterase and antioxidant effects

NADH interactions with WT- and S94A-acyl carrier protein reductase from Mycobacterium tuberculosis: an ab initio study

Neutralization of NGF-TrkA receptor interaction by the novel antagonistic anti-TrkA monoclonal antibody MNAC13: a structural insight.

Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease

Probing Torpedo californica acetylcholinesterase catalytic gorge with two novel bis-functional galanthamine derivatives

Proof of the Structure of the Stemodia chilensis Tetracyclic Diterpenoid (+)-19-Acetoxystemodan-12-ol by Synthesis from (+)-Podocarpic Acid: X-ray Structure Determination of a Key Intermediate

Purification, crystallization and preliminary X-ray analysis of an acetylxylan esterase from Bacillus pumilus

Purification, crystallization and preliminary X-ray analysis of an acetylxylan esterase fromBacillus pumilus. Erratum

Purification, crystallization and preliminary X-ray analysis of the Fab fragment from MNAC13, a novel antagonistic anti-tyrosine kinase A receptor monoclonal antibody

Purification, crystallization, X-ray diffraction analysis and phasing of a Fab fragment of monoclonal neuroantibody alphaD11 against nerve growth factor.

Reassessing the melatonin pharmacophore--enantiomeric resolution, pharmacological activity, structure analysis, and molecular modeling of a constrained chiral melatonin analogue

Refolding of the Cupressus arizonica major pollen allergen Cup a1.02 overexpressed in Escherichia coli

Regio- and Diastereoselective Synthesis and X-ray Structure Determination of (+)-2-Deoxyoryzalexin S from (+)-Podocarpic Acid. Structural Nonidentity with Its Nominal Natural Isolated Enantiomer

Role of metal ions on the activity of Mycobacterium tuberculosis pyrazinamidase.

Single cycle structure-based humanization of an anti-nerve growth factor therapeutic antibody

Solution conformation of a pectic acid fragment by 1H-NMR and molecular dynamics

Status of the crystallography beamlines at Elettra

Structural and biochemical analysis of the Rv0805 cyclic nucleotide phosphodiesterase from Mycobacterium tuberculosis

Structural and functional properties of mouse proNGF.

Structural basis for inhibition of 17β-hydroxysteroid dehydrogenases by phytoestrogens: The case of fungal 17β-HSDcl.

Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).

Structural insights into a novel interkingdom signaling circuit by cartography of the ligand-binding sites of the homologous quorum sensing LuxR-family

Structural studies of O-sulfated D-glucosamines. The crystal and molecular structures of 2-amino-2-deoxy-α/ β-D-glucopyranose 3-sulfate (free acid) and 2-amino-2-deoxy-β-D-glucopyranose 6-sulfate (free base)

Structure of (+)-(S)-1,3-dimethyl-6-oxiranyl-2,4-pyrimidinedione showing anti-ASFV activity ⬇️

Structure of 2-C-(hydroxymethyl)-D-ribose (hamamelose) in the solid-state analyzed by CP MAS NMR and X-ray crystallography

Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases

Studies on synthetic LuxR solo hybrids

Synthesis and X-ray crystallographic structure determination of methyl α-d-galactopyranoside 2,6-bis(sodium sulfate) · 2H2O

Synthesis of dimeric and tetrameric macrolactams with cytotoxic activity 1

The 2.3 A crystal structure of the catalytic domain of recombinant two-chain human tissue-type plasminogen activator

The Structure of the T190M Mutant of Murine α-Dystroglycan at High Resolution: Insight into the Molecular Basis of a Primary Dystroglycanopathy

The conundrum of the high-affinity NGF binding site formation unveiled?

The crystal and molecular structure of 2-sulfamino-2-deoxy-alpha-D-glucopyranose sodium salt.2H2O (glucosamine 2-sulfate).

The crystal and molecular structure of the ?-helical nonapeptide antibiotic leucinostatin A

The kiwifruit emerging pathogen Pseudomonas syringae pv. actinidiae does not produce AHLs but possesses three luxR solos.

The structure of the N-terminal region of murine skeletal muscle alpha-dystroglycan discloses a modular architecture.

Three-dimensional structure of a complex of galanthamine (Nivalin) with acetylcholinesterase from Torpedo californica: implications for the design of new anti-Alzheimer drugs