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List of works by Libor Vitek

A Comprehensive Evaluation of Steroid Metabolism in Women with Intrahepatic Cholestasis of Pregnancy.

scientific article

A Novel Perspective on the Biology of Bilirubin in Health and Disease.

scientific article

Albumin administration prevents neurological damage and death in a mouse model of severe neonatal hyperbilirubinemia.

scientific article

Albumin administration protects against bilirubin-induced auditory brainstem dysfunction in Gunn rat pups

scientific article published on 7 June 2013

Anti-Genotoxic Potential of Bilirubin In Vivo: Damage to DNA in Hyperbilirubinemic Human and Animal Models

scientific article published on 27 August 2013

Anti-angiogenic effects of the blue-green alga Arthrospira platensis on pancreatic cancer

scientific article published on 19 January 2020

Antiproliferative effects of carbon monoxide on pancreatic cancer.

scientific article published on 14 January 2014

Association of IL23R p.381Gln and ATG16L1 p.197Ala With Crohn Disease in the Czech Population

scientific article published on 01 October 2009

Association of serum bilirubin and promoter variations in HMOX1 and UGT1A1 genes with sporadic colorectal cancer.

scientific article published on 18 February 2012

Beyond plasma bilirubin: the effects of phototherapy and albumin on brain bilirubin levels in Gunn rats

scientific article published on 21 August 2012

Bile acid malabsorption in inflammatory bowel disease

scientific article published on February 2015

Bile acid malabsorption in inflammatory bowel disease: assessment by serum markers

scientific article published on 5 November 2010

Bile acids decrease intracellular bilirubin levels in the cholestatic liver: implications for bile acid-mediated oxidative stress.

scientific article published on 28 May 2010

Bilirubin accumulation and Cyp mRNA expression in selected brain regions of jaundiced Gunn rat pups

scientific article published on 15 February 2012

Bilirubin and colorectal cancer

scientific article published on 01 November 2006

Bilirubin as a signaling molecule

scientific article published on 04 February 2020

Bilirubin chemistry and metabolism; harmful and protective aspects.

scientific article published on January 2009

Bilirubin-induced ER stress contributes to the inflammatory response and apoptosis in neuronal cells

scientific article

Breath alcohol level and plasma amino acids: a comparison between older and younger chronic alcohol-dependent patients

scientific article published on 22 September 2008

CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection

scientific article published on 26 August 2008

Carbon monoxide inhibits sprouting angiogenesis and vascular endothelial growth factor receptor-2 phosphorylation.

scientific article published on 30 October 2014

Changes in GM1 ganglioside content and localization in cholestatic rat liver

scientific article published on 27 February 2007

Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated with Its Anticancer Effects

scientific article published on 02 July 2018

Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2.

scientific article

Clostridium difficile in piglets in the Czech Republic

scientific article published on 22 February 2012

Comparison of simple extraction procedures in liquid chromatography-mass spectrometry based determination of serum 7α-hydroxy-4-cholesten-3-one, a surrogate marker of bile acid synthesis.

scientific article published on 31 August 2016

Complex Evaluation of Antioxidant Capacity of Milk Thistle Dietary Supplements

scientific article published on 18 August 2019

Cytoprotective and Antiproliferative Effects of HMG-CoA Reductase Inhibitors

D. R. Bach et al.: Elevated bilirubin in acute and transient psychotic disorder. Pharmacopsychiatry 2010; 43: 12-16

scientific article published on 06 September 2010

Decreased serum antioxidant capacity in patients with Wilson disease is associated with neurological symptoms

scientific article

Determination of beta-defensin genomic copy number in different populations: A comparison of three methods

scientific article

Differences in antitumor effects of various statins on human pancreatic cancer.

scientific article published on March 2008

Diurnal variation in cholesterol 7α-hydroxylase activity is determined by the -203A>C polymorphism of the CYP7A1 gene

scientific article published on April 2016

Does hyperbilirubinemia protect from coronary heart disease? ⬇️

scientific article published on November 15, 2001

Effect of carvedilol on portal hypertension depends on the degree of endothelial activation and inflammatory changes

scientific article published on 01 December 2006

Effective treatment of unconjugated hyperbilirubinemia with oral bile salts in Gunn rats.

scientific article published on 6 November 2008

Effects of heme oxygenase-1 on induction and development of chemically induced squamous cell carcinoma in mice.

scientific article

Efficacy and safety of ursodeoxycholic acid in patients with intrahepatic cholestasis of pregnancy

article published in 2016

Endocrine effects of duodenal-jejunal exclusion in obese patients with type 2 diabetes mellitus

scientific article published on 29 July 2016

Enterohepatic cycling of bilirubin as a cause of 'black' pigment gallstones in adult life.

scientific article

Enzymatic methods may underestimate the total serum bile acid concentration

scientific article published on 24 July 2020

Estrogen-induced cholestasis results in a dramatic increase of b-series gangliosides in the rat liver

scientific article

Expression of Biliverdin Reductase A in peripheral blood leukocytes is associated with treatment response in HCV-infected patients

scientific article

Fasting-related hyperbilirubinemia in rats: the effect of decreased intestinal motility

scientific article published in July 1996

Fetal complications due to intrahepatic cholestasis of pregnancy

scientific article

Functional variants of eNOS and iNOS genes have no relationship to the portal hypertension in patients with liver cirrhosis

scientific article published on 04 March 2013

Gene variants at FTO, 9p21, and 2q36.3 are age-independently associated with myocardial infarction in Czech men

article

Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: possible protective effects and therapeutic applications of bilirubin.

scientific article

Heme Oxygenase-1 May Affect Cell Signalling via Modulation of Ganglioside Composition

article

Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells.

scientific article

High resolution mass spectrometry based method applicable for a wide range of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors in blood serum including intermediates and products of the cholesterol biosynthetic pathway.

scientific article published on 31 January 2017

Highly sensitive method for quantitative determination of bilirubin in biological fluids and tissues.

scientific article published on 18 March 2008

Hyperbilirubinemia Protects against Aging-Associated Inflammation and Metabolic Deterioration.

scientific article published on 31 July 2016

Hyperbilirubinemia in Gunn Rats is Associated with Decreased Inflammatory Response in LPS-Mediated Systemic Inflammation ⬇️

scientific article published on 09 May 2019

IL-1 receptor blockade alleviates endotoxin-mediated impairment of renal drug excretory functions in rats

scientific article published on 10 December 2014

Identification of bilirubin reduction products formed by Clostridium perfringens isolated from human neonatal fecal flora.

scientific article published on 28 February 2006

Impact of serum bilirubin on human diseases

scientific article published on 01 May 2005

Improved HPLC analysis of serum 7alpha-hydroxycholest-4-en-3-one, a marker of bile acid malabsorption

scientific article published in June 2008

Improved efficacy and reduced toxicity by ultrasound-guided intrahepatic injections of helper-dependent adenoviral vector in Gunn rats

scientific article

In Silico and In Vitro Studies of Mycotoxins and Their Cocktails; Their Toxicity and Its Mitigation by Silibinin Pre-Treatment

scientific article published on 28 February 2020

Indel in the FIC1/ATP8B1 gene?a novel rare type of mutation associated with benign recurrent intrahepatic cholestasis

article

Induction of Mild Hyperbilirubinemia: Hype or Real Therapeutic Opportunity?

scientific article published on 01 March 2019

Inflammatory signature of cerebellar neurodegeneration during neonatal hyperbilirubinemia in Ugt1 -/- mouse model.

scientific article published on 24 March 2017

Infliximab dependency in children with Crohn’s disease

scientific article published on 13 January 2009

Infliximab dependency is related to decreased surgical rates in adult Crohnʼs disease patients

article

Influence of VEGF polymorphism on progression of autosomal dominant polycystic kidney disease

scientific article published on 08 December 2008

Inhibition of Mitochondrial Metabolism Leads to Selective Eradication of Cells Adapted to Acidic Microenvironment

scientific article published in 2021

Interplay between heme oxygenase-1 and miR-378 affects non-small cell lung carcinoma growth, vascularization, and metastasis

scientific article published on 27 June 2013

Intestinal Excretion of Unconjugated Bilirubin in Man and Rats with Inherited Unconjugated Hyperbilirubinemia ⬇️

scientific article published on August 1, 1997

Intestinal colonization leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal jaundice

scholarly article by Libor Vitek et al published 1 March 2000 in Journal of Pediatric Gastroenterology and Nutrition

Intestinal metabolism of bilirubin in the pathogenesis of neonatal jaundice

scientific article published on 01 December 2003

Intracellular accumulation of bilirubin as a defense mechanism against increased oxidative stress ⬇️

scientific article published on May 10, 2012

Introduction of water into the heme distal side by Leu65 mutations of an oxygen sensor, YddV, generates verdoheme and carbon monoxide, exerting the heme oxygenase reaction

scientific article published on 24 June 2014

Is there really a link between hyperbilirubinemia and schizophrenia?

scientific article published on 23 April 2009

Isolated Silymarin Flavonoids Increase Systemic and Hepatic Bilirubin Concentrations and Lower Lipoperoxidation in Mice

scientific article published on 12 February 2019

Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

scientific article published on 20 December 2017

Laparoscopic sleeve gastrectomy differentially affects serum concentrations of FGF-19 and FGF-21 in morbidly obese subjects.

scientific article published on 13 May 2013

Letter by Vítek et al Regarding Article, “Niacin Inhibits Vascular Inflammation via the Induction of Heme Oxygenase-1”

scientific article published on 01 August 2012

Linkage between A(TA)7TAA and -3279T>G mutations in UGT1A1 is not essential for pathogenesis of Gilbert syndrome

scientific article published on 01 December 2006

Long-term follow-up of Wilson Disease: natural history, treatment, mutations analysis and phenotypic correlation

scientific article published on 20 October 2010

NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients ⬇️

scientific article published on November 7, 2010

Neuro-inflammatory effects of photodegradative products of bilirubin.

scientific article

New pathophysiological concepts underlying pathogenesis of pigment gallstones ⬇️

scientific article published on October 5, 2011

Optimizing exchange transfusion for severe unconjugated hyperbilirubinemia: studies in the Gunn rat.

scientific article

Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis.

scientific article published on March 2016

Photo-isomerization and oxidation of bilirubin in mammals is dependent on albumin binding

scientific article published on 18 August 2015

Poor chemical and microbiological quality of the commercial milk thistle-based dietary supplements may account for their reported unsatisfactory and non-reproducible clinical outcomes

scientific article published on 31 July 2019

Predictive role BLVRA mRNA expression in hepatocellular cancer

scientific article published on November 2016

Prognostic value of anti-CRP antibodies in lupus nephritis in long-term follow-up

scientific article

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome

scientific article published on 01 September 2013

Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury

scientific article

Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis

scientific article

Protective effects of inhaled carbon monoxide in endotoxin-induced cholestasis is dependent on its kinetics

scientific article published on 19 October 2013

Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy

Rapid protocol for electroporation of Clostridium perfringens

scientific article published on 01 July 2005

Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells.

scientific article published on 22 May 2015

Role of heme oxygenase-1 in human endothelial cells: lesson from the promoter allelic variants

scientific article published on 27 May 2010

Rotor-type hyperbilirubinaemia has no defect in the canalicular bilirubin export pump

scientific article published on 01 May 2007

Safe use of ursodeoxycholic acid in a breast-feeding patient with primary biliary cirrhosis.

scientific article published on 8 July 2010

Serum Bilirubin Levels and Promoter Variations in HMOX1 and UGT1A1 Genes in Patients with Fabry Disease

scientific article published on 16 August 2017

Serum Bilirubin and Genes Controlling Bilirubin Concentrations as Biomarkers for Cardiovascular Disease ⬇️

scientific article published on 06 August 2010

Serum bilirubin levels and UGT1A1 promoter variations in patients with schizophrenia

scientific article published on 21 May 2010

Serum bilirubin levels and the risk of Crohn's disease ⬇️

scientific article published on 05 April 2012

Simultaneous genotyping of microsatellite variations in HMOX1 and UGT1A1 genes using multicolored capillary electrophoresis

scientific article published on 10 February 2010

Sleep disorders in Wilson's disease

scientific article published in January 2011

Spirulina platensis and phycocyanobilin activate atheroprotective heme oxygenase-1: a possible implication for atherogenesis

scientific article published in November 2013

Statin treatment increases formation of carbon monoxide and bilirubin in mice: a novel mechanism of in vivo antioxidant protection.

scientific article published in August 2007

Statin use and serum bilirubin levels

scientific article published on 07 September 2011

Statins and pancreatic cancer: are all statins the same?

scientific article published on 06 January 2009

Sustained Reduction of Hyperbilirubinemia in Gunn Rats After Adeno-Associated Virus-Mediated Gene Transfer of Bilirubin UDP-Glucuronosyltransferase Isozyme 1A1 to Skeletal Muscle ⬇️

scientific article published on August 27, 2012

The Biological Effects of Bilirubin Photoisomers

scientific article published in February 2016

The CTLA4 variants may interact with the IL23R- and NOD2-conferred risk in development of Crohn's disease

scientific article

The Extent of Intracellular Accumulation of Bilirubin Determines Its Anti- or Pro-Oxidant Effect

scientific article published on 30 October 2020

The Role of Bilirubin and the Other "Yellow Players" in Neurodegenerative Diseases

scientific article published on 22 September 2020

The Role of Bilirubin in Diabetes, Metabolic Syndrome, and Cardiovascular Diseases ⬇️

scientific article published on April 3, 2012

The association of elevated serum bilirubin levels and coronary heart disease ⬇️

scientific article published on 01 November 2003

The effect of simvastatin on lipid droplets accumulation in human embryonic kidney cells and pancreatic cancer cells.

scientific article published on 21 August 2013

The effect of zinc salts on serum bilirubin levels in hyperbilirubinemic rats.

scientific article published in February 2005

The impact of intestinal microflora on serum bilirubin levels

scientific article published on 01 February 2005

The inverse association of elevated serum bilirubin levels with subclinical carotid atherosclerosis

scientific article published on 09 March 2006

The prevalence of nonalcoholic liver steatosis in patients with type 2 diabetes mellitus in the Czech Republic

scientific article published on 25 June 2014

The relationship between serum bilirubin and Crohn's disease

scientific article published on 01 March 2014

The risk of sporadic colorectal cancer development is not influenced by fat mass and obesity related gene polymorphism in Slavs

scientific article published on 01 August 2012

The role of bile acids in metabolic regulation

scientific article

Transition-Metal-Free CO-Releasing BODIPY Derivatives Activatable by Visible to NIR Light as Promising Bioactive Molecules

scientific article published on 23 December 2015

Two cases of spuriously elevated cerebrospinal glucose concentration.

scientific article published on 29 July 2014

Two independent genetic factors responsible for the associations of the IBD5 locus with Crohnʼs disease in the Czech population

scientific article published on 08 November 2010

Urea synthesis and cyclosporin a biotransformation in a laboratory scale hepatocyte bioreactor model.

scientific article published in December 2002

Urinary excretion of oxidative metabolites of bilirubin in subjects with Gilbert syndrome

scientific article published on 01 June 2007

Use of non-invasive parameters of non-alcoholic steatohepatitis and liver fibrosis in daily practice--an exploratory case-control study

scientific article

Valproic acid downregulates heme oxygenase-1 independently of Nrf2 by increasing ubiquitination and proteasomal degradation.

scientific article published on 8 February 2017

Variability in statin-induced changes in gene expression profiles of pancreatic cancer.

scientific article published on 09 March 2017

Variants of CARD15, TNFA and PTPN22 and susceptibility to Crohn's disease in the Czech population: high frequency of the CARD15 1007fs.

scientific article published in June 2008

Wavelength-Dependent Photochemistry and Biological Relevance of a Bilirubin Dipyrrinone Subunit

scientific article published on 01 October 2020

Xanthene-9-carboxylic acid: A photo-activatable transition-metal-free carbon monoxide-releasing molecule with extraordinary long half-life

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