List of works - Jaume Farrés

Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism.

scientific article

Alcohol dehydrogenase isoenzymes in rat development. Effect of maternal ethanol consumption.

scientific article

Alcohol dehydrogenase of human and rat blood vessels. Role in ethanol metabolism.

scientific article

Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels

scientific article published on 25 October 2008

Aldo-keto reductases in retinoid metabolism: search for substrate specificity and inhibitor selectivity.

scientific article

Amphibian alcohol dehydrogenase. Purification and characterization of classes I and III from Rana perezi

scientific article published on 01 January 1999

Arabidopsis formaldehyde dehydrogenase. Molecular properties of plant class III alcohol dehydrogenase provide further insights into the origins, structure and function of plant class p and liver class I alcohol dehydrogenases.

scientific article published in November 1996

Biocatalytic production of alpha-hydroxy ketones and vicinal diols by yeast and human aldo-keto reductases.

scientific article

Characterization of AKR1B16, a novel mouse aldo-keto reductase.

scientific article published on 17 March 2017

Characterization of three isoenzymes of rat alcohol dehydrogenase. Tissue distribution and physical and enzymatic properties

scientific article published on 01 January 1987

Class IV alcohol dehydrogenase: structure and function

scientific article published on 01 January 1993

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

scientific article

Complete reversal of coenzyme specificity by concerted mutation of three consecutive residues in alcohol dehydrogenase.

scientific article published on 4 August 2003

Crystallization and preliminary X-ray analysis of NADP(H)-dependent alcohol dehydrogenases from Saccharomyces cerevisiae and Rana perezi

scientific article

DNA footprint enhancement using tandem binding sites

scientific article published on 01 December 1991

Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors

scientific article published on 23 September 2021

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.

scientific article

Differential Th1/Th2 cytokine patterns in chronic arthritis: interferon gamma is highly expressed in synovium of rheumatoid arthritis compared with seronegative spondyloarthropathies

scientific article published on April 2000

Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. Consequences for brain ethanol and retinoid metabolism

scientific article

Editorial

Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation ⬇️

scientific article published on 28 February 2019

Engineering aldo-keto reductase 1B10 to mimic the distinct 1B15 topology and specificity towards inhibitors and substrates, including retinoids and steroids

scientific article published on 24 April 2019

Experimental design: a useful tool for PCR Optimization.

scientific article published in July 1996

Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract

scientific article

Formaldehyde dehydrogenase from yeast and plant. Implications for the general functional and structural significance of class III alcohol dehydrogenase

scientific article published on 01 January 1997

Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH22 allele decreases the risk for alcoholism and is associated with ADH31.

scientific article published in April 2000

Genetic polymorphism of liver alcohol dehydrogenase in Spanish subjects: significance of alcohol consumption and liver disease.

scientific article published in November 1994

Hepatic alcohol and aldehyde dehydrogenases in liver disease

scientific article published on 01 January 1987

Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism

scientific article

Human and rat class IV alcohol dehydrogenases. Correlations of primary structures with enzymatic properties

scientific article published on 01 January 1995

Human and rodent aldo–keto reductases from the AKR1B subfamily and their specificity with retinaldehyde ⬇️

scientific article published on February 15, 2011

Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.

scientific article published on 22 January 2015

Influence of liver disease on hepatic alcohol and aldehyde dehydrogenases

scientific article published on 01 September 1989

Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells

scientific article published on 05 April 2019

Investigation of the active site cysteine residue of rat liver mitochondrial aldehyde dehydrogenase by site-directed mutagenesis.

scientific article

Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.

scientific article

Kinetic effects of a single-amino acid mutation in a highly variable loop (residues 114-120) of class IV ADH.

scientific article published in January 2001

Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80

scientific article

Liver mitochondrial aldehyde dehydrogenase: in vitro expression, in vitro import, and effect of alcohols on import

scientific article published on 01 August 1989

Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegeneration

scientific article

Mammalian alcohol dehydrogenase: characteristics of class III isoenzymes

scientific article published on 01 January 1987

Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism

scientific article published on December 2008

Molecular basis for differential substrate specificity in class IV alcohol dehydrogenases: a conserved function in retinoid metabolism but not in ethanol oxidation

scientific journal article

Molecular biological studies on liver mitochondrial aldehyde dehydrogenase

scientific article published on January 1, 1991

Molecular cloning of the mitochondrial aldehyde dehydrogenase gene of Saccharomyces cerevisiae by genetic complementation.

scientific article

Molecular modelling of human gastric alcohol dehydrogenase (class IV) and substrate docking: differences towards the classical liver enzyme (class I)

scientific article published on 01 October 1996

N-terminal acetylation in a third protein family of vertebrate alcohol dehydrogenase/retinal reductase found through a 'proteomics' approach in enzyme characterization

scientific article

Novel alkenal/one reductase activity of yeast NADPH:quinone reductase Zta1p. Prospect of the functional role for the ζ-crystallin family.

scientific article

Organ specific alcohol metabolism: placental chi-ADH

scientific article published on 01 March 1984

Physiological substrates for rat alcohol dehydrogenase classes: aldehydes of lipid peroxidation, omega-hydroxyfatty acids, and retinoids

scientific article published on 01 November 1993

Precursors and post translational modification of mitochondrial aldehyde dehydrogenase

scientific article published on 01 January 1989

Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences.

scientific article

Probing the active site of aldehyde dehydrogenase by site directed mutagenesis.

scientific article published in January 1991

Properties of rat retina alcohol dehydrogenase

scientific article published on 01 January 1985

Purification and partial characterization of a rat retina alcohol dehydrogenase active with ethanol and retinol ⬇️

scientific article published on August 1, 1983

Purification of a novel 55 kDa HeLa cell nuclear DNA-binding protein

scientific article published on 01 January 1991

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

scientific article

Retinoic acid-induced differentiation into astrocytes and glutamatergic neurons is associated with expression of functional and activable phospholipase D.

scientific article published on April 2004

Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase

scientific article

Sequence of the signal peptide for rat liver mitochondrial aldehyde dehydrogenase

scientific article published in February 1988

Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3

scientific article

Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10

scientific article

Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008.

scientific article published in February 2017

Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase

scientific article published on 29 July 2015

Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis

scientific article published on 30 November 2005

Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1).

scientific article published on 11 October 2004

The Xenopus alcohol dehydrogenase gene family: characterization and comparative analysis incorporating amphibian and reptilian genomes

scientific article

The specificity of alcohol dehydrogenase with cis-retinoids. Activity with 11-cis-retinol and localization in retina

scientific article published in May 2004

The yeast ζ-crystallin/NADPH:quinone oxidoreductase (Zta1p) is under nutritional control by the target of rapamycin pathway and is involved in the regulation of argininosuccinate lyase mRNA half-life.

scientific article published on 18 March 2015

List of works by Jaume Farrés

Alcohol dehydrogenase 2 is a major hepatic enzyme for human retinol metabolism.

Alcohol dehydrogenase isoenzymes in rat development. Effect of maternal ethanol consumption.

Alcohol dehydrogenase of human and rat blood vessels. Role in ethanol metabolism.

Aldo-keto reductases from the AKR1B subfamily: retinoid specificity and control of cellular retinoic acid levels

Aldo-keto reductases in retinoid metabolism: search for substrate specificity and inhibitor selectivity.

Amphibian alcohol dehydrogenase. Purification and characterization of classes I and III from Rana perezi

Arabidopsis formaldehyde dehydrogenase. Molecular properties of plant class III alcohol dehydrogenase provide further insights into the origins, structure and function of plant class p and liver class I alcohol dehydrogenases.

Biocatalytic production of alpha-hydroxy ketones and vicinal diols by yeast and human aldo-keto reductases.

Characterization of AKR1B16, a novel mouse aldo-keto reductase.

Characterization of three isoenzymes of rat alcohol dehydrogenase. Tissue distribution and physical and enzymatic properties

Class IV alcohol dehydrogenase: structure and function

Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids

Complete reversal of coenzyme specificity by concerted mutation of three consecutive residues in alcohol dehydrogenase.

Crystallization and preliminary X-ray analysis of NADP(H)-dependent alcohol dehydrogenases from Saccharomyces cerevisiae and Rana perezi

DNA footprint enhancement using tandem binding sites

Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors

Design, synthesis, structure-activity relationships and X-ray structural studies of novel 1-oxopyrimido[4,5-c]quinoline-2-acetic acid derivatives as selective and potent inhibitors of human aldose reductase.

Differential Th1/Th2 cytokine patterns in chronic arthritis: interferon gamma is highly expressed in synovium of rheumatoid arthritis compared with seronegative spondyloarthropathies

Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. Consequences for brain ethanol and retinoid metabolism

Editorial

Efficacy of aldose reductase inhibitors is affected by oxidative stress induced under X-ray irradiation ⬇️

Engineering aldo-keto reductase 1B10 to mimic the distinct 1B15 topology and specificity towards inhibitors and substrates, including retinoids and steroids

Experimental design: a useful tool for PCR Optimization.

Expression, localization and potential physiological significance of alcohol dehydrogenase in the gastrointestinal tract

Formaldehyde dehydrogenase from yeast and plant. Implications for the general functional and structural significance of class III alcohol dehydrogenase

Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1.

Genetic polymorphism of liver alcohol dehydrogenase in Spanish subjects: significance of alcohol consumption and liver disease.

Hepatic alcohol and aldehyde dehydrogenases in liver disease

Human aldose reductase and human small intestine aldose reductase are efficient retinal reductases: consequences for retinoid metabolism

Human and rat class IV alcohol dehydrogenases. Correlations of primary structures with enzymatic properties

Human and rodent aldo–keto reductases from the AKR1B subfamily and their specificity with retinaldehyde ⬇️

Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis.

Influence of liver disease on hepatic alcohol and aldehyde dehydrogenases

Inhibitors of aldehyde dehydrogenases of the 1A subfamily as putative anticancer agents: Kinetic characterization and effect on human cancer cells

Investigation of the active site cysteine residue of rat liver mitochondrial aldehyde dehydrogenase by site-directed mutagenesis.

Kinetic and structural evidence of the alkenal/one reductase specificity of human ζ-crystallin.

Kinetic effects of a single-amino acid mutation in a highly variable loop (residues 114-120) of class IV ADH.

Kinetics of human alcohol dehydrogenase with ring-oxidized retinoids: effect of Tween 80

Liver mitochondrial aldehyde dehydrogenase: in vitro expression, in vitro import, and effect of alcohols on import

Lower somatostatin expression is an early event in diabetic retinopathy and is associated with retinal neurodegeneration

Mammalian alcohol dehydrogenase: characteristics of class III isoenzymes

Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism

Molecular basis for differential substrate specificity in class IV alcohol dehydrogenases: a conserved function in retinoid metabolism but not in ethanol oxidation

Molecular biological studies on liver mitochondrial aldehyde dehydrogenase

Molecular cloning of the mitochondrial aldehyde dehydrogenase gene of Saccharomyces cerevisiae by genetic complementation.

Molecular modelling of human gastric alcohol dehydrogenase (class IV) and substrate docking: differences towards the classical liver enzyme (class I)

N-terminal acetylation in a third protein family of vertebrate alcohol dehydrogenase/retinal reductase found through a 'proteomics' approach in enzyme characterization

Novel alkenal/one reductase activity of yeast NADPH:quinone reductase Zta1p. Prospect of the functional role for the ζ-crystallin family.

Organ specific alcohol metabolism: placental chi-ADH

Physiological substrates for rat alcohol dehydrogenase classes: aldehydes of lipid peroxidation, omega-hydroxyfatty acids, and retinoids

Precursors and post translational modification of mitochondrial aldehyde dehydrogenase

Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences.

Probing the active site of aldehyde dehydrogenase by site directed mutagenesis.

Properties of rat retina alcohol dehydrogenase

Purification and partial characterization of a rat retina alcohol dehydrogenase active with ethanol and retinol ⬇️

Purification of a novel 55 kDa HeLa cell nuclear DNA-binding protein

Retinaldehyde is a substrate for human aldo-keto reductases of the 1C subfamily

Retinoic acid-induced differentiation into astrocytes and glutamatergic neurons is associated with expression of functional and activable phospholipase D.

Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase

Sequence of the signal peptide for rat liver mitochondrial aldehyde dehydrogenase

Stimulation of retinoic acid production and growth by ubiquitously expressed alcohol dehydrogenase Adh3

Structural basis for the high all-trans-retinaldehyde reductase activity of the tumor marker AKR1B10

Structural basis for the inhibition of AKR1B10 by the C3 brominated TTNPB derivative UVI2008.

Substrate Specificity, Inhibitor Selectivity and Structure-Function Relationships of Aldo-Keto Reductase 1B15: A Novel Human Retinaldehyde Reductase

Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis

Synthesis of ring-oxidized retinoids as substrates of mouse class I alcohol dehydrogenase (ADH1).

The Xenopus alcohol dehydrogenase gene family: characterization and comparative analysis incorporating amphibian and reptilian genomes

The specificity of alcohol dehydrogenase with cis-retinoids. Activity with 11-cis-retinol and localization in retina

The yeast ζ-crystallin/NADPH:quinone oxidoreductase (Zta1p) is under nutritional control by the target of rapamycin pathway and is involved in the regulation of argininosuccinate lyase mRNA half-life.

Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH22 allele decreases the risk for alcoholism and is associated with ADH31.