Search filters

List of works by Vladimír Wsól

11Beta-hydroxysteroid dehydrogenase type 1: purification from human liver and characterization as carbonyl reductase of xenobiotics

scientific article

3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones: synthesis and biological activity of a novel group of potential antifungal drugs.

scientific article published in August 2001

A comparison between stereospecificity of oracin reduction and stereoselectivity of oxidation of 11-dihydrooracin enantiomersin vitro in rat and guinea pig

scientific article published on 01 January 1999

A simple identification of novel carbonyl reducing enzymes in the metabolism of the tobacco specific carcinogen NNK.

scientific article published in September 2012

Acetylcholinesterase Inhibitors and Drugs Acting on Muscarinic Receptors- Potential Crosstalk of Cholinergic Mechanisms During Pharmacological Treatment

scientific article

Activity, stereospecificity, and stereoselectivity of microsomal enzymes in dependence on storage and freezing of rat liver samples

scientific article published on 01 October 2000

Albendazole repeated administration induces cytochromes P4501A and accelerates albendazole deactivation in mouflon (Ovis musimon).

scientific article

Aldo-keto reductase 1C3 (AKR1C3): a missing piece of the puzzle in the dinaciclib interaction profile

scientific article published on 10 July 2018

Aldo-keto reductases (AKR) from the AKR1C subfamily catalyze the carbonyl reduction of the novel anticancer drug oracin in man

scientific article published on 26 May 2007

Anthracycline resistance mediated by reductive metabolism in cancer cells: the role of aldo-keto reductase 1C3.

scientific article published on 14 May 2014

Anthracyclines and their metabolism in human liver microsomes and the participation of the new microsomal carbonyl reductase

scientific article published in May 2011

Biochemical properties of human dehydrogenase/reductase (SDR family) member 7.

scientific article published on 16 November 2013

Biotransformation of flobufen enantiomers in ruminant hepatocytes and subcellular fractions

scientific article published in January 2001

Bruton's Tyrosine Kinase Inhibitors Ibrutinib and Acalabrutinib Counteract Anthracycline Resistance in Cancer Cells Expressing AKR1C3

scientific article published on 11 December 2020

Carbonyl reduction of warfarin: Identification and characterization of human warfarin reductases

scientific article published on 4 April 2016

Carbonyl reduction pathways in drug metabolism.

scientific article published on 31 October 2013

Carbonyl-reducing enzymes as targets of a drug-immobilised affinity carrier.

scientific article published on 13 January 2015

Central composite design as a powerful optimisation technique for enantioresolution of the rac-11-dihydrooracin--the principal metabolite of the potential cytostatic drug oracin

scientific article published in December 2002

Characterization of enzymes responsible for biotransformation of the new antileukotrienic drug quinlukast in rat liver microsomes and in primary cultures of rat hepatocytes

scientific article published in February 2004

Chiral aspects of metabolism of antiinflammatory drug flobufen in human hepatocytes

scientific article published in May 2003

Comparison of in vitro activities of biotransformation enzymes in pig, cattle, goat and sheep.

scientific article

Coordination compounds based on 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

scientific article published on 21 May 2007

Cyclin-dependent kinase inhibitors AZD5438 and R547 show potential for enhancing efficacy of daunorubicin-based anticancer therapy: Interaction with carbonyl-reducing enzymes and ABC transporters

scientific article published on 28 February 2019

Deeper insight into the reducing biotransformation of bupropion in the human liver

scientific article

Design, Synthesis, and Biological Evaluation of Isothiosemicarbazones with Antimycobacterial Activity

scientific article

Effect of ivermectin on activities of cytochrome P450 isoenzymes in mouflon (Ovis musimon) and fallow deer (Dama dama).

scientific article

Effect of substituents on microsomal reduction of benzo(c)fluorene N-oxides

scientific article published on 01 June 2000

Efficient isolation of carbonyl-reducing enzymes using affinity approach with anticancer drug oracin as a specific ligand.

scientific article published on 13 March 2013

Enzyme stereospecificity as a powerful tool in searching for new enzymes

scientific article published on July 2010

Expression of human carbonyl reductase 3 (CBR3; SDR21C2) is inducible by pro-inflammatory stimuli.

scientific article

Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment

scientific article published on 03 November 2015

HPLC-radiometric determination of quinlukast in biological fluids

scientific article published on 01 April 2004

High-performance liquid chromatographic assay for the separation and characterization of metabolites of the potential cytostatic drug oracine

scientific article published on 01 May 1996

High-performance liquid chromatography study of stereospecific microsomal enzymes catalysing the reduction of a potential cytostatic drug, oracin. Interspecies comparison

scientific article published on 01 February 1998

Human Carbonyl Reductases ⬇️

scientific article published on October 1, 2010

Human DHRS7, promising enzyme in metabolism of steroids and retinoids?

scientific article published in January 2016

Human dehydrogenase/reductase (SDR family) member 8 (DHRS8): a description and evaluation of its biochemical properties.

scientific article

Human microsomal carbonyl reducing enzymes in the metabolism of xenobiotics: well-known and promising members of the SDR superfamily ⬇️

scientific article published on December 19, 2011

In vitro functional interactions of acetylcholine esterase inhibitors and muscarinic receptor antagonists in the urinary bladder of the rat

scientific article published on 01 February 2014

Inactivation of the anticancer drugs doxorubicin and oracin by aldo-keto reductase (AKR) 1C3

scientific article published on 21 June 2008

Inhibition of human anthracycline reductases by emodin - A possible remedy for anthracycline resistance.

scientific article published on 7 January 2016

Inhibition of nitric oxide synthase prevents muscarinic and purinergic functional changes and development of cyclophosphamide-induced cystitis in the rat.

scientific article published on June 2014

Interactions of antileukemic drugs with daunorubicin reductases: could reductases affect the clinical efficacy of daunorubicin chemoregimens?

scientific article published on 25 June 2020

In vitro metabolism of fenofibric acid by carbonyl reducing enzymes.

scientific article

Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors

scientific article published on 24 April 2014

Liquid chromatographic-electrospray mass spectrometric determination (LC-ESI-MS) of phase II metabolites of flobufen in rat liver microsomes-Chiral discrimination

scientific article published on 22 November 2007

Liquid chromatography-tandem mass spectrometry in chiral study of amlodipine biotransformation in rat hepatocytes

scientific article published on 02 June 2006

Liver microsomal biotransformation of albendazole in deer, cattle, sheep and pig and some related wild breeds.

scientific article published in August 2005

Metabolite profile of sibutramine in human urine: a liquid chromatography-electrospray ionization mass spectrometric study

scientific article published on 01 September 2006

Molecular and biochemical characterisation of human short-chain dehydrogenase/reductase member 3 (DHRS3).

scientific article published on 29 October 2014

Olaparib Synergizes the Anticancer Activity of Daunorubicin via Interaction with AKR1C3

scientific article published on 26 October 2020

Partial purification and characterization of a new human membrane-bound carbonyl reductase playing a role in the deactivation of the anticancer drug oracin.

scientific article published on 25 July 2009

Pharmacokinetic interactions of breast cancer chemotherapeutics with human doxorubicin reductases.

scientific article published on 15 May 2015

Proteasome inhibitors MG-132 and bortezomib induce AKR1C1, AKR1C3, AKR1B1, and AKR1B10 in human colon cancer cell lines SW-480 and HT-29.

scientific article published on 6 January 2011

Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics

scientific article published on 28 December 2005

Purification and reconstitution of human membrane-bound DHRS7 (SDR34C1) from Sf9 cells

scientific article published on 4 December 2013

Reduction of flobufen in pig hepatocytes: effect of pig breed (domestic, wild) and castration.

scientific article

Reduction of the Potential Anticancer Drug Oracin in the Rat Liver In-vitro

scientific article published on 01 May 2000

Reductive metabolism of tiaprofenic acid by the human liver and recombinant carbonyl reducing enzymes

scientific article published on 17 March 2017

Role of carbonyl reducing enzymes in the phase I biotransformation of the non-steroidal anti-inflammatory drug nabumetonein vitro

scientific article published on 28 September 2012

S-nitrosoglutathione covalently modifies cysteine residues of human carbonyl reductase 1 and affects its activity

scientific article

Salicylanilide derivatives block Mycobacterium tuberculosis through inhibition of isocitrate lyase and methionine aminopeptidase

scientific article

Selective inhibition of aldo-keto reductase 1C3: a novel mechanism involved in midostaurin and daunorubicin synergism

scientific article published on 06 October 2020

Sex differences in stereospecificity of oracin reductases in ratin vitro andin vivo

scientific article published on 01 January 1999

Stereochemical aspects of carbonyl reduction of the original anticancer drug oracin by mouse liver microsomes and purified 11beta-hydroxysteroid dehydrogenase type 1.

scientific article published in February 2003

Stereoselective pharmacokinetics and metabolism of flobufen in guinea pigs.

scientific article published in October 2003

Stereoselective pharmacokinetics of flobufen in rats

scientific article published on 01 January 1999

Stereospecific biotransformation of albendazole in mouflon and rat-isolated hepatocytes.

scientific article published in August 2003

Stereospecific reduction of the original anticancer drug oracin in rat extrahepatic tissues

scientific article published on 01 July 2003

Stereospecificity and stereoselectivity of flobufen metabolic profile in male rats in vitro and in vivo: phase I of biotransformation

scientific article published in January 2001

Stereospecificity of flobufen metabolism in guinea pigs in vitro and in vivo: phase I of biotransformation

scientific article published in January 2004

Studies on reduction of S-nitrosoglutathione by human carbonyl reductases 1 and 3.

scientific article published on 21 January 2011

Synthesis and Biological Activity of Quaternary Ammonium Salt-Type Agents Containing Cholesterol and Terpenes

scientific article published on 24 March 2014

Synthesis and in vitro antimycobacterial and isocitrate lyase inhibition properties of novel 2-methoxy-2′-hydroxybenzanilides, their thioxo analogues and benzoxazoles

scientific article published on 16 August 2012

Targeting Pharmacokinetic Drug Resistance in Acute Myeloid Leukemia Cells with CDK4/6 Inhibitors

scientific article published on 16 June 2020

The novel anticancer drug oracin: different stereospecificity and cooperativity for carbonyl reduction by purified human liver 11beta-hydroxysteroid dehydrogenase type 1.

scientific article

The role of carbonyl reducing enzymes in oxcarbazepine in vitro metabolism in man.

scientific article published on 22 July 2014

The stereoselective biotransformation of the anti-obesity drug sibutramine in rat liver microsomes and in primary cultures of rat hepatocytes

scientific article

Use of chiral liquid chromatography for the evaluation of stereospecificity in the carbonyl reduction of potential benzo[c]fluorene antineoplastics benfluron and dimefluron in various species.

scientific article published on 28 November 2004

Paulina is supported by:

About Paulina

Help