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List of works by Timothy O'Brien

A Role for MRP8 in in stent restenosis in diabetes

scientific article published on 01 February 2012

A comparison of the efficacy of transplantation of bone marrow-derived mesenchymal stem cells and unrestricted somatic stem cells on outcome after acute myocardial infarction

scientific article published on 13 September 2012

A matrix reservoir for improved control of non-viral gene delivery

scientific article

A shape-controlled tuneable microgel platform to modulate angiogenic paracrine responses in stem cells.

scientific article published on 18 July 2014

A temporal gene delivery system based on fibrin microspheres.

scientific article

Adeno-associated virus serotype 2 induces cell-mediated immune responses directed against multiple epitopes of the capsid protein VP1

scientific article

Adenoviral transduction of mesenchymal stem cells: in vitro responses and in vivo immune responses after cell transplantation

scientific article

Advances in mesenchymal stem cell-mediated gene therapy for cancer.

scientific article

Aerosol-mediated delivery of AAV2/6-IκBα attenuates lipopolysaccharide-induced acute lung injury in rats.

scientific article

An injectable elastin-based gene delivery platform for dose-dependent modulation of angiogenesis and inflammation for critical limb ischemia

scientific article published on 26 June 2015

Assessment of stem cell carriers for tendon tissue engineering in pre-clinical models

scientific article

Assessment of wound healing in the alloxan-induced diabetic rabbit ear model

scientific article published in September 2008

Autologous circulating angiogenic cells treated with osteopontin and delivered via a collagen scaffold enhance wound healing in the alloxan-induced diabetic rabbit ear ulcer model

scientific article

Beta cell cytoprotection using lentiviral vector-based iNOS-specific shRNA delivery.

scientific article published on 28 March 2007

Biodistribution and retention of locally administered human mesenchymal stromal cells: Quantitative polymerase chain reaction-based detection of human DNA in murine organs

scientific article published on 12 January 2017

Bone Marrow-Derived Mesenchymal Stem Cells Have Innate Procoagulant Activity and Cause Microvascular Obstruction Following Intracoronary Delivery: Amelioration by Antithrombin Therapy.

scientific article published on 4 June 2015

Bone marrow-derived mesenchymal stem cells promote angiogenic processes in a time- and dose-dependent manner in vitro

scientific article published on 01 September 2009

Cardiovascular gene therapy: current status and therapeutic potential.

scientific article

Catalyzing Transcriptomics Research in Cardiovascular Disease: The CardioRNA COST Action CA17129

scientific article published on 29 March 2019

Characterization of patients with diabetic foot disease presenting to an Irish Podiatry Centre: profiling suitability for entry to a clinical trial of advanced wound therapeutics.

scientific article published on 11 October 2016

Clinical efficacy on glycemic control and safety of mesenchymal stem cells in patients with diabetes mellitus: Systematic review and meta-analysis of RCT data

scientific article published in 2021

Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture

scientific article published on 10 February 2016

Common definition for categories of clinical research: a prerequisite for a survey on regulatory requirements by the European Clinical Research Infrastructures Network (ECRIN)

scientific article published on 16 October 2009

Comparative evaluation of viral, nonviral and physical methods of gene delivery to normal and transformed lung epithelial cells.

scientific article

Comparison of viral and nonviral vectors for gene transfer to human endothelial progenitor cells

scientific article

Compassionate use of interventions: results of a European Clinical Research Infrastructures Network (ECRIN) survey of ten European countries

scientific article

Conditions of vector delivery improve efficiency of adenoviral-mediated gene transfer to the transplanted heart

article

Cytokine-induced beta-cell apoptosis is NO-dependent, mitochondria-mediated and inhibited by BCL-XL.

scientific article published on 10 December 2007

Developing cell-specific antibodies to endothelial progenitor cells using avian immune phage display technology.

scientific article

Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone

scientific article published on 13 December 2011

Dietary antioxidants preserve endothelium dependent vasorelaxation in overfed rats

scientific article published in April 2002

Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers

scientific article published on 2 March 2011

Differentiation of Vascular Stem Cells Contributes to Ectopic Calcification of Atherosclerotic Plaque

scientific article published on 3 February 2016

Distinct effects of high-glucose conditions on endothelial cells of macrovascular and microvascular origins.

scientific article published in January 2006

Distribution and function of recombinant endothelial nitric oxide synthase in transplanted hearts

scientific article published on 01 June 1999

ER stress contributes to ischemia-induced cardiomyocyte apoptosis

scientific journal article

Effect of cyclosporin A on functional recovery in the spinal cord following contusion injury.

scientific article published on 24 June 2009

Effect of gene delivery of NOS isoforms on intimal hyperplasia and endothelial regeneration after balloon injury

scientific article published on 2 November 2006

Effects of in vivo adventitial expression of recombinant endothelial nitric oxide synthase gene in cerebral arteries.

scientific article published on November 1997

Effects of intratracheal mesenchymal stromal cell therapy during recovery and resolution after ventilator-induced lung injury

scientific article published in April 2013

Efficacy of adenoviral gene transfer with manganese superoxide dismutase and endothelial nitric oxide synthase in reducing ischemia and reperfusion injury

article

Elevation of cAMP in mesenchymal stem cells transiently upregulates neural markers rather than inducing neural differentiation.

scientific article published in April 2009

Endothelial nitric oxide synthase induces heat shock protein HSPA6 (HSP70B') in human arterial smooth muscle cells

scientific article published on 01 December 2015

Endothelial progenitor cells for the treatment of diabetic vasculopathy: panacea or Pandora's box?

scientific article published on 06 September 2007

Engraftment, migration and differentiation of neural stem cells in the rat spinal cord following contusion injury.

scientific article published in May 2010

Enhanced lipoplex-mediated gene expression in mesenchymal stem cells using reiterated nuclear localization sequence peptides.

scientific article published in February 2010

Ex vivo gene transfer of endothelial nitric oxide synthase to atherosclerotic rabbit aortic rings improves relaxations to acetylcholine

article

Expression and function of a recombinant endothelial nitric oxide synthase gene in porcine coronary arteries

article

Expression and function of recombinant S1179D endothelial nitric oxide synthase in canine cerebral arteries

scientific article

Expression and function of recombinant endothelial nitric oxide synthase in human endothelial cells

scientific article published on 01 November 2000

Expression of Concern: Human amniotic epithelial cells can differentiate into granulosa cells and restore folliculogenesis in a mouse model of chemotherapy-induced premature ovarian failure

scientific article

Fabry's disease: a family study

scientific article published on 01 April 1990

Fibrin as a delivery system for therapeutic drugs and biomolecules

scientific article published on June 2009

Fibrin scaffold promotes adenoviral gene transfer and controlled vector delivery

scientific article published in June 2009

Fibrin-lipoplex system for controlled topical delivery of multiple genes

scientific article published on June 2009

Functionalized scaffold-mediated interleukin 10 gene delivery significantly improves survival rates of stem cells in vivo

scientific article

Gene Therapy for Type 1 Diabetes Moves a Step Closer to Reality ⬇️

scientific article published on May 1, 2013

Gene delivery to the vasculature mediated by low-titre adeno-associated virus serotypes 1 and 5.

scientific article published in February 2008

Gene therapy in lung transplantation: effective gene transfer via the airways

scientific article

Gene transfer into rat mesenchymal stem cells: a comparative study of viral and nonviral vectors.

scientific article published in February 2006

Gene transfer of manganese superoxide dismutase reverses vascular dysfunction in the absence but not in the presence of atherosclerotic plaque

scientific article published in July 2001

Gene transfer to coronary artery bypass conduits

scientific article published in October 2002

Gene-eluting stents: adenovirus-mediated delivery of eNOS to the blood vessel wall accelerates re-endothelialization and inhibits restenosis

scientific article published on 19 August 2008

Gene-eluting stents: comparison of adenoviral and adeno- associated viral gene delivery to the blood vessel wall in vivo.

scientific article published in July 2006

Gene-eluting stents: non-viral, liposome-based gene delivery of eNOS to the blood vessel wall in vivo results in enhanced endothelialization but does not reduce restenosis in a hypercholesterolemic model

scientific article published on 30 June 2011

Gene-modified mesenchymal stem cells express functionally active nerve growth factor on an engineered poly lactic glycolic acid (PLGA) substrate.

scientific article published in May 2008

General practitioners' attitudes and preparedness towards Clinical Decision Support in e-Prescribing (CDS-eP) adoption in the West of Ireland: a cross sectional study.

scientific article

H2O2 is required for UVB-induced EGF receptor and downstream signaling pathway activation

scientific article published on 01 December 1999

HDL subparticles and coronary artery disease in NIDDM.

scientific article published in April 1996

High levels of ephrinB2 over-expression increases the osteogenic differentiation of human mesenchymal stem cells and promotes enhanced cell mediated mineralisation in a polyethyleneimine-ephrinB2 gene-activated matrix

scientific article

Human mesenchymal stromal cells decrease the severity of acute lung injury induced by E. coli in the rat.

scientific article published on 18 May 2015

Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanism

scientific article published on 16 July 2009

Immunogenicity of allogeneic mesenchymal stem cells.

scientific article published on September 2012

Immunomodulatory effects of natural polysaccharides assessed in human whole blood culture and THP-1 cells show greater sensitivity of whole blood culture.

scientific article published on 21 May 2016

Immunosuppression prolongs adenoviral mediated transgene expression in cardiac allograft transplantation

scientific article

Impact of Syndecan-2-Selected Mesenchymal Stromal Cells on the Early Onset of Diabetic Cardiomyopathy in Diabetic db/db Mice

scientific article published on 21 May 2021

In vitro models for assessing therapeutic angiogenesis.

scientific article published on June 2016

In vivo gene transfer of inducible nitric oxide synthase to carotid arteries from hypercholesterolemic rabbits

scientific article published on 10 April 2003

Inefficiency in macromolecular transport of SCS-based microcapsules affects viability of primary human mesenchymal stem cells but not of immortalized cells.

scientific article published on May 2015

Influence of temperature on adenovirus-mediated gene transfer

scientific article

Interference: an alteRNAtive therapy following acute myocardial infarction.

scientific article published on 12 October 2012

Introduction to series on mesenchymal stromal (stem) cells-MSCs

scientific article published on 01 September 2010

Lentiviral vector delivery of short hairpin RNA to NG2 and neurotrophin-3 promotes locomotor recovery in injured rat spinal cord

scientific article

Lentiviral vector mediated modification of mesenchymal stem cells & enhanced survival in an in vitro model of ischaemia ⬇️

scientific article published on March 7, 2011

Liposomal gene delivery mediated by tissue-engineered scaffolds

scientific article

Liposomal surface coatings of metal stents for efficient non-viral gene delivery to the injured vasculature

scientific article published on 10 February 2013

Macromolecular crowding meets oxygen tension in human mesenchymal stem cell culture - A step closer to physiologically relevant in vitro organogenesis.

scientific article published on August 2016

Measurement of the Postgraduate Educational Environment of Junior Doctors Training in Medicine at an Irish University Teaching Hospital

scientific article published on 28 April 2015

Mesenchymal Stem Cell-mediated delivery of the sodium iodide symporter supports radionuclide imaging and treatment of breast cancer.

scientific article published on July 2011

Mesenchymal stem cell secretion of chemokines during differentiation into osteoblasts, and their potential role in mediating interactions with breast cancer cells.

scientific article

Mesenchymal stem cell survival in the infarcted heart is enhanced by lentivirus vector-mediated heat shock protein 27 expression

scientific article published on October 2013

Mesenchymal stem cell-based treatment for microvascular and secondary complications of diabetes mellitus

scientific article

Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat.

scientific article

Mesenchymal stem cells overexpressing ephrin-b2 rapidly adopt an early endothelial phenotype with simultaneous reduction of osteogenic potential

scientific article published on 01 September 2010

Metabolic flexibility permits mesenchymal stem cell survival in an ischemic environment.

scientific article

Monocyte chemotactic protein-1 secreted by primary breast tumors stimulates migration of mesenchymal stem cells.

scientific article published on September 2007

Multigene adenoviral therapy for the attenuation of ischemia-reperfusion injury after preservation for cardiac transplantation

scientific article published in May 2003

NRXN1α<sup>+/-</sup> is associated with increased excitability in ASD iPSC-derived neurons

scientific article published on 15 September 2021

Nitric oxide synthase gene therapy: progress and prospects.

scientific article published on July 2009

Non-viral gene therapy for myocardial engineering

scientific article published on May 2010

Optimization of a fibrin scaffold for sustained release of an adenoviral gene vector

scientific article published in September 2006

Optimized aerosol delivery to a mechanically ventilated rodent

scientific article

Overexpression of pulmonary extracellular superoxide dismutase attenuates endotoxin-induced acute lung injury.

scientific article published on 14 July 2011

OxLDL-induced gene expression patterns in CASMC are mimicked in apoE-/- mice aortas

scientific article published on 12 March 2007

Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT).

scientific article

Pretreatment of Endothelial Progenitor Cells with Osteopontin Enhances Cell Therapy for Peripheral Vascular Disease

scientific article published on 02 February 2012

Purification of adenoviral vectors by combined anion exchange and gel filtration chromatography.

scientific article

Purification of adenovirus and adeno-associated virus: comparison of novel membrane-based technology to conventional techniques.

scientific article published on October 2005

ROCK activity and the Gβγ complex mediate chemotactic migration of mouse bone marrow-derived stromal cells

scientific article

Rapamycin regulates autophagy and cell adhesion in induced pluripotent stem cells.

scientific article

Recovery of cardiac function mediated by MSC and interleukin-10 plasmid functionalised scaffold

scientific article

Relevance of an academic GMP Pan-European vector infra-structure (PEVI).

scientific article published on December 2010

Remnant lipoproteins induce endothelial plasminogen activator inhibitor-1.

scientific article

Restructuring of the Diabetes Day Centre: a pilot lean project in a tertiary referral centre in the West of Ireland.

scientific article published on 30 May 2013

Results of treatment of pituitary disease in multiple endocrine neoplasia, type I.

scientific article published in August 1996

Robust, Efficient, and Practical Electrogene Transfer Method for Human Mesenchymal Stem Cells Using Square Electric Pulses ⬇️

scientific article published on August 30, 2013

Scaffold and scaffold-free self-assembled systems in regenerative medicine.

scientific article

Stem Cell Research & Therapy in 2012.

scientific article published in January 2012

Stem cell therapy for cardiac disease.

scientific article published on February 2011

Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury

Surgical management of insulinoma associated with multiple endocrine neoplasia type I

scientific article published on 01 July 1994

Systematic evaluation of distribution of transgene expression after adenovirus-mediated gene transfer to the transplanted heart

scientific article published in January 1998

Temporal changes guided by mesenchymal stem cells on a 3D microgel platform enhance angiogenesis in vivo at a low-cell dose

scientific article published on 24 July 2020

The Promise of Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease.

scientific article published on May 2016

The behavioural and neuropathological impact of intranigral AAV-α-synuclein is exacerbated by systemic infusion of the Parkinson's disease-associated pesticide, rotenone, in rats

scientific article

The potential of cell-based therapy for diabetes and diabetes-related vascular complications

scientific article published on March 2014

The rational design of beta cell cytoprotective gene transfer strategies: targeting deleterious iNOS expression.

scientific article

The use of therapeutic gene eNOS delivered via a fibrin scaffold enhances wound healing in a compromised wound model

scientific article published on 28 April 2008

Therapeutic efficacy of human mesenchymal stromal cells in the repair of established ventilator-induced lung injury in the rat.

scientific article published in February 2015

Therapeutic potential for mesenchymal stem cell transplantation in critical limb ischemia.

scientific article published on 30 July 2012

Thermosensitive hydrogel for prolonged delivery of lentiviral vector expressing neurotrophin-3 in vitro

scientific article published in November 2011

Three years of Stem Cell Research & Therapy

scientific article published in May 2013

Topical administration of allogeneic mesenchymal stromal cells seeded in a collagen scaffold augments wound healing and increases angiogenesis in the diabetic rabbit ulcer

scientific article published on 19 February 2013

Transbronchial gene transfer of endothelial nitric oxide synthase to transplanted lungs

article

Transfer and expression of recombinant nitric oxide synthase genes in the cardiovascular system

scientific article published in July 1998

Translating stem cell research to the clinic: a primer on translational considerations for your first stem cell protocol

scientific article

Translation of science to surgery: linking emerging concepts in biological cartilage repair to surgical intervention.

scientific article published on September 2010

Typical investigational medicinal products follow relatively uniform regulations in 10 European Clinical Research Infrastructures Network (ECRIN) countries

scientific article published on 27 March 2012

Ulk4 Is Essential for Ciliogenesis and CSF Flow.

scientific article

Ulk4 Regulates Neural Stem Cell Pool

scientific article published on 14 June 2016

Ulk4 deficiency leads to hypomyelination in mice

scientific article published on 16 October 2017

Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds.

scientific article published on 10 December 2013

Variability in Endogenous Perfusion Recovery of Immunocompromised Mouse Models of Limb Ischemia

scientific article published on 2 February 2016

Vitamin D insufficiency in older female community-dwelling acute hospital admissions and the response to supplementation

scientific article published on 15 March 2006

When a nephrectomy cures hypoglycaemia ⬇️

scientific article published on May 17, 2009

When head rules heart

scientific article published on 01 November 2004

eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis

article

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