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List of works by William J. Martin

1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: application in the synthesis of potent human melanocortin-4 receptor selective agonists

scientific article published in July 2005

3-Amino-1,5-benzodiazepinones: Potent, state-dependent sodium channel blockers with anti-epileptic activity

article

A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model

scientific article published on August 2004

A novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: synthesis and structure-activity relationships

scientific article published on 22 December 2012

A role for the melanocortin 4 receptor in sexual function

scientific article

Activation of melanocortin MC(4) receptors increases erectile activity in rats ex copula

scientific article

An analgesia circuit activated by cannabinoids

scientific article

An examination of the central sites of action of cannabinoid-induced antinociception in the rat

scientific article published on 01 January 1995

Anatomical basis for cannabinoid-induced antinociception as revealed by intracerebral microinjections

scientific article

Antinociceptive actions of cannabinoids following intraventricular administration in rats

scientific article published on 01 December 1993

Application of the classical Einthoven model of bronchoconstriction to the study of inhaled bronchodilators in rodents

scientific article published on 8 June 2010

Benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

article

Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats.

scientific article published on 21 November 2005

Cannabinoid receptor-mediated inhibition of the rat tail-flick reflex after microinjection into the rostral ventromedial medulla

scientific article published in February 1998

Characterization of Wide Dynamic Range Neurons in the Deep Dorsal Horn of the Spinal Cord in Preprotachykinin-A Null Mice In Vivo

scientific article published on 07 January 2004

Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior

scientific article

Currying favor with central inhibitory circuits. Focus on: "effects of TRPA1 agonists mustard oil and cinnamaldehyde on lumbar wide-dynamic range neuronal responses to innocuous and noxious cutaneous stimuli in rats".

scientific article published on 31 October 2007

Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor ago

scientific article published in October 2002

Differential effects of neurotoxic destruction of descending noradrenergic pathways on acute and persistent nociceptive processing.

scientific article published on March 1999

Differential modulation of ventral tegmental area circuits by the nociceptin/orphanin FQ system

scientific article published on 03 August 2020

Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocorti

scientific article published in August 2005

Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist

scientific article published in January 2005

Discovery of a novel class of benzazepinone Nav1.7 blockers: Potential treatments for neuropathic pain

article

Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain

scientific article published on 14 October 2010

Discovery of a novel class of isoxazoline voltage gated sodium channel blockers

scientific article published on 6 August 2009

Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist

scientific article published on 01 March 2011

Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist

scientific article published on 19 February 2010

Discovery of isoxazole voltage gated sodium channel blockers for treatment of chronic pain

scientific article

Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists

scientific article published in April 2010

Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain

article

Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists

scientific article published on 17 June 2010

Effects of σ ligands on rat cerebellar purkinje neuron firing: An iontophoretic study

scientific article published on 01 January 1994

Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose

scientific article published on 11 February 2009

Hierarchy of transcriptomic specialization across human cortex captured by structural neuroimaging topography

article

Identification and characterization of novel mammalian neuropeptide FF-like peptides that attenuate morphine-induced antinociception

scientific journal article

Imidazopyridines: A novel class of hNav1.7 channel blockers

article

Impaired nociception and pain sensation in mice lacking the capsaicin receptor

scientific journal article

In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal models.

scientific article

Inflammation-induced up-regulation of protein kinase Cgamma immunoreactivity in rat spinal cord correlates with enhanced nociceptive processing.

scientific article published on January 1999

Influence of ligand binding kinetics on functional inhibition of human recombinant serotonin and norepinephrine transporters

scientific article

Inhibition of noxious stimulus-evoked activity of spinal cord dorsal horn neurons by the cannabinoid WIN 55,212-2

scientific article published on 01 January 1995

Melanocortin receptors and erectile function

scientific article published on June 2004

Novel cyclopentane dicarboxamide sodium channel blockers as a potential treatment for chronic pain

scientific article

Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands

scientific article published on 10 June 2010

Pain Processing: Paradoxes and Predictions

Pharmacologic characterization of GSK-961081 (TD-5959), a first-in-class inhaled bifunctional bronchodilator possessing muscarinic receptor antagonist and β2-adrenoceptor agonist properties

scientific article

Preclinical efficacy of THRX-200495, a dual pharmacology muscarinic receptor antagonist and β(2)-adrenoceptor agonist (MABA)

article

Preclinical to clinical translation of CNS transporter occupancy of TD-9855, a novel norepinephrine and serotonin reuptake inhibitor.

scientific article published on 13 December 2014

Relationship between sodium channel NaV1.3 expression and neuropathic pain behavior in rats

scientific article published in September 2005

Relationship between the firing frequency of injured peripheral neurons and inhibition of firing by sodium channel blockers

scientific article

Relative contributions of norepinephrine and serotonin transporters to antinociceptive synergy between monoamine reuptake inhibitors and morphine in the rat formalin model

scientific article

Reversal of neuropathic pain by alpha-hydroxyphenylamide: a novel sodium channel antagonist

scientific article

Sodium channel blockade may contribute to the analgesic efficacy of antidepressants

scientific article

Spinal cannabinoids are anti-allodynic in rats with persistent inflammation.

scientific article published on August 1999

Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers

article

Substituted biaryl pyrazoles as sodium channel blockers

article

Synthesis and SAR of 1,2-trans-(1-hydroxy-3-phenylprop-1-yl)cyclopentane carboxamide derivatives, a new class of sodium channel blockers

scientific article

The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. ⬇️

scientific article published in February 2002

The behavioral and neuroanatomical effects of IB4-saporin treatment in rat models of nociceptive and neuropathic pain

scientific article published on 01 December 2004

The rodent amygdala contributes to the production of cannabinoid-induced antinociception

scientific article published in January 2003

The voltage-gated sodium channel Nav1.9 is required for inflammation-based urinary bladder dysfunction

scientific article published on 6 January 2009

Varicella zoster virus induces neuropathic changes in rat dorsal root ganglia and behavioral reflex sensitisation that is attenuated by gabapentin or sodium channel blocking drugs

scientific article

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