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List of works by Sergio C. Chai

A timetable organizer for the planning and implementation of screenings in manual or semi-automation mode.

scientific article published on 07 May 2013

An automated approach to efficiently reformat a large collection of compounds.

scientific article

Analysis of the stoichiometric metal activation of methionine aminopeptidase

scientific article

Blocking an N-terminal acetylation-dependent protein interaction inhibits an E3 ligase.

scientific article

Bromodomain-selective BET inhibitors are potent antitumor agents against MYC-driven pediatric cancer

scientific article published on 10 July 2020

CITCO Directly Binds to and Activates Human Pregnane X Receptor

scientific article published on 27 December 2019

Catalysis and Inhibition of Mycobacterium tuberculosis Methionine Aminopeptidase

scientific article

Characterization of metal binding in the active sites of acireductone dioxygenase isoforms from Klebsiella ATCC 8724.

scientific article

Clobetasol Propionate Is a Heme-Mediated Selective Inhibitor of Human Cytochrome P450 3A5

scientific article published on 22 January 2020

Determination of binding affinity of metal cofactor to the active site of methionine aminopeptidase based on quantitation of functional enzyme

scientific journal article

Development of CINPA1 analogs as novel and potent inverse agonists of constitutive androstane receptor

scientific article

Discovery of Inhibitors of Escherichia coli Methionine Aminopeptidase with the Fe(II)-Form Selectivity and Antibacterial Activity †

scientific article

Drug discovery technologies to identify and characterize modulators of the pregnane X receptor and the constitutive androstane receptor

scientific article published on 04 February 2019

Exploiting a water network to achieve enthalpy-driven, bromodomain-selective BET inhibitors.

scientific article published on 4 November 2017

Growth inhibition of Escherichia coli and methicillin-resistant Staphylococcus aureus by targeting cellular methionine aminopeptidase

scientific article

Heterologous expression, purification, and characterization of recombinant rat cysteine dioxygenase.

scientific article

Hydrophilic residues are crucial for ribosomal protein L11 (RPL11) interaction with zinc finger domain of MDM2 and p53 protein activation

scientific article published on 8 September 2011

Identification and Characterization of CINPA1 Metabolites Facilitates Structure-Activity Studies of the Constitutive Androstane Receptor

scientific article published on 12 August 2016

Metal-mediated inhibition is a viable approach for inhibiting cellular methionine aminopeptidase.

scientific article published on 23 October 2009

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

scientific article published on 01 April 2022

Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell-Permeable Inhibitors of Protein−Protein Interactions ⬇️

scientific article published on February 2, 2011

One protein, two enzymes revisited: a structural entropy switch interconverts the two isoforms of acireductone dioxygenase

scientific article

Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1 ⬇️

scientific article published on May 22, 2013

Pregnane X receptor and drug-induced liver injury.

scientific article

Small-molecule modulators of PXR and CAR.

scientific article

Small-molecule modulators of the constitutive androstane receptor.

scientific article published on 15 May 2015

Tryptophan 299 is a conserved residue of human pregnane X receptor critical for the functional consequence of ligand binding.

scientific article published on 18 February 2016

Two methionine aminopeptidases from Acinetobacter baumannii are functional enzymes.

scientific article

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