List of works by Georges E Grau

A contrast agent recognizing activated platelets reveals murine cerebral malaria pathology undetectable by conventional MRI

scientific article

A murine model of infection with Rickettsia prowazekii: implications for pathogenesis of epidemic typhus

scientific article

A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria

scientific article

A potential role for interleukin-33 and γ-epithelium sodium channel in the pathogenesis of human malaria associated lung injury.

scientific article

A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction.

scientific article published on 18 September 2006

ABCA1 gene deletion protects against cerebral malaria: potential pathogenic role of microparticles in neuropathology.

scientific article

Abnormal blood vessels formed by human liver cavernous hemangioma endothelial cells in nude mice are suitable for drug evaluation

scientific article published on 31 August 2009

Anti-parasite effects of cytokines in malaria

scientific article published on August 1990

Anti-tumor necrosis factor modulates anti-CD3-triggered T cell cytokine gene expression in vivo

scientific article

Antiangiogenic effect of erythromycin: an in vitro model of Bartonella quintana infection

scientific article

Antigen presentation by endothelial cells: what role in the pathophysiology of malaria?

scientific article published on 25 February 2012

Assaying tumor necrosis factor concentrations in human serum. A WHO International Collaborative study

scientific article published in May 1995

Association of polymorphisms in pro and anti-inflammatory cytokines in children with cerebral malaria, non cerebral malaria and coma of other causes

scholarly article by Roslyn E McQueen et al published October 2002 in Human Immunology

Biochemical markers of nutritional status and childhood malaria severity in Cameroon

scientific article published on 9 July 2010

Both TNF receptors are required for direct TNF-mediated cytotoxicity in microvascular endothelial cells

scientific article published on 01 November 1998

Both functional LTbeta receptor and TNF receptor 2 are required for the development of experimental cerebral malaria

scientific article

Both soluble and membrane-associated TNF activate brain microvascular endothelium: relevance to multiple sclerosis.

scientific article published on March 1997

Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors

scientific article

Brain microvascular endothelial cells and leukocytes derived from patients with multiple sclerosis exhibit increased adhesion capacity

scientific article published in February 1997

Breast cancer-derived microparticles display tissue selectivity in the transfer of resistance proteins to cells

scientific article

Bronchial epithelial cell extracellular vesicles ameliorate epithelial-mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization

scientific article published on 11 April 2019

CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin

scientific article

Cascade modulation by anti-tumor necrosis factor monoclonal antibody of interferon-γ, interleukin 3 and interleukin 6 release after triggering of the CD33/T cell receptor activation pathway ⬇️

scientific article published on 01 October 1991

Cerebral malaria -- a neurovascular pathology with many riddles still to be solved.

scientific article

Cerebral malaria pathogenesis: revisiting parasite and host contributions.

scientific article published on February 2012

Cerebral malaria: gamma-interferon redux

scientific article

Cerebral malaria: mediators, mechanical obstruction or more?

scientific article published in October 1994

Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis

scientific article published on 31 May 2011

Circulating endothelial microparticles in malawian children with severe falciparum malaria complicated with coma

scientific article published in June 2004

Circulating plasma receptors for tumour necrosis factor in Malawian children with severe falciparum malaria

scientific article published in November 1993

Circulating red cell-derived microparticles in human malaria

scientific article published on March 2011

Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak

scientific article published on 08 March 2019

Coincident parasite and CD8 T cell sequestration is required for development of experimental cerebral malaria

scientific article published on 7 September 2010

Cooperation between β- and γ-cytoplasmic actins in the mechanical regulation of endothelial microparticle formation.

scientific article

Correlation of tumor necrosis factor levels in the serum and cerebrospinal fluid with clinical outcome in Japanese encephalitis patients

scientific article published on 01 February 1997

Crossing the wall: the opening of endothelial cell junctions during infectious diseases.

scientific article published on 26 March 2013

Crucial role of tumor necrosis factor (TNF) receptor 2 and membrane‐bound TNF in experimental cerebral malaria ⬇️

scientific article published on July 1, 1997

Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans var. grubii strain H99 and Cryptococcus gattii strain R265.

scientific article published on 11 September 2015

Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro.

scientific article published on 12 August 2013

Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria

scientific article

Delayed mortality and attenuated thrombocytopenia associated with severe malaria in urokinase- and urokinase receptor-deficient mice

scientific article

Differential microRNA expression in experimental cerebral and noncerebral malaria.

scientific article

Differential plasma microvesicle and brain profiles of microRNA in experimental cerebral malaria.

scientific article

Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-β signalling pathways

scientific article published in Scientific Reports

Divergent roles of β- and γ-actin isoforms during spread of vaccinia virus

scientific article published on 20 February 2017

Dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in Plasmodium vivax malaria ⬇️

scientific article published on April 15, 1992

Dysregulation of pulmonary endothelial protein C receptor and thrombomodulin in severe falciparum malaria-associated ARDS relevant to hemozoin.

scientific article published on 21 July 2017

Effect of polyunsaturated fatty acids (PUFAs) on airway epithelial cells' tight junction.

scientific article

Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria.

scientific article

Endothelial microparticles interact with and support the proliferation of T cells

scientific article

Endotoxin-induced monocytic microparticles have contrasting effects on endothelial inflammatory responses.

scientific article

Experimental cerebral malaria: possible new mechanisms in the TNF-induced microvascular pathology.

scientific article published on January 1995

Experimental severe malaria is resolved by targeting newly-identified monocyte subsets using immune-modifying particles combined with artesunate

scientific article published on 13 December 2018

Expression of VEGF 111 and other VEGF-A variants in the rat uterus is correlated with stage of pregnancy.

scientific article published on 8 October 2016

Expression of major histocompatibility complex antigens on mouse brain microvascular endothelial cells in relation to susceptibility to cerebral malaria

scientific article published in September 1997

Extracellular vesicles and microvascular pathology: Decoding the active dialogue

scientific article published on 23 July 2018

Extracellular vesicles as mediators of immunopathology in infectious diseases.

scientific article published on 25 March 2018

FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry

scientific article published on 11 September 2012

Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials

scientific article published on 22 May 2019

Flow Cytometric Analysis of Microparticles

scientific article published on 01 January 2011

Gene expression analysis reveals early changes in several molecular pathways in cerebral malaria-susceptible mice versus cerebral malaria-resistant mice

scientific article

Gene-expression profiling discriminates between cerebral malaria (CM)-susceptible mice and CM-resistant mice

scientific article published on 05 December 2005

Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells

scientific article published on 17 June 2013

HDL interfere with the binding of T cell microparticles to human monocytes to inhibit pro-inflammatory cytokine production

scientific article

Host Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling

scientific article

Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes.

scientific article

Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema.

scientific article published in August 2005

Immune mechanisms in bacterial and parasitic diseases: protective immunity versus pathology.

scientific article published on August 1991

Immuno-analysis of microparticles: probing at the limits of detection.

scientific article

Immunological processes in malaria pathogenesis.

scientific article

In the eye of experimental cerebral malaria

scientific article

In vitro culture of Plasmodium berghei-ANKA maintains infectivity of mouse erythrocytes inducing cerebral malaria

scientific article published on 25 November 2011

In vitro generation of endothelial microparticles and possible prothrombotic activity in patients with lupus anticoagulant.

scientific article

Infectious Diseases of the Nervous System and Their Impact in Developing Countries

scientific article (publication date: February 2009)

Infrared spectroscopic characterization of monocytic microvesicles (microparticles) released upon lipopolysaccharide stimulation.

scientific article published on 17 March 2017

Inhibition of Interleukin 1β Signaling by Anakinra Ameliorates Proinflammatory Cytokine Responses in Zika Virus-Infected Human Blood-Brain Barrier Endothelial Cells

scientific article published on 01 September 2019

Inhibition of leukocyte adherence and transendothelial migration in cultured human liver vascular endothelial cells by prostaglandin E1

scientific article published on 01 March 1998

Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica

scientific article published on 01 January 1993

Interplay of Extracellular Vesicles and other players in Cerebral Malaria Pathogenesis

scientific article published on 17 October 2018

Is TNF beneficial or deleterious in toxoplasmic encephalitis?

scientific article published on 01 October 1992

LMP-420, a new therapeutic approach for cerebral malaria?

scientific article published in April 2006

Late administration of monoclonal antibody to leukocyte function-antigen 1 abrogates incipient murine cerebral malaria ⬇️

scientific article published on September 1, 1991

Lectin-deficient TNF mutants display comparable anti-tumour but reduced pro-metastatic potential as compared to the wild-type molecule

scientific article published on 01 February 2001

Magnetic resonance spectroscopy reveals an impaired brain metabolic profile in mice resistant to cerebral malaria infected with Plasmodium berghei ANKA.

scientific article published on 15 March 2007

Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites

scientific article published on 18 December 2015

Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells.

scientific article published on 16 April 2009

Microparticle conferred microRNA profiles--implications in the transfer and dominance of cancer traits

scientific article

Microparticle drug sequestration provides a parallel pathway in the acquisition of cancer drug resistance

scientific article published on 3 October 2013

Microparticle-associated nucleic acids mediate trait dominance in cancer.

scientific article published on 30 September 2011

Microparticles and their emerging role in cancer multidrug resistance.

scientific article published on 14 July 2011

Microparticles as immune regulators in infectious disease - an opinion

scientific article published on 29 November 2011

Microparticles from mycobacteria-infected macrophages promote inflammation and cellular migration.

scientific article published on 14 December 2012

Microvesiculation and cell interactions at the brain-endothelial interface in cerebral malaria pathogenesis.

scientific article published on 29 January 2010

Modulation of soluble and membrane-bound TNF-induced phenotypic and functional changes of human brain microvascular endothelial cells by recombinant TNF binding protein I.

scientific article published in July 1997

Morphologic, Phenotypic and Functional Characteristics of Endothelial Cells Derived from Human Hepatic Cavernous Hemangioma

scientific article published on 28 September 2006

Murine cerebral malaria development is independent of toll-like receptor signaling

scientific article

Murine cerebral malaria: the whole story

scientific article published on 8 April 2010

New synthetic sulfated oligosaccharides prolong survival of cardiac xenografts by inhibiting release of heparan sulfate from endothelial cells.

scientific article

Nitric oxide and cerebral malaria

scientific article

P-cresol, a uremic toxin, decreases endothelial cell response to inflammatory cytokines

scientific article published in December 2002

Parasite-derived plasma microparticles contribute significantly to malaria infection-induced inflammation through potent macrophage stimulation

scientific article

Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans

scientific article

Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment

scientific article

Phenotypic and functional differences between human liver cancer endothelial cells and liver sinusoidal endothelial cells.

scientific article

Pho4 Is Essential for Dissemination of Cryptococcus neoformans to the Host Brain by Promoting Phosphate Uptake and Growth at Alkaline pH

scientific article published on 25 January 2017

Physiopathologic factors resulting in poor outcome in childhood severe malaria in Cameroon

scientific article published in December 2009

Plasma concentrations of cytokines, their soluble receptors, and antioxidant vitamins can predict the development of multiple organ failure in patients at risk.

scientific article published on March 1996

Plasma levels of endothelial and B-cell-derived microparticles are restored by fingolimod treatment in multiple sclerosis patients

scientific article

Plasmodium falciparum adhesion on human brain microvascular endothelial cells involves transmigration-like cup formation and induces opening of intercellular junctions.

scientific article

Platelet accumulation in brain microvessels in fatal pediatric cerebral malaria

scientific article published on 24 January 2003

Platelet-endothelial cell interactions in cerebral malaria: the end of a cordial understanding

scientific article

Platelet-induced clumping of Plasmodium falciparum-infected erythrocytes from Malawian patients with cerebral malaria-possible modulation in vivo by thrombocytopenia

scientific article

Platelets activate a pathogenic response to blood-stage Plasmodium infection but not a protective immune response

scientific article

Platelets alter gene expression profile in human brain endothelial cells in an in vitro model of cerebral malaria

scientific article

Platelets as pathogenetic effectors and killer cells in cerebral malaria.

scientific article published on 16 April 2016

Platelets potentiate brain endothelial alterations induced by Plasmodium falciparum

scientific article

Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhesion to activated endothelial cells

scientific article published on 9 January 2004

Potential efficacy of citicoline as adjunct therapy in treatment of cerebral malaria

scientific article published on 28 October 2013

Production, fate and pathogenicity of plasma microparticles in murine cerebral malaria

scientific article

Protective Effect of N-Acetylcysteine in Hapten-Induced Irritant and Contact Hypersensitivity Reactions

scientific article published on 01 June 1994

Protective effect of natural TNF-binding protein on human TNF-induced toxicity in mice

scientific article published on 01 September 1993

Rapid activation of endothelial cells enables Plasmodium falciparum adhesion to platelet-decorated von Willebrand factor strings

scientific article published on 6 November 2009

Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis

scientific article published in July 2014

Reduced activity of the epithelial sodium channel in malaria-induced pulmonary oedema in mice.

scientific article published on 17 September 2010

Reduced transendothelial migration of monocytes infected by Coxiella burnetii

scientific article published on June 2000

Regulation of parathyroid hormone-related protein production in a human lung squamous cell carcinoma line

scholarly article by R Rizzoli et al published November 1994 in Journal of Endocrinology

Repeated endotoxin treatment decreases immune and hypothalamo-pituitary-adrenal axis responses: effects of orchidectomy and testosterone therapy

scientific article

Requirement for tumor necrosis factor receptor 2 expression on vascular cells to induce experimental cerebral malaria

scientific article published on October 2002

Requirement of tumour necrosis factor for development of silica-induced pulmonary fibrosis

scientific article published in Nature

Respective role of TNF receptors in the development of experimental cerebral malaria.

scientific article published in February 1997

Rickettsia prowazekii infection of endothelial cells increases leukocyte adhesion through alphavbeta3 integrin engagement

scientific article published on 30 April 2009

Role of Granulocyte-Macrophage Colony-Stimulating Factor in Pulmonary Fibrosis Induced in Mice by Bleomycin

scientific article published on 01 September 1993

Role of TNF in immunopathology of leprosy

scientific article

Septic Shock due to Cytomegalovirus Infection in Acute Respiratory Distress Syndrome after Falciparum Malaria.

scientific article published on September 1997

Serum Profiles of Interleukin-6, Interleukin-8, and Interleukin-10 in Patients with Severe and Mild Acute Pancreatitis

scientific article published on 01 May 1999

Serum tumor necrosis factor and interleukin 1 in leprosy and during lepra reactions

scientific article published on 01 April 1992

Serum tumour necrosis factor in newborns at risk for infections

scientific article published in June 1990

Severe malaria: what's new on the pathogenesis front?

scientific article published on 23 September 2016

Significance of cytokine production and adhesion molecules in malarial immunopathology

scientific article published in August 1990

Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells.

scientific article published on 17 October 2013

Stable thrombus formation on irradiated microvascular endothelial cells under pulsatile flow: Pre-testing annexin V-thrombin conjugate for treatment of brain arteriovenous malformations

scientific article published on 17 May 2018

Stem Cell-Derived Extracellular Vesicles for Treating Joint Injury and Osteoarthritis

scientific article published on 14 February 2019

Strategies for inhibition of tumor necrosis factor in vivo

T cells and malaria: is Th1 cell activation a prerequisite for pathology?

scientific article published on July 1994

TNF in vascular pathology: the importance of platelet-endothelium interactions

scientific article

TNF inhibition and sepsis — sounding a cautionary note

scientific article published on 01 November 1997

TNF inhibits malaria hepatic stages in vitro via synthesis of IL-6.

scientific article published in April 1991

Targeting Vascular Endothelial-Cadherin in Tumor-Associated Blood Vessels Promotes T-cell-Mediated Immunotherapy

scientific article published on 27 June 2017

Technical advance: autofluorescence as a tool for myeloid cell analysis.

scientific article published on 9 June 2010

The CTLA-4 and PD-1/PD-L1 inhibitory pathways independently regulate host resistance to Plasmodium-induced acute immune pathology

scientific article published on 2 February 2012

The Early Innate Immune Response to, and Phagocyte-Dependent Entry of, Cryptococcus neoformans Map to the Perivascular Space of Cortical Post-Capillary Venules in Neurocryptococcosis

scientific article published on 19 June 2018

The Endothelium in Cerebral Malaria: Both a Target Cell and a Major Player

scholarly article

The Ins and Outs of Cerebral Malaria Pathogenesis: Immunopathology, Extracellular Vesicles, Immunometabolism, and Trained Immunity

scientific article published on 17 April 2019

The Poly-cistronic miR-23-27-24 Complexes Target Endothelial Cell Junctions: Differential Functional and Molecular Effects of miR-23a and miR-23b

scientific article published on 23 August 2016

The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes.

scientific article

The effect of non-specific tight junction modulators on the transepithelial transport of poorly permeable drugs across airway epithelial cells

scientific article published on 8 November 2016

The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection

scientific article published in March 1989

The kynurenine pathway and parasitic infections that affect CNS function

scientific article published on 25 February 2016

The lectin-like domain of tumor necrosis factor-α increases membrane conductance in microvascular endothelial cells and peritoneal macrophages

scientific article published on 01 October 1999

The microcirculation in severe malaria

scientific article

The responses of osteoblasts, osteoclasts and endothelial cells to zirconium modified calcium-silicate-based ceramic.

scientific article published on 30 August 2008

The role of adhesion molecules, alpha v beta 3, alpha v beta 5 and their ligands in the tumor cell and endothelial cell adhesion

scientific article

The role of animal models for research on severe malaria

scientific article published in February 2012

The role of reactive nitrogen intermediates in modulation of gametocyte infectivity of rodent malaria parasites.

scientific article published on January 1993

Toxoplasmic encephalitis

scientific article published on 01 November 1992

Tumor necrosis factor (cachectin) as an essential mediator in murine cerebral malaria

scientific article

Tumor necrosis factor alpha is involved in mouse growth and lymphoid tissue development.

scientific article

Tumor necrosis factor and disease severity in children with falciparum malaria

scientific article published in June 1989

Tumor necrosis factor and immunopathology

scientific article published on January 1991

Tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura

scientific article published on 01 August 1988

Tumour necrosis factor in neonatal listeriosis: a case report

scientific article

Tumour necrosis factor, interleukin-6, and malaria

scientific article

Unusual angiogenic factor plays a role in lizard pregnancy but is not unique to viviparity.

scientific article published on 2 March 2015

VEGF111: new insights in tissue invasion.

scientific article

VEGF: inflammatory paradoxes

scientific article published in September 2015

Vascular endothelial cells cultured from patients with cerebral or uncomplicated malaria exhibit differential reactivity to TNF.

scientific article

Paulina is supported by:

About Paulina

Help