List of works - Manuel Santos

A fluorescence-based sensor assay that monitors general protein aggregation in human cells

scientific article published on 18 January 2018

A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans

scientific article (publication date: 2007)

Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans.

scientific article published on July 2017

Cancer syndromes and therapy by stop-codon readthrough ⬇️

scientific article published on 06 October 2012

Candida albicans CUG mistranslation is a mechanism to create cell surface variation.

scientific article published on 30 August 2013

Candida albicans and three other Candida species contain an elongation factor structurally and functionally analogous to elongation factor 3

scientific article published in May 1991

Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?

scientific article

Codon reassignment in Candida species: an evolutionary conundrum.

scientific article published on January 1996

Codon-triplet context unveils unique features of the Candida albicans protein coding genome

scientific article

Comparative genomics of wild type yeast strains unveils important genome diversity

scientific article

Comparison of the compatible solute pool of two slightly halophilic planctomycetes species, Gimesia maris and Rubinisphaera brasiliensis

scientific article published on 9 August 2016

Conserved and highly expressed tRNA derived fragments in zebrafish.

scientific article published on 22 December 2015

Correction: Species-Specific Codon Context Rules Unveil Non-Neutrality Effects of Synonymous Mutations

scientific article

Critical roles for a genetic code alteration in the evolution of the genus Candida

scientific article

Development of the genetic code: insights from a fungal codon reassignment.

scientific article published on January 2010

Differences in the expression pattern of HCN isoforms among mammalian tissues: sources and implications

scientific article

Discovery and function of transfer RNA-derived fragments and their role in disease.

scientific article

Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos

scientific article

Driving change: the evolution of alternative genetic codes.

scientific article published on February 2004

Efficient translation of the UAG termination codon in Candida species

scientific article published in June 1990

Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast

scientific article published in PLoS ONE

Ethanol exposure induces upregulation of specific microRNAs in zebrafish embryos

scientific article

EuGene: maximizing synthetic gene design for heterologous expression.

scientific article published on 30 July 2012

EuGene: maximizing synthetic gene design for heterologous expression.

scientific article published on 7 March 2016

Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover

scientific article

Evolution of the genetic code in yeasts.

scientific article

Expression variability of co-regulated genes differentiates Saccharomyces cerevisiae strains ⬇️

scientific article published on April 20, 2011

Fungal Chitin Induces Trained Immunity in Human Monocytes during Cross-talk of the Host with Saccharomyces cerevisiae.

scientific article published on 17 February 2016

Genetic diversity and population structure of Saccharomyces cerevisiae strains isolated from different grape varieties and winemaking regions.

scientific article

Genotyping of Saccharomyces cerevisiae strains by interdelta sequence typing using automated microfluidics.

scientific article published on 31 May 2011

Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

scientific article

Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways.

scientific article published on 21 January 2016

High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin

scientific article published on 06 February 2014

Hyperpolarization-activated cyclic nucleotide-gated channels and cAMP-dependent modulation of exocytosis in cultured rat lactotrophs.

scientific article published in November 2014

Improving the accuracy of recombinant protein production through integration of bioinformatics, statistical and mass spectrometry methodologies.

scientific article published on 22 January 2015

Intrastrain genomic and phenotypic variability of the commercial Saccharomyces cerevisiae strain Zymaflore VL1 reveals microevolutionary adaptation to vineyard environments

scientific article

Involvement of yeast HSP90 isoforms in response to stress and cell death induced by acetic acid

scientific article

Large scale comparative codon-pair context analysis unveils general rules that fine-tune evolution of mRNA primary structure.

scientific article

Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast.

scientific article

Molecular reconstruction of a fungal genetic code alteration.

scientific article published on 17 April 2013

New insights into mRNA decoding--implications for heterologous protein synthesis.

scientific article published on December 1993

Next-generation sequencing of miRNAs with Roche 454 GS-FLX technology: steps for a successful application.

scientific article published on January 2012

Non-Standard Genetic Codes Define New Concepts for Protein Engineering

scientific article

P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model

scientific article published on 24 January 2013

Phenotypic heterogeneity promotes adaptive evolution.

scientific article

Presence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um) in the wobble position of the anticodon of tRNA(Leu) (U*AA) from brewer's yeast

scientific article published on 01 December 1992

Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.

scientific article published on 18 January 2017

Protein translation in Plasmodium parasites.

scientific article published on 07 July 2011

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

scientific article

Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA

scientific article

Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum.

scientific article published on March 2013

Stop codon decoding in Candida albicans: from non-standard back to standard.

scientific article

Surfactants as microbicides and contraceptive agents: a systematic in vitro study.

scientific article

Systems biology of infectious diseases: a focus on fungal infections

scientific article published on 16 August 2011

The Candida albicans CUG-decoding ser-tRNA has an atypical anticodon stem-loop structure

scientific article published in November 1999

The Fungus Candida albicans Tolerates Ambiguity at Multiple Codons.

scientific article

The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.

scientific article published in November 2017

The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation.

scientific article

Transfer RNA profiling: a new method for the identification of pathogenic Candida species

scientific article published in May 1994

Transfer RNA's latest port of call.

scientific article

Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen

scientific article

Yeast proteome map (update 2006)

scientific article published on 01 April 2007

beta, a novel repetitive DNA element associated with tRNA genes in the pathogenic yeast Candida albicans ⬇️

scientific article published on July 1, 1997

mRNA secondary structure optimization using a correlated stem-loop prediction

scientific article published on 24 February 2016

mRNA secondary structure optimization using a correlated stem-loop prediction.

scientific article published on 15 January 2013

List of works by Manuel Santos

A fluorescence-based sensor assay that monitors general protein aggregation in human cells

A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans

Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in Candida albicans.

Cancer syndromes and therapy by stop-codon readthrough ⬇️

Candida albicans CUG mistranslation is a mechanism to create cell surface variation.

Candida albicans and three other Candida species contain an elongation factor structurally and functionally analogous to elongation factor 3

Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?

Codon reassignment in Candida species: an evolutionary conundrum.

Codon-triplet context unveils unique features of the Candida albicans protein coding genome

Comparative genomics of wild type yeast strains unveils important genome diversity

Comparison of the compatible solute pool of two slightly halophilic planctomycetes species, Gimesia maris and Rubinisphaera brasiliensis

Conserved and highly expressed tRNA derived fragments in zebrafish.

Correction: Species-Specific Codon Context Rules Unveil Non-Neutrality Effects of Synonymous Mutations

Critical roles for a genetic code alteration in the evolution of the genus Candida

Development of the genetic code: insights from a fungal codon reassignment.

Differences in the expression pattern of HCN isoforms among mammalian tissues: sources and implications

Discovery and function of transfer RNA-derived fragments and their role in disease.

Dre-miR-2188 targets Nrp2a and mediates proper intersegmental vessel development in zebrafish embryos

Driving change: the evolution of alternative genetic codes.

Efficient translation of the UAG termination codon in Candida species

Errors in protein synthesis increase the level of saturated fatty acids and affect the overall lipid profiles of yeast

Ethanol exposure induces upregulation of specific microRNAs in zebrafish embryos

EuGene: maximizing synthetic gene design for heterologous expression.

EuGene: maximizing synthetic gene design for heterologous expression.

Evolution of Robustness to Protein Mistranslation by Accelerated Protein Turnover

Evolution of the genetic code in yeasts.

Expression variability of co-regulated genes differentiates Saccharomyces cerevisiae strains ⬇️

Fungal Chitin Induces Trained Immunity in Human Monocytes during Cross-talk of the Host with Saccharomyces cerevisiae.

Genetic diversity and population structure of Saccharomyces cerevisiae strains isolated from different grape varieties and winemaking regions.

Genotyping of Saccharomyces cerevisiae strains by interdelta sequence typing using automated microfluidics.

Guanabenz inhibits TLR9 signaling through a pathway that is independent of eIF2α dephosphorylation by the GADD34/PP1c complex

Helicobacter pylori Activates Matrix Metalloproteinase 10 in Gastric Epithelial Cells via EGFR and ERK-mediated Pathways.

High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin

Hyperpolarization-activated cyclic nucleotide-gated channels and cAMP-dependent modulation of exocytosis in cultured rat lactotrophs.

Improving the accuracy of recombinant protein production through integration of bioinformatics, statistical and mass spectrometry methodologies.

Intrastrain genomic and phenotypic variability of the commercial Saccharomyces cerevisiae strain Zymaflore VL1 reveals microevolutionary adaptation to vineyard environments

Involvement of yeast HSP90 isoforms in response to stress and cell death induced by acetic acid

Large scale comparative codon-pair context analysis unveils general rules that fine-tune evolution of mRNA primary structure.

Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast.

Molecular reconstruction of a fungal genetic code alteration.

New insights into mRNA decoding--implications for heterologous protein synthesis.

Next-generation sequencing of miRNAs with Roche 454 GS-FLX technology: steps for a successful application.

Non-Standard Genetic Codes Define New Concepts for Protein Engineering

P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model

Phenotypic heterogeneity promotes adaptive evolution.

Presence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um) in the wobble position of the anticodon of tRNA(Leu) (U*AA) from brewer's yeast

Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA.

Protein translation in Plasmodium parasites.

RUN and FYVE domain-containing protein 4 enhances autophagy and lysosome tethering in response to Interleukin-4.

Rescue of wild-type E-cadherin expression from nonsense-mutated cancer cells by a suppressor-tRNA

Selective inhibition of an apicoplastic aminoacyl-tRNA synthetase from Plasmodium falciparum.

Stop codon decoding in Candida albicans: from non-standard back to standard.

Surfactants as microbicides and contraceptive agents: a systematic in vitro study.

Systems biology of infectious diseases: a focus on fungal infections

The Candida albicans CUG-decoding ser-tRNA has an atypical anticodon stem-loop structure

The Fungus Candida albicans Tolerates Ambiguity at Multiple Codons.

The RNA-Binding Protein hnRNP K Mediates the Effect of BDNF on Dendritic mRNA Metabolism and Regulates Synaptic NMDA Receptors in Hippocampal Neurons.

The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation.

Transfer RNA profiling: a new method for the identification of pathogenic Candida species

Transfer RNA's latest port of call.

Unveiling the structural basis for translational ambiguity tolerance in a human fungal pathogen

Yeast proteome map (update 2006)

beta, a novel repetitive DNA element associated with tRNA genes in the pathogenic yeast Candida albicans ⬇️

mRNA secondary structure optimization using a correlated stem-loop prediction

mRNA secondary structure optimization using a correlated stem-loop prediction.