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List of works by Zdeněk Dvořák

A nonradioactive electrophoretic mobility shift assay for measurement of pregnane X receptor binding activity to CYP3A4 response element

scientific article published in July 2013

Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity

scientific article published on 4 February 2016

Activated thyroid hormone receptor modulates dioxin-inducible aryl hydrocarbon receptor-mediated CYP1A1 induction in human hepatocytes but not in human hepatocarcinoma HepG2 cells

scientific article

Activation of the aryl hydrocarbon receptor by berberine in HepG2 and H4IIE cells: Biphasic effect on CYP1A1.

scientific article

Agonistic effect of selected isoflavones on arylhydrocarbon receptor in a novel AZ-AhR transgenic gene reporter human cell line

scientific article published on 30 April 2015

Anthocyanidins pelargonidin and cyanidin reduce genotoxic stress in mice - possible involvement of aryl hydrocarbon receptor in the process

scientific article published on 18 April 2014

Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures.

scientific article published on 10 June 2011

Assessment of the aryl hydrocarbon receptor-mediated activities of polycyclic aromatic hydrocarbons in a human cell-based reporter gene assay.

scientific article published on 29 September 2016

Azole antimycotics differentially affect rifampicin-induced pregnane X receptor-mediated CYP3A4 gene expression.

scientific article published on 12 November 2007

Benzodiazepines medazepam and midazolam are activators of pregnane X receptor and weak inducers of CYP3A4: investigation in primary cultures of human hepatocytes and hepatocarcinoma cell lines

scientific article published on 18 January 2010

Berberine reduces insulin resistance: the roles for glucocorticoid receptor and aryl hydrocarbon receptor

scientific article published on 03 December 2010

Berberine: a multipotent remedy with unknown cellular target?

scientific article published in September 2010

Cellular responses induced by Cu(II) quinolinonato complexes in human tumor and hepatic cells.

scientific article published on 20 December 2012

Comment on "The role of redox-sensitive transcription factors NF-kB and AP-1 in the modulation of the Cyp1A1 gene by mercury, lead, and copper"

scientific article published on 11 June 2008

Comparative effect of colchicine and colchiceine on cytotoxicity and CYP gene expression in primary human hepatocytes.

scientific article published in June 2002

Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells.

scientific article published in May 2010

Construction and characterization of a reporter gene cell line for assessment of human glucocorticoid receptor activation.

scientific article

Construction and characterization of hepatocyte nuclear factor HNF4alpha1 over-expressing cell line derived from human hepatoma HepG2 cells

scientific article

Construction and characterization of peroxisome proliferator-activated receptor-gamma co-activator 1 alpha (PGC-1α over-expressing cell line derived from human hepatocyte carcinoma HepG2 cells).

scientific article

Conventional protein kinase C isoenzymes undergo dephosphorylation in neutrophil-like HL-60 cells treated by chelerythrine or sanguinarine

scientific article published on 03 July 2007

Cross-talk between endogenous compounds and regulatory pathways of drug metabolism

scientific article published on 01 February 2011

Cytotoxicity of natural compounds in hepatocyte cell culture models. The case of quaternary benzo[c]phenanthridine alkaloids

scientific article published in December 2001

Cytotoxicity of sanguinarine in primary rat hepatocytes is attenuated by dioxin and phenobarbital.

scientific article published on 12 May 2006

Dehydroepiandrosterone post-transcriptionally modifies CYP1A2 induction involving androgen receptor

scientific article published on 17 April 2013

Design and characterization of highly in vitro antitumor active ternary copper(II) complexes containing 2'-hydroxychalcone ligands

scientific article published on 09 July 2016

Development and Characterization of a Human Reporter Cell Line for the Assessment of Thyroid Receptor Transcriptional Activity: A Case of Organotin Endocrine Disruptors

scientific article published on 24 July 2015

Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line.

scientific article published on 30 September 2013

Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes.

scientific article published on 5 November 2008

Dexamethasone-mediated up-regulation of human CYP2A6 involves the glucocorticoid receptor and increased binding of hepatic nuclear factor 4 alpha to the proximal promoter

scientific article

Differential effects of omeprazole and lansoprazole enantiomers on aryl hydrocarbon receptor in human hepatocytes and cell lines

scientific article

Differential effects of selected natural compounds with anti-inflammatory activity on the glucocorticoid receptor and NF-kappaB in HeLa cells

scientific article

Disposition of sanguinarine in the rat

Drug–drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibition ⬇️

scientific article published on February 17, 2011

Dual effects of ketoconazole cis-enantiomers on CYP3A4 in human hepatocytes and HepG2 Cells

scientific article

Effect of silybin and its congeners on human liver microsomal cytochrome P450 activities.

scientific article published in November 2002

Effect of silybin and its glycosides on the expression of cytochromes P450 1A2 and 3A4 in primary cultures of human hepatocytes.

scientific article published in January 2005

Effects of anthocyanidins and anthocyanins on the expression and catalytic activities of CYP2A6, CYP2B6, CYP2C9, and CYP3A4 in primary human hepatocytes and human liver microsomes

scientific article published on 10 January 2014

Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines

scientific article published on 02 June 2013

Effects of anthocyans on the expression of organic anion transporting polypeptides (SLCOs/OATPs) in primary human hepatocytes.

scientific article published on March 2015

Effects of artificial sweeteners on the AhR- and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells

scientific article published on 9 October 2013

Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes

scientific article published on 23 October 2009

Effects of flavored mineral waters on AhR–CYP1A1 signaling pathway in primary human hepatocytes and in human hepatic and intestinal cancer cells ⬇️

scientific article published on April 1, 2012

Effects of human interleukins in the transgenic gene reporter cell lines IZ-VDRE and IZ-CYP24 designed to assess the transcriptional activity of vitamin D receptor.

scientific article

Effects of oral anorexiant sibutramine on the expression of cytochromes P450s in human hepatocytes and cancer cell lines

scientific article published on 23 August 2013

Ellipticine oxidation and DNA adduct formation in human hepatocytes is catalyzed by human cytochromes P450 and enhanced by cytochrome b5.

scientific article

Enantiospecific effects of chiral drugs on cytochrome P450 inhibition in vitro

scientific article published on 24 August 2015

Enantiospecific effects of ketoconazole on aryl hydrocarbon receptor

scientific article

Endogenous and exogenous ligands of aryl hydrocarbon receptor: current state of art.

scientific article published on February 2011

Environmental pollutants parathion, paraquat and bisphenol A show distinct effects towards nuclear receptors-mediated induction of xenobiotics-metabolizing cytochromes P450 in human hepatocytes.

scientific article published on 18 July 2015

Evaluation of in vitro cytotoxicity and hepatotoxicity of platinum(II) and palladium(II) oxalato complexes with adenine derivatives as carrier ligands.

scientific article published on 31 July 2010

Evaluation of in vitro cytotoxicity of 6-benzylaminopurine carboplatin derivatives against human cancer cell lines and primary human hepatocytes.

scientific article published on 11 January 2011

Evaluation of in vitro cytotoxicity of one-dimensional chain [Fe(salen)(L)](n) complexes against human cancer cell lines.

scientific article published on 17 January 2012

Examination of Glucocorticoid receptor alpha-mediated transcriptional regulation of P-glycoprotein, CYP3A4, and CYP2C9 genes in placental trophoblast cell lines.

scientific article

Examination of Zolpidem effects on AhR- and PXR-dependent expression of drug-metabolizing cytochromes P450 in primary cultures of human hepatocytes

scientific article published on 15 August 2009

Expression and activity of vitamin D receptor in the human placenta and in choriocarcinoma BeWo and JEG-3 cell lines

scientific article

Expression and transcriptional activities of nuclear receptors involved in regulation of drug-metabolizing enzymes are not altered by colchicine: focus on PXR, CAR, and GR in primary human hepatocytes.

scientific article published on 10 September 2006

Expression, protein stability and transcriptional activity of retinoic acid receptors are affected by microtubules interfering agents and all-trans-retinoic acid in primary rat hepatocytes

scientific article published on 18 January 2007

Glucocorticoid receptor functions in HeLa Cells are perturbed by 2,3,8,9-tetrachlorodibenzo-p-dioxin (TCDD).

scientific article

Gold(I) complexes of 9-deazahypoxanthine as selective antitumor and anti-inflammatory agents

scientific article

Gold(I)-triphenylphosphine complexes with hypoxanthine-derived ligands: in vitro evaluations of anticancer and anti-inflammatory activities

scientific article

Gut Microbial Catabolites of Tryptophan Are Ligands and Agonists of the Aryl Hydrocarbon Receptor: A Detailed Characterization

scientific article published on 09 April 2020

Half-Sandwich Ru(II) Halogenido, Valproato and 4-Phenylbutyrato Complexes Containing 2,2'-Dipyridylamine: Synthesis, Characterization, Solution Chemistry and In Vitro Cytotoxicity.

scientific article published on 15 December 2016

Highly and Broad-Spectrum In Vitro Antitumor Active cis-Dichloridoplatinum(II) Complexes with 7-Azaindoles

scientific article published on 26 August 2015

Hydroxystilbenes and methoxystilbenes activate human aryl hydrocarbon receptor and induce CYP1A genes in human hepatoma cells and human hepatocytes.

scientific article

Impurities contained in antifungal drug ketoconazole are potent activators of human aryl hydrocarbon receptor.

scientific article published on 9 September 2015

In Vitro Antitumor Active Gold(I) Triphenylphosphane Complexes Containing 7-Azaindoles.

scientific article

In vitro modulatory effects of functionalized pyrimidines and piperidine derivatives on Aryl hydrocarbon receptor (AhR) and glucocorticoid receptor (GR) activities

scientific article published on 21 February 2017

Influence of gold(I) complexes involving adenine derivatives on major drug-drug interaction pathway.

scientific article published on 21 October 2013

Intestinal cell-specific vitamin D receptor (VDR)-mediated transcriptional regulation of CYP3A4 gene

scientific article

Investigation of Orlistat effects on PXR activation and CYP3A4 expression in primary human hepatocytes and human intestinal LS174T cells

scientific article published on 3 July 2010

Investigation of the CYP2C9 induction profile in human hepatocytes by combining experimental and modelling approaches.

scientific article published on December 2009

Involvement of aryl hydrocarbon receptor (AhR) in polyphenol inhibition of benzo[a]pyrene-induced oxidative stress and neoplastic transformation

scientific article published on 01 July 2017

Iron-salophen complexes involving azole-derived ligands: A new group of compounds with high-level and broad-spectrum in vitro antitumor activity.

scientific article

Itraconazole cis-diastereoisomers activate aryl hydrocarbon receptor AhR and pregnane X receptor PXR and induce CYP1A1 in human cell lines and human hepatocytes

scientific article

JNK inhibitor SP600125 is a partial agonist of human aryl hydrocarbon receptor and induces CYP1A1 and CYP1A2 genes in primary human hepatocytes

scientific article published on 16 September 2007

Janus-faced Acrolein prevents allergy but accelerates tumor growth by promoting immunoregulatory Foxp3+ cells: Mouse model for passive respiratory exposure

scientific article published on 23 March 2017

Khellin and visnagin differentially modulate AHR signaling and downstream CYP1A activity in human liver cells

scientific article

Metabolism of sanguinarine: the facts and the myths.

scientific article published on February 2007

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

scientific article

Microtubules-interfering agents restrict aryl hydrocarbon receptor-mediated CYP1A2 induction in primary cultures of human hepatocytes via c-jun-N-terminal kinase and glucocorticoid receptor.

scientific article published on 3 December 2007

Mixed-ligand copper(II) complexes activate aryl hydrocarbon receptor AhR and induce CYP1A genes expression in human hepatocytes and human cell lines

scientific article published on 12 May 2016

Molecular, cellular and pharmacological effects of platinum(II) diiodido complexes containing 9-deazahypoxanthine derivatives: A group of broad-spectrum anticancer active agents

scientific article published on 19 June 2017

N-(2-Meth-oxy-benz-yl)-9-(oxolan-2-yl)-9H-purin-6-amine.

scientific article published on 23 March 2013

Novel stably transfected gene reporter human hepatoma cell line for assessment of aryl hydrocarbon receptor transcriptional activity: construction and characterization.

scientific article

Novel stably transfected human reporter cell line AIZ-AR as a tool for an assessment of human androgen receptor transcriptional activity

scientific article published on 26 March 2015

Omeprazole and lansoprazole enantiomers induce CYP3A4 in human hepatocytes and cell lines via glucocorticoid receptor and pregnane X receptor axis

scientific article

Opportunities and challenges in using human hepatocytes in cytochromes P450 induction assays.

scientific article

Optical Isomers of Atorvastatin, Rosuvastatin and Fluvastatin Enantiospecifically Activate Pregnane X Receptor PXR and Induce CYP2A6, CYP2B6 and CYP3A4 in Human Hepatocytes

scientific article

Optical isomers of dihydropyridine calcium channel blockers display enantiospecific effects on the expression and enzyme activities of human xenobiotics-metabolizing cytochromes P450.

scientific article published on 11 October 2016

Pathophysiological factors affecting CAR gene expression.

scientific article published on November 2003

Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T.

scientific article published on 16 February 2013

Pelargonidin and its glycosides as dietary chemopreventives attenuating inflammatory bowel disease symptoms through the aryl hydrocarbon receptor

scientific article published on 09 July 2020

Pharmacological and molecular effects of platinum(II) complexes involving 7-azaindole derivatives.

scientific article

Pivotal role of the aryl hydrocarbon receptor in modulations caused by benzo[a]pyrene and ketoconazole in the estrogenic responses induced by 17β-estradiol in male goldfish

scientific article published on 08 March 2016

Platinum(II) Iodido Complexes of 7-Azaindoles with Significant Antiproliferative Effects: An Old Story Revisited with Unexpected Outcomes

scientific article

Platinum(II) carboxylato complexes containing 7-azaindoles as N-donor carrier ligands showed cytotoxicity against cancer cell lines

scientific article published on 16 June 2016

Pleiotropic effects of gold(I) mixed-ligand complexes of 9-deazahypoxanthine on transcriptional activity of receptors for steroid hormones, nuclear receptors and xenoreceptors in human hepatocytes and cell lines.

scientific article published on 6 June 2016

Potentiating effect of UVA irradiation on anticancer activity of Carboplatin derivatives involving 7-azaindoles

scientific article

Primary cultures of human hepatocytes as a tool in cytotoxicity studies: cell protection against model toxins by flavonolignans obtained from Silybum marianum

scientific article published in February 2003

Profiling of Vitamin D Metabolic Intermediates toward VDR Using Novel Stable Gene Reporter Cell Lines IZ-VDRE and IZ-CYP24.

scientific article published on 21 June 2016

Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines.

scientific article published on 6 December 2013

Regulation of drug-metabolizing cytochrome P450 enzymes by glucocorticoids.

scientific article

Resveratrol enhances NK cell cytotoxicity: possible role for aryl hydrocarbon receptor

scientific article published in November 2010

Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human Hepatocytes

scientific article (publication date: 2012)

Role of Retinoids, Rexinoids and Thyroid Hormone in the Expression of Cytochrome P450 Enzymes ⬇️

scientific article published on February 1, 2011

Roscovitine-based CDK inhibitors acting as N-donor ligands in the platinum(II) oxalato complexes: preparation, characterization and in vitro cytotoxicity.

scientific article published on 21 July 2010

SB203580, a pharmacological inhibitor of p38 MAP kinase transduction pathway activates ERK and JNK MAP kinases in primary cultures of human hepatocytes.

scientific article

Sanguinarine activates polycyclic aromatic hydrocarbon associated metabolic pathways in human oral keratinocytes and tissues.

scientific article published in August 2005

Silybin and dehydrosilybin inhibit cytochrome P450 1A1 catalytic activity: a study in human keratinocytes and human hepatoma cells.

scientific article published on 9 March 2006

Stereoselective interactions of warfarin enantiomers with the pregnane X nuclear receptor in gene regulation of major drug-metabolizing cytochrome P450 enzymes

scientific article published on December 2010

Steroid regulation of drug-metabolizing cytochromes P450.

scientific article published on February 2011

Synthesis, characterization and in vitro antitumor activity of platinum(II) oxalato complexes involving 7-azaindole derivatives as coligands.

scientific article

Synthesis, characterization, DNA interaction and cleavage, and in vitro cytotoxicity of copper(II) mixed-ligand complexes with 2-phenyl-3-hydroxy-4(1H)-quinolinone.

scientific article

Targeting of nuclear factor-kappaB and proteasome by dithiocarbamate complexes with metals

scientific article

Targeting the pregnane X receptor using microbial metabolite mimicry

scientific article published on 10 March 2020

The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer

scientific article published on 01 May 2011

The aryl hydrocarbon receptor-dependent disruption of contact inhibition in rat liver WB-F344 epithelial cells is linked with induction of survivin, but not with inhibition of apoptosis

scientific article

The comparative effects of diethyldithiocarbamate-copper complex with established proteasome inhibitors on expression levels of CYP1A2/3A4 and their master regulators, aryl hydrocarbon and pregnane X receptor in primary cultures of human hepatocytes

scientific article published on 14 July 2016

The effect of anthocyans on the expression of selected phase II xenobiotic-metabolizing enzymes in primary cultures of human hepatocytes

scientific article published on 01 September 2014

The effects of drugs with immunosuppressive or immunomodulatory activities on xenobiotics-metabolizing enzymes expression in primary human hepatocytes.

scientific article published on 28 April 2015

The role of residues T248, Y249 and T422 in the function of human pregnane X receptor

scientific article

The toxicity and pharmacokinetics of dihydrosanguinarine in rat: a pilot study

scientific article published on 15 April 2008

The ubiquitin-proteasome system (UPS) and the mechanism of action of bortezomib.

scientific article published on January 2011

Transplant drugs affect the expression of phase II and antioxidant enzymes in human carcinoma cells HepG2 but not in primary cultures of human hepatocytes: In vitro comparative study.

scientific article published on 15 July 2016

Triorganotin compounds--ligands for "rexinoid" inducible transcription factors: biological effects.

scientific article

U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells.

scientific article published on 14 May 2014

Valproate activates ERK signaling pathway in primary human hepatocytes

scientific article

Valproic acid augments vitamin D receptor-mediated induction of CYP24 by vitamin D3: a possible cause of valproic acid-induced osteomalacia?

scientific article published on 27 November 2010

Valproic acid induces CYP3A4 and MDR1 gene expression by activation of constitutive androstane receptor and pregnane X receptor pathways.

scientific article published on 28 March 2007

WEAK MICROBIAL METABOLITES: A TREASURE TROVE FOR USING BIOMIMICRY TO DISCOVER AND OPTIMIZE DRUGS

scientific article published on 06 August 2020

Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues

scientific journal article

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