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List of works by Kevin J. Saliba

A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites

scientific article

A cross-metathesis approach to novel pantothenamide derivatives

scientific article published on 13 May 2016

A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices

scientific article published on 12 December 2013

A pantetheinase-resistant pantothenamide with potent, on-target, and selective antiplasmodial activity

scientific article published on 6 April 2015

A polymorphic drug pump in the malaria parasite

scientific article published in November 2008

A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites

scientific article published on 29 April 2008

Acidification of the malaria parasite's digestive vacuole by a H+-ATPase and a H+-pyrophosphatase.

scientific article published on 8 November 2002

An acid-loading chloride transport pathway in the intraerythrocytic malaria parasite, Plasmodium falciparum

scientific article

Analysis of Breath Specimens for Biomarkers of Plasmodium falciparum Infection

scientific article

Antiplasmodial Mode of Action of Pantothenamides: Pantothenate Kinase Serves as a Metabolic Activator Not as a Target

scientific article published on 24 April 2017

Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes

scientific article published on September 2004

Biological characterization of chemically diverse compounds targeting the Plasmodium falciparum coenzyme A synthesis pathway

scientific article (publication date: 17 November 2016)

CJ-15,801, a fungal natural product, inhibits the intraerythrocytic stage of Plasmodium falciparum in vitro via an effect on pantothenic acid utilisation

scientific article published in May 2005

Chemical and genetic validation of thiamine utilization as an antimalarial drug target

scientific article published on January 2013

Chloroquine resistance and the pH of the malaria parasite's digestive vacuole.

scientific article published on December 2001

Choline uptake into the malaria parasite is energized by the membrane potential

scientific article

Clotrimazole inhibits the growth of Plasmodium falciparum in vitro.

scientific article published in November 1998

Coenzyme A biosynthesis: an antimicrobial drug target

scientific article published on January 2008

Common dietary flavonoids inhibit the growth of the intraerythrocytic malaria parasite

scientific article

Distribution of acridine orange fluorescence in Plasmodium falciparum-infected erythrocytes and its implications for the evaluation of digestive vacuole pH.

scientific article

Editorial--Molecular Approaches to Malaria 2012 (MAM 2012).

scientific article published in May 2012

Electrophysiological studies of malaria parasite-infected erythrocytes: current status

scientific article published on 9 January 2007

Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides

scientific article

Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite

scientific article published on 20 June 2007

H+-coupled pantothenate transport in the intracellular malaria parasite.

scientific article published on 22 February 2001

Hexose transport in asexual stages of Plasmodium falciparum and kinetoplastidae.

scientific article

Human dihydrofolate reductase influences the sensitivity of the malaria parasite Plasmodium falciparum to ketotifen - A cautionary tale in screening transgenic parasites

scientific article published on 22 September 2016

Inhibition of Plasmodium falciparum pH regulation by small molecule indole derivatives results in rapid parasite death

scientific article

Inhibition of hexose transport and abrogation of pH homeostasis in the intraerythrocytic malaria parasite by an O-3-hexose derivative

scientific article published in July 2004

Loss of pH control in Plasmodium falciparum parasites subjected to oxidative stress

scientific article

Mutations in pfmdr1 modulate the sensitivity of Plasmodium falciparum to the intrinsic antiplasmodial activity of verapamil

scientific article

Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues

scientific article published on 3 April 2018

Na(+)-dependent pH regulation by the amitochondriate protozoan parasite Giardia intestinalis

scientific article published on 10 April 2001

Nutrient acquisition by intracellular apicomplexan parasites: staying in for dinner.

scientific article

Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801

scientific article published on 17 October 2019

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated

scientific article

Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum

scientific article (publication date: 24 February 2000)

Provitamin B5 (pantothenol) inhibits growth of the intraerythrocytic malaria parasite

scientific article

Purine nucleobase transport in the intraerythrocytic malaria parasite.

scientific article

Purine uptake in Plasmodium: transport versus metabolism.

scientific article published on 5 May 2009

Role for the Plasmodium falciparum Digestive Vacuole in Chloroquine Resistance ⬇️

scientific article published on August 1, 1998

Sodium-dependent uptake of inorganic phosphate by the intracellular malaria parasite

scientific article (publication date: 5 October 2006)

Stereochemical modification of geminal dialkyl substituents on pantothenamides alters antimicrobial activity

scientific article published on 18 June 2014

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity

scientific article

Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation

scientific article published on 25 August 2017

Structure-activity relationships of antiplasmodial pantothenamide analogs reveal a new way by which triazoles mimic amide bonds

scientific article published on 29 November 2018

Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis

scientific article (publication date: October 2013)

Targeting nutrient uptake mechanisms in Plasmodium

scientific article published on January 2007

The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides.

scientific article published on 8 December 2020

The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis

scientific article published on 07 July 2009

The inhibitory effect of 2-halo derivatives of D-glucose on glycolysis and on the proliferation of the human malaria parasite Plasmodium falciparum

scientific article published on 19 August 2008

The pH of the digestive vacuole of Plasmodium falciparum is not associated with chloroquine resistance

scientific article published on 21 February 2006

Transport and metabolism of the essential vitamin pantothenic acid in human erythrocytes infected with the malaria parasite Plasmodium falciparum.

scientific article published in April 1998

Transport of nucleosides across the Plasmodium falciparum parasite plasma membrane has characteristics of PfENT1

scientific article (publication date: May 2006)

Triazole Substitution of a Labile Amide Bond Stabilizes Pantothenamides and Improves Their Antiplasmodial Potency

scientific article published on 19 September 2016

Uptake of an antiplasmodial protease inhibitor into Plasmodium falciparum-infected human erythrocytes via a parasite-induced pathway.

scientific article published on August 1998

pH regulation in the intracellular malaria parasite, Plasmodium falciparum. H(+) extrusion via a V-type H(+)-ATPase

scientific article published in November 1999

pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum

scientific article

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