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List of works by Efstratios Stratikos

3,4-diaminobenzoic acid derivatives as inhibitors of the oxytocinase subfamily of M1 aminopeptidases with immune-regulating properties

scientific article

A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk.

scientific article published on July 2013

A continuous fluorigenic assay for the measurement of the activity of endoplasmic reticulum aminopeptidase 1: competition kinetics as a tool for enzyme specificity investigation.

scientific article published on 26 July 2009

A new role for Zn(II) aminopeptidases: antigenic peptide generation and destruction.

scientific article published on January 2009

A novel ERAP2 haplotype structure in a Chilean population: implications for ERAP2 protein expression and preeclampsia risk

scientific article published on 11 November 2013

A possible structural basis behind the pathogenic role of apolipoprotein E hereditary mutations associated with lipoprotein glomerulopathy.

scientific article published on 23 October 2013

A role for naturally occurring alleles of endoplasmic reticulum aminopeptidases in tumor immunity and cancer pre-disposition

scientific article

A simple approach for human recombinant apolipoprotein E4 expression and purification.

scientific article published on 25 June 2011

A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by ER aminopeptidase 1

scientific article published on 17 March 2020

Allele-dependent thermodynamic and structural perturbations in ApoE variants associated with the correction of dyslipidemia and formation of spherical ApoE-containing HDL particles.

scientific article published on 23 November 2012

Allotypic variation in antigen processing controls antigenic peptide generation from SARS-CoV-2 S1 spike glycoprotein

scientific article published on 22 October 2021

Aminobenzosuberone Scaffold as a Modular Chemical Tool for the Inhibition of Therapeutically Relevant M1 Aminopeptidases

scientific article published on 11 October 2018

Antigenic peptide trimming by ER aminopeptidases—Insights from structural studies ⬇️

scientific article published on March 29, 2013

ApoA-IV promotes the biogenesis of apoA-IV-containing HDL particles with the participation of ABCA1 and LCAT ⬇️

scientific article published on November 6, 2012

Autoimmune disease-associated variants of extracellular endoplasmic reticulum aminopeptidase 1 induce altered innate immune responses by human immune cells.

scientific article published on 14 January 2015

Biophysical Analysis of Apolipoprotein E3 Variants Linked with Development of Type III Hyperlipoproteinemia ⬇️

scientific article published on January 1, 2011

Change in environment of the P1 side chain upon progression from the Michaelis complex to the covalent serpin-proteinase complex

scientific article published on 01 September 1998

Common allotypes of ER aminopeptidase 1 have substrate-dependent and highly variable enzymatic properties

scientific article published on 01 January 2021

Contribution of RAD51D germline mutations in breast and ovarian cancer in Greece

scientific article published on 15 August 2018

Correction to "Macromolecular Architecture and Encapsulation of the Anticancer Drug Everolimus Control the Self-Assembly of Amphiphilic Polypeptide-Containing Hybrids"

scientific article published on 05 March 2020

Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.

scientific article published on 20 February 2017

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing

scientific article

Crystal Structures of ERAP2 Complexed with Inhibitors Reveal Pharmacophore Requirements for Optimizing Inhibitor Potency.

scientific article published on 21 February 2017

Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1

scientific article published on 30 December 2019

ERAP2 Increases the Abundance of a Peptide Submotif Highly Selective for the Birdshot Uveitis-Associated HLA-A29

scientific article published on 25 February 2021

Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1)

scientific article published on 20 June 2019

Effects of polymorphic variation on the mechanism of Endoplasmic Reticulum Aminopeptidase 1.

scientific article published on 26 July 2015

Endoplasmic reticulum aminopeptidase 1 polymorphism Ile276Met is associated with atopic dermatitis and affects the generation of an HLA-C associated antigenic epitope in vitro

scientific article published on 04 March 2019

Endoplasmic reticulum aminopeptidase-1 alleles associated with increased risk of ankylosing spondylitis reduce HLA-B27 mediated presentation of multiple antigens.

scientific article

Endoplasmic reticulum aminopeptidases as a double-faced tool to increase or decrease efficiency of antigen presentation in health and disease

scientific article published on 27 March 2019

Enhanced catalytic action of HLA-DM on the exchange of peptides lacking backbone hydrogen bonds between their N-terminal region and the MHC class II alpha-chain

scientific article published in January 2004

Exploration of zinc-binding groups for the design of inhibitors for the oxytocinase subfamily of M1 aminopeptidases

scientific article published on 01 November 2019

Functional characterization of CHEK2 variants in a Saccharomyces cerevisiae system

scientific article published on 09 March 2019

Generation of SARS-CoV-2 S1 spike glycoprotein putative antigenic epitopes in vitro by intracellular aminopeptidases

scientific article published on 15 September 2020

High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

scientific article published on 13 February 2019

Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1

scientific article

Identification of the lateral interaction surfaces of human histocompatibility leukocyte antigen (HLA)-DM with HLA-DR1 by formation of tethered complexes that present enhanced HLA-DM catalysis

scientific article published on July 2002

Impaired Antiatherogenic Functions of High-density Lipoprotein in Patients with Ankylosing Spondylitis

scientific article

Inhibitors of ER aminopeptidase 1 and 2: from design to clinical application.

scientific article published on 13 February 2018

Intracellular Antigen Processing by ERAP2: Molecular Mechanism and Roles in Health and Disease

article

Ligand-Induced Conformational Change of Insulin-Regulated Aminopeptidase: Insights on Catalytic Mechanism and Active Site Plasticity.

scientific article published on 22 March 2017

Mapping the serpin-proteinase complex using single cysteine variants of alpha1-proteinase inhibitor Pittsburgh

scientific article published in June 1998

Marcromolecular Architecture and Encapsulation of the Anticancer Drug Everolimus Control the Self-Assembly of Amphiphilic Polypeptide-Containing Hybrids

scientific article published on 18 November 2019

Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

scientific article published on 16 December 2019

Modulating antigen processing for cancer immunotherapy.

scientific article published on 03 January 2014

Molecular basis for increased risk for late-onset Alzheimer disease due to the naturally occurring L28P mutation in apolipoprotein E4.

scientific article

Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.

scientific article published on 17 April 2018

Novel selective inhibitors of aminopeptidases that generate antigenic peptides.

scientific article published on 23 July 2013

Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.

scientific article published on 8 September 2016

Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1

scientific article

Probing the S1 specificity pocket of the aminopeptidases that generate antigenic peptides.

scientific article published on April 2011

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

scientific article

Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides

scientific article

Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1.

scientific article published on 31 May 2016

Self-Healing pH- and Enzyme Stimuli-Responsive Hydrogels for Targeted Delivery of Gemcitabine To Treat Pancreatic Cancer

scientific article published on 27 August 2018

Significance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.

scientific article published on 12 October 2013

Simultaneous determination of naproxen and its desmethyl metabolite in human serum by second-derivative synchronous fluorescence spectrometry

article by Dimitrios G. Konstantianos et al published May 1994 in Analytica Chimica Acta

Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2

scientific article

Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1

scientific article

Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment

scientific article published on May 2002

Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation

scientific article published on 09 March 2020

The Pivotal Role of Protein Phosphorylation in the Control of Yeast Central Metabolism

scientific article

The Role of Antigen Processing and Presentation in Cancer and the Efficacy of Immune Checkpoint Inhibitor Immunotherapy

scientific article published on 04 January 2021

The Role of Conformational Dynamics in Antigen Trimming by Intracellular Aminopeptidases

scientific article published on 7 August 2017

The ability of apolipoprotein E fragments to promote intraneuronal accumulation of amyloid beta peptide 42 is both isoform and size-specific.

scientific article published on August 2016

The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing

scientific article

The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.

scientific article

The role of Endoplasmic Reticulum Aminopeptidase 2 (ERAP2) in modulating immune detection of choriocarcinoma

scientific article published on 9 January 2018

Thermodynamic and structural destabilization of apoE3 by hereditary mutations associated with the development of lipoprotein glomerulopathy ⬇️

scientific article published on October 30, 2012

Thermodynamic destabilization and aggregation propensity as the underlying mechanism behind the genetic association of apoE3 mutants and Lipoprotein Glomerulopathy

scientific article published on 11 October 2018

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