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List of works by Shinya Toyokuni

3-morpholinosydnonimine participates in the attenuation of neointima formation via inhibition of annexin A2-mediated vascular smooth muscle cell migration

scientific journal article

A high-throughput reporter gene assay to prove the ability of natural compounds to modulate glutathione peroxidase, superoxide dismutase and catalase gene promoters in V79 cells

scientific article published in August 2008

A quantitative trait locus responsible for inducing B-cell lymphoblastic lymphoma is a hotspot for microsatellite instability

scientific article published on 01 March 2010

A special issue of SFRR Asia: cross talk between free radicals and mitochondria in health and disease

scientific article published on 01 December 2018

A trial to find appropriate animal models of dichloropropane-induced cholangiocarcinoma based on the hepatic distribution of glutathione S-transferases.

scientific article

Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects

scientific article published on 18 February 2009

Acute fulminant invasive pulmonary aspergillosis in an immunocompetent host: An autopsy case report.

scientific article published on 9 February 2018

Administration of molecular hydrogen during pregnancy improves behavioral abnormalities of offspring in a maternal immune activation model.

scientific article

Adrenomedullin infusion attenuates myocardial ischemia/reperfusion injury through the phosphatidylinositol 3-kinase/Akt-dependent pathway

scientific article published on 22 December 2003

Adult pancreatic islets require differential pax6 gene dosage

article

Age- and sun exposure-dependent differences in 8-hydroxy-2'-deoxyguanosine and N-(carboxymethyl)lysine in human epidermis.

scientific article published on 25 May 2011

Aging rather than sun exposure is a major determining factor for the density of miR-125b-positive epidermal stem cells in human skin

scientific article

An autopsy case report: Differences in radiological images correlate with histology in Erdheim-Chester disease

scientific article published on 30 March 2018

Angiotensin II, oxidative stress, and extracellular matrix degradation during transition to LV failure in rats with hypertension

scientific article published on 18 September 2006

Antenatal Saireito (TJ-114) Can Improve Pulmonary Hypoplasia and Pulmonary Vascular Remodeling in Nitrofen-Induced Congenital Diaphragmatic Hernia.

scientific article published on 25 May 2016

Application of Intermittent Microwave Irradiation to Western Blot Analysis.

scientific article published in January 2015

As a host society to SFRRI 2014 in Kyoto.

scientific article published on January 2014

Asbestos and multi-walled carbon nanotubes generate distinct oxidative responses in inflammatory cells

scientific article published on 28 November 2014

Asbestos surface provides a niche for oxidative modification.

scientific article

Astaxanthin ameliorates ferric nitrilotriacetate-induced renal oxidative injury in rats.

scientific article

Augmented oxidative stress increases 8-oxoguanine preferentially in the transcriptionally active genomic regions

scientific article published on 16 April 2020

Biopersistent fiber-induced inflammation and carcinogenesis: lessons learned from asbestos toward safety of fibrous nanomaterials.

scientific article published on 17 June 2010

Biphasic effects of l-ascorbate on the tumoricidal activity of non-thermal plasma against malignant mesothelioma cells.

scientific article published on 24 May 2016

Bovine lactoferrin ameliorates ferric nitrilotriacetate-induced renal oxidative damage in rats ⬇️

scientific article published on August 4, 2012

CD146 and insulin-like growth factor 2 mRNA-binding protein 3 predict prognosis of asbestos-induced rat mesothelioma.

scientific article published on 26 May 2013

CD8+CD122+ regulatory T cells (Tregs) and CD4+ Tregs cooperatively prevent and cure CD4+ cell-induced colitis

scientific article published on 22 November 2010

Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production

scientific article published on 5 August 2013

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering

scientific article published on 10 November 2020

Catalytic ferrous iron in amniotic fluid as a predictive marker of human maternal-fetal disorders

scientific article

Chemical conversion of human fibroblasts into neuronal cells: dawn of future clinical trials.

scientific article published on May 2015

Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma

scientific article published on 16 June 2014

Connective tissue growth factor-specific monoclonal antibody inhibits growth of malignant mesothelioma in an orthotopic mouse model.

scientific article published on 6 April 2018

Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis

scientific article published in October 2006

Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis.

scientific article published on June 2016

Deferasirox induces mesenchymal-epithelial transition in crocidolite-induced mesothelial carcinogenesis in rats.

scientific article published on 11 September 2013

Development of a novel monoclonal antibody against 4-hydroxy-2E,6Z-dodecadienal (4-HDDE)-protein adducts: Immunochemical application in quantitative and qualitative analyses of lipid peroxidation in vitro and ex vivo

scientific article published on 25 May 2018

Dexamethasone palmitate ameliorates macrophages-rich graft-versus-host disease by inhibiting macrophage functions

scientific article

Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis

scientific article (publication date: 6 December 2011)

Dietary Fish Oil Promotes Colonic Apoptosis and Mitochondrial Proton Leak in Oxidatively Stressed Mice ⬇️

scientific article published on April 13, 2011

Differences and similarities between carbon nanotubes and asbestos fibers during mesothelial carcinogenesis: Shedding light on fiber entry mechanism ⬇️

scientific article published on June 14, 2012

Direct exposure of non-equilibrium atmospheric pressure plasma confers simultaneous oxidative and ultraviolet modifications in biomolecules

scientific article

Distinct affinity of nuclear proteins to the surface of chrysotile and crocidolite ⬇️

scientific article published on September 5, 2012

Dual preventive benefits of iron elimination by desferal in asbestos-induced mesothelial carcinogenesis

scientific article published on 18 April 2016

Editorial: The cutting edge of zinc biology

scientific article published on 15 September 2016

Effect of edaravone, a novel free radical scavenger, supplemented to cardioplegia on myocardial function after cardioplegic arrest: in vitro study of isolated rat heart.

scientific article published on 24 May 2009

Effect of molecular hydrogen on uterine inflammation during preterm labour.

scientific article

Endogenous YAP1 Activation Drives Immediate Onset of Cervical Carcinoma In Situ in Mice

scientific article published on 27 July 2020

Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart

scientific journal article

Expression of P-REX2a is associated with poor prognosis in endometrial malignancies.

scientific article

Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation.

scientific article published on 10 January 2014

FGF2 mediates mouse spermatogonial stem cell self-renewal via upregulation ofEtv5andBcl6bthrough MAP2K1 activation ⬇️

scientific article published on April 4, 2012

Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer

scientific article

Fenton reaction-induced renal carcinogenesis in Mutyh-deficient mice exhibits less chromosomal aberrations than the rat model

scientific article published on 13 October 2017

Ferroptosis at the crossroads of infection, aging and cancer

scientific article published on 21 May 2020

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

scientific article

Frequent homozygous deletion of Cdkn2a/2b in tremolite-induced malignant mesothelioma in rats

scientific article published on 20 February 2020

Functional assessment of self-renewal activity of male germline stem cells following cytotoxic damage and serial transplantation

scientific article published on 11 December 2002

Future perspective of strategic non-thermal plasma therapy for cancer treatment

scientific article published on 17 December 2016

Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes

scientific article

Genetic reconstruction of mouse spermatogonial stem cell self-renewal in vitro by Ras-cyclin D2 activation

scientific article published on 01 July 2009

Genome-wide analysis identifies a tumor suppressor role for aminoacylase 1 in iron-induced rat renal cell carcinoma.

scientific article published on 21 November 2008

Genome-wide assessment of oxidatively generated DNA damage.

scientific article published on 22 February 2012

Genome-wide profiling of 8-oxoguanine reveals its association with spatial positioning in nucleus

scientific article published on 9 July 2014

Genotoxicity and carcinogenicity risk of carbon nanotubes.

scientific article published on 07 June 2013

Germline niche transplantation restores fertility in infertile mice

scientific article published on 26 May 2005

Global overexpression of divalent metal transporter 1 delays crocidolite-induced mesothelial carcinogenesis in male mice

scientific article published on 01 September 2018

Glycine ameliorates lung reperfusion injury after cold preservation in an ex vivo rat lung model

scientific article published in March 2003

Granulocyte colony-stimulating factor protects cardiac mitochondria in the early phase of cardiac injury

scientific article

Hepatocyte growth factor derived from senescent cells attenuates cell competition-induced apical elimination of oncogenic cells

scientific article published in 2022

Histological detection of catalytic ferrous iron with the selective turn-on fluorescent probe RhoNox-1 in a Fenton reaction-based rat renal carcinogenesis model

scientific article published on 21 July 2014

Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma.

scientific article published on 11 January 2010

ITPase-deficient mice show growth retardation and die before weaning.

scientific article published on 5 June 2009

In response to Sharing different perspectives to understand asbestos-induced carcinogenesis: A comment to Jiang et al. (2016) by Alessandro Francesco Gualtieri (2017).

scientific article published on May 2017

In vitro transformation of mouse testis cells by oncogene transfection.

scientific article published on 10 May 2012

Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice.

scientific article published on August 2008

Induction of autophagy in malignant rhabdoid tumor cells by the histone deacetylase inhibitor FK228 through AIF translocation.

scientific article published on January 2009

Inhibition of gastric inhibitory polypeptide signaling prevents obesity

scientific article

Intraperitoneal administration of tangled multiwalled carbon nanotubes of 15 nm in diameter does not induce mesothelial carcinogenesis in rats.

scientific article published in September 2013

Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis.

scientific article published on 19 April 2017

Iron and thiols as two major players in carcinogenesis: friends or foes?

scientific article

Iron as a target of chemoprevention for longevity in humans.

scientific article published on 26 May 2011

Iron overload as a major targetable pathogenesis of asbestos-induced mesothelial carcinogenesis.

scientific article

Iron overload signature in chrysotile-induced malignant mesothelioma

scientific article

LATS2 is a tumor suppressor gene of malignant mesothelioma.

scientific article published on 18 January 2011

Lack of presence of the human cytomegalovirus in human glioblastoma.

scientific article published on 13 December 2013

Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x ⬇️

scientific article published on December 15, 2012

Long-term culture of mouse male germline stem cells under serum-or feeder-free conditions

scientific article published on 15 December 2004

Low-temperature plasma in biology and medicine.

scientific article published on 22 June 2016

Malignant mesothelioma as an oxidative stress-induced cancer: An update

scientific article published on 11 May 2015

Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion.

scientific article

Maternal molecular hydrogen administration on lipopolysaccharide-induced mouse fetal brain injury.

scientific article

Maternal molecular hydrogen treatment attenuates lipopolysaccharide-induced rat fetal lung injury.

scientific article published on 7 May 2015

Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis

scientific article

Metamorphosis of mesothelial cells with active horizontal motility in tissue culture

scientific article

Mitochondria and free radical studies on health, disease and pollution

scientific article published on 01 August 2012

Mitochondrial dysfunction is related to necrosis-like programmed cell death induced by A23187 in CEM cells.

scientific article published on June 2005

Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model.

scientific article published on 24 October 2016

Molecular hydrogen suppresses activated Wnt/β-catenin signaling

scientific article published on 25 August 2016

Molecular mechanisms of oxidative stress-induced carcinogenesis: from epidemiology to oxygenomics.

scientific article

Napsin A is a specific marker for ovarian clear cell adenocarcinoma.

scientific article published on 11 April 2014

Neuroprotection by hyperbaric oxygenation after experimental focal cerebral ischemia monitored by MRI.

scientific article published in April 2004

Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia.

scientific article

Non-thermal plasma as a simple ferroptosis inducer in cancer cells: A possible role of ferritin

scientific article published on 06 April 2018

Non-thermal plasma induces a stress response in mesothelioma cells resulting in increased endocytosis, lysosome biogenesis and autophagy.

scientific article

Non-thermal plasma prevents progression of endometriosis in mice

scientific article

Novel Intraperitoneal Treatment With Non-Thermal Plasma-Activated Medium Inhibits Metastatic Potential of Ovarian Cancer Cells

scientific article published on 20 July 2017

Novel surrogate end-point biomarker to evaluate agents for use in the chemoprevention of reactive oxygen species-associated cancer

scientific article published in January 2002

Osteogenic differentiation in dedifferentiated liposarcoma: a study of 36 cases in comparison to the cases without ossification.

scientific article

Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron

scientific article

Ovarian mucinous tumors arising from mature cystic teratomas--a molecular genetic approach for understanding the cellular origin.

scientific article published on 13 November 2013

Overexpression of CYP3A aggravates endotoxin-induced liver injury in hypophysectomized female rats

scientific article published on 20 July 2007

Overexpression of a transcription factor LYL1 induces T- and B-cell lymphoma in mice

scientific article published on 07 May 2007

Overexpression of miR-199/214 is a distinctive feature of iron- and asbestos-induced sarcomatoid mesothelioma in rats

scientific article published on 04 April 2020

Oxidative stress as an iceberg in carcinogenesis and cancer biology.

scientific article published on April 2016

Oxidative stress is related to the formation of Antoni B patterns and eosinophilic hyaline droplets in schwannomas

scientific article published on 01 June 2007

Oxidative stress-dependent and -independent death of glioblastoma cells induced by non-thermal plasma-exposed solutions

scientific article published on 20 September 2019

Pain-reducing anesthesia prevents oxidative stress in human term placenta

scientific article published on 17 February 2016

Partial correction of abnormal cardiac development in caspase-8-deficient mice by cardiomyocyte expression of p 35.

scientific article published in October 2005

Phlebotomy as a preventive measure for crocidolite-induced mesothelioma in male rats

scientific article published on 29 November 2017

Plasma-activated medium promotes autophagic cell death along with alteration of the mTOR pathway

scientific article published on 31 January 2020

Possible involvement of iron-induced oxidative insults in neurodegeneration.

scientific article published on 27 December 2014

Potent antioxidative activity of Vineatrol30 grapevine-shoot extract.

scientific article

Preliminary characterization of a murine model for 1-bromopropane neurotoxicity: Role of cytochrome P450.

scientific article published on 12 July 2016

Prevention of myocardial reperfusion injury by poly(ADP-ribose) synthetase inhibitor, 3-aminobenzamide, in cardioplegic solution: in vitro study of isolated rat heart model

scientific article

Primary extraskeletal osteosarcoma: a clinicopathological study of 18 cases focusing on MDM2 amplification status.

scientific article published on 21 February 2017

Proapoptotic effects of dietary (n-3) fatty acids are enhanced in colonocytes of manganese-dependent superoxide dismutase knockout mice.

scientific article published on 20 May 2009

Production of knockout mice by gene targeting in multipotent germline stem cells

scientific article published on 26 September 2007

Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro.

scientific article published on August 2004

Protective effect of cardioplegia with poly (ADP-ribose) polymerase-1 inhibitor against myocardial ischemia-reperfusion injury: in vitro study of isolated rat heart model

scientific article published on 14 December 2011

Protective effect of colored rice over white rice on Fenton reaction-based renal lipid peroxidation in rats

scientific article published in May 2002

Protein N-acylation: H2O2-mediated covalent modification of protein by lipid peroxidation-derived saturated aldehydes

scientific article published on 31 May 2008

Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor.

scientific article

Receptor role of the annexin A2 in the mesothelial endocytosis of crocidolite fibers.

scientific article published on 27 April 2015

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics

scientific article published on February 2016

Repeated short-term daily exercise ameliorates oxidative cerebral damage and the resultant motor dysfunction after transient ischemia in rats.

scientific article published on 9 April 2013

Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma

scientific article

Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114).

scientific article published on 5 September 2017

Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation

scientific article

Significance of low mTORC1 activity in defining the characteristics of brain tumor stem cells

scientific article

Special issue for the 7th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia 2015 Thailand).

scientific article

Stage-specific roles offibulin-5 during oxidative stress-induced renal carcinogenesis in rats ⬇️

scientific article published on October 13, 2010

Stapled BIG3 helical peptide ERAP potentiates anti-tumour activity for breast cancer therapeutics

scientific article

Superiority of rat over murine model for studies on the evolution of cancer genome

scientific article published on 07 May 2018

Susceptibility of actin to modification by 4-hydroxy-2-nonenal

scientific article published in November 2005

The Human Cytomegalovirus Gene Products Essential for Late Viral Gene Expression Assemble into Prereplication Complexes before Viral DNA Replication ⬇️

scientific article published on April 20, 2011

The circadian clock gene BMAL1 is a novel therapeutic target for malignant pleural mesothelioma.

scientific article

The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer

scientific article

Transient but not stable ZEB1 knockdown dramatically inhibits growth of malignant pleural mesothelioma cells.

scientific article

Tribute issue: Helmut Sies and oxidative stress: Venit, vidit, vicit

scientific article published in April 2016

Urokinase-type plasminogen activator receptor promotes proliferation and invasion with reduced cisplatin sensitivity in malignant mesothelioma ⬇️

scientific article published on 02 September 2016

Variable susceptibility of ovarian cancer cells to non-thermal plasma-activated medium

scientific article

Visualization and characterization of UVB-induced reactive oxygen species in a human skin equivalent model

scientific article published in April 2008

XCR1 expression and biased VH gene usage are distinct features of diffuse large B-cell lymphoma initially manifesting in the bone marrow

scientific article

YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes.

scientific article published on 30 January 2012

miR-375 is activated by ASH1 and inhibits YAP1 in a lineage-dependent manner in lung cancer.

scientific article

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