Search filters

List of works by Alfred S. Lewin

A C-terminal peptide from type I interferon protects the retina in a mouse model of autoimmune uveitis

scientific article published on 26 February 2020

A cell penetrating peptide from SOCS-1 prevents ocular damage in experimental autoimmune uveitis

scientific article published on 23 July 2018

A comprehensive review of retinal gene therapy

scientific article

AAV Delivery of Wild-Type Rhodopsin Preserves Retinal Function in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa ⬇️

scientific article published on March 7, 2011

AAV Mediated Delivery of Myxoma Virus M013 Gene Protects the Retina against Autoimmune Uveitis

scientific article published on 29 November 2019

AAV-mediated knockdown of phospholamban leads to improved contractility and calcium handling in cardiomyocytes.

scientific article published on February 2008

ACE2 and Ang-(1-7) confer protection against development of diabetic retinopathy.

scientific article published on 26 July 2011

Ablation of C/EBP homologous protein does not protect T17M RHO mice from retinal degeneration

scientific article

Ablation of Chop Transiently Enhances Photoreceptor Survival but Does Not Prevent Retinal Degeneration in Transgenic Mice Expressing Human P23H Rhodopsin

scientific article published in January 2016

Access to conservative surgical therapy for adolescents with benign ovarian masses.

scientific article published on February 2012

Adeno-Associated Virus Delivery of Viral Serpins for Ocular Diseases: Design and Validation

scientific article published on 01 January 2018

Adeno-associated Virus Vectors Efficiently Transduce Mouse and Rabbit Sensory Neurons Coinfected with Herpes Simplex Virus 1 following Peripheral Inoculation.

scientific article published on 22 June 2016

Alternative topogenic signals in peroxisomal citrate synthase of Saccharomyces cerevisiae ⬇️

scientific article published on December 1, 1992

An RNA binding motif in the Cbp2 protein required for protein-stimulated RNA catalysis.

scientific article

Anti-clarin-1 AAV-delivered ribozyme induced apoptosis in the mouse cochlea.

scientific article published on 5 April 2007

Assessment of anti-scarring therapies in ex vivo organ cultured rabbit corneas

scientific article

Autocatalytic activities of intron 5 of the cob gene of yeast mitochondria.

scientific article published on June 1988

Cell-specific gene therapy driven by an optimized hypoxia-regulated vector reduces choroidal neovascularization

article

Characterization of Ribozymes Targeting a Congenital Night Blindness Mutation in Rhodopsin Mutation.

scientific article published on January 2016

Characterization of a transgenic short hairpin RNA-induced murine model of Tafazzin deficiency

scientific article

Clinically Relevant Outcome Measures for the I307N Rhodopsin Mouse: A Model of Inducible Autosomal Dominant Retinitis Pigmentosa

scientific article published on 01 November 2018

Co-Delivery of a Short-Hairpin RNA and a shRNA-Resistant Replacement Gene with Adeno-Associated Virus: An Allele-Independent Strategy for Autosomal-Dominant Retinal Disorders

scientific article published on 01 January 2019

Conditional Induction of Oxidative Stress in RPE: A Mouse Model of Progressive Retinal Degeneration.

scientific article published in January 2016

Consequences of zygote injection and germline transfer of mutant human mitochondrial DNA in mice.

scientific article

Cotranscriptional splicing of a group I intron is facilitated by the Cbp2 protein.

scientific article published on December 1995

Cytoplasmically made subunits of yeast mitochondrial F1-ATPase and cytochrome c oxidase are synthesized as individual precursors, not as polyproteins.

scientific article

Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium (RPE) in a mouse model of mitochondrial oxidative stress

scientific article published in PLoS ONE

Decreased expression of the insulin-like growth factor 1 receptor by ribozyme cleavage

scientific article published in September 2003

Delivery of CR2-fH Using AAV Vector Therapy as Treatment Strategy in the Mouse Model of Choroidal Neovascularization.

scientific article published on 10 November 2017

Delivery of antioxidant enzyme genes to protect against ischemia/reperfusion-induced injury to retinal microvasculature.

scientific article published on 23 July 2009

Derepression of citrate synthase in Saccharomyces cerevisiae may occur at the level of transcription.

scientific article published on February 1984

Design and Validation of Therapeutic Hammerhead Ribozymes for Autosomal Dominant Diseases

article

Designing and characterizing hammerhead ribozymes for use in AAV vector-mediated retinal gene therapies

scientific article published in January 2002

Development of an anti-angiogenic therapeutic model combining scAAV2-delivered siRNAs and noninvasive photoacoustic imaging of tumor vasculature development

scientific article

Development of hammerhead ribozymes to modulate endogenous gene expression for functional studies.

scientific article

Down-regulation of rhodopsin gene expression by AAV-vectored short interfering RNA.

scientific article published on January 2006

Drug and gene delivery to the back of the eye: from bench to bedside.

scientific article published on 28 April 2014

Efficiency and safety of AAV-mediated gene delivery of the human ND4 complex I subunit in the mouse visual system

scientific article

Endurance training ameliorates complex 3 deficiency in a mouse model of Barth syndrome.

scientific article published on 10 April 2015

Erythropoietin Slows Photoreceptor Cell Death in a Mouse Model of Autosomal Dominant Retinitis Pigmentosa

scientific article

Functional Rescue of P23H Rhodopsin Photoreceptors by Gene Delivery ⬇️

scientific article published on January 1, 2012

Gene augmentation for X-linked retinitis pigmentosa caused by mutations in RPGR

scientific article

Gene augmentation for adRP mutations in RHO.

scientific article

Gene delivery of a viral anti-inflammatory protein to combat ocular inflammation

scientific article

Gene delivery of wild-type rhodopsin rescues retinal function in an autosomal dominant retinitis pigmentosa mouse model.

scientific article published on January 2012

Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.

scientific article

Gene therapy for autosomal dominant disorders of keratin.

scientific article

Gene therapy rescues photoreceptor blindness in dogs and paves the way for treating human X-linked retinitis pigmentosa

scientific article published on 23 January 2012

Gene therapy to rescue retinal degeneration caused by mutations in rhodopsin.

scientific article

Gene therapy with the caspase activation and recruitment domain reduces the ocular inflammatory response

scientific article published on 20 February 2015

Geographic Atrophy in Age-Related Macular Degeneration andTLR3

scientific article published on 01 May 2009

Glucose regulated protein 78 diminishes α-synuclein neurotoxicity in a rat model of Parkinson disease.

scientific article

Hammerhead Ribozyme-Mediated Knockdown of mRNA for Fibrotic Growth Factors: Transforming Growth Factor-Beta 1 and Connective Tissue Growth Factor ⬇️

scientific article published on January 1, 2012

Hammerhead ribozyme targeting connective tissue growth factor mRNA blocks transforming growth factor-beta mediated cell proliferation.

scientific article

Hypothesis—A chemical mechanism for the biosynthesis of ATP involving ion-exchange reactions ⬇️

scientific article published on August 1, 1984

In vitro analysis of ribozyme-mediated knockdown of an ADRP associated rhodopsin mutation

scientific article published on January 2008

Increased sensitivity to light-induced damage in a mouse model of autosomal dominant retinal disease

scientific article

Inhibition of gene expression by ribozymes

scientific article published in January 2001

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

scientific article published on October 2005

Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency

scientific article published on 31 July 2018

LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile.

scientific article

Long-term rescue of retinal structure and function by rhodopsin RNA replacement with a single adeno-associated viral vector in P23H RHO transgenic mice.

scientific article published on 28 March 2012

Long-term suppression of neurodegeneration in chronic experimental optic neuritis: antioxidant gene therapy

scientific article published in December 2007

Longterm Reversal of Severe Visual Loss by Mitochondrial Gene Transfer in a Mouse Model of Leber Hereditary Optic Neuropathy.

scientific article published on 3 April 2018

MRI of Retinal Free Radical Production With Laminar Resolution In Vivo.

scientific article published on February 2016

Mitochondria: Potential Targets for Protection in Age-Related Macular Degeneration

Mitochondrial Protein Nitration Primes Neurodegeneration in Experimental Autoimmune Encephalomyelitis

scientific article published in Journal of Biological Chemistry

Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

scientific article published on 20 April 2019

Mitochondrial oxidative stress in the retinal pigment epithelium leads to localized retinal degeneration

scientific article

Modulation of the rate of retinal degeneration in T17M RHO mice by reprogramming the unfolded protein response.

scientific article

Mutants of Saccharomyces cerevisiae deficient in adenine phosphoribosyltransferase.

scientific article

Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector ⬇️

article published in the Proceedings of the National Academy of Sciences of the United States of America

Mutational evidence for competition between the P1 and the P10 helices of a mitochondrial group I intron ⬇️

scientific article published on May 11, 1992

Myxoma virus M013 protein antagonizes NF-κB and inflammasome pathways via distinct structural motifs

scientific article published on 02 April 2019

NADH-dehydrogenase type-2 suppresses irreversible visual loss and neurodegeneration in the EAE animal model of MS.

scientific article published on 11 June 2013

Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview

scientific article published on 01 January 2018

Optic neuropathy induced by reductions in mitochondrial superoxide dismutase

scientific article published on March 2003

Oxidative stress-mediated NFκB phosphorylation upregulates p62/SQSTM1 and promotes retinal pigmented epithelial cell survival through increased autophagy

scientific article

Pathological consequences of long-term mitochondrial oxidative stress in the mouse retinal pigment epithelium ⬇️

scientific article published on June 8, 2012

Physical mapping and characterization of the mitochondrial DNA and RNA sequences from mit- mutants defective in cytochrome oxidase peptide 1 (OXI 3) ⬇️

scientific article published on February 16, 1979

Physical mapping of genes on yeast mitochondrial DNA: Localization of antibiotic resistance loci, and rRNA and tRNA genes ⬇️

scientific article published on July 25, 1978

Potentiation of antifungal activity of amphotericin B by azithromycin against Aspergillus species.

scientific article

Preface: Translational Gene Therapy Coming of Age!

article

Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme.

scientific article published on November 2006

Propagation of restriction fragments from the mitochondrial DNA of Saccharomyces cerevisiae in E coli by means of plasmid vectors ⬇️

scientific article published on January 1, 1979

Protein-induced folding of a group I intron in cytochrome b pre-mRNA.

scientific article published in September 1995

RNA knockdown as a potential therapeutic strategy in Parkinson's disease.

scientific article

Recombinant adeno-associated virus vector-based gene transfer for defects in oxidative metabolism.

scientific article

Reduction in preretinal neovascularization by ribozymes that cleave the A2B adenosine receptor mRNA.

scientific article published on 14 August 2003

Reduction in severity of a herpes simplex virus type 1 murine infection by treatment with a ribozyme targeting the UL20 gene RNA.

scientific article published on 28 May 2008

Rescue of a mitochondrial deficiency causing Leber Hereditary Optic Neuropathy

scientific article published in November 2002

Restoration of visual function in P23H rhodopsin transgenic rats by gene delivery of BiP/Grp78

scientific article

Restriction cleavage map of mitochondrial DNA from the yeast Saccharomyces cerevisiae ⬇️

scientific article published on July 1, 1977

Restriction endonuclease analysis of mitochondrial DNA from grande and genetically characterized cytoplasmic petite clones of Saccharomyces cerevisiae ⬇️

scientific article published on October 1, 1975

Restriction enzyme analysis of mitochondrial DNAs of petite mutants of yeast: Classification of petites, and deletion mapping of mitochondrial genes ⬇️

scientific article published on July 25, 1978

Ribozyme gene therapy for autosomal dominant retinal disease.

scientific article published in February 2000

Ribozyme knockdown of the gamma-subunit of rod cGMP phosphodiesterase alters the ERG and retinal morphology in wild-type mice

scientific article published in October 2005

Ribozyme rescue of photoreceptor cells in P23H transgenic rats: long-term survival and late-stage therapy.

scientific article

Ribozyme rescue of photoreceptor cells in a transgenic rat model of autosomal dominant retinitis pigmentosa.

scientific article published in August 1998

Ribozyme uses in retinal gene therapy.

scientific article

SOD2 gene transfer protects against optic neuropathy induced by deficiency of complex I.

scientific article published on August 2004

SOD2 knockdown mouse model of early AMD.

scientific article published in October 2007

Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.

scientific article

Splicing defective mutants of the COXI gene of yeast mitochondrial DNA: initial definition of the maturase domain of the group II intron aI2

scientific article published on June 1994

Splicing of COB intron 5 requires pairing between the internal guide sequence and both flanking exons.

scientific article

Stable heterogeneity of mitochondrial DNA in grande and petite strains of S. cerevisiae ⬇️

scientific article published on July 1, 1979

Structure-induced strain determining the internal cyclization site in the yeast cobI5 autocatalytic intron: theory and experimental tests

scientific article published in September 1993

Submitochondrial localization, cell-free synthesis, and mitochondrial import of 2-isopropylmalate synthase of yeast.

scientific article published on March 1983

Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease

scientific article

Suppression of complex I gene expression induces optic neuropathy

scientific article published on February 2003

Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritis

scientific article

Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery

scientific article

Suppression of rds expression by siRNA and gene replacement strategies for gene therapy using rAAV vector.

scientific article published on January 2012

Systemic Injection of RPE65-Programmed Bone Marrow-Derived Cells Prevents Progression of Chronic Retinal Degeneration.

scientific article published on 12 February 2017

Systemic treatment with a 5HT1a agonist induces anti-oxidant protection and preserves the retina from mitochondrial oxidative stress

scientific article published on 24 August 2015

Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide

scientific article

The 5HT1a receptor agonist 8-Oh DPAT induces protection from lipofuscin accumulation and oxidative stress in the retinal pigment epithelium

scientific article

The NLRP3 Inflammasome and its Role in Age-Related Macular Degeneration

scientific article published on January 2016

The importance of mitochondria in age-related and inherited eye disorders.

scientific article published on 09 September 2010

The mutant human ND4 subunit of complex I induces optic neuropathy in the mouse

scientific article published in January 2007

The structure and organization of mitochondrial DNA from petite yeast ⬇️

scientific article published on April 1, 1979

Tight Long-term dynamic doxycycline responsive nigrostriatal GDNF using a single rAAV vector.

scientific article

Timing of Antioxidant Gene Therapy: Implications for Treating Dry AMD.

scientific article published on February 2017

Triple combination of siRNAs targeting TGFβ1, TGFβR2, and CTGF enhances reduction of collagen I and smooth muscle actin in corneal fibroblasts.

scientific article published on 17 December 2013

Unexpected off-targeting effects of anti-huntingtin ribozymes and siRNA in vivo.

scientific article

Use of mitochondrial antioxidant defenses for rescue of cells with a Leber hereditary optic neuropathy-causing mutation

scientific article published in February 2007

Viral-vectored ribozymes as therapy for autosomal dominant retinal disease

article

[49] Ribozymes in treatment of inherited retinal disease

article

rAAV-mediated nigral human parkin over-expression partially ameliorates motor deficits via enhanced dopamine neurotransmission in a rat model of Parkinson's disease

scientific article published on 10 July 2007

Paulina is supported by:

About Paulina

Help