List of works - Ute Krengel

1.6 A crystal structure of the secreted chorismate mutase from Mycobacterium tuberculosis: novel fold topology revealed

scientific article published on 6 February 2006

1H, 13C, 15N backbone assignment of the human heat-labile enterotoxin B-pentamer and chemical shift mapping of neolactotetraose binding.

scientific article

A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis

scientific journal article

A strategically positioned cation is crucial for efficient catalysis by chorismate mutase

scientific article

An Unusual Member of the Papain Superfamily: Mapping the Catalytic Cleft of the Marasmius oreades agglutinin (MOA) with a Caspase Inhibitor

scientific article

Atomic-resolution structure of the α-galactosyl binding Lyophyllum decastes lectin reveals a new protein family found in both fungi and plants

scientific article

Blood group antigen recognition by Escherichia coli heat-labile enterotoxin

scientific article published on 17 August 2007

Both El Tor and classical cholera toxin bind blood group determinants.

scientific article published on 28 January 2012

Comprehensive analysis of blood group antigen binding to classical and El Tor cholera toxin B-pentamers by NMR.

scientific article

Coping with oxidative stress

scientific article published in Science

Crystal structure of MOA in complex with a peptide fragment: A protease caught <i>in flagranti</i>

scientific article published on 22 April 2020

Crystal structure of a murine alpha-class glutathione S-transferase involved in cellular defense against oxidative stress

scientific article

Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture

scientific article published in Scientific Reports

Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody

scientific article

Crystal structure of the Marasmius oreades mushroom lectin in complex with a xenotransplantation epitope

scientific article

Crystal structure of the double azurin mutant Cys3Ser/Ser100Pro from Pseudomonas aeruginosa at 1.8 A resolution: its folding-unfolding energy and unfolding kinetics

scientific article

Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin

scientific article

Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site

scientific article published on 22 August 2019

Crystal structures reveal that Lewis-x and fucose bind to secondary cholera toxin binding site - in contrast to fucosyl-GM1

Crystallization and preliminary X-ray crystallographic studies of a lectin from the mushroom Marasmius oreades.

scientific article published on 20 October 2004

Crystallization and preliminary crystallographic analysis of endo-1,4-beta-xyalanase I from Aspergillus niger.

scientific article published in May 1996

Crystallization and preliminary crystallographic analysis of the NAD(H)-binding domain of Escherichia coli transhydrogenase

scientific article published on 23 March 2004

Crystallography and Lectin Structure Database

scholarly article published 2007

Editorial overview: A feast of structural glycobiology

scholarly article by Ute Krengel published in June 2017

Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.

scientific article

Engineering the binding site of an antibody against N-glycolyl GM3: from functional mapping to novel anti-ganglioside specificities.

scientific article

Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance

scientific article published on 09 October 2020

Family of Papain-Like Fungal Chimerolectins with Distinct Ca2+-Dependent Activation Mechanism.

scientific article published on 30 June 2017

Function of the CysD domain of the gel-forming MUC2 mucin

scientific article published on May 2011

Glucose kinase of Streptomyces coelicolor A3(2): large-scale purification and biochemical analysis

scientific article published on 01 December 2000

High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence

scientific article

High-resolution crystal structures of Erythrina cristagalli lectin in complex with lactose and 2'-alpha-L-fucosyllactose and correlation with thermodynamic binding data

scientific article

Histo-blood group antigens as mediators of infections

scientific article

Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute

scientific article published on 28 November 2017

Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells

scientific article

Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp.

scientific article published on 27 November 2017

Light-chain shuffling results in successful phage display selection of functional prokaryotic-expressed antibody fragments to N-glycolyl GM3 ganglioside

scientific article

Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity

scientific article published on 12 April 2011

Molecular basis of cholera blood-group dependence and implications for a world characterized by climate change

scientific article

Molecular recognition of gangliosides and their potential for cancer immunotherapies

scientific article

Nimotuzumab and cetuximab block ligand-independent EGF receptor signaling efficiently at different concentrations.

scientific article published on September 2011

Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation

scientific article

Novel Binding Site Identified in a Hybrid between Cholera Toxin and Heat-Labile Enterotoxin: 1.9 Å Crystal Structure Reveals the Details

Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin: 1.9 A crystal structure reveals the details

scientific article

Polyporus squamosus Lectin 1a (PSL1a) Exhibits Cytotoxicity in Mammalian Cells by Disruption of Focal Adhesions, Inhibition of Protein Synthesis and Induction of Apoptosis

scientific article

Preliminary X-ray crystallographic analysis of the secreted chorismate mutase from Mycobacterium tuberculosis: a tricky crystallization problem solved.

scientific article

Quantum chemical modeling of the reaction path of chorismate mutase based on the experimental substrate/product complex

scientific article published on 2 May 2017

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

scientific article

Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway

scientific article

Restriction fragment length polymorphisms at the human parathyroid hormone gene locus

article

Specificity of Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography ⬇️

scientific article published on 06 February 2019

Structural Characterization of a Lectin from the Mushroom Marasmius oreades in Complex with the Blood Group B Trisaccharide and Calcium

scientific article

Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner

scientific article

Structure and molecular interactions of a unique antitumor antibody specific for N-glycolyl GM3

scientific article

Structure of the Fab fragment of the anti-murine EGFR antibody 7A7 and exploration of its receptor binding site

scientific article

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

scientific article (publication date: 21 September 1989)

The fungal chimerolectin MOA inhibits protein and DNA synthesis in NIH/3T3 cells and may induce BAX-mediated apoptosis

scientific article published on 18 April 2014

The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection

scientific article published on 23 February 2021

Three-dimensional structure of Endo-1,4-beta-xylanase I from Aspergillus niger: molecular basis for its low pH optimum

scientific article

Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant

scientific article

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

scientific article

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

scientific article

Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics

scientific article published on 24 May 2017

Using <i>Vibrio natriegens</i> for High-Yield Production of Challenging Expression Targets and for Protein Perdeuteration

scientific article published in 2024

Virus-like Immune Defense Protein in Mushrooms.

scientific article

When Inhibitors Do Not Inhibit: Critical Evaluation of Rational Drug Design Targeting Chorismate Mutase fromMycobacterium tuberculosis

scholarly article by Steffi Munack et al published November 2012 in Chemistry and Biodiversity

X-ray structure of antistasin at 1.9 A resolution and its modelled complex with blood coagulation factor Xa

scientific article

X-ray structure of domain I of the proton-pumping membrane protein transhydrogenase from Escherichia coli.

scientific article published in September 2005

List of works by Ute Krengel

1.6 A crystal structure of the secreted chorismate mutase from Mycobacterium tuberculosis: novel fold topology revealed

1H, 13C, 15N backbone assignment of the human heat-labile enterotoxin B-pentamer and chemical shift mapping of neolactotetraose binding.

A novel noncovalent complex of chorismate mutase and DAHP synthase from Mycobacterium tuberculosis: protein purification, crystallization and X-ray diffraction analysis

A strategically positioned cation is crucial for efficient catalysis by chorismate mutase

An Unusual Member of the Papain Superfamily: Mapping the Catalytic Cleft of the Marasmius oreades agglutinin (MOA) with a Caspase Inhibitor

Atomic-resolution structure of the α-galactosyl binding Lyophyllum decastes lectin reveals a new protein family found in both fungi and plants

Blood group antigen recognition by Escherichia coli heat-labile enterotoxin

Both El Tor and classical cholera toxin bind blood group determinants.

Comprehensive analysis of blood group antigen binding to classical and El Tor cholera toxin B-pentamers by NMR.

Coping with oxidative stress

Crystal structure of MOA in complex with a peptide fragment: A protease caught <i>in flagranti</i>

Crystal structure of a murine alpha-class glutathione S-transferase involved in cellular defense against oxidative stress

Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture

Crystal structure of an anti-ganglioside antibody, and modelling of the functional mimicry of its NeuGc-GM3 antigen by an anti-idiotypic antibody

Crystal structure of the Marasmius oreades mushroom lectin in complex with a xenotransplantation epitope

Crystal structure of the double azurin mutant Cys3Ser/Ser100Pro from Pseudomonas aeruginosa at 1.8 A resolution: its folding-unfolding energy and unfolding kinetics

Crystal structures exploring the origins of the broader specificity of escherichia coli heat-labile enterotoxin compared to cholera toxin

Crystal structures of cholera toxin in complex with fucosylated receptors point to importance of secondary binding site

Crystal structures reveal that Lewis-x and fucose bind to secondary cholera toxin binding site - in contrast to fucosyl-GM1

Crystallization and preliminary X-ray crystallographic studies of a lectin from the mushroom Marasmius oreades.

Crystallization and preliminary crystallographic analysis of endo-1,4-beta-xyalanase I from Aspergillus niger.

Crystallization and preliminary crystallographic analysis of the NAD(H)-binding domain of Escherichia coli transhydrogenase

Crystallography and Lectin Structure Database

Editorial overview: A feast of structural glycobiology

Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis.

Engineering the binding site of an antibody against N-glycolyl GM3: from functional mapping to novel anti-ganglioside specificities.

Evolving the naturally compromised chorismate mutase from Mycobacterium tuberculosis to top performance

Family of Papain-Like Fungal Chimerolectins with Distinct Ca2+-Dependent Activation Mechanism.

Function of the CysD domain of the gel-forming MUC2 mucin

Glucose kinase of Streptomyces coelicolor A3(2): large-scale purification and biochemical analysis

High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence

High-resolution crystal structures of Erythrina cristagalli lectin in complex with lactose and 2'-alpha-L-fucosyllactose and correlation with thermodynamic binding data

Histo-blood group antigens as mediators of infections

Hypothesis: Hypoxia induces de novo synthesis of NeuGc gangliosides in humans through CMAH domain substitute

Hypoxia Strongly Affects Mitochondrial Ribosomal Proteins and Translocases, as Shown by Quantitative Proteomics of HeLa Cells

Inter-Enzyme Allosteric Regulation of Chorismate Mutase in Corynebacterium glutamicum: Structural Basis of Feedback Activation by Trp.

Light-chain shuffling results in successful phage display selection of functional prokaryotic-expressed antibody fragments to N-glycolyl GM3 ganglioside

Marasmius oreades agglutinin (MOA) is a chimerolectin with proteolytic activity

Molecular basis of cholera blood-group dependence and implications for a world characterized by climate change

Molecular recognition of gangliosides and their potential for cancer immunotherapies

Nimotuzumab and cetuximab block ligand-independent EGF receptor signaling efficiently at different concentrations.

Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation

Novel Binding Site Identified in a Hybrid between Cholera Toxin and Heat-Labile Enterotoxin: 1.9 Å Crystal Structure Reveals the Details

Novel binding site identified in a hybrid between cholera toxin and heat-labile enterotoxin: 1.9 A crystal structure reveals the details

Polyporus squamosus Lectin 1a (PSL1a) Exhibits Cytotoxicity in Mammalian Cells by Disruption of Focal Adhesions, Inhibition of Protein Synthesis and Induction of Apoptosis

Preliminary X-ray crystallographic analysis of the secreted chorismate mutase from Mycobacterium tuberculosis: a tricky crystallization problem solved.

Quantum chemical modeling of the reaction path of chorismate mutase based on the experimental substrate/product complex

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis

Remote Control by Inter-Enzyme Allostery: A Novel Paradigm for Regulation of the Shikimate Pathway

Restriction fragment length polymorphisms at the human parathyroid hormone gene locus

Specificity of Heat-Labile Enterotoxin Investigated by Single-Site Mutagenesis and Crystallography ⬇️

Structural Characterization of a Lectin from the Mushroom Marasmius oreades in Complex with the Blood Group B Trisaccharide and Calcium

Structure and function of a complex between chorismate mutase and DAHP synthase: efficiency boost for the junior partner

Structure and molecular interactions of a unique antitumor antibody specific for N-glycolyl GM3

Structure of the Fab fragment of the anti-murine EGFR antibody 7A7 and exploration of its receptor binding site

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

The fungal chimerolectin MOA inhibits protein and DNA synthesis in NIH/3T3 cells and may induce BAX-mediated apoptosis

The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection

Three-dimensional structure of Endo-1,4-beta-xylanase I from Aspergillus niger: molecular basis for its low pH optimum

Three-dimensional structure of p21 in the active conformation and analysis of an oncogenic mutant

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics

Using <i>Vibrio natriegens</i> for High-Yield Production of Challenging Expression Targets and for Protein Perdeuteration

Virus-like Immune Defense Protein in Mushrooms.

When Inhibitors Do Not Inhibit: Critical Evaluation of Rational Drug Design Targeting Chorismate Mutase fromMycobacterium tuberculosis

X-ray structure of antistasin at 1.9 A resolution and its modelled complex with blood coagulation factor Xa

X-ray structure of domain I of the proton-pumping membrane protein transhydrogenase from Escherichia coli.