List of works - Holger Cynis

A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues

scientific article

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

scientific article published on 16 November 2020

Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta

scientific article

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain

scientific article published on 21 August 2009

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

scientific article

Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease

scientific article

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

scientific article published on 28 September 2008

Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development

scientific article

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration

scientific article

Glutaminyl cyclases as novel targets for the treatment of septic arthritis

scientific article published on 29 November 2012

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges

scientific article

Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.

scientific article published on 8 April 2013

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

scientific article

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

scientific article

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

scientific article

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes

scientific article published on 20 August 2015

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease

scientific article

Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery

scientific article

Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.

scientific article

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics

scientific article published on 5 October 2009

Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC.

scientific article published on 2 June 2014

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

scientific article published on 28 March 2012

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.

scientific article

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models

scientific article published on 07 June 2013

Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion

scientific article

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

scientific article published in September 2011

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.

scientific article

List of works by Holger Cynis

A quantitative analysis of spontaneous isoaspartate formation from N-terminal asparaginyl and aspartyl residues

Acute targeting of pre-amyloid seeds in transgenic mice reduces Alzheimer-like pathology later in life

Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of glutaminyl cyclase in generation of pyroglutamate-modified amyloid-beta

Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain

Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms

Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-β load and cognitive decline in Alzheimer's disease

Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology

Glutaminyl cyclase knock-out mice exhibit slight hypothyroidism but no hypogonadism: implications for enzyme function and drug development

Glutaminyl cyclase-mediated toxicity of pyroglutamate-beta amyloid induces striatal neurodegeneration

Glutaminyl cyclases as novel targets for the treatment of septic arthritis

Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges

Inhibition of Glutaminyl Cyclases alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease in mice.

Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells

Inhibition of glutaminyl cyclase prevents pGlu-Abeta formation after intracortical/hippocampal microinjection in vivo/in situ.

Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model

IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes

Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease

Isolation of an isoenzyme of human glutaminyl cyclase: retention in the Golgi complex suggests involvement in the protein maturation machinery

Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase.

Mammalian glutaminyl cyclases and their isoenzymes have identical enzymatic characteristics

Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC.

N-Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long-term potentiation

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β.

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models

Pyroglutamate-amyloid-β and glutaminyl cyclase are colocalized with amyloid-β in secretory vesicles and undergo activity-dependent, regulated secretion

Selective hippocampal neurodegeneration in transgenic mice expressing small amounts of truncated Aβ is induced by pyroglutamate-Aβ formation.

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions.