List of works - Luis Sigal

A lactate dehydrogenase (LDH)-based immunoassay for detection of cell surface antigens and its application to the study of MHC class I-binding peptides.

scientific article published on December 1994

A role for NKG2D in NK cell-mediated resistance to poxvirus disease

scientific article

Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking

scientific article

Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver.

scientific article

CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization

scientific article

CD94 is essential for NK cell-mediated resistance to a lethal viral disease

scientific article published on April 2011

Changes in mononuclear peripheral blood cells in cattle with foot-and-mouth disease

scientific article published on 01 January 1992

Characterization of ectromelia virus deficient in EVM036, the homolog of vaccinia virus F13L, and its application for rapid generation of recombinant viruses

scientific article published on 3 October 2012

Chronic Lymphocytic Choriomeningitis Infection Causes Susceptibility to Mousepox and Impairs Natural Killer Cell Maturation and Function

scientific article published on 14 February 2020

Cross priming or direct priming: is that really the question?

scientific article

Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection.

scientific article published on June 2013

Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts

scientific article published on 11 April 2018

Db-binding peptides from influenza virus: effect of non-anchor residues on stability and immunodominance

scientific article

Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation

scientific article published on 12 July 2020

Development and function of CD94-deficient natural killer cells

scientific article

Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response

scientific article

Enhanced NK-cell development and function in BCAP-deficient mice

scientific article published on 12 March 2008

Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response

scientific article published on 14 September 2011

Getting in front and behind the enemy lines to counter virus infection

scientific article published in February 2013

Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host

scientific article

Immunology: Memory cells sound the alarm

scientific article published in May 2013

Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses

scientific article

Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo

scientific journal article

Loss of Resistance to Mousepox during Chronic Lymphocytic Choriomeningitis Virus Infection Is Associated with Impaired T-Cell Responses and Can Be Rescued by Immunization

scientific article published on 14 February 2020

Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection

scientific article

Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease

scientific article

Memory CD8⁺ T cell protection

scientific article published on January 2013

Memory CD8⁺ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection.

scientific article published on May 2013

MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2

scientific article published on 08 January 2014

Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection

scientific article

Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen ⬇️

scientific article published on July 7, 1998

Protective CD8+ T cell memory without help.

scientific article published on September 2015

Replication of the human hepatitis delta virus genome Is initiated in mouse hepatocytes following intravenous injection of naked DNA or RNA sequences

scientific article

Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy

scientific article published on 26 December 2019

Role of non-anchor residues of Db-restricted peptides in class I binding and TCR triggering

scientific article published on 01 December 1996

STING Sensing of Murine Cytomegalovirus Alters the Tumor Microenvironment to Promote Antitumor Immunity

scientific article published on 13 April 2020

Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection

scientific article

The Pathogenesis and Immunobiology of Mousepox

scientific article

The amino acid sequences flanking an antigenic determinant can strongly affect MHC class I cross-presentation without altering direct presentation

scientific article published on April 2009

The multiple routes of MHC-I cross-presentation

scientific article published on May 2004

The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment.

scientific article

With some risk-taking and luck: A veterinarian's adventures in viral immunology

scientific article published on 05 July 2018

α2β1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell-Mediated Virus Control

scientific article published on 03 February 2020

List of works by Luis Sigal

A lactate dehydrogenase (LDH)-based immunoassay for detection of cell surface antigens and its application to the study of MHC class I-binding peptides.

A role for NKG2D in NK cell-mediated resistance to poxvirus disease

Age-dependent susceptibility to a viral disease due to decreased natural killer cell numbers and trafficking

Antibody inhibition of a viral type 1 interferon decoy receptor cures a viral disease by restoring interferon signaling in the liver.

CD4+ T cell help is dispensable for protective CD8+ T cell memory against mousepox virus following vaccinia virus immunization

CD94 is essential for NK cell-mediated resistance to a lethal viral disease

Changes in mononuclear peripheral blood cells in cattle with foot-and-mouth disease

Characterization of ectromelia virus deficient in EVM036, the homolog of vaccinia virus F13L, and its application for rapid generation of recombinant viruses

Chronic Lymphocytic Choriomeningitis Infection Causes Susceptibility to Mousepox and Impairs Natural Killer Cell Maturation and Function

Cross priming or direct priming: is that really the question?

Crosstalk between the type 1 interferon and nuclear factor kappa B pathways confers resistance to a lethal virus infection.

Cutting Edge: Protection by Antiviral Memory CD8 T Cells Requires Rapidly Produced Antigen in Large Amounts

Db-binding peptides from influenza virus: effect of non-anchor residues on stability and immunodominance

Defective early innate immune response to ectromelia virus in the draining lymph nodes of aged mice due to impaired dendritic cell accumulation

Development and function of CD94-deficient natural killer cells

Direct presentation is sufficient for an efficient anti-viral CD8+ T cell response

Enhanced NK-cell development and function in BCAP-deficient mice

Gamma interferon and perforin control the strength, but not the hierarchy, of immunodominance of an antiviral CD8+ T cell response

Getting in front and behind the enemy lines to counter virus infection

Immunization with a single extracellular enveloped virus protein produced in bacteria provides partial protection from a lethal orthopoxvirus infection in a natural host

Immunology: Memory cells sound the alarm

Impact of distinct poxvirus infections on the specificities and functionalities of CD4+ T cell responses

Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo

Loss of Resistance to Mousepox during Chronic Lymphocytic Choriomeningitis Virus Infection Is Associated with Impaired T-Cell Responses and Can Be Rescued by Immunization

Memory CD8+ T cells are gatekeepers of the lymph node draining the site of viral infection

Memory CD8+ T cells specific for a single immunodominant or subdominant determinant induced by peptide-dendritic cell immunization protect from an acute lethal viral disease

Memory CD8⁺ T cell protection

Memory CD8⁺ T cells can outsource IFN-γ production but not cytolytic killing for antiviral protection.

MyD88-dependent immunity to a natural model of vaccinia virus infection does not involve Toll-like receptor 2

Perforin-dependent CD4+ T-cell cytotoxicity contributes to control a murine poxvirus infection

Poliovirus vaccine vectors elicit antigen-specific cytotoxic T cells and protect mice against lethal challenge with malignant melanoma cells expressing a model antigen ⬇️

Protective CD8+ T cell memory without help.

Replication of the human hepatitis delta virus genome Is initiated in mouse hepatocytes following intravenous injection of naked DNA or RNA sequences

Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy

Role of non-anchor residues of Db-restricted peptides in class I binding and TCR triggering

STING Sensing of Murine Cytomegalovirus Alters the Tumor Microenvironment to Promote Antitumor Immunity

Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection

The Pathogenesis and Immunobiology of Mousepox

The amino acid sequences flanking an antigenic determinant can strongly affect MHC class I cross-presentation without altering direct presentation

The multiple routes of MHC-I cross-presentation

The natural killer cell dysfunction of aged mice is due to the bone marrow stroma and is not restored by IL-15/IL-15Rα treatment.

With some risk-taking and luck: A veterinarian's adventures in viral immunology

α2β1 Integrin Is Required for Optimal NK Cell Proliferation during Viral Infection but Not for Acquisition of Effector Functions or NK Cell-Mediated Virus Control