List of works - Alexander J. Szalai

A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans

scientific article

An About-Face for C-Reactive Protein? ⬇️

scientific article published on 05 August 2011

Anti-atherosclerotic effect of amlodipine, alone and in combination with atorvastatin, in APOE*3-Leiden/hCRP transgenic mice

scientific article published in January 2006

Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular health

scientific article

Associations of C-Reactive Protein to Indices of Vascular Health and the Influence of Serum 25(OH)D Status in Healthy Adults

scientific article

Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirus

scientific article published in October 2004

Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae

scientific article

C-reactive protein (CRP) and autoimmune disease: facts and conjectures.

scientific article

C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice.

scientific article published on 26 January 2004

C-reactive protein and arteriosclerosis

scientific article

C-reactive protein directly suppresses Th1 cell differentiation and alleviates experimental autoimmune encephalomyelitis.

scientific article published on 27 April 2015

C-reactive protein exacerbates renal ischemia-reperfusion injury

scientific article published on 27 March 2013

C-reactive protein exacerbates renal ischemia-reperfusion injury: are myeloid-derived suppressor cells to blame?

scientific article published on 06 April 2016

C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk

scientific article published on 04 September 2007

C-reactive protein induces expression of tissue factor and plasminogen activator inhibitor-1 and promotes fibrin accumulation in vein grafts

scientific article published on 23 August 2014

C-reactive protein polymorphism and Crohn's disease

scientific article published on 01 February 2007

C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration.

scientific article published on May 2014

C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.

scientific article published on 25 July 2016

C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice.

scientific article published on 7 March 2011

C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease.

scientific article published on 15 February 2010

C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes ⬇️

scientific article published on July 9, 2011

C-reactive protein-mediated vascular injury requires complement.

scientific article

C-reactive protein: a physiological activator of interleukin 6 receptor shedding.

scientific article published on February 1999

C-reactive protein: structural biology and host defense function

scientific article

C3a expressed in the central nervous system protects against LPS-induced shock.

scientific article published in October 2005

Chelation affects the conformation, lability and aggregation of channel catfish (Ictalurus punctatus) phosphorylcholine-reactive protein (PRP).

scientific article

Collagen‐induced arthritis is exacerbated in C‐reactive protein–deficient mice ⬇️

scientific article published on September 1, 2011

Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patients

scientific article published on 30 September 2014

Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated

scientific article published on 28 November 2005

Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease.

scientific article published on 13 March 2007

Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence

scientific article

Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI.

scientific article published in June 2004

Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene

scientific article published on 01 June 2003

Deletion of C-reactive protein ameliorates experimental cerebral malaria?

scientific article

Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice.

scientific article published on 28 October 2004

Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors.

scientific article

Estrogen treatment abrogates neointima formation in human C-reactive protein transgenic mice

scientific article published on 28 July 2005

Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent.

scientific article

Experimental autoimmune uveitis in the C57BL/6 mouse

scientific article published on 09 March 2006

Fc receptors and the common gamma-chain in experimental autoimmune encephalomyelitis

scientific article published on March 2004

Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis

scientific article

Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA.

scientific article published in May 1999

Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice.

scientific article

Human C-reactive protein is protective against fatal Salmonella enterica serovar typhimurium infection in transgenic mice

scientific article

Human neutrophil flow chamber adhesion assay.

scientific article

Impaired endothelial function in C-reactive protein overexpressing mice.

scientific article published on 20 March 2008

Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice

scientific article

Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models.

scientific article published on 02 April 2014

Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent.

scientific article

Isolation of an acute-phase phosphorylcholine-reactive pentraxin from channel catfish (Ictalurus punctatus).

scientific article published in July 1992

Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement

scientific article

Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils

scientific article

Murine complement C4 is not required for experimental autoimmune encephalomyelitis

scientific article published in January 2005

No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-leiden/human C-reactive protein transgenic mice.

scientific article published on 26 May 2005

Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholine

scientific article

PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation

scientific article

Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis

scientific article published on 01 December 2005

Serum eotaxin-1 is increased in extremely-low-birth-weight infants with bronchopulmonary dysplasia or death

scientific article

Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level.

scientific article

Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events

scientific article published on 29 March 2005

The antimicrobial activity of C-reactive protein

scientific article

The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk

scientific article

The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis

scientific article

Varied biologic functions of C-reactive protein: lessons learned from transgenic mice.

scientific article

List of works by Alexander J. Szalai

A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans

An About-Face for C-Reactive Protein? ⬇️

Anti-atherosclerotic effect of amlodipine, alone and in combination with atorvastatin, in APOE*3-Leiden/hCRP transgenic mice

Associations between abnormal rod-mediated dark adaptation and health and functioning in older adults with normal macular health

Associations of C-Reactive Protein to Indices of Vascular Health and the Influence of Serum 25(OH)D Status in Healthy Adults

Bioluminescence imaging reveals a significant role for complement in liver transduction following intravenous delivery of adenovirus

Both family 1 and family 2 PspA proteins can inhibit complement deposition and confer virulence to a capsular serotype 3 strain of Streptococcus pneumoniae

C-reactive protein (CRP) and autoimmune disease: facts and conjectures.

C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice.

C-reactive protein and arteriosclerosis

C-reactive protein directly suppresses Th1 cell differentiation and alleviates experimental autoimmune encephalomyelitis.

C-reactive protein exacerbates renal ischemia-reperfusion injury

C-reactive protein exacerbates renal ischemia-reperfusion injury: are myeloid-derived suppressor cells to blame?

C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk

C-reactive protein induces expression of tissue factor and plasminogen activator inhibitor-1 and promotes fibrin accumulation in vein grafts

C-reactive protein polymorphism and Crohn's disease

C-reactive protein promotes acute kidney injury by impairing G1/S-dependent tubular epithelium cell regeneration.

C-reactive protein promotes acute kidney injury via Smad3-dependent inhibition of CDK2/cyclin E.

C-reactive protein promotes acute renal inflammation and fibrosis in unilateral ureteral obstructive nephropathy in mice.

C-reactive protein promotes cardiac fibrosis and inflammation in angiotensin II-induced hypertensive cardiac disease.

C-reactive protein promotes diabetic kidney disease in a mouse model of type 1 diabetes ⬇️

C-reactive protein-mediated vascular injury requires complement.

C-reactive protein: a physiological activator of interleukin 6 receptor shedding.

C-reactive protein: structural biology and host defense function

C3a expressed in the central nervous system protects against LPS-induced shock.

Chelation affects the conformation, lability and aggregation of channel catfish (Ictalurus punctatus) phosphorylcholine-reactive protein (PRP).

Collagen‐induced arthritis is exacerbated in C‐reactive protein–deficient mice ⬇️

Complement C3 activation in cyst fluid and urine from autosomal dominant polycystic kidney disease patients

Complement in BuB/BnJ mice revisited: serum C3 levels and complement opsonic activity are not elevated

Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease.

Complement receptor 1 expression on mouse erythrocytes mediates clearance of Streptococcus pneumoniae by immune adherence

Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI.

Delayed lupus onset in (NZB x NZW)F1 mice expressing a human C-reactive protein transgene

Deletion of C-reactive protein ameliorates experimental cerebral malaria?

Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice.

Estrogen effects on vascular inflammation are age dependent: role of estrogen receptors.

Estrogen treatment abrogates neointima formation in human C-reactive protein transgenic mice

Exaggerated neointima formation in human C-reactive protein transgenic mice is IgG Fc receptor type I (Fc gamma RI)-dependent.

Experimental autoimmune uveitis in the C57BL/6 mouse

Fc receptors and the common gamma-chain in experimental autoimmune encephalomyelitis

Genetic deficiency of C3 as well as CNS-targeted expression of the complement inhibitor sCrry ameliorates experimental autoimmune uveoretinitis

Genetic disruption of the murine complement C3 promoter region generates deficient mice with extrahepatic expression of C3 mRNA.

Hepatic but Not CNS-Expressed Human C-Reactive Protein Inhibits Experimental Autoimmune Encephalomyelitis in Transgenic Mice.

Human C-reactive protein is protective against fatal Salmonella enterica serovar typhimurium infection in transgenic mice

Human neutrophil flow chamber adhesion assay.

Impaired endothelial function in C-reactive protein overexpressing mice.

Increased thrombosis after arterial injury in human C-reactive protein-transgenic mice

Inhibiting C-reactive protein for the treatment of cardiovascular disease: promising evidence from rodent models.

Inhibition of Experimental Autoimmune Encephalomyelitis in Human C-Reactive Protein Transgenic Mice Is FcγRIIB Dependent.

Isolation of an acute-phase phosphorylcholine-reactive pentraxin from channel catfish (Ictalurus punctatus).

Kidney injury accelerates cystogenesis via pathways modulated by heme oxygenase and complement

Multiple lupus-associated ITGAM variants alter Mac-1 functions on neutrophils

Murine complement C4 is not required for experimental autoimmune encephalomyelitis

No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-leiden/human C-reactive protein transgenic mice.

Pneumococcal surface protein A inhibits complement deposition on the pneumococcal surface by competing with the binding of C-reactive protein to cell-surface phosphocholine

PspA and PspC minimize immune adherence and transfer of pneumococci from erythrocytes to macrophages through their effects on complement activation

Requirement of the Fc receptor common gamma-chain for gamma delta T cell-mediated promotion of murine experimental autoimmune encephalomyelitis

Serum eotaxin-1 is increased in extremely-low-birth-weight infants with bronchopulmonary dysplasia or death

Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level.

Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: association between C-reactive protein (CRP) gene polymorphisms and vascular events

The antimicrobial activity of C-reactive protein

The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk

The role of genetic variants in CRP in radiographic severity in African Americans with early and established rheumatoid arthritis

Varied biologic functions of C-reactive protein: lessons learned from transgenic mice.