List of works - Samuel C. Dudley

A Circulating Biomarker Risk-Prediction Model Correlates with CHADS-2 Risk Score in Chronic Atrial Fibrillation.

scientific article

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality

scientific article published on 19 February 2018

A possible mechanism of halocarbon-induced cardiac sensitization arrhythmias

scientific article

A program encouraging early defibrillation results in improved in-hospital resuscitation efficacy

scientific article published on 01 August 2004

A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling.

scientific article published on 24 May 2007

Abnormal sodium channel mRNA splicing in hypertrophic cardiomyopathy.

scientific article

Activation of the unfolded protein response downregulates cardiac ion channels in human induced pluripotent stem cell-derived cardiomyocytes.

scientific article published on 20 February 2018

Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide

scientific article published in February 2003

An imperfect syllogism: granulocyte colony-stimulating factor mobilization and cardiac regeneration

scientific article published on April 2008

Analysis of arrhythmic potential of embryonic stem cell-derived cardiomyocytes.

scientific article

Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure.

scientific article published on 9 August 2012

Antioxidant therapy for atrial fibrillation: lost in translation? ⬇️

scientific article published on August 15, 2012

Association between Heat Shock Protein-60 and Development of Atrial Fibrillation: Results from the Multi-Ethnic Study of Atherosclerosis (MESA).

scientific article published on 3 November 2016

Association of Low Plasma Adiponectin With Early Diastolic Dysfunction ⬇️

scientific article published on January 9, 2012

Associations of Prolonged QTc in Sickle Cell Disease

scientific article

Atrial Fibrillation: The Emerging Role of Inflammation and Oxidative Stress ⬇️

scientific article published on December 1, 2010

Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases

scientific article published in August 2005

Beware of Cells Bearing Gifts

scientific article published on 01 July 2005

Bursting of cardiac sodium channels after acute exposure to 3,5,3'-triiodo-L-thyronine

scientific article published in August 1993

Cardiac Sodium Channel Mutations: Why so Many Phenotypes?

scientific article published on 14 March 2016

Cardiac autoantibodies from patients affected by a new variant of endemic pemphigus foliaceus in Colombia, South America.

scientific article published on 28 July 2011

Cardiac sodium channel mutations: why so many phenotypes?

scientific article published on 24 June 2014

Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation.

scientific article

Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase

scientific article

Characterization and functionality of cardiac progenitor cells in congenital heart patients

scientific article published on 17 January 2011

Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.

scientific article

Correlation between Subclinical Heart Disease and Cardiovascular Risk Profiles in an Urban Emergency Department Population with Elevated Blood Pressures: A Pilot Study.

scientific article published on 20 March 2015

Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation

scientific article published on 8 June 2012

Diastolic dysfunction

scientific article

Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse

scientific article

Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule. ⬇️

scientific article

Downregulation of Endocardial Nitric Oxide Synthase Expression and Nitric Oxide Production in Atrial Fibrillation

scientific article published on 01 November 2002

Early determinants of H2O2-induced endothelial dysfunction

scientific article

Effect of angiotensin-converting enzyme inhibitors and receptor blockers on appropriate implantable cardiac defibrillator shock in patients with severe systolic heart failure (from the GRADE Multicenter Study).

scientific article

Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure

scientific article published on 3 March 2017

Effective antioxidant therapy for the management of arrhythmia ⬇️

scientific article published on July 1, 2011

Energetic localization of saxitoxin in its channel binding site.

scientific article

Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial

scientific article

Fatty acids differentially modulate insulin-stimulated endothelial nitric oxide production by an Akt-independent pathway

scientific article published in March 2004

Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy.

scientific article

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

scientific article published on 09 January 2020

Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel

scientific article

Impact of treatment crossovers on clinical outcomes in the rate and rhythm control strategies for atrial fibrillation: Insights from the AFFIRM (Atrial Fibrillation Follow-up Investigation of Rhythm Management) trial.

scientific article

Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients

scientific article

Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death.

scientific article published on November 2011

Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43.

scientific article

Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?

scientific article published on 23 July 2002

Ion channelopathies: a tapped-out mine?

scientific article published on 30 December 2010

Left Ventricular Dilatation Increases the Risk of Ventricular Arrhythmias in Patients With Reduced Systolic Function

scientific article

Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel

scientific article

Lipid-lowering drug use is associated with reduced prevalence of atrial fibrillation in patients with left ventricular systolic dysfunction.

scientific article

Long-term survival after successful inhospital cardiac arrest resuscitation

scientific article

Lost in translation: what is limiting cardiomyoplasty and can tissue engineering help?

scientific article published on September 2009

Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease

scientific article published on 23 September 2020

Mechanisms of sudden cardiac death: oxidants and metabolism

scientific article

Metabolic stress, reactive oxygen species, and arrhythmia.

scientific article published on 25 September 2011

Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.

scientific article

Mitochondria and arrhythmias

scientific article published on 01 July 2013

Mitochondria and arrhythmias.

scientific article

Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death

scientific article published on 04 April 2013

Mitochondrial Ca2+ flux modulates spontaneous electrical activity in ventricular cardiomyocytes

scientific article published on 12 July 2018

Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy

scientific article published on November 2012

Modulation of human mesenchymal stem cell function in a three-dimensional matrix promotes attenuation of adverse remodelling after myocardial infarction

scientific article published on 18 November 2011

Multi-ethnic genome-wide association study for atrial fibrillation

article

Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias

scientific article

NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II.

scientific article published on 10 October 2002

New diagnostic and therapeutic possibilities for diastolic heart failure

scientific article

Nitroglycerin tolerance in caveolin-1 deficient mice

scientific article

Obstructive Sleep Apnea and Circulating Potassium Channel Levels.

scientific article published on 19 August 2016

Oxidative stress and atrial fibrillation: finding a missing piece to the puzzle

scientific article published on 12 September 2013

Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.

journal article published in 2012

Pore-blocking toxins as probes of voltage-dependent channels

scientific article published in January 1999

Prediction of atrial fibrillation following cardiac surgery using rough set derived rules

scientific article

Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis

scientific article published in March 1998

RBM25/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure.

scientific article

Ranolazine Improves Cardiac Diastolic Dysfunction Through Modulation of Myofilament Calcium Sensitivity ⬇️

scientific article published on February 16, 2012

Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel.

scientific article

Reactive oxygen species-targeted therapeutic interventions for atrial fibrillation.

scientific article

Redox regulation, NF-kappaB, and atrial fibrillation.

scientific article

Renin-Angiotensin Activation and Oxidative Stress in Early Heart Failure with Preserved Ejection Fraction

scientific article

Reversal of low voltage and infarction pattern on the surface electrocardiogram after renal hemodialysis for pulmonary edema.

scientific article

Role for the Unfolded Protein Response in Heart Disease and Cardiac Arrhythmias

scientific article

Role of Mitochondrial Oxidative Stress in Glucose Tolerance, Insulin Resistance, and Cardiac Diastolic Dysfunction

scientific article published on 05 May 2016

Role of RBM25/LUC7L3 in abnormal cardiac sodium channel splicing regulation in human heart failure.

scientific article

Role of protein kinase C in metabolic regulation of the cardiac Na+ channel.

scientific article

SCN5A splicing variants and the possibility of predicting heart failure-associated arrhythmia.

scientific article published on February 2013

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients.

scientific article published on 25 October 2015

Sodium channel selectivity filter regulates antiarrhythmic drug binding ⬇️

scientific article published on December 9, 1997

Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis.

scientific article

Speeding the recovery from ultraslow inactivation of voltage-gated Na+ channels by metal ion binding to the selectivity filter: a foot-on-the-door?

scientific article

Statin therapy for the prevention of atrial fibrillation trial (SToP AF trial)

scientific article

Statins Decrease Oxidative Stress and ICD Therapies.

scientific article

Sudden death in myotonic dystrophy.

scientific article

Targeting the unfolded protein response in heart diseases

scientific article published on 28 May 2014

Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties ⬇️

scientific article published on December 14, 2012

The Measurement of Nitric Oxide Production by Cultured Endothelial Cells

scientific article published on 01 January 2005

The endosomal trafficking regulator LITAF controls the cardiac Nav1.5 channel via the ubiquitin ligase NEDD4-2

scientific article published on 22 October 2020

The renin-angiotensin-aldosterone system (RAAS) and cardiac arrhythmias

scientific article published on 04 March 2008

The role of the unfolded protein response in arrhythmias

scientific article published on 01 January 2018

The selectivity filter of the voltage-gated sodium channel is involved in channel activation

scientific article published on 29 May 2001

The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker.

scholarly article

The tail of the cardiac sodium channel

scientific article

Time to defibrillation after in-hospital cardiac arrest.

scientific article published in April 2008

Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction

scientific article

Unfolded protein response regulates cardiac sodium current in systolic human heart failure

scientific article published on 13 September 2013

Unitary conductance of Na+ channel isoforms in cardiac and NB2a neuroblastoma cells

scientific article published in December 1995

Use of human embryonic stem cell derived‐mesenchymal cells for cardiac repair ⬇️

scientific article published on September 2, 2011

Using Serum Transforming Growth Factor-β To Predict Myocardial Fibrosis

scientific article published on 01 March 2010

Varicella-zoster virus (VZV) and alpha 1 antitrypsin: a fatal outcome in a patient affected by endemic pemphigus foliaceus.

scientific article published in July 2012

c-Src kinase inhibition reduces arrhythmia inducibility and connexin43 dysregulation after myocardial infarction

scientific article published on 08 January 2014

List of works by Samuel C. Dudley

A Circulating Biomarker Risk-Prediction Model Correlates with CHADS-2 Risk Score in Chronic Atrial Fibrillation.

A common variant alters SCN5A-miR-24 interaction and associates with heart failure mortality

A possible mechanism of halocarbon-induced cardiac sensitization arrhythmias

A program encouraging early defibrillation results in improved in-hospital resuscitation efficacy

A tissue engineering approach to progenitor cell delivery results in significant cell engraftment and improved myocardial remodeling.

Abnormal sodium channel mRNA splicing in hypertrophic cardiomyopathy.

Activation of the unfolded protein response downregulates cardiac ion channels in human induced pluripotent stem cell-derived cardiomyocytes.

Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide

An imperfect syllogism: granulocyte colony-stimulating factor mobilization and cardiac regeneration

Analysis of arrhythmic potential of embryonic stem cell-derived cardiomyocytes.

Angiotensin receptor type 1 single nucleotide polymorphism 1166A/C is associated with malignant arrhythmias and altered circulating miR-155 levels in patients with chronic heart failure.

Antioxidant therapy for atrial fibrillation: lost in translation? ⬇️

Association between Heat Shock Protein-60 and Development of Atrial Fibrillation: Results from the Multi-Ethnic Study of Atherosclerosis (MESA).

Association of Low Plasma Adiponectin With Early Diastolic Dysfunction ⬇️

Associations of Prolonged QTc in Sickle Cell Disease

Atrial Fibrillation: The Emerging Role of Inflammation and Oxidative Stress ⬇️

Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases

Beware of Cells Bearing Gifts

Bursting of cardiac sodium channels after acute exposure to 3,5,3'-triiodo-L-thyronine

Cardiac Sodium Channel Mutations: Why so Many Phenotypes?

Cardiac autoantibodies from patients affected by a new variant of endemic pemphigus foliaceus in Colombia, South America.

Cardiac sodium channel mutations: why so many phenotypes?

Cardiac-restricted angiotensin-converting enzyme overexpression causes conduction defects and connexin dysregulation.

Caveolin-1 modulates cardiac gap junction homeostasis and arrhythmogenecity by regulating cSrc tyrosine kinase

Characterization and functionality of cardiac progenitor cells in congenital heart patients

Clockwise domain arrangement of the sodium channel revealed by (mu)-conotoxin (GIIIA) docking orientation.

Correlation between Subclinical Heart Disease and Cardiovascular Risk Profiles in an Urban Emergency Department Population with Elevated Blood Pressures: A Pilot Study.

Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation

Diastolic dysfunction

Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse

Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule. ⬇️

Downregulation of Endocardial Nitric Oxide Synthase Expression and Nitric Oxide Production in Atrial Fibrillation

Early determinants of H2O2-induced endothelial dysfunction

Effect of angiotensin-converting enzyme inhibitors and receptor blockers on appropriate implantable cardiac defibrillator shock in patients with severe systolic heart failure (from the GRADE Multicenter Study).

Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: a mechanism underlying RV fibrosis associated with cigarette smoke exposure

Effective antioxidant therapy for the management of arrhythmia ⬇️

Energetic localization of saxitoxin in its channel binding site.

Enhanced risk profiling of implanted defibrillator shocks with circulating SCN5A mRNA splicing variants: a pilot trial

Fatty acids differentially modulate insulin-stimulated endothelial nitric oxide production by an Akt-independent pathway

Genetic variation in the alternative splicing regulator RBM20 is associated with dilated cardiomyopathy.

Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure

Human heart failure is associated with abnormal C-terminal splicing variants in the cardiac sodium channel

Impact of treatment crossovers on clinical outcomes in the rate and rhythm control strategies for atrial fibrillation: Insights from the AFFIRM (Atrial Fibrillation Follow-up Investigation of Rhythm Management) trial.

Inactivation of Endothelial Small/Intermediate Conductance of Calcium-Activated Potassium Channels Contributes to Coronary Arteriolar Dysfunction in Diabetic Patients

Inhibition of c-Src tyrosine kinase prevents angiotensin II-mediated connexin-43 remodeling and sudden cardiac death.

Inhibition of renin-angiotensin system (RAS) reduces ventricular tachycardia risk by altering connexin43.

Interaction between fast and ultra-slow inactivation in the voltage-gated sodium channel. Does the inactivation gate stabilize the channel structure?

Ion channelopathies: a tapped-out mine?

Left Ventricular Dilatation Increases the Risk of Ventricular Arrhythmias in Patients With Reduced Systolic Function

Lidocaine: a foot in the door of the inner vestibule prevents ultra-slow inactivation of a voltage-gated sodium channel

Lipid-lowering drug use is associated with reduced prevalence of atrial fibrillation in patients with left ventricular systolic dysfunction.

Long-term survival after successful inhospital cardiac arrest resuscitation

Lost in translation: what is limiting cardiomyoplasty and can tissue engineering help?

Magnesium, Oxidative Stress, Inflammation, and Cardiovascular Disease

Mechanisms of sudden cardiac death: oxidants and metabolism

Metabolic stress, reactive oxygen species, and arrhythmia.

Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.

Mitochondria and arrhythmias

Mitochondria and arrhythmias.

Mitochondria oxidative stress, connexin43 remodeling, and sudden arrhythmic death

Mitochondrial Ca2+ flux modulates spontaneous electrical activity in ventricular cardiomyocytes

Mitochondrial dysfunction causing cardiac sodium channel downregulation in cardiomyopathy

Modulation of human mesenchymal stem cell function in a three-dimensional matrix promotes attenuation of adverse remodelling after myocardial infarction

Multi-ethnic genome-wide association study for atrial fibrillation

Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias

NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II.

New diagnostic and therapeutic possibilities for diastolic heart failure

Nitroglycerin tolerance in caveolin-1 deficient mice

Obstructive Sleep Apnea and Circulating Potassium Channel Levels.

Oxidative stress and atrial fibrillation: finding a missing piece to the puzzle

Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.

Pore-blocking toxins as probes of voltage-dependent channels

Prediction of atrial fibrillation following cardiac surgery using rough set derived rules

Predominant interactions between mu-conotoxin Arg-13 and the skeletal muscle Na+ channel localized by mutant cycle analysis

RBM25/LUC7L3 function in cardiac sodium channel splicing regulation of human heart failure.

Ranolazine Improves Cardiac Diastolic Dysfunction Through Modulation of Myofilament Calcium Sensitivity ⬇️

Reactive oxygen species originating from mitochondria regulate the cardiac sodium channel.

Reactive oxygen species-targeted therapeutic interventions for atrial fibrillation.

Redox regulation, NF-kappaB, and atrial fibrillation.