List of works - Alexander Agoulnik

A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice

scientific article published on 01 March 2003

A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism.

scientific article published on 22 October 2010

A transgenic insertion causing cryptorchidism in mice

scientific article published on 01 May 2001

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290.

scientific article

Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene

scientific article

Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice

scientific article

Constitutive Notch Signaling Causes Abnormal Development of the Oviducts, Abnormal Angiogenesis, and Cyst Formation in Mouse Female Reproductive Tract

scientific article published on 3 February 2016

Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis

scientific article

Cryptorchidism--an estrogen spoil?

scientific article published on 01 August 2005

Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas

scientific article

Endocrine effects of relaxin overexpression in mice

scientific article

Estrogen and TCDD influence RLN2 gene activity in estrogen receptor-positive human breast cancer cells.

scientific article published on April 2009

Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis ⬇️

scientific article published on August 12, 2011

GREAT/LGR8 is the only receptor for insulin-like 3 peptide

scientific article published on 21 August 2003

Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays.

scientific article published on January 2002

Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis

scientific article published on 20 February 2015

Genetic targeting of relaxin and insulin-like factor 3 receptors in mice

scientific journal article

INPP4B protects from metabolic syndrome and associated disorders

scientific article published on 26 March 2021

INSL3 plays a role in the balance between bone formation and resorption

scientific article published in April 2009

INSL3/LGR8 role in testicular descent and cryptorchidism

scientific article

INSL3/RXFP2 signaling in testicular descent.

scientific article

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

scientific article

Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes

scientific article published on 01 November 2001

Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay

scientific article

Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice

scientific article published on June 2012

Insulin-like 3 signalling in testicular descent

scientific article published in October 2004

Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization.

scientific article published on 10 May 2006

Isolation and expression analysis of the canine insulin-like factor 3 gene

scientific article published on 30 July 2003

Left-sided cryptorchidism in mice with Wilms' tumour 1 gene deletion in gubernaculum testis

scientific article published on 12 March 2013

Long-Lasting Consequences of Testosterone Exposure

scientific article

Mechanisms of INSL3 signaling in male reproductive organs

Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism

scientific article published in November 2004

Mutations in the insulin-like factor 3 receptor are associated with osteoporosis

scientific article

Mutations of the GREAT gene cause cryptorchidism

scientific journal article

NOTCH1 gain of function in germ cells causes failure of spermatogenesis in male mice

scientific article

New roles for INSL3 in adults

scientific article published on April 2009

Normal fertility in male mice with deletion of β-catenin gene in germ cells

scientific article

Normal prostate morphology in relaxin-mutant mice.

scientific article published on January 2009

Novel mutations involving the INSL3 gene associated with cryptorchidism

scientific article

Over expression of insulin-like 3 does not prevent cryptorchidism in GNRHR or HOXA10 deficient mice

scientific article published in July 2006

Physical and genetic linkage of glutaminase (Gls), signal transducer and activator of transcription 1 (Stat1), and xeroderma pigmentosum complementation group G (Xpg) on mouse proximal chromosome 1.

scientific article published in December 1998

Protein expression profiling of endometriosis: validation of 2-mm tissue microarrays

scientific article published in December 2004

Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice

scientific article

Relative roles of the epithelial and stromal tissue compartment(s) in mediating the actions of relaxin and estrogen on cell proliferation and apoptosis in the mouse lower reproductive tract

scientific article published on April 2009

Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina

scientific article published on 24 January 2008

Relaxin and related peptides in male reproduction

scientific article published on January 2007

Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice

scientific article published on 25 October 2011

Relaxin-like peptides in male reproduction - a human perspective.

scientific article published on 9 December 2016

Rethinking dog domestication by integrating genetics, archeology, and biogeography

scientific article

Spermatogenesis in cryptorchidism

scientific article published in January 2012

Successful targeting of mouse Y chromosome genes using a site-directed insertion vector

scientific article published in January 2002

Suppression of insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum development

scientific article

T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane

scientific article

Testicular cancer and cryptorchidism ⬇️

scientific article published on 20 March 2013

The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice

scientific article

The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane

scientific article published on 07 December 2006

Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor

scientific article published in December 2003

Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2

scientific article

List of works by Alexander Agoulnik

A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice

A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism.

A transgenic insertion causing cryptorchidism in mice

Activation of Relaxin Family Receptor 1 from Different Mammalian Species by Relaxin Peptide and Small-Molecule Agonist ML290.

Caveolin-1 is down-regulated in human ovarian carcinoma and acts as a candidate tumor suppressor gene

Conditional deletion of the relaxin receptor gene in cells of smooth muscle lineage affects lower reproductive tract in pregnant mice

Constitutive Notch Signaling Causes Abnormal Development of the Oviducts, Abnormal Angiogenesis, and Cyst Formation in Mouse Female Reproductive Tract

Cryptorchidism in mice with an androgen receptor ablation in gubernaculum testis

Cryptorchidism--an estrogen spoil?

Down-regulation of caveolin-1, a candidate tumor suppressor gene, in sarcomas

Endocrine effects of relaxin overexpression in mice

Estrogen and TCDD influence RLN2 gene activity in estrogen receptor-positive human breast cancer cells.

Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis ⬇️

GREAT/LGR8 is the only receptor for insulin-like 3 peptide

Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays.

Genetic ablation of androgen receptor signaling in fetal Leydig cell lineage affects Leydig cell functions in adult testis

Genetic targeting of relaxin and insulin-like factor 3 receptors in mice

INPP4B protects from metabolic syndrome and associated disorders

INSL3 plays a role in the balance between bone formation and resorption

INSL3/LGR8 role in testicular descent and cryptorchidism

INSL3/RXFP2 signaling in testicular descent.

Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1.

Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes

Identification of small-molecule agonists of human relaxin family receptor 1 (RXFP1) by using a homogenous cell-based cAMP assay

Insulin-like 3 signaling is important for testicular descent but dispensable for spermatogenesis and germ cell survival in adult mice

Insulin-like 3 signalling in testicular descent

Insulin-like factor 3 gene mutations in testicular dysgenesis syndrome: clinical and functional characterization.

Isolation and expression analysis of the canine insulin-like factor 3 gene

Left-sided cryptorchidism in mice with Wilms' tumour 1 gene deletion in gubernaculum testis

Long-Lasting Consequences of Testosterone Exposure

Mechanisms of INSL3 signaling in male reproductive organs

Mutation analysis of INSL3 and GREAT/LGR8 genes in familial cryptorchidism

Mutations in the insulin-like factor 3 receptor are associated with osteoporosis

Mutations of the GREAT gene cause cryptorchidism

NOTCH1 gain of function in germ cells causes failure of spermatogenesis in male mice

New roles for INSL3 in adults

Normal fertility in male mice with deletion of β-catenin gene in germ cells

Normal prostate morphology in relaxin-mutant mice.

Novel mutations involving the INSL3 gene associated with cryptorchidism

Over expression of insulin-like 3 does not prevent cryptorchidism in GNRHR or HOXA10 deficient mice

Physical and genetic linkage of glutaminase (Gls), signal transducer and activator of transcription 1 (Stat1), and xeroderma pigmentosum complementation group G (Xpg) on mouse proximal chromosome 1.

Protein expression profiling of endometriosis: validation of 2-mm tissue microarrays

Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice

Relative roles of the epithelial and stromal tissue compartment(s) in mediating the actions of relaxin and estrogen on cell proliferation and apoptosis in the mouse lower reproductive tract

Relaxin acts on stromal cells to promote epithelial and stromal proliferation and inhibit apoptosis in the mouse cervix and vagina

Relaxin and related peptides in male reproduction

Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice

Relaxin-like peptides in male reproduction - a human perspective.

Rethinking dog domestication by integrating genetics, archeology, and biogeography

Spermatogenesis in cryptorchidism

Successful targeting of mouse Y chromosome genes using a site-directed insertion vector

Suppression of insulin-like3 receptor reveals the role of β-catenin and Notch signaling in gubernaculum development

T222P mutation of the insulin-like 3 hormone receptor LGR8 is associated with testicular maldescent and hinders receptor expression on the cell surface membrane

Testicular cancer and cryptorchidism ⬇️

The fate of spermatogonial stem cells in the cryptorchid testes of RXFP2 deficient mice

The low-density lipoprotein class A module of the relaxin receptor (leucine-rich repeat containing G-protein coupled receptor 7): its role in signaling and trafficking to the cell membrane

Transabdominal testicular descent is disrupted in mice with deletion of insulinlike factor 3 receptor

Uterine cysts in female mice deficient for caveolin-1 and insulin-like 3 receptor RXFP2