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List of works by Hervé Guillou

A Specific ChREBP and PPARα Cross-Talk Is Required for the Glucose-Mediated FGF21 Response

scientific article published on October 2017

A link between hepatic glucose production and peripheral energy metabolism via hepatokines

scientific article

A minimal model for hepatic fatty acid balance during fasting: application to PPAR alpha-deficient mice.

scientific article published on 25 July 2009

A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARα.

scientific article

ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences

scientific article published on 25 September 2009

Ablation of the very-long-chain fatty acid elongase ELOVL3 in mice leads to constrained lipid storage and resistance to diet-induced obesity

scientific article published on 6 July 2010

Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way.

scientific article published on 11 May 2016

Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice

scientific article published on 26 August 2014

Although it is rapidly metabolized in cultured rat hepatocytes, lauric acid is used for protein acylation

scientific article published in September 2003

Coelomocytes Regulate Starvation-Induced Fat Catabolism and Lifespan Extension through the Lipase LIPL-5 in Caenorhabditis elegans

scientific article published on 01 July 2019

Combined QTL and selective sweep mappings with coding SNP annotation and cis-eQTL analysis revealed PARK2 and JAG2 as new candidate genes for adiposity regulation

scientific article

Comparative effect of fenofibrate on hepatic desaturases in wild-type and peroxisome proliferator-activated receptor alpha-deficient mice

scientific article published in October 2002

Complementary intestinal mucosa and microbiota responses to caloric restriction

article

Conversion of hexadecanoic acid to hexadecenoic acid by rat Delta 6-desaturase

scientific article

Depletion of Gram-Positive Bacteria Impacts Hepatic Biological Functions During the Light Phase

scientific article published on 14 February 2019

Developmental regulation of p70 S6 kinase by a G protein-coupled receptor dynamically modelized in primary cells

scientific article published in November 2009

Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates

scientific article

Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling ⬇️

scientific article published on 21 July 2017

Distinct roles of endoplasmic reticulum cytochrome b5 and fused cytochrome b5-like domain for rat Delta6-desaturase activity.

scientific article

Dual extraction of mRNA and lipids from a single biological sample.

scientific article published on 4 May 2018

ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice

scientific journal article

Early life stress induces type 2 diabetes-like features in ageing mice

scientific article published on 11 April 2019

Effect of obesity and metabolic syndrome on plasma oxysterols and fatty acids in human

scientific article published on 18 April 2015

Effects of pesticide mixtures in human and animal models: An update of the recent literature

scientific article published on 13 June 2016

Erratum: Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals

scientific article published on 20 April 2016

Erratum: The gut microbiota: a major player in the toxicity of environmental pollutants?

scientific article published on 22 June 2017

Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.

scientific article

FSH-stimulated PTEN activity accounts for the lack of FSH mitogenic effect in prepubertal rat Sertoli cells.

scientific article

GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.

scientific article

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

scientific article

Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

scientific article published on 15 October 2006

Gene Expression Profiling Reveals that PXR Activation Inhibits Hepatic PPARα Activity and Decreases FGF21 Secretion in Male C57Bl6/J Mice

scientific article published on 01 August 2019

Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism

scientific article published on July 2016

Glycerol-3-phosphate acyltransferase 2 expression modulates cell roughness and membrane permeability: An atomic force microscopy study

scientific article published on 6 December 2017

Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids

scientific article published on 24 September 2016

Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals

scientific article published on 16 February 2016

Identification of Signaling Pathways Targeted by the Food Contaminant FB1: Transcriptome and Kinome Analysis of Samples from Pig Liver and Intestine.

scientific article published on 5 September 2017

Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach

scientific article published on 23 February 2009

Important Considerations for Sample Collection in Metabolomics Studies with a Special Focus on Applications to Liver Functions

scientific article published on 12 March 2020

In vivo hepatic lipid quantification using MRS at 7 Tesla in a mouse model of glycogen storage disease type 1a

scientific article published on 17 April 2013

Inhibition of monoacylglycerol lipase, an anti-inflammatory and antifibrogenic strategy in the liver

Insights into the role of hepatocyte PPARα activity in response to fasting.

scientific article published on 31 July 2017

Intestinal PPARγ signalling is required for sympathetic nervous system activation in response to caloric restriction

scientific article

Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context

scholarly article by Laure Monteillet published in October 2018

Is Crohn's creeping fat an adipose tissue?

scientific article

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD.

scientific article published on February 2016

Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis.

scientific article published on 12 June 2011

Liver X receptor alpha regulates fatty acid synthase expression in chicken

scientific article

Localizing the lipid products of PI3Kγ in neutrophils

scientific article

Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver.

scientific article

Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

scientific article published on 25 June 2018

Myristic acid increases delta6-desaturase activity in cultured rat hepatocytes.

scientific article

New insights into the organ-specific adverse effects of fumonisin B1: comparison between lung and liver

scientific article

Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance

scientific article published on 23 May 2016

Novel aspects of PPARalpha-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study.

scientific article published in March 2007

Novel role for carbohydrate responsive element binding protein in the control of ethanol metabolism and susceptibility to binge drinking

scientific article published on 06 May 2015

Nuclear HMGB1 protects from nonalcoholic fatty liver disease through negative regulation of liver X receptor

scientific article published on 25 March 2022

Oxidative Stress in NAFLD: Role of Nutrients and Food Contaminants

scientific article published on 21 December 2020

P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice

scientific article

PGC-1α induced browning promotes involution and inhibits lactation in mammary glands

scientific article published on 01 June 2019

PI3Kβ plays a critical role in neutrophil activation by immune complexes.

scientific article

Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle.

scientific article published on 06 December 2016

Peroxisome Proliferator-Activated Receptors and Caloric Restriction-Common Pathways Affecting Metabolism, Health, and Longevity

scientific article published on 16 July 2020

Peroxisome Proliferator-Activated Receptors and Their Novel Ligands as Candidates for the Treatment of Non-Alcoholic Fatty Liver Disease

scientific article published on 08 July 2020

Protective effects of n-6 fatty acids-enriched diet on intestinal ischaemia/reperfusion injury involve lipoxin A4 and its receptor.

scientific article published on 15 December 2014

Proton NMR Enables the Absolute Quantification of Aqueous Metabolites and Lipid Classes in Unique Mouse Liver Samples

scientific article published on 21 December 2019

Quantitative measurement of phosphatidylinositol 3,4,5-trisphosphate

scientific article published on January 2007

Regulation of LPCAT3 by LXR

scientific article

Regulation of hepatokine gene expression in response to fasting and feeding: Influence of PPAR-α and insulin-dependent signalling in hepatocytes

scientific article published on 01 June 2019

Selective Activation of Estrogen Receptor α Activation Function-1 Is Sufficient to Prevent Obesity, Steatosis, and Insulin Resistance in Mouse

scientific article

Selective Liver Estrogen Receptor α Modulation Prevents Steatosis, Diabetes, and Obesity Through the Anorectic Growth Differentiation Factor 15 Hepatokine in Mice ⬇️

scientific article published on 29 April 2019

Small non-coding RNA landscape is modified by GPAT2 silencing in MDA-MB-231 cells.

scientific article

Sphingolipid metabolism in non-alcoholic fatty liver diseases

scientific article published on 31 July 2018

The class 3 PI3K coordinates autophagy and mitochondrial lipid catabolism by controlling nuclear receptor PPARα

scientific article published on 05 April 2019

The gut microbiota: a major player in the toxicity of environmental pollutants?

scientific article

The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity.

scientific article published on 29 May 2018

The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.

scientific article published on 16 December 2009

The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans

scientific article

The liver X receptor: a master regulator of the gut-liver axis and a target for non alcoholic fatty liver disease.

scientific article published on 28 March 2013

The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

scientific article published on 20 April 2021

The protective role of liver X receptor (LXR) during fumonisin B1-induced hepatotoxicity

scientific article published on 17 November 2018

The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis

scientific journal article

The suppression of hepatic glucose production improves metabolism and insulin sensitivity in subcutaneous adipose tissue in mice

scientific article published on 9 September 2016

The surprising diversity of Delta6-desaturase substrates

scientific article published in February 2004

Transcriptional control of physiological and pathological processes by the nuclear receptor PPARβ/δ.

scientific article published on 22 September 2016

Transcriptional regulation of hepatic fatty acid metabolism

scientific article published on January 2008

Use of the GRP1 PH domain as a tool to measure the relative levels of PtdIns(3,4,5)P3 through a protein-lipid overlay approach

scientific article published on 27 November 2006

White-to-brite conversion in human adipocytes promotes metabolic reprogramming towards fatty acid anabolic and catabolic pathways.

scientific article published on 18 March 2016

β-catenin oncogenic activation rewires fatty acid catabolism to fuel hepatocellular carcinoma

scientific article published on 04 August 2018

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