List of works - Younis Baqi

3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17

scientific article published on 05 September 2018

A study of the epoxidation of cycloolefins by the t-BuOH copper-permanganate system

scientific article published on 01 February 2009

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

scientific article published on 2 December 2014

A2B Adenosine Receptor Antagonists with Picomolar Potency

scientific article published on 15 April 2019

Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation.

scientific article published on 28 February 2012

Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice.

scientific article published on 10 January 2012

Adenosine receptor antagonists including caffeine alter fetal brain development in mice

scientific article published in August 2013

Agonists and Antagonists for Purinergic Receptors

scientific article published on 01 January 2020

Allosteric modulators of rhodopsin-like G protein-coupled receptors: Opportunities in drug development ⬇️

scientific article published on June 19, 2012

Anthraquinones as a privileged scaffold in drug discovery targeting nucleotide-binding proteins

scientific article published on 30 June 2016

Antifibrotic and tumor microenvironment modulating effect of date palm fruit (Phoenix dactylifera L.) extracts in pancreatic cancer

scientific article published on 29 October 2019

Beneficial Effect of a Selective Adenosine A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

article

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

scientific article

Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.

scientific article

Catalyst-Free Microwave-Assisted Amination of 2-Chloro-5-nitrobenzoic Acid

scientific article published on 22 June 2007

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

scientific article

Chronic and acute adenosine A2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation

scientific article

Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists

scientific article

Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor

scientific article published on 29 September 2014

Convergent Synthesis of the Potent P2Y Receptor Antagonist MG 50-3-1 Based on a Regioselective Ullmann Coupling Reaction ⬇️

scientific article published on March 5, 2012

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

scientific article

Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options.

scientific article published on 23 May 2017

Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor.

scientific article

Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor

scientific article published on 5 January 2011

Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences

scientific article

Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease

scientific article published on 4 June 2015

Ecto-nucleotidase inhibitors: recent developments in drug discovery

scientific article

Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A(2A)R KO mice

scientific article published in April 2013

Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.

scientific article published on December 2013

Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task

scientific article published on 18 October 2013

Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization

scientific article published on 6 August 2016

Erratum: A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

article

Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A2A and A1 Receptors

scientific article

Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity.

scientific article

High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.

scientific article

Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP.

scientific article published on 18 April 2014

Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: Reversal with adenosine A2A antagonism

scientific article published on 9 October 2015

Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila

scientific article published on 17 July 2016

Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor

scientific article published on 18 August 2009

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies

scientific article published on 9 January 2014

Ligand binding and activation of UTP-activated G protein-coupled P2Y2 and P2Y4 receptors elucidated by mutagenesis, pharmacological and computational studies

scientific article published on 05 December 2019

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism

scientific article published on 16 May 2019

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

scientific article

Modulating P1 Adenosine Receptors in Disease Progression of SOD1G93A Mutant Mice

scientific article published on 12 February 2019

Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor.

scientific article

Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease.

scientific article published in May 2014

Oral tremor induced by galantamine in rats: a model of the parkinsonian side effects of cholinomimetics used to treat Alzheimer's disease

scientific article published on 27 May 2011

P2Y12 Receptor Localizes in the Renal Collecting Duct and Its Blockade Augments Arginine Vasopressin Action and Alleviates Nephrogenic Diabetes Insipidus.

scientific article

Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

scientific article published on 25 September 2006

Rapid and Efficient Microwave-Assisted Copper(0)-Catalyzed Ullmann Coupling Reaction: General Access to Anilinoanthraquinone Derivatives

article

Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists.

scientific article

Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases).

scientific article published on 5 June 2008

Syntheses of 2-substituted 1-amino-4-bromoanthraquinones (bromaminic acid analogues) - precursors for dyes and drugs.

scientific article published on 26 November 2015

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

scientific article published on 01 December 2020

Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions

scientific article published on 29 April 2010

The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs.

scientific article

The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion

scientific article

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.

scientific article published on 11 August 2016

The novel adenosine A(2A) antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions

scientific article published on 15 June 2012

The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor.

scientific article published on 15 July 2013

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

scientific article published on 5 October 2017

List of works by Younis Baqi

3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17

A study of the epoxidation of cycloolefins by the t-BuOH copper-permanganate system

A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

A2B Adenosine Receptor Antagonists with Picomolar Potency

Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation.

Adenosine A2A receptor antagonism and genetic deletion attenuate the effects of dopamine D2 antagonism on effort-based decision making in mice.

Adenosine receptor antagonists including caffeine alter fetal brain development in mice

Agonists and Antagonists for Purinergic Receptors

Allosteric modulators of rhodopsin-like G protein-coupled receptors: Opportunities in drug development ⬇️

Anthraquinones as a privileged scaffold in drug discovery targeting nucleotide-binding proteins

Antifibrotic and tumor microenvironment modulating effect of date palm fruit (Phoenix dactylifera L.) extracts in pancreatic cancer

Beneficial Effect of a Selective Adenosine A Receptor Antagonist in the APPswe/PS1dE9 Mouse Model of Alzheimer's Disease

Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation.

Catalyst-Free Microwave-Assisted Amination of 2-Chloro-5-nitrobenzoic Acid

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

Chronic and acute adenosine A2A receptor blockade prevents long-term episodic memory disruption caused by acute cannabinoid CB1 receptor activation

Combinatorial synthesis of anilinoanthraquinone derivatives and evaluation as non-nucleotide-derived P2Y2 receptor antagonists

Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor

Convergent Synthesis of the Potent P2Y Receptor Antagonist MG 50-3-1 Based on a Regioselective Ullmann Coupling Reaction ⬇️

Crystal structure of NTPDase2 in complex with the sulfoanthraquinone inhibitor PSB-071

Date Palm Tree (Phoenix dactylifera L.): Natural Products and Therapeutic Options.

Development of Potent and Selective Antagonists for the UTP-Activated P2Y4 Receptor.

Discovery of potent competitive antagonists and positive modulators of the P2X2 receptor

Dopaminergic modulation of effort-related choice behavior as assessed by a progressive ratio chow feeding choice task: pharmacological studies and the role of individual differences

Dual target strategy: combining distinct non-dopaminergic treatments reduces neuronal cell loss and synergistically modulates L-DOPA-induced rotational behavior in a rodent model of Parkinson's disease

Ecto-nucleotidase inhibitors: recent developments in drug discovery

Effect of subtype-selective adenosine receptor antagonists on basal or haloperidol-regulated striatal function: studies of exploratory locomotion and c-Fos immunoreactivity in outbred and A(2A)R KO mice

Effort-related motivational effects of the VMAT-2 inhibitor tetrabenazine: implications for animal models of the motivational symptoms of depression.

Effort-related motivational effects of the pro-inflammatory cytokine interleukin 1-beta: studies with the concurrent fixed ratio 5/ chow feeding choice task

Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization

Erratum: A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

Ethanol and Caffeine Effects on Social Interaction and Recognition in Mice: Involvement of Adenosine A2A and A1 Receptors

Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity.

High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.

Impact of in vivo chronic blockade of adenosine A2A receptors on the BDNF-mediated facilitation of LTP.

Induction of oral tremor in mice by the acetylcholinesterase inhibitor galantamine: Reversal with adenosine A2A antagonism

Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila

Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies

Ligand binding and activation of UTP-activated G protein-coupled P2Y2 and P2Y4 receptors elucidated by mutagenesis, pharmacological and computational studies

Memory deficits induced by chronic cannabinoid exposure are prevented by adenosine A2AR receptor antagonism

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information

Modulating P1 Adenosine Receptors in Disease Progression of SOD1G93A Mutant Mice

Molecular Recognition of Agonists and Antagonists by the Nucleotide-Activated G Protein-Coupled P2Y2 Receptor.

Neuroprotective potential of adenosine A2A and cannabinoid CB1 receptor antagonists in an animal model of Parkinson disease.

Oral tremor induced by galantamine in rats: a model of the parkinsonian side effects of cholinomimetics used to treat Alzheimer's disease

P2Y12 Receptor Localizes in the Renal Collecting Duct and Its Blockade Augments Arginine Vasopressin Action and Alleviates Nephrogenic Diabetes Insipidus.

Polyoxometalates—a new class of potent ecto-nucleoside triphosphate diphosphohydrolase (NTPDase) inhibitors

Rapid and Efficient Microwave-Assisted Copper(0)-Catalyzed Ullmann Coupling Reaction: General Access to Anilinoanthraquinone Derivatives

Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists.

Structure-activity relationships of anthraquinone derivatives derived from bromaminic acid as inhibitors of ectonucleoside triphosphate diphosphohydrolases (E-NTPDases).

Syntheses of 2-substituted 1-amino-4-bromoanthraquinones (bromaminic acid analogues) - precursors for dyes and drugs.

Synthesis and structure-activity relationships of cerebroside analogues as substrates of cerebroside sulphotransferase and discovery of a competitive inhibitor

Synthesis of alkyl- and aryl-amino-substituted anthraquinone derivatives by microwave-assisted copper(0)-catalyzed Ullmann coupling reactions

The VMAT-2 inhibitor tetrabenazine affects effort-related decision making in a progressive ratio/chow feeding choice task: reversal with antidepressant drugs.

The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion

The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.

The novel adenosine A(2A) antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions

The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: implications for pharmacological models of parkinsonian tremor.

Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage