List of works - Susan P.C. Cole

A monoclonal antibody detecting cell surface epitope on some drug resistant human tumour cell lines

scientific article

A new series of titanocene dichloride derivatives bearing chiral alkylammonium groups; assessment of their cytotoxic properties

A new series of titanocene dichloride derivatives bearing cyclic alkylammonium groups: Assessment of their cytotoxic properties

A single point mutation in Drosophila dihydrofolate reductase confers methotrexate resistance to a transgenic CHO cell line

scientific article published in August 2003

ABCC1 G2012T single nucleotide polymorphism is associated with patient outcome in primary neuroblastoma and altered stability of the ABCC1 gene transcript.

scientific article published in May 2011

ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells

scientific article published on 01 November 1999

Analysis of human multidrug resistance protein 1 (ABCC1) by matrix-assisted laser desorption ionization/time of flight mass spectrometry: toward identification of leukotriene C4 binding sites

scientific article published on 16 August 2005

Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA

scientific journal article

Antibody production by human × human hybridomas in serum-free medium

scientific article published on 01 April 1985

Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer.

scientific article published on 17 May 2016

Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23.

scientific article published on 13 June 2016

Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).

scientific article published on January 2003

Biology of the multidrug resistance-associated protein, MRP.

scientific article

Bipartite nuclear localization signals in the C terminus of human topoisomerase II alpha

scientific article

CFTR directly mediates nucleotide-regulated glutathione flux.

scientific article

Cellular and karyotypic characterization of two doxorubicin resistant cell lines isolated from the same parental human leukemia cell line.

scientific article published on May 1994

Cellular toxicities of new titanocene dichloride derivatives containing pendant cyclic alkylammonium groups

article

Chalcogenopyrylium Compounds as Modulators of the ATP-Binding Cassette Transporters P-Glycoprotein (P-gp/ABCB1) and Multidrug Resistance Protein 1 (MRP1/ABCC1)

article

Chalcogenopyrylium dyes as differential modulators of organic anion transport by multidrug resistance protein 1 (MRP1), MRP2, and MRP4

scientific article published on 25 March 2013

Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein.

scientific article

Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites.

scientific article published on December 2002

Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity

scientific article published on 18 August 2002

Chemosensitivity testing of small cell lung cancer using the MTT assay.

scientific article

Clinical Significance of Multi-Drug Resistance Associated Protein and P-Glycoprotein in Patients with Bladder Cancer

scientific article published on 01 April 1997

Cloning and Characterization of the Murine and Rat mrp1 Promoter Regions.

scientific article published on November 2003

Cloning, transfer, and characterization of multidrug resistance protein.

scientific article

Comparative phenotypic analysis of available human hybridoma fusion partners

scientific article

Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1.

scientific article

Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4).

scientific article published on 11 April 2016

Deletion of gene for multidrug resistance in acute myeloid leukaemia with inversion in chromosome 16: prognostic implications

scientific article published in The Lancet

Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17.

scientific article

Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter

scientific article published on 11 November 2013

Differential growth inhibition and enhancement of major histocompatibility complex class I antigen expression by interferons in a small-cell lung cancer cell line and its doxorubicin-selected multidrug-resistant variant ⬇️

scientific article published on January 1, 1991

Differential inhibition of hepatic ferrochelatase by the isomers of N-ethylprotoporphyrin IX

scientific article published on 01 November 1981

Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4.

scientific article published in June 2008

Drug-induced porphyrin biosynthesis--XIX. Potentiation of the porphyrin-inducing effects of SKF 525-A in the chick embryo liver by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine, an antihibitor of ferrochelatase

scientific article published in December 1979

Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein

scientific article

Elevated expression of annexin II (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line ⬇️

scientific article published on April 1, 1992

Evidence that the MYCN oncogene regulates MRP gene expression in neuroblastoma

article

Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2.

scientific article published on 20 December 2010

Expression of multidrug resistance protein gene in patients with glioma after chemotherapy.

scientific article published in October 1998

Ferrochelatase and N-alkylated porphyrins.

scientific article published on September 1984

Function, evolution and structure of multidrug resistance protein (MRP).

scientific article

Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1).

scientific article published in May 2003

Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1).

scientific article published on 17 October 2005

Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1).

scientific article published on 8 March 2005

Growth of human × human hybridomas in protein-free medium supplemented with ethanolamine

scientific article published on 01 February 1987

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

scientific article

Human monoclonal antibodies.

scientific article

Identification of DNA-protein interactions in the 5' flanking and 5' untranslated regions of the human multidrug resistance protein (MRP1) gene: evaluation of a putative antioxidant response element/AP-1 binding site

scientific article published in July 2001

Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta

scientific article

Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution.

scientific article

Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.

scientific article published on 13 January 2004

Identification of regions required for apical membrane localization of human multidrug resistance protein 2.

scientific article

Inhibition of hepatic ferrochelatase by the four isomers of N-methylprotoporphyrin IX

scientific article published on 01 December 1980

Limited modulation of the transport activity of the human multidrug resistance proteins MRP1, MRP2 and MRP3 by nicotine glucuronide metabolites

scientific article published in May 2005

Localization of a Substrate Specificity Domain in the Multidrug Resistance Protein

scientific article published in Journal of Biological Chemistry

MRP1 polymorphisms associated with citalopram response in patients with major depression

scientific article published in April 2010

Mammalian multidrug-resistance proteins (MRPs).

scientific article published on September 2011

Mapping of the MRPm5 epitope to the cytosolic region between transmembrane helices 13 and 14 in the drug and organic anion transporter, MRP1 (ABCC1).

scientific article published on March 2004

Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux

scientific article published on 19 March 2012

Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport.

scientific article published on 2 September 2008

Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.

scientific article

Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1).

scientific article published on 27 April 2009

Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1)

scientific journal article

Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1).

scientific article published on 15 October 2003

Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1).

scientific article published on 31 October 2007

Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein

scientific article

Multidrug resistance genes (MRP) and MDR1 expression in small cell lung cancer xenografts: relationship with response to chemotherapy.

scientific article

Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.

scientific article

Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter

scientific article

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

scientific article

Multidrug resistance-associated antigens on drug-sensitive and -resistant human tumour cell lines.

scientific article

Multiple roles of charged amino acids in cytoplasmic loop 7 for expression and function of the multidrug and organic anion transporter MRP1 (ABCC1).

scientific article published on 17 November 2008

Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.

scientific article published on 10 August 2001

Mutation of proline residues in the NH(2)-terminal region of the multidrug resistance protein, MRP1 (ABCC1): effects on protein expression, membrane localization, and transport function

scientific article published in September 2003

Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transp

scientific article published on 18 June 2004

Mutational analysis of polar amino acid residues within predicted transmembrane helices 10 and 16 of multidrug resistance protein 1 (ABCC1): effect on substrate specificity.

scientific article published on 13 January 2006

Mutations of charged amino acids in or near the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein MRP1 (ABCC1).

scientific article

N-linked glycans do not affect plasma membrane localization of multidrug resistance protein 4 (MRP4) but selectively alter its prostaglandin E2 transport activity

scientific article published on 22 December 2015

Non-P-glycoprotein-mediated multidrug-resistant human KB cells selected in medium containing adriamycin, cepharanthine, and mezerein

scientific article

Nuclear interactions of topoisomerase II alpha and beta with phospholipid scramblase 1

scientific article

Polymorphic variants of MRP4/ABCC4 differentially modulate the transport of methylated arsenic metabolites and physiological organic anions.

scientific article published on 19 September 2016

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

scientific journal article

Rapid chemosensitivity testing of human lung tumor cells using the MTT assay

scientific article published in January 1986

Reconstitution of ATP-dependent leukotriene C4 transport by Co-expression of both half-molecules of human multidrug resistance protein in insect cells.

scientific article published on November 1996

Residues responsible for the asymmetric function of the nucleotide binding domains of multidrug resistance protein 1.

scientific article

Retrovirus-mediated gene transfer of the human multidrug resistance-associated protein into hematopoietic cells protects mice from chemotherapy-induced leukopenia

scientific article published in March 1999

Role of carboxylate residues adjacent to the conserved core Walker B motifs in the catalytic cycle of multidrug resistance protein 1 (ABCC1).

scientific article published on 27 July 2003

Role of proline 1150 in functional interactions between the membrane spanning domains and nucleotide binding domains of the MRP1 (ABCC1) transporter.

scientific article

Role of the NH2-terminal membrane spanning domain of multidrug resistance protein 1/ABCC1 in protein processing and trafficking

scientific article

Role of two adjacent cytoplasmic tyrosine residues in MRP1 (ABCC1) transport activity and sensitivity to sulfonylureas

scientific article published on 16 December 2004

Sequence determinants of nuclear localization in the alpha and beta isoforms of human topoisomerase II.

scientific article published in September 1999

Specific immunoglobulin production and enhanced tumorigenicity following ascites growth of human hybridomas

scientific article published in July 1985

Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3).

scientific article published on 5 September 2008

Structural organization of the human TOP2A and TOP2B genes.

scientific article

Structural requirements for functional interaction of glutathione tripeptide analogs with the human multidrug resistance protein 1 (MRP1).

scientific article published in February 2003

Structural requirements in dihydropyridines for ferrochelatase inhibition and δ-aminolevulinic acid synthetase induction

scientific article published on 01 January 1980

Structural, mechanistic and clinical aspects of MRP1.

scientific article

Structure-activity studies of verapamil analogs that modulate transport of leukotriene C(4) and reduced glutathione by multidrug resistance protein MRP1.

scientific article published in September 2000

Subcellular localization analysis of the closely related Fps/Fes and Fer protein-tyrosine kinases suggests a distinct role for Fps/Fes in vesicular trafficking

scientific article

Substrate recognition and transport by multidrug resistance protein 1 (ABCC1).

scientific article

Targeting multidrug resistance protein 1 (MRP1, ABCC1): past, present, and future

scientific article

The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation

scientific article

Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells.

scientific article published on 10 November 2006

Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.

scientific article

Transmembrane helix 11 of multidrug resistance protein 1 (MRP1/ABCC1): identification of polar amino acids important for substrate specificity and binding of ATP at nucleotide binding domain 1.

scientific article

Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins

scientific article published on July 2006

Transport of glutathione and glutathione conjugates by MRP1.

scientific article published on 3 July 2006

Tumourigenic multidrug-resistant HT1080 cells do not overexpress receptors for epidermal growth factor

scientific article

Two polymorphic variants of ABCC1 selectively alter drug resistance and inhibitor sensitivity of the multidrug and organic anion transporter multidrug resistance protein 1.

scientific article published on 30 September 2013

Two-dimensional electrophoretic display of restriction fragments from genomic DNA

scientific article published on 01 August 1985

Use of the MTT assay for rapid determination of chemosensitivity of human leukemic blast cells

scientific article published in January 1988

[12] The EBV-hybridoma technique

scientific article published on 01 January 1986

List of works by Susan P.C. Cole

A monoclonal antibody detecting cell surface epitope on some drug resistant human tumour cell lines

A new series of titanocene dichloride derivatives bearing chiral alkylammonium groups; assessment of their cytotoxic properties

A new series of titanocene dichloride derivatives bearing cyclic alkylammonium groups: Assessment of their cytotoxic properties

A single point mutation in Drosophila dihydrofolate reductase confers methotrexate resistance to a transgenic CHO cell line

ABCC1 G2012T single nucleotide polymorphism is associated with patient outcome in primary neuroblastoma and altered stability of the ABCC1 gene transcript.

ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells

Analysis of human multidrug resistance protein 1 (ABCC1) by matrix-assisted laser desorption ionization/time of flight mass spectrometry: toward identification of leukotriene C4 binding sites

Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA

Antibody production by human × human hybridomas in serum-free medium

Applications of nanoparticle drug delivery systems for the reversal of multidrug resistance in cancer.

Arsenic Triglutathione [As(GS)3] Transport by Multidrug Resistance Protein 1 (MRP1/ABCC1) Is Selectively Modified by Phosphorylation of Tyr920/Ser921 and Glycosylation of Asn19/Asn23.

Bioflavonoid stimulation of glutathione transport by the 190-kDa multidrug resistance protein 1 (MRP1).

Biology of the multidrug resistance-associated protein, MRP.

Bipartite nuclear localization signals in the C terminus of human topoisomerase II alpha

CFTR directly mediates nucleotide-regulated glutathione flux.

Cellular and karyotypic characterization of two doxorubicin resistant cell lines isolated from the same parental human leukemia cell line.

Cellular toxicities of new titanocene dichloride derivatives containing pendant cyclic alkylammonium groups

Chalcogenopyrylium Compounds as Modulators of the ATP-Binding Cassette Transporters P-Glycoprotein (P-gp/ABCB1) and Multidrug Resistance Protein 1 (MRP1/ABCC1)

Chalcogenopyrylium dyes as differential modulators of organic anion transport by multidrug resistance protein 1 (MRP1), MRP2, and MRP4

Characterization of binding of leukotriene C4 by human multidrug resistance protein 1: evidence of differential interactions with NH2- and COOH-proximal halves of the protein.

Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites.

Charged amino acids in the sixth transmembrane helix of multidrug resistance protein 1 (MRP1/ABCC1) are critical determinants of transport activity

Chemosensitivity testing of small cell lung cancer using the MTT assay.

Clinical Significance of Multi-Drug Resistance Associated Protein and P-Glycoprotein in Patients with Bladder Cancer

Cloning and Characterization of the Murine and Rat mrp1 Promoter Regions.

Cloning, transfer, and characterization of multidrug resistance protein.

Comparative phenotypic analysis of available human hybridoma fusion partners

Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1.

Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4).

Deletion of gene for multidrug resistance in acute myeloid leukaemia with inversion in chromosome 16: prognostic implications

Determinants of the substrate specificity of multidrug resistance protein 1: role of amino acid residues with hydrogen bonding potential in predicted transmembrane helix 17.

Differential functional rescue of Lys(513) and Lys(516) processing mutants of MRP1 (ABCC1) by chemical chaperones reveals different domain-domain interactions of the transporter

Differential growth inhibition and enhancement of major histocompatibility complex class I antigen expression by interferons in a small-cell lung cancer cell line and its doxorubicin-selected multidrug-resistant variant ⬇️

Differential inhibition of hepatic ferrochelatase by the isomers of N-ethylprotoporphyrin IX

Down-regulation of Na+/H+ exchanger regulatory factor 1 increases expression and function of multidrug resistance protein 4.

Drug-induced porphyrin biosynthesis--XIX. Potentiation of the porphyrin-inducing effects of SKF 525-A in the chick embryo liver by 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6-trimethylpyridine, an antihibitor of ferrochelatase

Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein

Elevated expression of annexin II (lipocortin II, p36) in a multidrug resistant small cell lung cancer cell line ⬇️

Evidence that the MYCN oncogene regulates MRP gene expression in neuroblastoma

Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2.

Expression of multidrug resistance protein gene in patients with glioma after chemotherapy.

Ferrochelatase and N-alkylated porphyrins.

Function, evolution and structure of multidrug resistance protein (MRP).

Functional and structural consequences of cysteine substitutions in the NH2 proximal region of the human multidrug resistance protein 1 (MRP1/ABCC1).

Functional importance of three basic residues clustered at the cytosolic interface of transmembrane helix 15 in the multidrug and organic anion transporter MRP1 (ABCC1).

Functional interactions between nucleotide binding domains and leukotriene C4 binding sites of multidrug resistance protein 1 (ABCC1).

Growth of human × human hybridomas in protein-free medium supplemented with ethanolamine

High-throughput screening identifies Ceefourin 1 and Ceefourin 2 as highly selective inhibitors of multidrug resistance protein 4 (MRP4).

Human monoclonal antibodies.

Identification of DNA-protein interactions in the 5' flanking and 5' untranslated regions of the human multidrug resistance protein (MRP1) gene: evaluation of a putative antioxidant response element/AP-1 binding site

Identification of functional nuclear export sequences in human topoisomerase IIalpha and beta

Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution.

Identification of proline residues in the core cytoplasmic and transmembrane regions of multidrug resistance protein 1 (MRP1/ABCC1) important for transport function, substrate specificity, and nucleotide interactions.

Identification of regions required for apical membrane localization of human multidrug resistance protein 2.

Inhibition of hepatic ferrochelatase by the four isomers of N-methylprotoporphyrin IX

Limited modulation of the transport activity of the human multidrug resistance proteins MRP1, MRP2 and MRP3 by nicotine glucuronide metabolites

Localization of a Substrate Specificity Domain in the Multidrug Resistance Protein

MRP1 polymorphisms associated with citalopram response in patients with major depression

Mammalian multidrug-resistance proteins (MRPs).

Mapping of the MRPm5 epitope to the cytosolic region between transmembrane helices 13 and 14 in the drug and organic anion transporter, MRP1 (ABCC1).

Mechanism of RPE cell death in α-crystallin deficient mice: a novel and critical role for MRP1-mediated GSH efflux

Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport.

Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus.

Molecular basis for reduced estrone sulfate transport and altered modulator sensitivity of transmembrane helix (TM) 6 and TM17 mutants of multidrug resistance protein 1 (ABCC1).

Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1)

Molecular modeling correctly predicts the functional importance of Phe594 in transmembrane helix 11 of the multidrug resistance protein, MRP1 (ABCC1).

Molecular modeling of the human multidrug resistance protein 1 (MRP1/ABCC1).

Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein

Multidrug resistance genes (MRP) and MDR1 expression in small cell lung cancer xenografts: relationship with response to chemotherapy.

Multidrug resistance mediated by the multidrug resistance protein (MRP) gene.

Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter

Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

Multidrug resistance-associated antigens on drug-sensitive and -resistant human tumour cell lines.

Multiple roles of charged amino acids in cytoplasmic loop 7 for expression and function of the multidrug and organic anion transporter MRP1 (ABCC1).

Mutation of Trp1254 in the multispecific organic anion transporter, multidrug resistance protein 2 (MRP2) (ABCC2), alters substrate specificity and results in loss of methotrexate transport activity.

Mutation of proline residues in the NH(2)-terminal region of the multidrug resistance protein, MRP1 (ABCC1): effects on protein expression, membrane localization, and transport function

Mutational analysis of ionizable residues proximal to the cytoplasmic interface of membrane spanning domain 3 of the multidrug resistance protein, MRP1 (ABCC1): glutamate 1204 is important for both the expression and catalytic activity of the transp

Mutational analysis of polar amino acid residues within predicted transmembrane helices 10 and 16 of multidrug resistance protein 1 (ABCC1): effect on substrate specificity.

Mutations of charged amino acids in or near the transmembrane helices of the second membrane spanning domain differentially affect the substrate specificity and transport activity of the multidrug resistance protein MRP1 (ABCC1).