List of works - J Gerry Kenna

A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

scientific article published on October 2013

A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism

scientific article published on 24 August 2011

A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N-acetyl-meta-aminophenol (AMAP) ⬇️

scientific article published on September 23, 2012

Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model.

scientific article published on 14 April 2015

Advancing nonclinical innovation and safety in pharmaceutical testing

scientific article published on 20 November 2018

An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy.

scientific article published on 17 June 2016

Assessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibition

scientific article published on 07 April 2013

Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.

scientific article published on 12 December 2012

Cell based approaches for evaluation of drug-induced liver injury.

scientific article published on 13 August 2009

Cellular models for ADMET predictions and evaluation of drug-drug interactions.

scientific article published on January 2004

Characterization of THLE-cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity.

scientific article

Current Concepts in Drug-Induced Bile Salt Export Pump (BSEP) Interference

scientific article published on 7 August 2014

Differential effect of troglitazone on the human bile acid transporters, MRP2 and BSEP, in the PXB hepatic chimeric mouse.

scientific article

Do e-cigarettes pose a risk to human health?

scientific article published on 01 December 2015

Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury

scientific article published on 10 November 2009

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

scientific article published on 27 December 2011

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

scientific article published on November 2013

Evidence of impaired antigen non-specific but normal antigen specific suppressor cell function in children with autoimmune chronic active hepatitis.

scientific article

Fabrication and evaluation of a micro(bio)sensor array chip for multiple parallel measurements of important cell biomarkers

scientific article

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.

scientific article

Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy

scientific article published on 30 April 2013

HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium

scientific article published on 13 June 2011

HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium

scientific article published on 2 December 2010

Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity

scientific article

Hepatic effects of repeated oral administration of diclofenac to hepatic cytochrome P450 reductase null (HRN™) and wild-type mice

scientific article published on 28 March 2015

Human biology-based drug safety evaluation: scientific rationale, current status and future challenges.

scientific article published on 2 February 2017

Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.

scientific article published in May 2008

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

scientific article published on 31 May 2012

In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid.

scientific article published on 23 April 2013

In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

scientific article published on 30 September 2011

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

scientific article

Managing the challenge of chemically reactive metabolites in drug development.

scientific article published on April 2011

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

scientific article

Microfabricated glucose biosensor for culture well operation.

scientific article

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification

scientific article published on 7 September 2012

Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists

scientific article

Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats

scientific article

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

scientific article published on January 2007

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging

scientific article published on 27 July 2015

Recommendations to qualify biomarker candidates of drug-induced liver injury

scientific article published in June 2010

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

scientific article published on 11 November 2010

Safety pharmacology--current and emerging concepts.

scientific article

Systems biology tools for toxicology

scientific article published on 09 May 2012

Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism

scientific article published on 16 July 2015

The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human ⬇️

scientific article published on 08 May 2012

The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613.

scientific article

List of works by J Gerry Kenna

A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.

A mathematical modelling approach to assessing the reliability of biomarkers of glutathione metabolism

A new twist to an old tale: novel insights into the differential toxicities of acetaminophen and its regioisomer N-acetyl-meta-aminophenol (AMAP) ⬇️

Activation of Flucloxacillin-Specific CD8+ T-Cells With the Potential to Promote Hepatocyte Cytotoxicity in a Mouse Model.

Advancing nonclinical innovation and safety in pharmaceutical testing

An international network (PlaNet) to evaluate a human placental testing platform for chemicals safety testing in pregnancy.

Assessment of gadoxetate DCE-MRI as a biomarker of hepatobiliary transporter inhibition

Bioactivation of the cannabinoid receptor antagonist rimonabant to a cytotoxic iminium ion metabolite.

Cell based approaches for evaluation of drug-induced liver injury.

Cellular models for ADMET predictions and evaluation of drug-drug interactions.

Characterization of THLE-cytochrome P450 (P450) cell lines: gene expression background and relationship to P450-enzyme activity.

Current Concepts in Drug-Induced Bile Salt Export Pump (BSEP) Interference

Differential effect of troglitazone on the human bile acid transporters, MRP2 and BSEP, in the PXB hepatic chimeric mouse.

Do e-cigarettes pose a risk to human health?

Enhancing the utility of alanine aminotransferase as a reference standard biomarker for drug-induced liver injury

Evaluation of the pharmacokinetics, biotransformation and hepatic transporter effects of troglitazone in mice with humanized livers

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

Evidence of impaired antigen non-specific but normal antigen specific suppressor cell function in children with autoimmune chronic active hepatitis.

Fabrication and evaluation of a micro(bio)sensor array chip for multiple parallel measurements of important cell biomarkers

Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.

Glutathione metabolism modeling: a mechanism for liver drug-robustness and a new biomarker strategy

HPLC-MS/MS methods for the quantitative analysis of 5-oxoproline (pyroglutamate) in rat plasma and hepatic cell line culture medium

HPLC-MS/MS methods for the quantitative analysis of ophthalmic acid in rodent plasma and hepatic cell line culture medium

Hepatic adducts, circulating antibodies, and cytokine polymorphisms in patients with diclofenac hepatotoxicity

Hepatic effects of repeated oral administration of diclofenac to hepatic cytochrome P450 reductase null (HRN™) and wild-type mice

Human biology-based drug safety evaluation: scientific rationale, current status and future challenges.

Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.

In vitro approach to assess the potential for risk of idiosyncratic adverse reactions caused by candidate drugs.

In vitro exploration of potential mechanisms of toxicity of the human hepatotoxic drug fenclozic acid.

In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans

Managing the challenge of chemically reactive metabolites in drug development.

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

Microfabricated glucose biosensor for culture well operation.

Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification

Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists

Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione-depletion biomarkers ophthalmic acid and 5-oxoproline in humans and rats

Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies.

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging

Recommendations to qualify biomarker candidates of drug-induced liver injury

Risk assessment and mitigation strategies for reactive metabolites in drug discovery and development

Safety pharmacology--current and emerging concepts.

Systems biology tools for toxicology

Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism

The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human ⬇️

The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613.