List of works - Rubia Casagrande

-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

scientific article published on 02 October 2018

15d-PGJ-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

scientific article published in Scientific Reports

5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality

scientific article published on 31 October 2013

Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.

scientific article published on 28 January 2012

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice

scientific article published on 16 July 2013

Analgesic activity and mechanism of action of a Beta vulgaris dye enriched in betalains in inflammatory models in mice

scientific article published on 05 March 2020

Analgesic activity of piracetam: effect on cytokine production and oxidative stress

scientific article published on 6 March 2013

Anti-inflammatory activity of betalain-rich dye of Beta vulgaris: effect on edema, leukocyte recruitment, superoxide anion and cytokine production

scientific article published on 31 August 2014

Assessment of the antioxidant activities of Brazilian extracts of propolis alone and in topical pharmaceutical formulations

scientific article published in September 2005

Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice.

scientific article

Budlein A, a Sesquiterpene Lactone From , Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice

scholarly article by Victor Fattori et al published 2018 in Frontiers in Pharmacology

Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice

scientific article published on 28 May 2019

Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation

scientific article

Diosmin Treats Lipopolysaccharide-Induced Inflammatory Pain and Peritonitis by Blocking NF-κB Activation in Mice

scientific article published on 21 February 2020

Diosmin reduces chronic constriction injury-induced neuropathic pain in mice

scientific article published on 15 June 2017

Efficacy of topical formulations containing Pimenta pseudocaryophyllus extract against UVB-induced oxidative stress and inflammation in hairless mice

scientific article

Erratum to: The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines

scientific article published on 6 September 2017

Evaluation of in vivo efficacy of topical formulations containing soybean extract

scientific article

Evaluation of the antioxidant activity of soybean extract by different in vitro methods and investigation of this activity after its incorporation in topical formulations

scientific article published on 16 June 2006

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

article

Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10

scientific article published on 10 January 2015

Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation

scientific article published on 13 June 2018

Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage

scientific article published on 13 April 2015

Hypericum perforatumReduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress

scientific article published on 08 April 2015

IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis

scientific article published on 04 September 2020

In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity

scientific article published on 14 August 2006

Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice.

scientific article

Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis.

scientific article

Jararhagin-induced mechanical hyperalgesia depends on TNF-α, IL-1β and NFκB in mice

scientific article

Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.

scientific article published on 10 May 2012

Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice

scientific article published on 08 July 2015

Naringenin mitigates titanium dioxide (TiO)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

scholarly article by Marília F Manchope et al published 28 October 2018 in Inflammation Research

Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

scholarly article by Marília F. Manchope et al published 28 October 2018 in Inflammation Research

Naringenin reduces inflammatory pain in mice.

scientific article published on 18 February 2016

Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway

scientific article

Pimaradienoic Acid Inhibits Carrageenan-Induced Inflammatory Leukocyte Recruitment and Edema in Mice: Inhibition of Oxidative Stress, Nitric Oxide and Cytokine Production.

scientific article published on 19 February 2016

Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.

scientific article published on 13 November 2014

Preclinical Evaluation of Rutin-Loaded Microparticles with an Enhanced Analgesic Effect

Preparation and characterization of microcapsules based on biodegradable polymers: pectin/casein complex for controlled drug release systems.

scientific article

Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production

scientific article published on 10 May 2017

Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects

scientific article published on 6 April 2017

Protective effect of fermented soybean dried extracts against TPA-induced oxidative stress in hairless mice skin.

scientific article published on 29 August 2013

Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice

scientific article published on 21 February 2006

Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro.

scientific article

Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-κB and oxidative stress

scientific article published on 09 May 2016

Quercetin Inhibits Inflammatory Bone Resorption in a Mouse Periodontitis Model

scientific article published on 18 November 2013

Quercetin Reduces Neutrophil Recruitment Induced by CXCL8, LTB4, and fMLP: Inhibition of Actin Polymerization

scientific article published on 28 January 2011

Quercetin promotes antipromastigote effect by increasing the ROS production and anti-amastigote by upregulating Nrf2/HO-1 expression, affecting iron availability

scientific article published on 02 March 2019

Quercetin reduces Ehrlich tumor-induced cancer pain in mice.

scientific article

Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production

scientific article published in November 2009

Quercetin-Loaded Microcapsules Ameliorate Experimental Colitis in Mice by Anti-inflammatory and Antioxidant Mechanisms

scientific article published on 24 January 2013

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

scientific article published on 31 March 2019

Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice

scientific article published on 08 February 2014

Specialized pro-resolving lipid mediators: A new class of non-immunosuppressive and non-opioid analgesic drugs

scientific article published on 17 November 2019

Studies on the extraction and purification of phytic acid from rice bran

Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice

scientific article published on 18 August 2015

Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice.

scientific article

Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice.

scientific article published on 14 May 2017

Tephrosia sinapou ethyl acetate extract inhibits inflammatory pain in mice: opioid receptor dependent inhibition of TNFα and IL-1β production

scientific article

Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production

The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.

scientific article published on 29 August 2013

The Lipoxin Receptor/FPR2 Agonist BML-111 Protects Mouse Skin Against Ultraviolet B Radiation

scientific article published on 26 June 2020

The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines

scientific article published on 01 December 2017

The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β

The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation

scientific article published in April 2016

The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats

scientific article published on 27 March 2013

The nitroxyl donor, Angeli's salt, reduces chronic constriction injury-induced neuropathic pain

scientific article published on 7 June 2016

The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory pain: involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway

scientific article published on 5 March 2013

The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway.

scientific article published on 13 August 2014

The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2.

scientific article published on 13 February 2015

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

scientific article published on 10 February 2020

Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice

scientific article published on 7 January 2016

Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation-induced injury of hairless mouse skin

scientific article published on 22 August 2018

Topical formulations containing Pimenta pseudocaryophyllus extract: In vitro antioxidant activity and in vivo efficacy against UV-B-induced oxidative stress

scientific article

Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice

scientific article published on 2 May 2017

Validação de métodos para determinação de fluoxetina em cápsulas

Vanillic Acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice

scientific article published on 20 July 2015

Vinpocetine reduces carrageenan-induced inflammatory hyperalgesia in mice by inhibiting oxidative stress, cytokine production and NF-κB activation in the paw and spinal cord

scientific article published on 30 March 2015

Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB.

scientific article published on 14 May 2015

Vitexin inhibits inflammatory pain in mice by targeting TRPV1, oxidative stress, and cytokines

scientific article published on 6 June 2013

trans-Chalcone, a flavonoid precursor, inhibits UV-induced skin inflammation and oxidative stress in mice by targeting NADPH oxidase and cytokine production

scientific article published on 8 June 2017

List of works by Rubia Casagrande

-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

15d-PGJ-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice

5-lipoxygenase deficiency reduces acetaminophen-induced hepatotoxicity and lethality

Acetic acid- and phenyl-p-benzoquinone-induced overt pain-like behavior depends on spinal activation of MAP kinases, PI(3)K and microglia in mice.

An interleukin-33/ST2 signaling deficiency reduces overt pain-like behaviors in mice

Analgesic activity and mechanism of action of a Beta vulgaris dye enriched in betalains in inflammatory models in mice

Analgesic activity of piracetam: effect on cytokine production and oxidative stress

Anti-inflammatory activity of betalain-rich dye of Beta vulgaris: effect on edema, leukocyte recruitment, superoxide anion and cytokine production

Assessment of the antioxidant activities of Brazilian extracts of propolis alone and in topical pharmaceutical formulations

Bosentan, a mixed endothelin receptor antagonist, inhibits superoxide anion-induced pain and inflammation in mice.

Budlein A, a Sesquiterpene Lactone From , Alleviates Pain and Inflammation in a Model of Acute Gout Arthritis in Mice

Contribution of spinal cord glial cells to L. amazonensis experimental infection-induced pain in BALB/c mice

Curcumin inhibits superoxide anion-induced pain-like behavior and leukocyte recruitment by increasing Nrf2 expression and reducing NF-κB activation

Diosmin Treats Lipopolysaccharide-Induced Inflammatory Pain and Peritonitis by Blocking NF-κB Activation in Mice

Diosmin reduces chronic constriction injury-induced neuropathic pain in mice

Efficacy of topical formulations containing Pimenta pseudocaryophyllus extract against UVB-induced oxidative stress and inflammation in hairless mice

Erratum to: The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines

Evaluation of in vivo efficacy of topical formulations containing soybean extract

Evaluation of the antioxidant activity of soybean extract by different in vitro methods and investigation of this activity after its incorporation in topical formulations

Flavonoids as Anti-Inflammatory and Analgesic Drugs: Mechanisms of Action and Perspectives in the Development of Pharmaceutical Forms

Granulocyte-colony stimulating factor (G-CSF)-induced mechanical hyperalgesia in mice: Role for peripheral TNFα, IL-1β and IL-10

Hesperidin Methylchalcone Suppresses Experimental Gout Arthritis in Mice by Inhibiting NF-κB Activation

Hesperidin methyl chalcone inhibits oxidative stress and inflammation in a mouse model of ultraviolet B irradiation-induced skin damage

Hypericum perforatumReduces Paracetamol-Induced Hepatotoxicity and Lethality in Mice by Modulating Inflammation and Oxidative Stress

IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis

In vitro evaluation of quercetin cutaneous absorption from topical formulations and its functional stability by antioxidant activity

Interleukin-10 limits intense acute swimming-induced muscle mechanical hyperalgesia in mice.

Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis.

Jararhagin-induced mechanical hyperalgesia depends on TNF-α, IL-1β and NFκB in mice

Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.

Naringenin Inhibits UVB Irradiation-Induced Inflammation and Oxidative Stress in the Skin of Hairless Mice

Naringenin mitigates titanium dioxide (TiO)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

Naringenin mitigates titanium dioxide (TiO2)-induced chronic arthritis in mice: role of oxidative stress, cytokines, and NFκB

Naringenin reduces inflammatory pain in mice.

Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway

Pimaradienoic Acid Inhibits Carrageenan-Induced Inflammatory Leukocyte Recruitment and Edema in Mice: Inhibition of Oxidative Stress, Nitric Oxide and Cytokine Production.

Pimaradienoic acid inhibits inflammatory pain: inhibition of NF-κB activation and cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.

Preclinical Evaluation of Rutin-Loaded Microparticles with an Enhanced Analgesic Effect

Preparation and characterization of microcapsules based on biodegradable polymers: pectin/casein complex for controlled drug release systems.

Probucol attenuates lipopolysaccharide-induced leukocyte recruitment and inflammatory hyperalgesia: effect on NF-кB activation and cytokine production

Probucol attenuates overt pain-like behavior and carrageenan-induced inflammatory hyperalgesia and leukocyte recruitment by inhibiting NF-кB activation and cytokine production without antioxidant effects

Protective effect of fermented soybean dried extracts against TPA-induced oxidative stress in hairless mice skin.

Protective effect of topical formulations containing quercetin against UVB-induced oxidative stress in hairless mice

Pyrrolidine dithiocarbamate inhibits UVB-induced skin inflammation and oxidative stress in hairless mice and exhibits antioxidant activity in vitro.

Pyrrolidine dithiocarbamate inhibits superoxide anion-induced pain and inflammation in the paw skin and spinal cord by targeting NF-κB and oxidative stress

Quercetin Inhibits Inflammatory Bone Resorption in a Mouse Periodontitis Model

Quercetin Reduces Neutrophil Recruitment Induced by CXCL8, LTB4, and fMLP: Inhibition of Actin Polymerization

Quercetin promotes antipromastigote effect by increasing the ROS production and anti-amastigote by upregulating Nrf2/HO-1 expression, affecting iron availability

Quercetin reduces Ehrlich tumor-induced cancer pain in mice.

Quercetin reduces inflammatory pain: inhibition of oxidative stress and cytokine production

Quercetin-Loaded Microcapsules Ameliorate Experimental Colitis in Mice by Anti-inflammatory and Antioxidant Mechanisms

Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti-Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion-Triggered Inflammation

Role of TNF-α/TNFR1 in intense acute swimming-induced delayed onset muscle soreness in mice

Specialized pro-resolving lipid mediators: A new class of non-immunosuppressive and non-opioid analgesic drugs

Studies on the extraction and purification of phytic acid from rice bran

Superoxide anion-induced pain and inflammation depends on TNFα/TNFR1 signaling in mice

Targeting interleukin-1β reduces intense acute swimming-induced muscle mechanical hyperalgesia in mice.

Tempol, a Superoxide Dismutase Mimetic Agent, Inhibits Superoxide Anion-Induced Inflammatory Pain in Mice.

Tephrosia sinapou ethyl acetate extract inhibits inflammatory pain in mice: opioid receptor dependent inhibition of TNFα and IL-1β production

Tephrosia sinapou extract reduces inflammatory leukocyte recruitment in mice: effect on oxidative stress, nitric oxide and cytokine production

The Ehrlich tumor induces pain-like behavior in mice: a novel model of cancer pain for pathophysiological studies and pharmacological screening.

The Lipoxin Receptor/FPR2 Agonist BML-111 Protects Mouse Skin Against Ultraviolet B Radiation

The Sesquiterpene Lactone, Budlein A, Inhibits Antigen-Induced Arthritis in Mice: Role of NF-κB and Cytokines

The citrus flavanone naringenin reduces gout-induced joint pain and inflammation in mice by inhibiting the activation of NFκB and macrophage release of IL-1β

The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation

The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats

The nitroxyl donor, Angeli's salt, reduces chronic constriction injury-induced neuropathic pain

The ruthenium NO donor, [Ru(bpy)2(NO)SO3](PF6), inhibits inflammatory pain: involvement of TRPV1 and cGMP/PKG/ATP-sensitive potassium channel signaling pathway

The ruthenium nitric oxide donor, [Ru(HEDTA)NO], inhibits acute nociception in mice by modulating oxidative stress, cytokine production and activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway.

The superoxide anion donor, potassium superoxide, induces pain and inflammation in mice through production of reactive oxygen species and cyclooxygenase-2.

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

Topical Formulation Containing Naringenin: Efficacy against Ultraviolet B Irradiation-Induced Skin Inflammation and Oxidative Stress in Mice

Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation-induced injury of hairless mouse skin

Topical formulations containing Pimenta pseudocaryophyllus extract: In vitro antioxidant activity and in vivo efficacy against UV-B-induced oxidative stress

Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice

Validação de métodos para determinação de fluoxetina em cápsulas

Vanillic Acid Inhibits Inflammatory Pain by Inhibiting Neutrophil Recruitment, Oxidative Stress, Cytokine Production, and NFκB Activation in Mice

Vinpocetine reduces carrageenan-induced inflammatory hyperalgesia in mice by inhibiting oxidative stress, cytokine production and NF-κB activation in the paw and spinal cord

Vinpocetine reduces lipopolysaccharide-induced inflammatory pain and neutrophil recruitment in mice by targeting oxidative stress, cytokines and NF-κB.