List of works - Esben Lorentzen

A single subunit, Dis3, is essentially responsible for yeast exosome core activity

scientific article

Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

scientific article published on 13 June 2019

Architecture and function of IFT complex proteins in ciliogenesis

scientific article

Atomic resolution structure of human -tubulin acetyltransferase bound to acetyl-CoA

scientific article

Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly

scientific article published on 02 April 2019

Biochemical mapping of interactions within the intraflagellar transport (IFT) B core complex: IFT52 binds directly to four other IFT-B subunits

scientific article published on 3 June 2011

Chapter 20 Expression, Reconstitution, and Structure of an Archaeal RNA Degrading Exosome

article

Characterization of native and reconstituted exosome complexes from the hyperthermophilic archaeon Sulfolobus solfataricus

scientific article

Complex Reconstitution from Individual Protein Modules.

scientific article published on January 2016

Corrigendum to "The intraflagellar transport machinery in ciliary signaling" [Curr Opin Struct Biol 2016, 41:98-108]

scientific article published on 18 August 2016

Crystal Structure of a 9-Subunit Archaeal Exosome in Pre-Catalytic States of the Phosphorolytic Reaction ⬇️

scientific article published on December 20, 2012

Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax

scientific article

Crystal structure of a Chlamydomonas reinhardtii flagellar RabGAP TBC-domain at 1.8 Å resolution

scientific article

Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins

scientific article

Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis

scientific article published on 16 April 2018

Crystal structure of tetrameric human Rabin8 GEF domain

scientific article published on 10 January 2018

Crystal structure of the intraflagellar transport complex 25/27

scientific article

Crystal structure of the invertebrate bifunctional purine biosynthesis enzyme PAICS at 2.8 Å resolution

scientific article

Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly

scientific article published on October 2014

Evolutionary markers in the (beta/alpha)8-barrel fold.

scientific article

Getting tubulin to the tip of the cilium: one IFT train, many different tubulin cargo-binding sites?

scientific article published on 10 March 2014

Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion

scientific article published on 01 August 2019

IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis

scientific article published on 09 April 2020

IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.

scientific article published on 4 December 2017

IFT81, encoding an IFT-B core protein, as a very rare cause of a ciliopathy phenotype.

scientific article

Intraflagellar transport complex structure and cargo interactions ⬇️

scientific article published on August 14, 2013

Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella.

scientific article

Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex

scientific article

Mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase: structural analysis of reaction intermediates

scientific article

Mechanisms of RNA recruitment by the exosome ⬇️

scientific article published on May 1, 2011

Membrane association and remodeling by intraflagellar transport protein IFT172

scientific article published in Nature Communications

Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.

scientific article

Moving proteins along in the cilium

scientific article published on 13 February 2020

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization

scientific journal article

Mutations of IFT81, encoding an IFT-B core protein, as a rare cause of a ciliopathy.

scientific article published on 13 July 2015

Novel topography of the Rab11-effector interaction network within a ciliary membrane targeting complex

scientific article published on 23 September 2015

Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding

scientific article published on 30 June 2021

Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

scientific article published on 29 March 2019

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

scientific journal article

Purification and crystal structure of human ODA16: implications for ciliary import of outer dynein arms by the intraflagellar transport machinery

scientific article published on 02 April 2020

RNA channelling by the archaeal exosome

scientific article

RNA channelling by the eukaryotic exosome

scientific article

RNA polyadenylation in Archaea: not observed in Haloferax while the exosome polynucleotidylates RNA in Sulfolobus

scientific article

Structural Basis of allosteric regulation and substrate specificity of the non-phosphorylating glyceraldehyde 3-Phosphate dehydrogenase from Thermoproteus tenax

scientific article

Structural and biochemical characterization of the yeast exosome component Rrp40

scientific article

Structural basis for membrane targeting of the BBSome by ARL6

scientific article published on 17 November 2014

Structural basis of 3' end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core

scientific article

Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46.

scientific article

Structural organization of the RNA-degrading exosome

scientific article

Structural studies of ciliary components

scientific article published on 06 June 2012

Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature

scientific article published in September 2004

Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11

scientific article

Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family

scientific article

Structure of the ciliogenesis-associated CPLANE complex

scientific article published on 15 April 2022

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

scientific article published on 10 November 2017

The archaeal exosome core is a hexameric ring structure with three catalytic subunits

scientific article

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

scientific article

The ins and outs of the Arf4-based ciliary membrane-targeting complex

scientific article published on 09 May 2019

The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation

scientific article

List of works by Esben Lorentzen

A single subunit, Dis3, is essentially responsible for yeast exosome core activity

Akt Regulates a Rab11-Effector Switch Required for Ciliogenesis

Architecture and function of IFT complex proteins in ciliogenesis

Atomic resolution structure of human -tubulin acetyltransferase bound to acetyl-CoA

Binding of IFT22 to the intraflagellar transport complex is essential for flagellum assembly

Biochemical mapping of interactions within the intraflagellar transport (IFT) B core complex: IFT52 binds directly to four other IFT-B subunits

Chapter 20 Expression, Reconstitution, and Structure of an Archaeal RNA Degrading Exosome

Characterization of native and reconstituted exosome complexes from the hyperthermophilic archaeon Sulfolobus solfataricus

Complex Reconstitution from Individual Protein Modules.

Corrigendum to "The intraflagellar transport machinery in ciliary signaling" [Curr Opin Struct Biol 2016, 41:98-108]

Crystal Structure of a 9-Subunit Archaeal Exosome in Pre-Catalytic States of the Phosphorolytic Reaction ⬇️

Crystal structure and stereochemical studies of KD(P)G aldolase from Thermoproteus tenax

Crystal structure of a Chlamydomonas reinhardtii flagellar RabGAP TBC-domain at 1.8 Å resolution

Crystal structure of an archaeal class I aldolase and the evolution of (betaalpha)8 barrel proteins

Crystal structure of intraflagellar transport protein 80 reveals a homo-dimer required for ciliogenesis

Crystal structure of tetrameric human Rabin8 GEF domain

Crystal structure of the intraflagellar transport complex 25/27

Crystal structure of the invertebrate bifunctional purine biosynthesis enzyme PAICS at 2.8 Å resolution

Crystal structures of IFT70/52 and IFT52/46 provide insight into intraflagellar transport B core complex assembly

Evolutionary markers in the (beta/alpha)8-barrel fold.

Getting tubulin to the tip of the cilium: one IFT train, many different tubulin cargo-binding sites?

Human IFT52 mutations uncover a novel role for the protein in microtubule dynamics and centrosome cohesion

IFT proteins interact with HSET to promote supernumerary centrosome clustering in mitosis

IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning.

IFT81, encoding an IFT-B core protein, as a very rare cause of a ciliopathy phenotype.

Intraflagellar transport complex structure and cargo interactions ⬇️

Intraflagellar transport protein IFT52 recruits IFT46 to the basal body and flagella.

Intraflagellar transport proteins 172, 80, 57, 54, 38, and 20 form a stable tubulin-binding IFT-B2 complex

Mechanism of the Schiff base forming fructose-1,6-bisphosphate aldolase: structural analysis of reaction intermediates

Mechanisms of RNA recruitment by the exosome ⬇️

Membrane association and remodeling by intraflagellar transport protein IFT172

Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.

Moving proteins along in the cilium

Mutations in TRAF3IP1/IFT54 reveal a new role for IFT proteins in microtubule stabilization

Mutations of IFT81, encoding an IFT-B core protein, as a rare cause of a ciliopathy.

Novel topography of the Rab11-effector interaction network within a ciliary membrane targeting complex

Nse5/6 inhibits the Smc5/6 ATPase and modulates DNA substrate binding

Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

Purification and crystal structure of human ODA16: implications for ciliary import of outer dynein arms by the intraflagellar transport machinery

RNA channelling by the archaeal exosome

RNA channelling by the eukaryotic exosome

RNA polyadenylation in Archaea: not observed in Haloferax while the exosome polynucleotidylates RNA in Sulfolobus

Structural Basis of allosteric regulation and substrate specificity of the non-phosphorylating glyceraldehyde 3-Phosphate dehydrogenase from Thermoproteus tenax

Structural and biochemical characterization of the yeast exosome component Rrp40

Structural basis for membrane targeting of the BBSome by ARL6

Structural basis of 3' end RNA recognition and exoribonucleolytic cleavage by an exosome RNase PH core

Structural basis of outer dynein arm intraflagellar transport by the transport adaptor protein ODA16 and the intraflagellar transport protein IFT46.

Structural organization of the RNA-degrading exosome

Structural studies of ciliary components

Structure and function of a regulated archaeal triosephosphate isomerase adapted to high temperature

Structure of Rab11-FIP3-Rabin8 reveals simultaneous binding of FIP3 and Rabin8 effectors to Rab11

Structure of the active subunit of the yeast exosome core, Rrp44: diverse modes of substrate recruitment in the RNase II nuclease family

Structure of the ciliogenesis-associated CPLANE complex

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

The archaeal exosome core is a hexameric ring structure with three catalytic subunits

The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNA

The ins and outs of the Arf4-based ciliary membrane-targeting complex

The yeast exosome functions as a macromolecular cage to channel RNA substrates for degradation