List of works - Stephen Caddick

3,5-Isoxazoles from alpha-bromo-pentafluorophenyl vinylsulfonates: synthesis of sulfonates and sulfonamides

scientific article published on 25 August 2009

A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy

scientific article

A facile synthesis of dibenzopyrroloazepinones as tetracyclic allocolchicinoids--an unusual 1,2-phenyl shift

scientific article published on 30 November 2009

A facile synthesis of pyrrolo-(di)-benzazocinones via an intramolecular N-acyliminium ion cyclisation

scientific article

A microwave enhanced cross-metathesis approach to peptidomimetics

scientific article published on 05 February 2007

A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates.

scientific article published in March 2015

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

scientific article published on July 2013

A new route to sulfonamides via intermolecular radical addition to pentafluorophenyl vinylsulfonate and subsequent aminolysis

scientific article published on 01 July 2002

A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification.

scientific article published on 18 June 2013

A novel synthesis of (di)-benzazocinones via an endocyclic N-acyliminium ion cyclisation

scientific article published on 13 January 2011

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

scientific article published on 4 March 2015

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.

scientific article published on 25 June 2015

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.

scientific article

A rapid, site-selective and efficient route to the dual modification of DARPins.

scientific article

Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.

scientific article published on September 2013

Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones.

scientific article published on 29 November 2013

An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity.

scientific article published on 30 April 2010

An efficient synthesis of epoxydiynes and a key fragment of neocarzinostatin chromophore

scientific article published on 01 January 2007

An investigation into the electrophilic cyclisation of N-acyl-pyrrolidinium ions: a facile synthesis of pyrrolo-tetrahydroisoquinolones and pyrrolo-benzazepinones

scientific article published on 9 July 2009

Axial coordination of NHC ligands on dirhodium(II) complexes: generation of a new family of catalysts.

scientific article

Bioconjugation of green fluorescent protein via an unexpectedly stable cyclic sulfonium intermediate.

scientific article

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents

scientific article published on 01 January 2014

Bromomaleimide-linked bioconjugates are cleavable in mammalian cells

scientific article published on 18 November 2011

Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1).

scientific article published on February 2006

Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore.

scientific article published on June 2003

Controlling diastereoselectivity in the reactions of enantiomerically pure alpha-bromoacyl-imidazolidinones with nitrogen nucleophiles: substitution reactions with retention or inversion of configuration

scientific article published on 8 February 2005

Corrigendum: Recent advances in the construction of antibody-drug conjugates

scientific article published on 01 March 2016

Cyclisation reactions of N-cinnamoyl-9-aminoanthracenes

scientific article published on 11 April 2014

Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins

scientific article

Density functional and spectroscopic studies of nitrogen inversion in substituted dizocilpines

Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin

scientific article published in September 2004

Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst

scientific article published on 6 June 2008

Diastereomer configurations from joint experimental-computational analysis

scientific article published on 5 July 2012

Dioxygen mediated hydroacylation of vinyl sulfonates and sulfones on water

scientific article published on 13 November 2009

Direct synthesis of sulfonamides and activated sulfonate esters from sulfonic acids

scientific article published in February 2004

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

scientific article

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

scientific article published on 05 June 2015

Functionalisation of aldehydes via aerobic hydroacylation of azodicarboxylates 'on' water

scientific article published on 01 February 2011

Generalized epilepsies: emerging insights into cellular and genetic mechanisms.

scientific article published on April 1997

Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

scientific article published on 21 March 2012

Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones.

scientific article

Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'.

scientific article published on January 2013

Hydroacylation of alpha,beta-unsaturated esters via aerobic C-H activation

scientific article published on 06 June 2010

Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability

scientific article published on 01 March 2016

Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides

scientific article

Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.

scientific article published on 11 October 2005

Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors

scientific article

Metal-free, hydroacylation of C=C and N=N bonds via aerobic C-H activation of aldehydes, and reaction of the products thereof

scientific article published on 01 November 2013

Microwave enhanced palladium catalysed coupling reactions: a diversity-oriented synthesis approach to functionalised flavones

scientific article published on 01 December 2006

NHC/Iron cooperative catalysis: aerobic oxidative esterification of aldehydes with phenols

scientific article published on 21 March 2011

NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat

scientific article published on 01 November 1997

New synthesis of beta-sultams from pentafluorophenyl sulfonates

scientific article published on 01 November 2006

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

scientific article published on October 2014

Next-generation disulfide stapling: reduction and functional re-bridging all in one.

scientific article published on 15 September 2015

Observations on the reactivity of pentafluorophenyl sulfonate esters

scientific article published on 15 April 2005

Optical control of trimeric P2X receptors and acid-sensing ion channels

scientific article published on 23 December 2013

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

scientific article published on 14 March 2017

Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.

scientific article published in June 2014

Photodetachment spectra of deprotonated fluorescent protein chromophore anions.

scientific article published on 19 July 2012

Polymeric Dibromomaleimides As Extremely Efficient Disulfide Bridging Bioconjugation and Pegylation Agents

scientific article published on 13 January 2012

Post-translational site-selective protein backbone α-deuteration

article

Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic.

scientific article published in May 2007

Recent advances in the construction of antibody-drug conjugates

scientific article published on 04 January 2016

Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment

scientific article published on 7 March 2014

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.

scientific article published on 4 September 2015

Solid-phase intermolecular radical reactions 2: synthesis of C-glycopeptide mimetics via a novel acrylate acceptor

scientific article published on 01 May 2002

Studies of the lethargic (lh/lh) mouse model of absence seizures: regulatory mechanisms and identification of the lh gene.

scientific article

Studies on high-temperature amination reactions of aromatic chlorides using discrete palladium-N-heterocyclic carbene (NHC) complexes and in situ palladium/imidazolium salt protocols

scientific article published in January 2003

Synthesis and reactivity of alkyl-palladium N-heterocyclic carbene complexes.

scientific article

Synthesis of functionalized sulfonamides via 1,3-dipolar cycloaddition of pentafluorophenyl vinylsulfonate.

scientific article published on July 2003

Synthesis of inositol phosphate ligands of plant hormone-receptor complexes: pathways of inositol hexakisphosphate turnover

scientific article published in June 2012

Synthesis of novel and potent vorapaxar analogues.

scientific article published in March 2016

Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates

scientific article

Synthetic and structural studies on amine coordination to Pd-N-heterocyclic carbene complexes

scientific article published on 21 July 2009

Synthetic ligands for apo-neocarzinostatin

scientific article published on 01 April 2006

Synthetic strategies to epoxydiynes and a key synthon of the neocarzinostatin chromophore

scientific article published on 3 October 2007

Synthetic, structural, and mechanistic studies on the oxidative addition of aromatic chlorides to a palladium (N-heterocyclic carbene) complex: relevance to catalytic amination

scientific article published in August 2003

TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

scientific article

Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.

scientific article published on 21 November 2013

The acid-mediated ring opening reactions of α-aryl-lactams

scientific article published on 12 March 2012

The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists.

scientific article

The triflic acid-mediated cyclization reactions of N-cinnamoyl-1-naphthylamines

scientific article published on 24 October 2013

Trichlorophenol (TCP) sulfonate esters: a selective alternative to pentafluorophenol (PFP) esters and sulfonyl chlorides for the preparation of sulfonamides

scientific article published on 21 December 2006

Triflic acid-mediated phenylation of N-acylaminoalkyl diethylacetals and N-acyl-2-phenyl cyclic amides

scientific article published on 20 April 2011

Tuning the Reactivity of Dirhodium(II) Complexes with Axial N-Heterocyclic Carbene Ligands: The Arylation of Aldehydes

scientific article published on 01 January 2007

Unusual reactivity of a nickel N-heterocyclic carbene complex: tert-butyl group cleavage and silicone grease activation

scientific article published in November 2004

Wiki and other ways to share learning online.

scientific article published in August 2006

List of works by Stephen Caddick

3,5-Isoxazoles from alpha-bromo-pentafluorophenyl vinylsulfonates: synthesis of sulfonates and sulfonamides

A HER2 selective theranostic agent for surgical resection guidance and photodynamic therapy

A facile synthesis of dibenzopyrroloazepinones as tetracyclic allocolchicinoids--an unusual 1,2-phenyl shift

A facile synthesis of pyrrolo-(di)-benzazocinones via an intramolecular N-acyliminium ion cyclisation

A microwave enhanced cross-metathesis approach to peptidomimetics

A mild TCEP-based para-azidobenzyl cleavage strategy to transform reversible cysteine thiol labelling reagents into irreversible conjugates.

A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones

A new route to sulfonamides via intermolecular radical addition to pentafluorophenyl vinylsulfonate and subsequent aminolysis

A novel approach to the site-selective dual labelling of a protein via chemoselective cysteine modification.

A novel synthesis of (di)-benzazocinones via an endocyclic N-acyliminium ion cyclisation

A novel synthetic chemistry approach to linkage-specific ubiquitin conjugation.

A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine.

A plug-and-play approach to antibody-based therapeutics via a chemoselective dual click strategy.

A rapid, site-selective and efficient route to the dual modification of DARPins.

Acid-cleavable thiomaleamic acid linker for homogeneous antibody-drug conjugation.

Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones.

An efficient asymmetric synthesis of the potent beta-blocker ICI-118,551 allows the determination of enantiomer dependency on biological activity.

An efficient synthesis of epoxydiynes and a key fragment of neocarzinostatin chromophore

An investigation into the electrophilic cyclisation of N-acyl-pyrrolidinium ions: a facile synthesis of pyrrolo-tetrahydroisoquinolones and pyrrolo-benzazepinones

Axial coordination of NHC ligands on dirhodium(II) complexes: generation of a new family of catalysts.

Bioconjugation of green fluorescent protein via an unexpectedly stable cyclic sulfonium intermediate.

Bromo- and thiomaleimides as a new class of thiol-mediated fluorescence 'turn-on' reagents

Bromomaleimide-linked bioconjugates are cleavable in mammalian cells

Characterization of an Arabidopsis inositol 1,3,4,5,6-pentakisphosphate 2-kinase (AtIPK1).

Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore.

Controlling diastereoselectivity in the reactions of enantiomerically pure alpha-bromoacyl-imidazolidinones with nitrogen nucleophiles: substitution reactions with retention or inversion of configuration

Corrigendum: Recent advances in the construction of antibody-drug conjugates

Cyclisation reactions of N-cinnamoyl-9-aminoanthracenes

Cysteine promoted C-terminal hydrazinolysis of native peptides and proteins

Density functional and spectroscopic studies of nitrogen inversion in substituted dizocilpines

Design and synthesis of a nitrogen mustard derivative stabilized by apo-neocarzinostatin

Development of a practical Buchwald-Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst

Diastereomer configurations from joint experimental-computational analysis

Dioxygen mediated hydroacylation of vinyl sulfonates and sulfones on water

Direct synthesis of sulfonamides and activated sulfonate esters from sulfonic acids

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody-drug conjugate (ADC)

Functionalisation of aldehydes via aerobic hydroacylation of azodicarboxylates 'on' water

Generalized epilepsies: emerging insights into cellular and genetic mechanisms.

Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides

Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones.

Homogeneous antibody fragment conjugation by disulfide bridging introduces 'spinostics'.

Hydroacylation of alpha,beta-unsaturated esters via aerobic C-H activation

Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability

Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides

Inhibition of dimethylarginine dimethylaminohydrolase (DDAH) and arginine deiminase (ADI) by pentafluorophenyl (PFP) sulfonates.

Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors

Metal-free, hydroacylation of C=C and N=N bonds via aerobic C-H activation of aldehydes, and reaction of the products thereof

Microwave enhanced palladium catalysed coupling reactions: a diversity-oriented synthesis approach to functionalised flavones

NHC/Iron cooperative catalysis: aerobic oxidative esterification of aldehydes with phenols

NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat

New synthesis of beta-sultams from pentafluorophenyl sulfonates

Next generation maleimides enable the controlled assembly of antibody-drug conjugates via native disulfide bond bridging

Next-generation disulfide stapling: reduction and functional re-bridging all in one.

Observations on the reactivity of pentafluorophenyl sulfonate esters

Optical control of trimeric P2X receptors and acid-sensing ion channels

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

Pharmacological inhibition of DDAH1 improves survival, haemodynamics and organ function in experimental septic shock.

Photodetachment spectra of deprotonated fluorescent protein chromophore anions.

Polymeric Dibromomaleimides As Extremely Efficient Disulfide Bridging Bioconjugation and Pegylation Agents

Post-translational site-selective protein backbone α-deuteration

Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic.

Recent advances in the construction of antibody-drug conjugates

Regioselective and stoichiometrically controlled conjugation of photodynamic sensitizers to a HER2 targeting antibody fragment

Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic.

Solid-phase intermolecular radical reactions 2: synthesis of C-glycopeptide mimetics via a novel acrylate acceptor

Studies of the lethargic (lh/lh) mouse model of absence seizures: regulatory mechanisms and identification of the lh gene.

Studies on high-temperature amination reactions of aromatic chlorides using discrete palladium-N-heterocyclic carbene (NHC) complexes and in situ palladium/imidazolium salt protocols

Synthesis and reactivity of alkyl-palladium N-heterocyclic carbene complexes.

Synthesis of functionalized sulfonamides via 1,3-dipolar cycloaddition of pentafluorophenyl vinylsulfonate.

Synthesis of inositol phosphate ligands of plant hormone-receptor complexes: pathways of inositol hexakisphosphate turnover

Synthesis of novel and potent vorapaxar analogues.

Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates

Synthetic and structural studies on amine coordination to Pd-N-heterocyclic carbene complexes

Synthetic ligands for apo-neocarzinostatin

Synthetic strategies to epoxydiynes and a key synthon of the neocarzinostatin chromophore

Synthetic, structural, and mechanistic studies on the oxidative addition of aromatic chlorides to a palladium (N-heterocyclic carbene) complex: relevance to catalytic amination

TGFβ upregulates PAR-1 expression and signalling responses in A549 lung adenocarcinoma cells

Targeting cancer cells with folic acid-iminoboronate fluorescent conjugates.