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List of works by Wilfried Niessen

A high-throughput sample preparation method for cellular proteomics using 96-well filter plates ⬇️

scientific article published on September 17, 2013

A microfluidic-based enzymatic assay for bioactivity screening combined with capillary liquid chromatography and mass spectrometry

scientific article published on 22 September 2005

A new method for the analysis of styrene mercapturic acids by liquid chromatography/electrospray tandem mass spectrometry

scientific article published on 01 January 2000

Advances in instrumentation in liquid chromatography-mass spectrometry and related liquid-introduction techniques.

scientific article

Advances in mass spectrometry-based post-column bioaffinity profiling of mixtures

scientific article

An efficient analytical platform for on-line microfluidic profiling of neuroactive snake venoms towards nicotinic receptor affinity

scientific article

Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism.

scientific article published on 10 December 2010

Analysis of antibiotics by liquid chromatography–mass spectrometry ⬇️

scientific article published on 01 July 1998

Analytical separation and detection methods for flavonoids.

scientific article

At-line coupling of LC-MS to bioaffinity and selectivity assessment for metabolic profiling of ligands towards chemokine receptors CXCR1 and CXCR2.

scientific article published on 10 August 2015

At-line nanofractionation with parallel mass spectrometry and bioactivity assessment for the rapid screening of thrombin and factor Xa inhibitors in snake venoms.

scientific article published on 18 December 2015

Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry.

scientific article published on 19 September 2007

Bioanalytical LC-MS of therapeutic oligonucleotides

scientific article published on March 2011

Bioanalytical LC-MS/MS of protein-based biopharmaceuticals

scientific article published on 26 April 2013

Characterization of photodegradation products of alachlor in water by on-line solid-phase extraction liquid chromatography combined with tandem mass spectrometry and orthogonal-acceleration time-of-flight mass spectrometry

scientific article published on 01 January 2000

Confirmation of organic micropollutants detected in environmental samples by liquid chromatography tandem mass spectrometry: Achievements and pitfalls

Derivatization of carboxylic acids with 4-APEBA for detection by positive-ion LC-ESI-MS(/MS) applied for the analysis of prostanoids and NSAID in urine

scientific article published on 03 December 2010

Derivatization of the tricarboxylic acid cycle intermediates and analysis by online solid-phase extraction-liquid chromatography-mass spectrometry with positive-ion electrospray ionization

scientific article published on 6 August 2011

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.

scientific article

Determination of naphthalene metabolites in human urine by liquid chromatography-mass spectrometry with electrospray ionization

scientific article published on 01 June 1999

Determination of patterns of biologically relevant aldehydes in exhaled breath condensate of healthy subjects by liquid chromatography/atmospheric chemical ionization tandem mass spectrometry.

scientific article

Determination of pesticides in vegetables using large-volume injection column liquid chromatography-electrospray tandem mass spectrometry

scientific article published on 01 September 2000

Determination ofn-hexane metabolites by liquid chromatography/mass spectrometry 1. 2,5-Hexanedione and other phase I metabolites in untreated and hydrolyzed urine samples by atmospheric pressure chemical ionization ⬇️

scientific article published on January 1, 1998

Developing strategies for isolation of minor impurities with mass spectrometry-directed fractionation

scientific article published in September 2002

Development and optimization of a system for comprehensive two-dimensional liquid chromatography with UV and mass spectrometric detection for the separation of complex samples by multi-step gradient elution

scientific article published on 04 March 2008

Development of a selective ESI-MS derivatization reagent: synthesis and optimization for the analysis of aldehydes in biological mixtures.

scientific article published in December 2008

Development of a simplified method for the simultaneous determination of retinol, alpha-tocopherol, and beta-carotene in serum by liquid chromatography-tandem mass spectrometry with atmospheric pressure chemical ionization.

scientific article

Development of an on-line weak-cation exchange liquid chromatography-tandem mass spectrometric method for screening aldehyde products in biological matrices

scientific article published on 14 October 2009

Development of on-line liquid chromatography-biochemical detection for soluble epoxide hydrolase inhibitors in mixtures

journal article published in 2013

EC-SPE-stripline-NMR analysis of reactive products: a feasibility study

scientific article published on 30 June 2013

Evaluation of Alternate Isotope-Coded Derivatization Assay (AIDA) in the LC-MS/MS analysis of aldehydes in exhaled breath condensate

scientific article published on 16 February 2010

Evaluation of different column chemistries for fast urinary metabolic profiling

scientific article

Fragmentation of toxicologically relevant drugs in negative‐ion liquid chromatography–tandem mass spectrometry ⬇️

scientific article published on July 24, 2012

Fragmentation of toxicologically relevant drugs in positive‐ion liquid chromatography–tandem mass spectrometry ⬇️

scientific article published on February 3, 2011

Fragmentation pathways of drugs of abuse and their metabolites based on QTOF MS/MS and MS(E) accurate-mass spectra.

scientific article published in September 2011

Group-specific fragmentation of pesticides and related compounds in liquid chromatography-tandem mass spectrometry

scientific article published on 26 September 2009

HPLC coupled on-line to ESI-MS and a DPPH-based assay for the rapid identification of anti-oxidants in Butea superba

scientific article published in November 2005

High temperature liquid chromatography hyphenated with ESI-MS and ICP-MS detection for the structural characterization and quantification of halogen containing drug metabolites

scientific article published on 05 May 2011

High throughput screening methodologies classified for major drug target classes according to target signaling pathways

scientific article published on July 2010

High-performance liquid chromatography-mass spectrometry-based acetylcholinesterase assay for the screening of inhibitors in natural extracts

scientific article published on 3 March 2006

High-resolution bioactivity profiling of mixtures toward the acetylcholine binding protein using a nanofractionation spotter technology

scientific article published on 28 July 2011

High-resolution metabolic profiling towards G protein-coupled receptors: rapid and comprehensive screening of histamine H₄ receptor ligands.

scientific article

High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection

scientific article

Identification and quantification of drug-albumin adducts in serum samples from a drug exposure study in mice

scientific article published on 9 January 2013

Identification of 4-hydroxyandrost-4-ene-3,17-dione metabolites in prostatic cancer patients by liquid chromatography-mass spectrometry

scientific article published on 01 May 1992

Identification of topaquinone, as illustrated for pig kidney diamine oxidase and Escherichia coli amine oxidase

scientific article published on 01 September 1995

Investigation of degradation products of cocaine and benzoylecgonine in the aquatic environment.

scientific article

LC-MS systems for quantitative bioanalysis

scientific article published on 01 October 2012

Ligand-exchange detection of phosphorylated peptides using liquid chromatography electrospray mass spectrometry

scientific article published in December 2003

Liquid chromatography with triple-quadrupole and quadrupole-time-of-flight mass spectrometry for the determination of micro-constituents - a comparison

scientific article published on 5 February 2004

Liquid chromatography-mass spectrometry in occupational toxicology: a novel approach to the study of biotransformation of industrial chemicals

scientific article

Liquid chromatography-thermospray tandem mass spectrometry for identification of a heptabarbital metabolite and sample work-up artefacts

scientific article published on 01 August 1991

Liquid chromatography/electrospray tandem mass spectrometry characterization of styrene metabolism in man and in rat.

scientific article published in January 2002

Metal-complex formation in continuous-flow ligand-exchange reactors studied by electrospray mass spectrometry

scientific article published on 18 January 2007

Mild and selective labeling of malondialdehyde with 2-aminoacridone: assessment of urinary malondialdehyde levels

scientific article published on 25 May 2011

Nanofractionation spotter technology for rapid contactless and high-resolution deposition of LC eluent for further off-line analysis.

scientific article published on 30 November 2010

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

scientific article published on 04 May 2018

On-capillary isotachophoresis for loadability enhancement in capillary zone electrophoresis/mass spectrometry of β-agonists

scientific article published on 01 June 1994

On-line continuous-flow dialysis thermospray tandem mass spectrometry for quantitative screening of drugs in plasma: rogletimide

scientific article published on 01 May 1992

On-line coupling of high-performance liquid chromatography to a continuous-flow enzyme assay based on electrospray ionization mass spectrometry

scientific article published in June 2004

On-line coupling of surface plasmon resonance optical sensing to size-exclusion chromatography for affinity assessment of antibody samples

scientific article published on 9 May 2016

On-line dual-precolumn-based trace enrichment for the determination of polar and acidic microcontaminants in river water by liquid chromatography with diode-array UV and tandem mass spectrometric detection

scientific article published on 01 July 2000

On-line electrochemistry-bioaffinity screening with parallel HR-LC-MS for the generation and characterization of modified p38α kinase inhibitors.

scientific article published on 8 January 2012

On-line formation, separation, and estrogen receptor affinity screening of cytochrome P450-derived metabolites of selective estrogen receptor modulators

scientific article published on 21 June 2006

On-line solid-phase extraction-short-column liquid chromatography combined with various tandem mass spectrometric scanning strategies for the rapid study of transformation of pesticides in surface water

scientific article published on 01 May 1999

Online magnetic bead based dynamic protein affinity selection coupled to LC-MS for the screening of acetylcholine binding protein ligands.

scientific article

Optimization of information content in a mass spectrometry based flow-chemistry system by investigating different ionization approaches

scientific article

Photohuperzine A-A new photoisomer of huperzine A: structure elucidation, formation kinetics and activity assessment

scientific article published on 20 January 2010

Photon-independent gas-phase-ion formation in capillary electrophoresis-mass spectrometry using atmospheric pressure photoionization

scientific article

Production and on-line acetylcholinesterase bioactivity profiling of chemical and biological degradation products of tacrine

scientific article published on 18 April 2010

Protein digestion optimization for characterization of drug-protein adducts using response surface modeling

scientific article published on 21 December 2010

Pseudo-electrochromatography--negative-ion electrospray mass spectrometry of aromatic glucuronides and food colours

scientific article published on 01 September 1993

Quantitative determination of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine, 8-oxo-7,8-dihydroguanine, 8-oxo-7,8-dihydroguanosine, and their non-oxidized forms: daily concentration profile in healthy volunteers.

scientific article published in May 2010

Rapid target analysis of microcontaminants in water by on-line single-short-column liquid chromatography combined with atmospheric pressure chemical ionization ion-trap mass spectrometry.

scientific article

Rapid target analysis of microcontaminants in water by on-line single-short-column liquid chromatography combined with atmospheric pressure chemical ionization tandem mass spectrometry.

scientific article

Recent Advancements in the LC- and GC-Based Analysis of Malondialdehyde (MDA): A Brief Overview.

scientific article published on 08 April 2012

Recent developments in protein-ligand affinity mass spectrometry.

scientific article

Screening for metal ligands by liquid chromatography--ligand-exchange--electrospray mass spectrometry

scientific article published on 12 September 2005

Selective detection and identification of phosphorylated proteins by simultaneous ligand-exchange fluorescence detection and mass spectrometry

scientific article published on 03 July 2006

Selective quantitative bioanalysis of proteins in biological fluids by on-line immunoaffinity chromatography-protein digestion-liquid chromatography-mass spectrometry

scientific article published on 28 November 2005

Stability-indicating study of the anti-Alzheimer's drug galantamine hydrobromide

scientific article published on 22 January 2011

Static and scanning array detection in capillary electrophoresis-mass spectrometry

scientific article published on 01 September 1990

Structural elucidation of biologically active neomycin N-octyl derivatives in a regioisomeric mixture by means of liquid chromatography/ion trap time-of-flight mass spectrometry

scientific article published in May 2010

Studying protein-protein affinity and immobilized ligand-protein affinity interactions using MS-based methods

scientific article published on 14 July 2011

Tandem mass spectrometry of silver-adducted ferrocenyl catalyst complexes

scientific article published on 20 October 2010

Tandem mass spectrometry study of p38α kinase inhibitors and related substances.

scientific article

Targeted LC-MS derivatization for aldehydes and carboxylic acids with a new derivatization agent 4-APEBA

scientific article

The use of combined high-performance anion-exchange chromatography-thermospray mass spectrometry in the structural analysis of pectic oligosaccharides

scientific article published on 01 August 1994

Trace analysis of proteins using postseparation solution-phase digestion and electrospray mass spectrometric detection of marker peptides

scientific article published on 01 February 2007

Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s

scientific article published in November 2008

Use of quadrupole time-of-flight mass spectrometry in the elucidation of unknown compounds present in environmental water

scientific article

Use of soft and hard ionization techniques for elucidation of unknown compounds by gas chromatography/time‐of‐flight mass spectrometry ⬇️

scientific article published on June 15, 2011

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