List of works - Jaime Modiano

Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach

scientific article

The dog as a cancer model

article

Rethinking dog domestication by integrating genetics, archeology, and biogeography

scientific article

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

scientific article published on 11 May 2015

NFATc2-mediated repression of cyclin-dependent kinase 4 expression

scientific journal article

MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma

scientific article published on 11 January 2013

Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma

scientific article

Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes

scientific article published on 01 January 2003

Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk

scientific article

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

scientific article

Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

scientific article

Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed

scientific article

Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation.

scientific article published on July 2006

Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study

scientific article

Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: recent progress and applications

scientific article published on 24 February 2014

Molecular profiling reveals prognostically significant subtypes of canine lymphoma

scientific article

A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations

scientific article published on 6 November 2012

Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma

scientific article

Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression.

scientific article

Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium.

scientific article published on May 2004

Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

scientific article published on April 2009

Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart.

scientific article published on 11 August 2011

Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma

scientific article

Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment.

scientific article

Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization.

scientific article published on 11 February 2014

Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines

scientific article

Enhancing antimelanoma immune responses through apoptosis

scientific article

Canine cancer immunotherapy studies: linking mouse and human

scientific article

CD20 expression in normal canine B cells and in canine non-Hodgkin lymphoma

scientific article published on 01 July 2005

Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma

scientific article published in July 2001

Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors

scientific article published in December 2005

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers

scientific article

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

scientific article published on 16 September 2015

Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.

scientific article published on September 2005

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

scientific article

Development of a novel anti-canine CD20 monoclonal antibody with diagnostic and therapeutic potential

scientific article published on 16 June 2014

Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer

scientific article

Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.

scientific article published on 19 December 2017

Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma

scientific article published on 01 July 2007

Isolation and characterization of canine natural killer cells

scientific article

Posttranscriptional regulation of T-cell IL-2 production by human pooled immunoglobin

scientific article published on 01 April 1997

Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma

scientific article published on 21 September 2006

Comparative transcriptome analysis quantifies immune cell transcript levels, metastatic progression and survival in osteosarcoma.

scientific article published on 24 October 2017

Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

scientific article published on 25 April 2013

Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives.

scientific article published on 6 November 2015

MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines.

scientific article

Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis

scientific article

Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition

scientific article published on 01 September 2000

Progress in Adaptive Immunotherapy for Cancer in Companion Animals: Success on the Path to a Cure

scientific article published on 19 October 2015

Immunophysiological studies of interleukin-2 and canine lymphocytes

scientific article published on 01 June 1992

List of works by Jaime Modiano

Molecular subtypes of osteosarcoma identified by reducing tumor heterogeneity through an interspecies comparative approach

The dog as a cancer model

Rethinking dog domestication by integrating genetics, archeology, and biogeography

A Sleeping Beauty forward genetic screen identifies new genes and pathways driving osteosarcoma development and metastasis

NFATc2-mediated repression of cyclin-dependent kinase 4 expression

MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma

Perturbation of 14q32 miRNAs-cMYC gene network in osteosarcoma

Diagnosis of canine lymphoid neoplasia using clonal rearrangements of antigen receptor genes

Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Gene expression profiles of sporadic canine hemangiosarcoma are uniquely associated with breed

Canine hemangiosarcoma originates from hematopoietic precursors with potential for endothelial differentiation.

Preclinical evaluation of the novel, orally bioavailable Selective Inhibitor of Nuclear Export (SINE) KPT-335 in spontaneous canine cancer: results of a phase I study

Canine lymphoma as a comparative model for human non-Hodgkin lymphoma: recent progress and applications

Molecular profiling reveals prognostically significant subtypes of canine lymphoma

A genome-wide approach to comparative oncology: high-resolution oligonucleotide aCGH of canine and human osteosarcoma pinpoints shared microaberrations

Gene expression profiling identifies inflammation and angiogenesis as distinguishing features of canine hemangiosarcoma

Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression.

Canine malignant hemangiosarcoma as a model of primitive angiogenic endothelium.

Influence of genetic background on tumor karyotypes: evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart.

Targeting of beta adrenergic receptors results in therapeutic efficacy against models of hemangioendothelioma and angiosarcoma

Interleukin-8 promotes canine hemangiosarcoma growth by regulating the tumor microenvironment.

Identification of three molecular and functional subtypes in canine hemangiosarcoma through gene expression profiling and progenitor cell characterization.

Combinatorial treatment of DNA and chromatin-modifying drugs cause cell death in human and canine osteosarcoma cell lines

Enhancing antimelanoma immune responses through apoptosis

Canine cancer immunotherapy studies: linking mouse and human

CD20 expression in normal canine B cells and in canine non-Hodgkin lymphoma

Expression of S100a, vimentin, NSE, and melan A/MART-1 in seven canine melanoma cells lines and twenty-nine retrospective cases of canine melanoma

Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma.

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

Development of a novel anti-canine CD20 monoclonal antibody with diagnostic and therapeutic potential

Inflammation, apoptosis, and necrosis induced by neoadjuvant fas ligand gene therapy improves survival of dogs with spontaneous bone cancer

Radiotherapy enhances natural killer cell cytotoxicity and localization in pre-clinical canine sarcomas and first-in-dog clinical trial.

Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-cell lymphoma

Isolation and characterization of canine natural killer cells

Posttranscriptional regulation of T-cell IL-2 production by human pooled immunoglobin

Predictive value of p16 or Rb inactivation in a model of naturally occurring canine non-Hodgkin's lymphoma

Comparative transcriptome analysis quantifies immune cell transcript levels, metastatic progression and survival in osteosarcoma.

Hemangiosarcoma and its cancer stem cell subpopulation are effectively killed by a toxin targeted through epidermal growth factor and urokinase receptors

Pathobiology of Hemangiosarcoma in Dogs: Research Advances and Future Perspectives.

MiR-9 is overexpressed in spontaneous canine osteosarcoma and promotes a metastatic phenotype including invasion and migration in osteoblasts and osteosarcoma cell lines.

Chronic nicotine consumption does not influence 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis

Sustained nuclear localization of p21/WAF-1 upon growth arrest induced by contact inhibition

Progress in Adaptive Immunotherapy for Cancer in Companion Animals: Success on the Path to a Cure

Immunophysiological studies of interleukin-2 and canine lymphocytes