List of works - Robert L. Geahlen

A Mouse Model for the Study of SYK Function through Chemical Genetics Demonstrates SYK-Dependent Signaling through the B Cell Receptor, but Not TLR4

scientific article published on 01 July 2019

A Quantitative Proteomics-Based Competition Binding Assay to Characterize pITAM–Protein Interactions ⬇️

scientific article published on 08 May 2013

A general method for preparation of peptides biotinylated at the carboxy terminus

scientific article published on 01 April 1992

A novel quantitative proteomics strategy to study phosphorylation-dependent peptide-protein interactions

scientific article

Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck.

scientific article published on November 1996

Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores ⬇️

scientific article published on January 11, 2012

Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics.

scientific article

Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.

scientific article

DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase

scientific journal article

Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization

scientific article published in February 2001

Detection of a novel lymphocyte protein-tyrosine kinase by renaturation in polyacrylamide gels

scientific article published on 01 January 1986

Detection of kinase translocation using microfluidic electroporative flow cytometry

scientific article

Detection of myristoyl CoA:protein N-myristoyltransferase activity by ion-exchange chromatography

scientific article published on 01 September 1989

Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels

scientific article published on 01 February 1986

Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain

scientific article

Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.

scientific article published on 2 December 2004

Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid

scientific article published in February 2005

Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscope

scientific article

Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells ⬇️

scientific article published on October 1, 1992

Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor

scientific article published on 3 October 2007

Getting Syk: spleen tyrosine kinase as a therapeutic target.

scientific article

Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers.

scientific article

Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases

scientific article

Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics

scientific article published on 22 June 2013

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

scientific journal article

Identification of tyrosine 67 in bovine brain myelin basic protein as a specific phosphorylation site for thymus p56lck

scientific article published in August 1991

In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC.

scientific article published on February 2015

In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers

scientific article

Induction of a substrate for casein kinase II during lymphocyte mitogenesis

scientific article published on 01 June 1984

Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr

scientific journal article

Kinetics of NF-κB nucleocytoplasmic transport probed by single-cell screening without imaging ⬇️

scientific article published on September 8, 2010

Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells.

scientific article published on 16 May 2013

Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase

scientific article

Molecular interdiction of Src-family kinase signaling in hematopoietic cells.

scientific article published in October 2004

Multiplexed Quantitation of Protein Expression and Phosphorylation Based on Functionalized Soluble Nanopolymers ⬇️

scientific article published on October 24, 2012

Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B.

scientific article

One-step extraction of subcellular proteins from eukaryotic cells

scientific article published on 14 June 2010

PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac.

scientific article published in January 2002

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

scientific article

Phosphorylation of glycogen synthase by a bovine thymus protein-tyrosine kinase, p40

scientific article published on 01 August 1988

Posttranslational acylation of the transferrin receptor in LSTRA cells with myristate, palmitate and stearate: evidence for distinct acyltransferases.

scientific article published on June 1994

Properties of a tyrosine protein kinase from calf thymus. Response to ionic strength and divalent cations

scientific article published on 01 June 1985

Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap

scientific article

Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry

scientific article

Renaturation and assay of protein kinases after electrophoresis in sodium dodecyl sulfate-polyacrylamide gels

scientific article published in January 1991

Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.

scientific article published on 12 May 2009

Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor.

scientific article

Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.

scientific article published on 26 March 2012

Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease.

scientific article

Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase

scientific journal article

Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor

scientific article

Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.

scientific article

Syk and pTyr'd: Signaling through the B cell antigen receptor

scientific article published on 21 March 2009

Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit

scientific article published on 27 February 2013

Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.

scientific article

Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol

scientific article published on 01 October 1993

Synthesis and use of azido photoaffinity analogs of adenine and guanine nucleotides

scientific article published on January 1, 1979

Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity.

scientific article published on June 2012

Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA:protein N-myristoyltransferase

scientific article published on 01 February 1994

The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl

scientific article

The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.

scientific article

The microtubule-associated protein tau is phosphorylated by Syk

scientific article

The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling

scientific article (publication date: 3 April 2002)

The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2

scientific article

The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2 ⬇️

scientific article published on October 12, 2011

Total internal reflection fluorescence flow cytometry

scientific article

Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with Vav

scientific article

Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases

scientific article published in November 2001

List of works by Robert L. Geahlen

A Mouse Model for the Study of SYK Function through Chemical Genetics Demonstrates SYK-Dependent Signaling through the B Cell Receptor, but Not TLR4

A Quantitative Proteomics-Based Competition Binding Assay to Characterize pITAM–Protein Interactions ⬇️

A general method for preparation of peptides biotinylated at the carboxy terminus

A novel quantitative proteomics strategy to study phosphorylation-dependent peptide-protein interactions

Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck.

Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores ⬇️

Anti-sulfonylbenzoate antibodies as a tool for the detection of nucleotide-binding proteins for functional proteomics.

Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.

DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase

Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization

Detection of a novel lymphocyte protein-tyrosine kinase by renaturation in polyacrylamide gels

Detection of kinase translocation using microfluidic electroporative flow cytometry

Detection of myristoyl CoA:protein N-myristoyltransferase activity by ion-exchange chromatography

Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels

Differential recognition of syk-binding sites by each of the two phosphotyrosine-binding pockets of the Vav SH2 domain

Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.

Effect of phosphorylation of ovalbumin on adsorption by aluminum-containing adjuvants and elution upon exposure to interstitial fluid

Fast, multi-frequency, and quantitative nanomechanical mapping of live cells using the atomic force microscope

Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells ⬇️

Generation of an analog-sensitive Syk tyrosine kinase for the study of signaling dynamics from the B cell antigen receptor

Getting Syk: spleen tyrosine kinase as a therapeutic target.

Global phosphoproteomics of activated B cells using complementary metal ion functionalized soluble nanopolymers.

Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases

Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics

Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

Identification of tyrosine 67 in bovine brain myelin basic protein as a specific phosphorylation site for thymus p56lck

In-Depth Analyses of B Cell Signaling Through Tandem Mass Spectrometry of Phosphopeptides Enriched by PolyMAC.

In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers

Induction of a substrate for casein kinase II during lymphocyte mitogenesis

Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr

Kinetics of NF-κB nucleocytoplasmic transport probed by single-cell screening without imaging ⬇️

Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells.

Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase

Molecular interdiction of Src-family kinase signaling in hematopoietic cells.

Multiplexed Quantitation of Protein Expression and Phosphorylation Based on Functionalized Soluble Nanopolymers ⬇️

Nanomechanical property maps of breast cancer cells as determined by multiharmonic atomic force microscopy reveal Syk-dependent changes in microtubule stability mediated by MAP1B.

One-step extraction of subcellular proteins from eukaryotic cells

PTEN controls immunoreceptor (immunoreceptor tyrosine-based activation motif) signaling and the activation of Rac.

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

Phosphorylation of glycogen synthase by a bovine thymus protein-tyrosine kinase, p40

Posttranslational acylation of the transferrin receptor in LSTRA cells with myristate, palmitate and stearate: evidence for distinct acyltransferases.

Properties of a tyrosine protein kinase from calf thymus. Response to ionic strength and divalent cations

Proteomic studies of Syk-interacting proteins using a novel amine-specific isotope tag and GFP nanotrap

Quantitative analysis of protein translocations by microfluidic total internal reflection fluorescence flow cytometry

Renaturation and assay of protein kinases after electrophoresis in sodium dodecyl sulfate-polyacrylamide gels

Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells.

Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor.

Sensitive kinase assay linked with phosphoproteomics for identifying direct kinase substrates.

Stress Granules Modulate SYK to Cause Microglial Cell Dysfunction in Alzheimer's Disease.

Structural basis for the requirement of two phosphotyrosine residues in signaling mediated by Syk tyrosine kinase

Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor

Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.

Syk and pTyr'd: Signaling through the B cell antigen receptor

Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit

Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival.

Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol

Synthesis and use of azido photoaffinity analogs of adenine and guanine nucleotides

Synthesis of a phosphoserine mimetic prodrug with potent 14-3-3 protein inhibitory activity.

Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA:protein N-myristoyltransferase

The Lck SH3 domain negatively regulates localization to lipid rafts through an interaction with c-Cbl

The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.

The microtubule-associated protein tau is phosphorylated by Syk

The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling

The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2

The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2 ⬇️

Total internal reflection fluorescence flow cytometry

Two Closely Spaced Tyrosines Regulate NFAT Signaling in B Cells via Syk Association with Vav

Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases