List of works - Huck Hui Ng

2013 Runme Shaw memorial lecture: clinical applications of stem cells in modern medicine--21st century and beyond

scientific article published in January 2014

A biophysical model for analysis of transcription factor interaction and binding site arrangement from genome-wide binding data

scientific article (publication date: December 2009)

A core Klf circuitry regulates self-renewal of embryonic stem cells

scientific article published on 10 February 2008

A fluorescent rosamine compound selectively stains pluripotent stem cells

scientific article

A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.

scientific article published on June 2013

A role for polyamine regulators in ESC self-renewal

scientific article published on 19 November 2012

Active repression of methylated genes by the chromosomal protein MBD1

scientific article

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

scientific article

Application of advanced technologies in ageing research

scientific article published on 17 November 2006

BLIMP1 regulates cell growth through repression of p53 transcription.

scholarly article

Biological Networks Governing the Acquisition, Maintenance, and Dissolution of Pluripotency: Insights from Functional Genomics Approaches

scientific article

CTRL+INSERT: retrotransposons and their contribution to regulation and innovation of the transcriptome

scientific article

Choreographing pluripotency and cell fate with transcription factors ⬇️

scientific article published on June 21, 2011

Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure

scientific article published in July 2014

Comprehensive benchmarking reveals H2BK20 acetylation as a distinctive signature of cell-state-specific enhancers and promoters

scientific article published on 8 March 2016

Computer and Statistical Analysis of Transcription Factor Binding and Chromatin Modifications by ChIP-seq data in Embryonic Stem Cell

scientific article published in June 2012

Cross-species de novo identification of cis-regulatory modules with GibbsModule: application to gene regulation in embryonic stem cells

scientific article published on 15 May 2008

Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways.

scientific article published on July 2015

Dissecting early differentially expressed genes in a mixture of differentiating embryonic stem cells

scientific article

Driving pluripotency and reprogramming: nuclear receptors at the helm.

scientific article published on 02 August 2013

Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells

scientific article published on February 2015

ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

scientific article published on 16 September 2015

Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells

scientific article

Evolution of the mammalian transcription factor binding repertoire via transposable elements

scientific article published on 5 August 2008

FoxO: A New Addition to the ESC Cartel ⬇️

scientific article published on September 2, 2011

Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells

scientific article published on 30 May 2013

Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.

scientific article published on April 2002

Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation

scientific article published on August 2007

Identifiability and privacy in pluripotent stem cell research

scientific article

In vivo epigenomic profiling of germ cells reveals germ cell molecular signatures

scientific article

Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges

scientific article

Investigating the bona fide differentiation capacity of human pluripotent stem cells

scientific article

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

scientific article

KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells

scientific article

Lab-grown mini-brains upgraded

scientific article published in August 2017

Looping around Reprogramming: The Topological Memory of Induced Pluripotency

scientific article published in May 2016

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

scientific article

Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation

scholarly article

Mapping the networks for pluripotency ⬇️

scientific article published on August 12, 2011

Mark the transition: chromatin modifications and cell fate decision ⬇️

scientific article published on September 20, 2011

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

scientific journal article

MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1.

scientific article

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

scientific article published on 26 July 2016

Molecular framework underlying pluripotency

scientific article published on 22 January 2008

Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells

scientific article published on April 2009

Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements

scientific article published on 10 July 2014

Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

scientific journal article

Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.

scientific article published on 22 July 2014

Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species

scientific article

SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells

scientific article

Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells

scientific article

Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

scientific article

Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.

scientific article published on 18 September 2008

Sox2: masterminding the root of cancer.

scientific article

Stem cell genome‐to‐systems biology ⬇️

scientific article published on April 11, 2011

T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways

scientific journal article

TGFbeta and SMADs talk to NANOG in human embryonic stem cells

scientific article

Tackling the epigenome: challenges and opportunities for collaboration ⬇️

scientific article published on October 1, 2010

Tbx3 improves the germ-line competency of induced pluripotent stem cells

scientific article

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

scientific article

The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

scientific journal article

The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.

scientific article

The metabolic programming of stem cells

scientific article published on February 2017

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

scientific article published on 30 March 2014

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation

scientific article published on 7 December 2017

The role of SON in splicing, development, and disease

scientific article

The transcriptional and signalling networks of pluripotency

scientific article published on May 2011

The transcriptional regulation of pluripotency

scientific article

Transcriptional Regulation in Embryonic Stem Cells ⬇️

scientific article published on January 1, 2010

Transcriptional and epigenetic regulations of embryonic stem cells

scientific article published on 20 August 2008

Transcriptional regulation of nanog by OCT4 and SOX2.

scientific article

Transcriptomic analysis of pluripotent stem cells: insights into health and disease

scientific article published on 27 October 2011

Translational potential of human brain organoids

scientific article

Transposable elements have rewired the core regulatory network of human embryonic stem cells

scientific article published on 6 June 2010

Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.

scientific article published on 6 August 2002

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

scientific article (publication date: 20 February 2004)

Uniform, optimal signal processing of mapped deep-sequencing data

scientific article

Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells

scientific article

Zfp143 regulates Nanog through modulation of Oct4 binding

scientific article published on 07 August 2008

Zic3 is required for maintenance of pluripotency in embryonic stem cells.

scientific article published on 31 January 2007

p53 functions as a negative regulator of osteoblastogenesis, osteoblast-dependent osteoclastogenesis, and bone remodeling

scientific article

p53-regulated transcriptional program associated with genotoxic stress-induced apoptosis

scientific article published on 11 March 2004

p73 supports cellular growth through c-Jun-dependent AP-1 transactivation

scientific article published on 13 May 2007

List of works by Huck Hui Ng

2013 Runme Shaw memorial lecture: clinical applications of stem cells in modern medicine--21st century and beyond

A biophysical model for analysis of transcription factor interaction and binding site arrangement from genome-wide binding data

A core Klf circuitry regulates self-renewal of embryonic stem cells

A fluorescent rosamine compound selectively stains pluripotent stem cells

A genetic and developmental pathway from STAT3 to the OCT4-NANOG circuit is essential for maintenance of ICM lineages in vivo.

A role for polyamine regulators in ESC self-renewal

Active repression of methylated genes by the chromosomal protein MBD1

Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation

Application of advanced technologies in ageing research

BLIMP1 regulates cell growth through repression of p53 transcription.

Biological Networks Governing the Acquisition, Maintenance, and Dissolution of Pluripotency: Insights from Functional Genomics Approaches

CTRL+INSERT: retrotransposons and their contribution to regulation and innovation of the transcriptome

Choreographing pluripotency and cell fate with transcription factors ⬇️

Coactivators p300 and CBP maintain the identity of mouse embryonic stem cells by mediating long-range chromatin structure

Comprehensive benchmarking reveals H2BK20 acetylation as a distinctive signature of cell-state-specific enhancers and promoters

Computer and Statistical Analysis of Transcription Factor Binding and Chromatin Modifications by ChIP-seq data in Embryonic Stem Cell

Cross-species de novo identification of cis-regulatory modules with GibbsModule: application to gene regulation in embryonic stem cells

Deterministic Restriction on Pluripotent State Dissolution by Cell-Cycle Pathways.

Dissecting early differentially expressed genes in a mixture of differentiating embryonic stem cells

Driving pluripotency and reprogramming: nuclear receptors at the helm.

Dynamic transcription of distinct classes of endogenous retroviral elements marks specific populations of early human embryonic cells

ELABELA Is an Endogenous Growth Factor that Sustains hESC Self-Renewal via the PI3K/AKT Pathway.

Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells

Evolution of the mammalian transcription factor binding repertoire via transposable elements

FoxO: A New Addition to the ESC Cartel ⬇️

Genome-wide kinase-chromatin interactions reveal the regulatory network of ERK signaling in human embryonic stem cells

Genome-wide location and regulated recruitment of the RSC nucleosome-remodeling complex.

Genome-wide mapping of RELA(p65) binding identifies E2F1 as a transcriptional activator recruited by NF-kappaB upon TLR4 activation

Identifiability and privacy in pluripotent stem cell research

In vivo epigenomic profiling of germ cells reveals germ cell molecular signatures

Induced pluripotent stem cells in Parkinson's disease: scientific and clinical challenges

Investigating the bona fide differentiation capacity of human pluripotent stem cells

Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells

KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells

Lab-grown mini-brains upgraded

Looping around Reprogramming: The Topological Memory of Induced Pluripotency

Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association

Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation

Mapping the networks for pluripotency ⬇️

Mark the transition: chromatin modifications and cell fate decision ⬇️

Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain

MicroRNA-134 modulates the differentiation of mouse embryonic stem cells, where it causes post-transcriptional attenuation of Nanog and LRH1.

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

Molecular framework underlying pluripotency

Molecules that promote or enhance reprogramming of somatic cells to induced pluripotent stem cells

Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements

Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells

Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.

Rewirable gene regulatory networks in the preimplantation embryonic development of three mammalian species

SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells

Sall4 interacts with Nanog and co-occupies Nanog genomic sites in embryonic stem cells

Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1

Sall4 regulates distinct transcription circuitries in different blastocyst-derived stem cell lineages.

Sox2: masterminding the root of cancer.

Stem cell genome‐to‐systems biology ⬇️

T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways

TGFbeta and SMADs talk to NANOG in human embryonic stem cells

Tackling the epigenome: challenges and opportunities for collaboration ⬇️

Tbx3 improves the germ-line competency of induced pluripotent stem cells

Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients

The Nuclear Receptor Nr5a2 Can Replace Oct4 in the Reprogramming of Murine Somatic Cells to Pluripotent Cells

The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells

The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.

The metabolic programming of stem cells

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

The role of Cdx2 as a lineage specific transcriptional repressor for pluripotent network during the first developmental cell lineage segregation

The role of SON in splicing, development, and disease

The transcriptional and signalling networks of pluripotency

The transcriptional regulation of pluripotency

Transcriptional Regulation in Embryonic Stem Cells ⬇️

Transcriptional and epigenetic regulations of embryonic stem cells

Transcriptional regulation of nanog by OCT4 and SOX2.

Transcriptomic analysis of pluripotent stem cells: insights into health and disease

Translational potential of human brain organoids

Transposable elements have rewired the core regulatory network of human embryonic stem cells

Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.

Unbiased mapping of transcription factor binding sites along human chromosomes 21 and 22 points to widespread regulation of noncoding RNAs

Uniform, optimal signal processing of mapped deep-sequencing data

Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells