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List of works by Spencer Williams

'Click' cycloaddition catalysts: copper(I) and copper(II) tris(triazolylmethyl)amine complexes

scientific article published on 27 March 2008

1,6-epithio- and 1,6-episeleno-β-d-glucopyranose: Useful adjuncts in the synthesis of 6-deoxy-β-d-glucopyranosides

2,6-Disubstituted benzoates as neighboring groups for enhanced diastereoselectivity in beta-galactosylation reactions: synthesis of beta-1,3-linked oligogalactosides related to arabinogalactan proteins

scientific article published on December 2009

2-Morpholinoisoflav-3-enes as flexible intermediates in the synthesis of phenoxodiol, isophenoxodiol, equol and analogues: vasorelaxant properties, estrogen receptor binding and Rho/RhoA kinase pathway inhibition.

scientific article

3',4'-Bis-difluoromethoxycinnamoylanthranilate (FT061): an orally-active antifibrotic agent that reduces albuminuria in a rat model of progressive diabetic nephropathy.

scientific article published on 8 October 2013

3′,4′-Dihydroxyflavonol reduces vascular contraction through Ca2+ desensitization in permeabilized rat mesenteric artery

scientific article published on 14 October 2011

5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice.

scientific article published in March 2006

5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria

scientific journal article

A Click Chemistry Approach to 5,5′-Disubstituted-3,3′-Bisisoxazoles from Dichloroglyoxime and Alkynes: Luminescent Organometallic Iridium and Rhenium Bisisoxazole Complexes

scientific article published on 02 July 2013

A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites

scientific article published on 01 September 2019

A building block approach to the synthesis of a family of S-linked α-1,6-oligomannosides.

scientific article

A carbon tetrachloride-free synthesis of N-phenyltrifluoroacetimidoyl chloride

scientific article published on 10 August 2017

A convenient gram-scale synthesis of uridine diphospho(13C6)glucose

scientific article published on 05 April 2006

A master of its sulfate

scientific article published on 01 August 2004

A new anti-fibrotic drug attenuates cardiac remodeling and systolic dysfunction following experimental myocardial infarction

scientific article published on 06 December 2012

A practical synthesis of long-chain iso-fatty acids (iso-C12-C19) and related natural products

scientific article published on 4 September 2013

A purpose-synthesised anti-fibrotic agent attenuates experimental kidney diseases in the rat

scientific article

A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties

scientific article

A sulfoglycolytic Entner-Doudoroff pathway in Rhizobium leguminosarum bv. trifolii SRDI565

scientific article published on 22 May 2020

A surface endogalactanase in Bacteroides thetaiotaomicron confers keystone status for arabinogalactan degradation

scientific article published on 22 October 2018

Acetylation of trehalose mycolates is required for efficient MmpL-mediated membrane transport in Corynebacterineae.

scientific article

Active-site peptide "fingerprinting" of glycosidases in complex mixtures by mass spectrometry. Discovery of a novel retaining beta-1,4-glycanase in Cellulomonas fimi

scientific article

An atypical interaction explains the high-affinity of a non-hydrolyzable S-linked 1,6-α-mannanase inhibitor

scientific article

An improved method to prepare an injectable microemulsion of the galanin-receptor 3 selective antagonist, SNAP 37889, using Kolliphor(®) HS 15.

scientific article published on 26 September 2014

Antigen Specificity of Type I NKT Cells Is Governed by TCR β-Chain Diversity.

scientific article published on 30 September 2015

Antioxidant activity contributes to flavonol cardioprotection during reperfusion of rat hearts ⬇️

scientific article published on July 18, 2011

Aryl sulfamates are broad spectrum inactivators of sulfatases: Effects on sulfatases from various sources

scientific article published on 20 November 2008

Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state

scientific article

Atomic resolution analyses of the binding of xylobiose-derived deoxynojirimycin and isofagomine to xylanase Xyn10A.

scientific article

Bacterial β-Glucosidase Reveals the Structural and Functional Basis of Genetic Defects in Human Glucocerebrosidase 2 (GBA2).

scientific article published on 26 April 2016

Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif.

scientific article published on 24 April 2018

C2-Oxyanion Neighboring Group Participation: Transition State Structure for the Hydroxide-Promoted Hydrolysis of 4-Nitrophenyl α-d-Mannopyranoside

scientific article published on 18 October 2016

Candida albicans steryl 6-O-acyl-α-D-mannosides agonize signalling through Mincle

scientific article published on 16 November 2020

Carbohydrate-active enzymes: sequences, shapes, contortions and cells

scientific article published on February 2016

Cardioprotective 3',4'-dihydroxyflavonol attenuation of JNK and p38(MAPK) signalling involves CaMKII inhibition.

scientific article published on December 2013

Chemical approaches for the study of the mycobacterial glycolipids phosphatidylinositol mannosides, lipomannan and lipoarabinomannan

scientific article published on 14 April 2010

Cholesteryl 6-O-acyl-α-glucosides from diverse Helicobacter spp. signal through the C-type lectin receptor Mincle

scientific article published on 30 September 2020

Chronic Brain Inflammation: The Neurochemical Basis for Drugs to Reduce Inflammation

scientific article published on 16 July 2015

Compartmentalization of lipid biosynthesis in mycobacteria.

scientific article

Comprehensive Synthesis of Substrates, Intermediates, and Products of the Sulfoglycolytic Embden-Meyerhoff-Parnas Pathway

scientific article published on 20 February 2019

Comprehensive two-dimensional gas chromatography, retention indices and time-of-flight mass spectra of flavonoids and chalcones

scientific article

Computational Design of Experiment Unveils the Conformational Reaction Coordinate of GH125 α-Mannosidases

scientific article published on 27 December 2016

Concise synthesis of sulfoquinovose and sulfoquinovosyl diacylglycerides, and development of a fluorogenic substrate for sulfoquinovosidases

scientific article published on 02 January 2020

Conformational Analysis of the Mannosidase Inhibitor Kifunensine: A Quantum Mechanical and Structural Approach

scientific article published on 11 May 2017

Conjugation of Transferrin to Azide-Modified CdSe/ZnS Core-Shell Quantum Dots using Cyclooctyne Click Chemistry

scientific article published on 20 September 2012

Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase

scientific article (publication date: 25 January 2017)

Copper and Silver Complexes of Tris(triazole)amine and Tris(benzimidazole)amine Ligands: Evidence that Catalysis of an Azide–Alkyne Cycloaddition (“Click”) Reaction by a Silver Tris(triazole)amine Complex Arises from Copper Impurities

scientific article published on 20 June 2014

Copper(I)-catalyzed cycloaddition of silver acetylides and azides: incorporation of volatile acetylenes into the triazole core

scientific article

Correction to "Synthetic β-1,2-Mannosyloxymannitol Glycolipid from the Fungus Malassezia pachydermatis Signals through Human Mincle"

scientific article published on 27 June 2019

Corrigendum: Evidence for a Boat Conformation at the Transition State of GH76 α-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism

scientific article published on 01 February 2016

Corynomycolic acid-containing glycolipids signal through the pattern recognition receptor Mincle

scientific article

Design of potent Mincle signalling agonists based on an alkyl β-glucoside template

scientific article published on 17 March 2020

Detailed structural analysis of glycosidase/inhibitor interactions: complexes of Cex from Cellulomonas fimi with xylobiose-derived aza-sugars

scientific article

Diazepam is not a direct allosteric modulator of α-adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase-4

scientific article published on 26 December 2018

Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates

scientific article

Discovery and characterization of a sulfoquinovose mutarotase using kinetic analysis at equilibrium by exchange spectroscopy

scientific article published on 13 March 2018

Discovery of N -Aryloxypropylbenzylamines as Voltage-Gated Sodium Channel NaV 1.2-Subtype-Selective Inhibitors

scientific article published on 12 February 2019

Discovery of inhibitors of Leishmania β-1,2-mannosyltransferases using a click-chemistry-derived guanosine monophosphate library

scientific article (publication date: 2012)

Discovery of sulfated metabolites in mycobacteria with a genetic and mass spectrometric approach

scientific article

Discovery of water-soluble antioxidant flavonols without vasorelaxant activity

scientific article published on October 2008

Dissecting conformational contributions to glycosidase catalysis and inhibition

scientific article published on 10 July 2014

Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors

scientific article published on 20 November 2019

Distortion of mannoimidazole supports a B2,5 boat transition state for the family GH125 α-1,6-mannosidase from Clostridium perfringens

scientific article published on 01 August 2019

Effects of 3',4'-dihydroxyflavonol on vascular contractions of rat aortic rings

scientific article published on 30 March 2010

Electronic Structure of the Sulfonyl and Phosphonyl Groups: A Computational and Crystallographic Study

scientific article published on 19 September 2007

Erratum: Corrigendum: Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

scientific article published in Nature

Evaluation and optimization of antifibrotic activity of cinnamoyl anthranilates

scientific article published on 7 October 2009

Evidence for a boat conformation at the transition state of GH76 α-1,6-mannanases--key enzymes in bacterial and fungal mannoprotein metabolism

scientific article

Experimental and theoretical insights into the mechanisms of sulfate and sulfamate ester hydrolysis and the end products of type I sulfatase inactivation by aryl sulfamates

scientific article published on 20 February 2014

Exploration of strategies for mechanism-based inhibitor design for family GH99 endo-α-1,2-mannanases

scientific article published on 5 March 2018

FT011, a new anti-fibrotic drug, attenuates fibrosis and chronic heart failure in experimental diabetic cardiomyopathy

scientific article published on 14 March 2012

FT23, an orally active antifibrotic compound, attenuates structural and functional abnormalities in an experimental model of diabetic cardiomyopathy

scientific article published in August 2012

Galactose-derived phosphonate analogues as potential inhibitors of phosphatidylinositol biosynthesis in mycobacteria

scientific article published on 30 January 2007

Galanin-3 receptor antagonism by SNAP 37889 reduces motivation to self-administer alcohol and attenuates cue-induced reinstatement of alcohol-seeking in iP rats

scientific article

Glycoconjugates: Structure and Biosynthesis

Glycoprotein misfolding in the endoplasmic reticulum: identification of released oligosaccharides reveals a second ER-associated degradation pathway for Golgi-retrieved proteins.

scientific article

Glycosyl fluorides in enzymatic reactions.

scientific article

Gram scale preparation of clozapine -oxide (CNO), a synthetic small molecule actuator for muscarinic acetylcholine DREADDs

Ground state structures of sulfate monoesters and sulfamates reveal similar reaction coordinates for sulfuryl and sulfamyl transfer

scientific article published on 21 November 2005

Halide-ion-templated Ag8Cu6 rhombic dodecahedrons: synthesis, structure and reactivity of [Ag8Cu6(CCtBu)12X]BF4 (X = Cl, Br)

scientific article published on 01 April 2013

High-resolution crystal structures of the lectin-like xylan binding domain from Streptomyces lividans xylanase 10A with bound substrates reveal a novel mode of xylan binding

scientific article

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

scientific article

Immune sensing of microbial glycolipids and related conjugates by T cells and the pattern recognition receptors MCL and Mincle

scientific article published on 08 December 2015

Investigation of benzoyloximes as benzoylating reagents: benzoyl-Oxyma as a selective benzoylating reagent

scientific article published on 04 November 2015

Leishmania beta-1,2-mannan is assembled on a mannose-cyclic phosphate primer.

scholarly article

Letter to the Glycoforum Transforming Glycoscience: An Australian Perspective

article

Lipid structure influences the ability of glucose monocorynomycolate to signal through Mincle

scientific article published in October 2016

Lipidomic Profiling of Adipose Tissue Reveals an Inflammatory Signature in Cancer-Related and Primary Lymphedema.

scientific article

Localization of oleuropeyl glucose esters and a flavanone to secretory cavities of Myrtaceae

scientific article

MCL and Mincle: C-Type Lectin Receptors That Sense Damaged Self and Pathogen-Associated Molecular Patterns

scientific article

Mechanistic insights into a Ca2+-dependent family of α-mannosidases in a human gut symbiont

scientific article

Mycobacterium tuberculosis β-gentiobiosyl diacylglycerides signal through the pattern recognition receptor Mincle: total synthesis and structure activity relationships

scientific article

Non-volatile components of the essential oil secretory cavities of Eucalyptus leaves: discovery of two glucose monoterpene esters, cuniloside B and froggattiside A.

scientific article published in June 2009

Novel microsomal triglyceride transfer protein inhibitors

Nucleus incertus promotes cortical desynchronization and behavioral arousal.

scientific article

Protein--carbohydrate interactions: learning lessons from nature.

scientific article

Quantitation in the regioselectivity of acylation of glycosyl diglycerides: total synthesis of a Streptococcus pneumoniae α-glucosyl diglyceride

scientific article published on 5 January 2017

Rapid, iterative assembly of octyl alpha-1,6-oligomannosides and their 6-deoxy equivalents

scientific article published on 20 April 2005

Spiro-epoxyglycosides as Activity-Based Probes for Glycoside Hydrolase Family 99 Endomannosidase/Endomannanase

scientific article published on 21 June 2018

Structural and Biochemical Insights into the Function and Evolution of Sulfoquinovosidases

scientific article published on 05 September 2018

Structural and kinetic dissection of the endo-α-1,2-mannanase activity of bacterial GH99 glycoside hydrolases from Bacteroides spp

scientific article

Structural and mechanistic insight into N-glycan processing by endo-α-mannosidase

scientific article

Structural and mechanistic insights into a Bacteroides vulgatus retaining N-acetyl-β-galactosaminidase that uses neighbouring group participation

scientific article published on 22 August 2016

Structure of human endo-α-1,2-mannosidase (MANEA), an antiviral host-glycosylation target

scientific article published on 05 November 2020

Structure-reactivity correlations of the abnormal Beckmann reaction of dihydrolevoglucosenone oxime

scientific article published on 24 November 2017

Sulfatase inhibitors: a patent review ⬇️

scientific article published on November 8, 2012

Sulfotransferases and sulfatases in mycobacteria

scientific article

Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination

scientific article published on October 2008

Synthesis and evaluation of dithiolethiones as novel cyclooxygenase inhibitors

scientific article

Synthesis and testing of mechanism-based protein-profiling probes for retaining endo-glycosidases

scientific article published on January 2006

Synthesis of a hypoxia-targeted conjugate of the cardioprotective agent 3′,4′-dihydroxyflavonol and evaluation of its ability to reduce ischaemia/reperfusion injury

scientific article published on 17 March 2011

Synthesis of glycoconjugate fragments of mycobacterial phosphatidylinositol mannosides and lipomannan

scientific article

Synthesis of sulfated glucosaminides for profiling substrate specificities of sulfatases and fungal beta-N-acetylhexosaminidases

scientific article published in February 2009

Synthesis of the monoterpenoid esters cypellocarpin C and cuniloside B and evidence for their widespread occurrence in Eucalyptus

article

Synthesis, structural elucidation, and biochemical analysis of immunoactive glucuronosyl diacylglycerides of mycobacteria and corynebacteria

scientific article published on 30 January 2013

Synthetic β-1,2-Mannosyloxymannitol Glycolipid from the Fungus Malassezia pachydermatis Signals through Human Mincle

scientific article published on 14 May 2019

The carbohydrate-binding promiscuity of Euonymus europaeus lectin is predicted to involve a single binding site.

scientific article published on 10 September 2014

The galanin-3 receptor antagonist, SNAP 37889, reduces operant responding for ethanol in alcohol-preferring rats

scientific article published on 22 August 2010

The metabolic repair enzyme phospho-glycolate phosphatase regulates central carbon metabolism and fosmidomycin sensitivity in Plasmodium falciparum

The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth

scientific article published in 2024

The reaction coordinate of a bacterial GH47 α-mannosidase: a combined quantum mechanical and structural approach

scientific article

Total Synthesis of Mycobacterium tuberculosis Dideoxymycobactin-838 and Stereoisomers: Diverse CD1a-Restricted T Cells Display a Common Hierarchy of Lipopeptide Recognition.

scientific article published on 7 December 2016

Total syntheses of cis-cyclopropane fatty acids: dihydromalvalic acid, dihydrosterculic acid, lactobacillic acid, and 9,10-methylenehexadecanoic acid

scientific article published on 16 October 2014

Total synthesis and mass spectrometric analysis of a Mycobacterium tuberculosis phosphatidylglycerol featuring a two-step synthesis of (R)-tuberculostearic acid.

scientific article

Total synthesis of a cyclopropane-fatty acid α-glucosyl diglyceride from Lactobacillus plantarum and identification of its ability to signal through Mincle

scientific article

Transition-State Mimicry by Glycosidase Inhibitors: A Critical Kinetic Analysis

scientific article published on 27 March 2007

Trehalose is required for growth of Mycobacterium smegmatis

scientific article published on 21 April 2004

Understanding the cardioprotective effects of flavonols: discovery of relaxant flavonols without antioxidant activity

scientific article

Use of click chemistry to define the substrate specificity of Leishmania beta-1,2-mannosyltransferases

scientific article published in September 2006

Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant.

scientific article published in April 2007

YihQ is a sulfoquinovosidase that cleaves sulfoquinovosyl diacylglyceride sulfolipids

scientific article

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