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List of works by Kwok Kin Wong

A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations

scientific article (publication date: 2 April 2010)

A dual role for the immune response in a mouse model of inflammation-associated lung cancer

scientific article

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

scientific article

A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer

scientific article published on 03 April 2013

A novel ALK secondary mutation and EGFR signaling cause resistance to ALK kinase inhibitors

scientific article

A systems biology pipeline identifies regulatory networks for stem cell engineering

scientific article published on 01 July 2019

Acquired resistance to dasatinib in lung cancer cell lines conferred by DDR2 gatekeeper mutation and NF1 loss

scientific article published on 02 December 2013

Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment

scientific article published on 23 April 2013

Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids

scientific article published on 05 December 2019

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints.

scientific article

Allele-dependent variation in the relative cellular potency of distinct EGFR inhibitors

scientific article published on 13 February 2007

Alterations of LKB1 and KRAS and risk of brain metastasis: comprehensive characterization by mutation analysis, copy number, and gene expression in non-small-cell lung carcinoma.

scientific article

Alu elements mediate MYB gene tandem duplication in human T-ALL

scientific article published on 10 December 2007

An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.

scientific article published on August 2005

Assessing Therapeutic Efficacy of MEK Inhibition in a KRASG12C-Driven Mouse Model of Lung Cancer

scientific article published on 26 June 2018

Author Correction: A systems biology pipeline identifies regulatory networks for stem cell engineering

scientific article published on 01 August 2019

Author Correction: Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models

scientific article published on 09 April 2020

Author Correction: MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

scientific article published on 24 February 2020

Author Correction: Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition

scientific article published on 01 October 2018

Autophagy sustains pancreatic cancer growth through both cell autonomous and non-autonomous mechanisms

scientific article

BAC consensus conference, November 4-6, 2004: epidemiology, pathogenesis, and preclinical models.

scientific article published on November 2006

BET Bromodomain Inhibition Cooperates with PD-1 Blockade to Facilitate Antitumor Response in Kras-Mutant Non-Small Cell Lung Cancer

scientific article published on 07 August 2018

BORIS promotes chromatin regulatory interactions in treatment-resistant cancer cells

scientific article published on 07 August 2019

CCAAT/enhancer binding protein β is dispensable for development of lung adenocarcinoma.

scientific article

CDK4/6 Inhibition Augments Anti-Tumor Immunity by Enhancing T Cell Activation.

scientific article published on 3 November 2017

CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury.

scientific article published on 11 December 2013

CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma

scientific article published on 06 January 2017

CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer

scientific article published on 26 December 2019

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

scientific article

CT angiography clot burden score and collateral score: correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct

scientific article published on 15 January 2009

CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC

scientific article published on 04 July 2019

Cetuximab response of lung cancer-derived EGF receptor mutants is associated with asymmetric dimerization

scientific article published on 24 September 2013

Characterization of the cell of origin for small cell lung cancer

scientific article published on 15 August 2011

Chromosomal end fusion resulting from telomere erosion increases susceptibility to radiation via multinucleation: effect of p53.

scientific article published in October 2006

Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer

scientific article

Clinical implications of monitoring nivolumab immunokinetics in non-small cell lung cancer patients

scientific article published on 04 October 2018

Co-clinical trials demonstrate superiority of crizotinib to chemotherapy in ALK-rearranged non-small cell lung cancer and predict strategies to overcome resistance

scientific article published on 10 December 2013

Co-occurring genomic alterations define major subsets of KRAS-mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

scientific article

Combined EGFR/MEK Inhibition Prevents the Emergence of Resistance in EGFR-Mutant Lung Cancer

scientific article published on 2 June 2015

Combined Use of ALK Immunohistochemistry and FISH for Optimal Detection of ALK-Rearranged Lung Adenocarcinomas ⬇️

scientific article published on March 1, 2013

Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

scientific article published on 26 June 2011

Correction to: Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

scientific article published on 04 July 2019

Corrigendum: Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

scientific article published in Nature

Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1

scientific article published on 28 January 2019

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

scientific article published on March 2014

DNA-dependent protein kinase catalytic subunit is not required for dysfunctional telomere fusion and checkpoint response in the telomerase-deficient mouse

scientific journal article

Design and generation of MLPA probe sets for combined copy number and small-mutation analysis of human genes: EGFR as an example.

scientific article

Development of Selective Covalent Janus Kinase 3 Inhibitors.

scientific article published on 10 August 2015

Differences underlying EGFR and HER2 oncogene addiction

scientific article

Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition.

scientific article published on 22 October 2009

Differential roles of telomere attrition in type I and II endometrial carcinogenesis.

scientific article published on 3 July 2008

Drug-sensitive FGFR2 mutations in endometrial carcinoma

scholarly article

Dual targeting of the PI3K/Akt/mTOR pathway as an antitumor strategy in Waldenstrom macroglobulinemia.

scientific article

EGFR targeted therapy: view from biological standpoint

scientific article published on 15 September 2006

ER stress signaling promotes the survival of cancer 'persister cells' tolerant to EGFR tyrosine kinase inhibitors

scientific article published on 19 December 2017

EZH2 Inhibitors: Take It EZy, It Is All About Context

scientific article published on 01 April 2019

EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors

scientific article

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation

scientific article published on 28 June 2018

Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

scientific article

Efficacy of BET bromodomain inhibition in Kras-mutant non-small cell lung cancer

scientific article published on 17 September 2013

Epidermal growth factor receptor variant III mutations in lung tumorigenesis and sensitivity to tyrosine kinase inhibitors

scholarly article

Epigenetic CRISPR screens identify Npm1 as a therapeutic vulnerability in non-small cell lung cancer

scientific article published on 09 July 2020

Erratum: Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

scientific article published on 9 June 2017

Evaluating TBK1 as a therapeutic target in cancers with activated IRF3.

scientific article published on 21 April 2014

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

scientific article published in Nature

Ewing sarcoma mimicking atypical carcinoid tumor: detection of unexpected genomic alterations demonstrates the use of next generation sequencing as a diagnostic tool

scientific article published in July 2014

Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors.

scientific article published on September 2011

Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers

scientific article published on 27 March 2014

False positive plasma genotyping due to clonal hematopoiesis

scientific article published on 22 March 2018

Fine needle aspirate flow cytometric phenotyping characterizes immunosuppressive nature of the mesothelioma microenvironment.

scientific article published on 19 August 2016

GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

scientific article

Gain-of-Function RHOA Mutations Promote Focal Adhesion Kinase Activation and Dependency in Diffuse Gastric Cancer

scientific article published on 26 November 2019

Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer.

scientific article

Gemcitabine and Chk1 Inhibitor AZD7762 Synergistically Suppress the Growth of Lkb1-Deficient Lung Adenocarcinoma

scientific article published on 28 July 2017

Generation of genetically engineered mouse lung organoid models for squamous cell lung cancers allows for the study of combinatorial immunotherapy

scientific article published on 24 March 2020

Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts.

scientific article published on 26 February 2018

Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors

scientific article published on 27 August 2018

Ground-glass opacity-featured lung adenocarcinoma has no response to chemotherapy

scientific article published on 30 April 2020

HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy

scientific article

HIF1α and HIF2α independently activate SRC to promote melanoma metastases

scientific article

HKI-272 in non small cell lung cancer.

scientific article published on August 2007

IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment

scientific article published on 05 July 2018

Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2.

scientific article published on 5 June 2015

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

scientific article published on 05 October 2009

Image-guided radiotherapy platform using single nodule conditional lung cancer mouse models

scientific article

In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma

scientific article published on 19 November 2019

In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis

scientific article published on 9 April 2018

Inhibition of ALK, PI3K/MEK, and HSP90 in murine lung adenocarcinoma induced by EML4-ALK fusion oncogene

scientific article

Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

scientific article

Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas

scientific article published on February 2016

Inhibitor-sensitive FGFR2 and FGFR3 mutations in lung squamous cell carcinoma

scientific article published on 20 June 2013

Innate αβ T Cells Mediate Antitumor Immunity by Orchestrating Immunogenic Macrophage Programming

scientific article published on 02 July 2019

Integrative genomic analysis reveals a high frequency of LKB1 genetic alteration in Chinese lung adenocarcinomas

scientific article published on 01 February 2014

Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors

scientific article

Integrative radiogenomic profiling of squamous cell lung cancer

scientific article published on 26 August 2013

Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma.

scientific article published on 24 November 2017

Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition

scientific article

Intron retention is a source of neoepitopes in cancer.

scientific article published on 16 August 2018

KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs

scientific article

Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a Pan-FGFR inhibitor in a mouse model of NSCLC

scientific article

LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response

scientific article published on 30 April 2015

LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling

scientific article

LKB1 loss promotes endometrial cancer progression via CCL2-dependent macrophage recruitment

scientific article

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

scientific article published on June 2012

Lkb1 inactivation drives lung cancer lineage switching governed by Polycomb Repressive Complex 2.

scientific article published on 7 April 2017

Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy

scientific article

Loss of Lkb1 and Pten leads to lung squamous cell carcinoma with elevated PD-L1 expression

scientific article

Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas

scientific article published in February 2008

Loss of p53 attenuates the contribution of IL-6 deletion on suppressed tumor progression and extended survival in Kras-driven murine lung cancer

scientific article (publication date: 2013)

Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.

scientific article

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells

scientific article

MUC1-C integrates type II interferon and chromatin remodeling pathways in immunosuppression of prostate cancer

scientific article published on 01 February 2022

MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

scientific article published on 17 January 2020

Mechanisms and clinical activity of an EGFR and HER2 exon 20-selective kinase inhibitor in non-small cell lung cancer.

scientific article published on 23 April 2018

Metformin prevents liver tumorigenesis by inhibiting pathways driving hepatic lipogenesis.

scientific article

Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition.

scientific article

Molecular determinants of response to matuzumab in combination with paclitaxel for patients with advanced non-small cell lung cancer

scientific article published on 10 March 2009

Mouse models of lung cancer.

scientific article published on July 2006

Multiparametric profiling of non-small-cell lung cancers reveals distinct immunophenotypes

scientific article published on 08 September 2016

Multiple roles of cyclin-dependent kinase 4/6 inhibitors in cancer therapy

scientific article published in February 2012

Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer

scientific article published on 2 July 2014

Mutations and PD-1 Inhibitor Resistance in -Mutant Lung Adenocarcinoma

scientific article published on 17 May 2018

Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models

scientific article published on 01 May 2007

Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer

scientific article

NF-kappaB fans the flames of lung carcinogenesis

scientific article published on 30 March 2010

NK Cells Mediate Synergistic Antitumor Effects of Combined Inhibition of HDAC6 and BET in a SCLC Preclinical Model

scientific article published on 14 May 2018

NSCLC Driven by DDR2 Mutation Is Sensitive to Dasatinib and JQ1 Combination Therapy

scientific article published on 23 July 2015

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis.

scientific article

New cast for a new era: preclinical cancer drug development revisited.

scientific article published on 03 September 2013

Non-small-cell lung cancers: a heterogeneous set of diseases

scientific article

Noncanonical agonist PPARγ ligands modulate the response to DNA damage and sensitize cancer cells to cytotoxic chemotherapy

scientific article published on 2 January 2018

Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma

scientific article published on 01 February 2020

Novel agents in the treatment of lung cancer: Fourth Cambridge Conference

scientific article published in August 2007

Novel mutant-selective EGFR kinase inhibitors against EGFR T790M

scientific article

Oncogenic Deregulation of EZH2 as an Opportunity for Targeted Therapy in Lung Cancer.

scientific article published on 16 June 2016

Outcomes by tumor histology and KRAS mutation status after lung stereotactic body radiation therapy for early-stage non-small-cell lung cancer

scientific article published on 30 September 2014

Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors

scientific article published on 25 May 2016

Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

scientific article published on 01 September 2018

Overcoming Therapeutic Resistance in HER2-Positive Breast Cancers with CDK4/6 Inhibitors

scientific article published on March 2016

Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer.

scientific article published on 4 December 2015

PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer

scientific article published on 09 March 2020

PEPCK Coordinates the Regulation of Central Carbon Metabolism to Promote Cancer Cell Growth

scientific article

Palbociclib resistance confers dependence on an FGFR-MAP kinase-mTOR-driven pathway in -mutant non-small cell lung cancer

scientific article published on 03 August 2018

Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity

scientific article published on 03 October 2019

Potent and Selective Covalent Quinazoline Inhibitors of KRAS G12C.

scientific article published on 27 July 2017

Preexisting oncogenic events impact trastuzumab sensitivity in ERBB2-amplified gastroesophageal adenocarcinoma

scientific article

Primary tumor genotype is an important determinant in identification of lung cancer propagating cells

scientific article

Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

scientific article published on 20 March 2018

Prospective association between major depressive disorder and leukocyte telomere length over two years.

scientific article published on 21 February 2018

Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer ⬇️

scientific article published on 01 April 2019

RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

scientific article published on 01 November 2018

RMRP is a non-coding RNA essential for early murine development

scientific article

Rapamycin prevents the development and progression of mutant epidermal growth factor receptor lung tumors with the acquired resistance mutation T790M.

scientific article

Rationale for co-targeting IGF-1R and ALK in ALK fusion-positive lung cancer

scientific article

Reactivation of ERK signaling causes resistance to EGFR kinase inhibitors.

scientific article

Receptor tyrosine kinases exert dominant control over PI3K signaling in human KRAS mutant colorectal cancers

scientific article

Regression of drug-resistant lung cancer by the combination of rosiglitazone and carboplatin.

scientific article published on October 2008

Reprogramming of the esophageal squamous carcinoma epigenome by SOX2 promotes ADAR1 dependence

scientific article published on 10 May 2021

Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers.

scientific article

Resistance to irreversible EGF receptor tyrosine kinase inhibitors through a multistep mechanism involving the IGF1R pathway

scientific article

Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice.

scientific article

SOX2 and p63 colocalize at genetic loci in squamous cell carcinomas

scientific article published on 03 March 2014

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment.

scientific article published on February 2016

Searching for a magic bullet in NSCLC: the role of epidermal growth factor receptor mutations and tyrosine kinase inhibitors

scientific article published on June 2008

Sensitive mutation detection in heterogeneous cancer specimens by massively parallel picoliter reactor sequencing

scientific article published on 25 June 2006

Serial single-cell profiling analysis of metastatic TNBC during Nab-paclitaxel and pembrolizumab treatment

scientific article published on 19 September 2020

Somatic LKB1 mutations promote cervical cancer progression

scientific article

Summary statement: novel agents in the treatment of lung cancer: advances in epidermal growth factor receptor-targeted agents

scientific article

Sunitinib prolongs survival in genetically engineered mouse models of multistep lung carcinogenesis

scientific article published on 31 March 2009

Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression.

scientific article

Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

scientific article published on 06 February 2019

Synergy of WEE1 and mTOR Inhibition in Mutant KRAS-Driven Lung Cancers

scientific article published on 18 August 2017

Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models

scientific article

TSC2-deficient tumors have evidence of T cell exhaustion and respond to anti-PD-1/anti-CTLA-4 immunotherapy.

scientific article published on 19 April 2018

Targeting HER2 Aberrations in Non-Small Cell Lung Cancer with Osimertinib.

scientific article published on 3 January 2018

Targeting PKCδ as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer

scientific article published on 01 December 2018

Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

scientific article

Targeting glutamine-addiction and overcoming CDK4/6 inhibitor resistance in human esophageal squamous cell carcinoma

scientific article published on 21 March 2019

Targeting the PI3K signaling pathway in cancer

scientific article

Targeting the human MUC1-C oncoprotein with an antibody-drug conjugate.

scientific article published on 21 June 2018

Targeting the oncogenic MUC1-C protein inhibits mutant EGFR-mediated signaling and survival in non-small cell lung cancer cells

scientific article

Targeting transcriptional addictions in small cell lung cancer with a covalent CDK7 inhibitor

scientific article

Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition.

scientific article published on 28 May 2018

Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing

scientific article published in Nature

Telomere dysfunction promotes genome instability and metastatic potential in a K-ras p53 mouse model of lung cancer

scientific article published on 17 February 2008

Telomere length and telomerase in a well-characterized sample of individuals with major depressive disorder compared to controls.

scientific article published on 13 April 2015

Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging

scientific article published on 11 April 2006

Temporal Molecular and Biological Assessment of an Erlotinib-Resistant Lung Adenocarcinoma Model Reveals Markers of Tumor Progression and Treatment Response ⬇️

scientific article published on September 11, 2012

Temporal dissection of K-ras(G12D) mutant in vitro and in vivo using a regulatable K-ras(G12D) mouse allele

scientific article

The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss

scientific article published on 16 October 2012

The Combined Effect of FGFR Inhibition and PD-1 Blockade Promotes Tumor-Intrinsic Induction of Antitumor Immunity

scientific article published on 22 July 2019

The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis

scientific article published on 14 November 2019

The LKB1 tumor suppressor as a biomarker in mouse and human tissues

scientific article

The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP

scientific article

The dTAG system for immediate and target-specific protein degradation.

scientific article published on 26 March 2018

The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies

scientific article

The impact of the MYB-NFIB fusion proto-oncogene in vivo.

scientific article published on 18 May 2016

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins ⬇️

scientific article

The pivotal role of IKKα in the development of spontaneous lung squamous cell carcinomas.

scientific article published on April 2013

Therapeutic anti-EGFR antibody 806 generates responses in murine de novo EGFR mutant-dependent lung carcinomas

scientific article published on 25 January 2007

Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair

scientific article published on 02 May 2016

Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop

scientific article published on 22 May 2019

Transdifferentiation of lung adenocarcinoma in mice with Lkb1 deficiency to squamous cell carcinoma

scientific article published on January 2014

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway

scientific article published on 01 January 2020

Tumor-propagating cells and Yap/Taz activity contribute to lung tumor progression and metastasis.

scientific article published on 04 February 2014

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

scientific article published on 17 May 2021

Upregulation of IGF1R by mutant RAS in leukemia and potentiation of RAS signaling inhibitors by small-molecule inhibition of IGF1R

scientific article

Use of Ex Vivo Patient-Derived Tumor Organotypic Spheroids to Identify Combination Therapies for HER2 Mutant Non-Small Cell Lung Cancer

scientific article published on 07 February 2020

Walking the telomere plank into cancer

scientific article

Workshop on challenges, insights, and future directions for mouse and humanized models in cancer immunology and immunotherapy: a report from the associated programs of the 2016 annual meeting for the Society for Immunotherapy of cancer.

scientific article published on 19 September 2017

mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis

scientific article published in Nature

β-catenin contributes to lung tumor development induced by EGFR mutations

scientific article

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