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List of works by Ross Bathgate

'Relaxin' the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease

scientific article published on 11 July 2006

A Novel Ultra-Stable, Monomeric Green Fluorescent Protein For Direct Volumetric Imaging of Whole Organs Using CLARITY.

scientific article published on 12 January 2018

A missense mutation in LRR8 of RXFP2 is associated with cryptorchidism.

scientific article published on 22 October 2010

A simple approach for the preparation of mature human relaxin-3.

scientific article published on 3 August 2010

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

scientific article published on 26 February 2016

Activation of relaxin-related receptors by short, linear peptides derived from a collagen-containing precursor.

scientific article published in April 2009

Adenovirus-mediated delivery of relaxin reverses cardiac fibrosis

scientific article published on 22 September 2007

An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii

scientific article published on 16 April 2019

Analogs of insulin-like peptide 3 (INSL3) B-chain are LGR8 antagonists in vitro and in vivo.

scientific article published on 17 March 2006

Arginine vasopressin- and oxytocin-like peptides in the testis of two Australian marsupials

scientific article published on 01 July 1993

B7-33 replicates the vasoprotective functions of human relaxin-2 (serelaxin).

scientific article published on 3 May 2017

Binding conformation and determinants of a single-chain peptide antagonist at the relaxin-3 receptor RXFP3

scientific article published on 21 August 2018

Brain content and plasma concentrations of arginine vasopressin in an Australian marsupial, the brushtail possum Trichosurus vulpecula

scientific article published in November 1992

C-terminus of the B-chain of relaxin-3 is important for receptor activity

scientific article

Cardiovascular effects of relaxin: from basic science to clinical therapy

scientific article

Cell-free protein synthesis as a tool to study RXFP3-relaxin-3 protein interactions.

scientific article published in January 2013

Challenges in the design of insulin and relaxin/insulin-like peptide mimetics

scientific article

Characterisation of a cell-free synthesised G-protein coupled receptor

scientific article

Characterization and localization of oxytocin receptors in the rat testis

scientific article published on 01 May 1994

Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules

scientific article

Characterization of the rat INSL3 receptor

scientific journal article

Chemical synthesis and biological activity of rat INSL3.

scientific article

Chemical synthesis and orexigenic activity of rat/mouse relaxin-3.

scientific article

Chemically synthesized dicarba H2 relaxin analogues retain strong RXFP1 receptor activity but show an unexpected loss of in vitro serum stability

scientific article published on 14 September 2015

Chimeric RXFP1 and RXFP2 Receptors Highlight the Similar Mechanism of Activation Utilizing Their N-Terminal Low-Density Lipoprotein Class A Modules.

scientific article

Chimeric relaxin peptides highlight the role of the A-chain in the function of H2 relaxin ⬇️

scientific article published on 05 March 2012

Coatings Releasing the Relaxin Peptide Analogue B7-33 Reduce Fibrotic Encapsulation

scientific article published on 02 December 2019

Coevolution of the relaxin-like peptides and their receptors

scientific article published on 01 May 2005

Comparison of Signaling Pathways Activated by the Relaxin Family Peptide Receptors, RXFP1 and RXFP2, Using Reporter Genes

scientific article published on 27 June 2006

Cooperative binding of insulin-like Peptide 3 to a dimeric relaxin family peptide receptor 2.

scientific article published on 6 December 2007

De novo design and synthesis of cyclic and linear peptides to mimic the binding cassette of human relaxin

scientific article published in April 2009

Defining the LGR8 residues involved in binding insulin-like peptide 3.

scientific article

Design and development of analogues of dimers of insulin-like peptide 3 B-chain as high-affinity antagonists of the RXFP2 receptor

scientific article

Design and recombinant expression of insulin-like peptide 5 precursors and the preparation of mature human INSL5.

scientific article published on 11 April 2010

Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain.

scientific article published on February 2007

Detection, localization, and action of the INSL3 receptor, LGR8, in rat kidney

scientific journal article

Determinants of Ligand Subtype-Selectivity at α1A-Adrenoceptor Revealed Using Saturation Transfer Difference (STD) NMR.

scientific article published on 22 March 2018

Development of a Single-Chain Peptide Agonist of the Relaxin-3 Receptor Using Hydrocarbon Stapling

scientific article published on 27 July 2016

Development of a scaffold displaying exoloops of RXFP1

Development of human cells with RXFP1 knockdown using retroviral delivery of microRNA against human RXFP1.

scientific article

Diazepam is not a direct allosteric modulator of α-adrenoceptors, but modulates receptor signaling by inhibiting phosphodiesterase-4

scientific article published on 26 December 2018

Differential expression of mesotocin receptors in the uterus and ovary of the pregnant tammar wallaby.

scientific article

Dimerization and negative cooperativity in the relaxin family peptide receptors

scientific article published in April 2009

Distinct activation modes of the Relaxin Family Peptide Receptor 2 in response to insulin-like peptide 3 and relaxin

scientific article

Distinct but overlapping binding sites of agonist and antagonist at the relaxin family peptide 3 (RXFP3) receptor

scientific article published on 21 August 2018

Effect of helix-promoting strategies on the biological activity of novel analogues of the B-chain of INSL3.

scientific article

Elucidation of relaxin-3 binding interactions in the extracellular loops of RXFP3.

scientific article published on 22 February 2013

Endogenous relaxin does not affect chronic pressure overload-induced cardiac hypertrophy and fibrosis

scientific article published on 8 November 2007

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

scientific article published on 29 January 2016

Engineering of chimeric peptides as antagonists for the G protein-coupled receptor, RXFP4

scientific article published on 28 November 2019

Enhanced serelaxin signalling in co-cultures of human primary endothelial and smooth muscle cells

scientific article published on 23 October 2015

Evidence for a Local Fetal Influence on Myometrial Oxytocin Receptors during Pregnancy in the Tammar Wallaby (Macropus eugenii)1

article

Evolution of the relaxin-like peptide family

scientific article

Evolution of the relaxin-like peptide family: from neuropeptide to reproduction.

scientific article published in May 2005

Examination of relaxin and its receptors expression in pig gametes and embryos

scientific article

Exploring the Use of Helicogenic Amino Acids for Optimising Single Chain Relaxin-3 Peptide Agonists

scientific article published on 14 October 2020

Expression and regulation of relaxin-like factor gene transcripts in the bovine ovary: differentiation-dependent expression in theca cell cultures

scientific article published on 01 October 1999

Expression of LGR7 and LGR8 by neonatal porcine uterine tissues and transmission of milk-borne relaxin into the neonatal circulation by suckling

scientific article

Expression of the insulin-like peptide 3 (INSL3) hormone-receptor (LGR8) system in the testis.

scientific article published on 8 February 2006

Familial bilateral cryptorchidism is caused by recessive variants in RXFP2

scientific article published on 05 June 2019

Functional link between bone morphogenetic proteins and insulin-like peptide 3 signaling in modulating ovarian androgen production

scientific article published on 25 March 2013

H3 relaxin is a specific ligand for LGR7 and activates the receptor by interacting with both the ectodomain and the exoloop 2

scientific article (publication date: 7 March 2003)

Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. Novel members of the relaxin peptide family

scientific journal article

INSL3/Leydig insulin-like peptide activates the LGR8 receptor important in testis descent

scientific journal article

INSL3/RXFP2 signaling in testicular descent.

scientific article

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells.

scientific article published in April 2018

INSL5 is a high affinity specific agonist for GPCR142 (GPR100)

scientific article

Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7

scientific article

Identification of Binding Sites with Differing Affinity and Potency for Relaxin Analogues on LGR7 and LGR8 Receptors

scientific article published in May 2005

Identification of the N-linked glycosylation sites of the human relaxin receptor and effect of glycosylation on receptor function.

scientific article

Improved chemical synthesis and demonstration of the relaxin receptor binding affinity and biological activity of mouse relaxin.

scientific article published on 11 April 2007

Improving the apo-state detergent stability of NTS1 with CHESS for pharmacological and structural studies

scientific article published on 23 July 2014

In a Class of Their Own - RXFP1 and RXFP2 are Unique Members of the LGR Family

scientific article

Increased feeding and body weight gain in rats after acute and chronic activation of RXFP3 by relaxin-3 and receptor-selective peptides: functional and therapeutic implications

scientific article published on September 2012

Insulin-relaxin family peptide signaling and receptors in mouse brain membranes and neuronal cells.

scientific article published on May 2005

International Union of Basic and Clinical Pharmacology. XCV. Recent advances in the understanding of the pharmacology and biological roles of relaxin family peptide receptors 1-4, the receptors for relaxin family peptides.

scientific article

International Union of Pharmacology LVII: recommendations for the nomenclature of receptors for relaxin family peptides

scientific article

Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1).

scientific article

Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation

scientific article published on April 2009

Label-free screening of single biomolecules through resistive pulse sensing technology for precision medicine applications.

scientific article

Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation

scientific article published in May 2006

Localization of LGR7 (relaxin receptor) mRNA and protein in rat forebrain: correlation with relaxin binding site distribution

scientific article published in May 2005

Localization of LGR7 gene expression in adult mouse brain using LGR7 knock-out/LacZ knock-in mice: correlation with LGR7 mRNA distribution

scientific article published in May 2005

Luteal peptides and their genes as important markers of ovarian differentiation.

scientific article

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1.

scientific article

Mammalian mesotocin: cDNA sequence and expression of an oxytocin-like gene in a macropodid marsupial, the tammar wallaby

scientific article published on 01 May 2000

Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation

scientific article published on 10 July 2014

Mesotocin Gene Expression and Evidence of Gene Duplication in the Tammar Wallaby ⬇️

scientific article published on May 15, 1998

Mesotocin Gene Expression in the Diencephalon of Domestic Fowl: Cloning and Sequencing of the MT cDNA and Distribution of MT Gene Expressing Neurons in the Chicken Hypothalamus ⬇️

scientific article published on October 1, 1997

Mesotocin and arginine-vasopressin in the corpus luteum of an Australian marsupial, the brushtail possum (Trichosurus vulpecula)

scientific article published on 01 February 1994

Mesotocin and oxytocin in the brain and plasma of an Australian marsupial, the northern brown bandicoot, Isoodon macrourus

scientific article published on 01 May 1992

Mesotocin in the brain and plasma of an Australian marsupial, the brushtail possum (Trichosurus vulpecula).

scientific article published in July 1990

Mesotocin receptor gene and protein expression in the prostate gland, but not testis, of the tammar wallaby, Macropus eugenii

scientific article published on 01 November 1998

Minimization of human relaxin-3 leading to high-affinity analogues with increased selectivity for relaxin-family peptide 3 receptor (RXFP3) over RXFP1.

scientific article published on 8 February 2012

Minimum active structure of insulin-like peptide 5.

scientific article published on 21 November 2013

Modeling the primary hormone-binding site of RXFP1 and RXFP2.

scientific article published in April 2009

Modulation of feeding by chronic rAAV expression of a relaxin-3 peptide agonist in rat hypothalamus.

scientific article

Molecular biology of the oxytocin receptor: a comparative approach.

scientific article published on August 1997

Multi-Component Mechanism of H2 Relaxin Binding to RXFP1 through NanoBRET Kinetic Analysis

scientific article published on 10 December 2018

Multiple binding sites revealed by interaction of relaxin family peptides with native and chimeric relaxin family peptide receptors 1 and 2 (LGR7 and LGR8).

scientific article

Native Chemical Ligation to Minimize Aspartimide Formation during Chemical Synthesis of Small LDLa Protein

scientific article published on 27 November 2015

Negative cooperativity in H2 relaxin binding to a dimeric relaxin family peptide receptor 1

scientific article published on 03 August 2008

Neohormone systems as exciting targets for drug development

scientific article published on 31 March 2006

Nucleus incertus promotes cortical desynchronization and behavioral arousal.

scientific article

Optimization and 13 CH 3 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies

scientific article published on 26 March 2018

Oxytocin and Male Reproductive Function ⬇️

scientific article published on January 1, 1997

Paracrine regulation of mammalian oocyte maturation and male germ cell survival

scientific journal article

Posterior pituitary of the newborn marsupial possum, Trichosurus vulpecula

scientific article published on 01 October 1993

Probing the functional domains of relaxin-3 and the creation of a selective antagonist for RXFP3/GPCR135 over relaxin receptor RXFP1/LGR7.

scientific article

Prolonged RXFP1 and RXFP2 signaling can be explained by poor internalization and a lack of beta-arrestin recruitment

scientific article published on 11 March 2009

Promise and Limitations of Relaxin-based Therapies in Chronic Fibrotic Lung Diseases

scientific article published on 01 December 2016

Purification and characterization of relaxin from the tammar wallaby (Macropus eugenii): bioactivity and expression in the corpus luteum.

scientific article

R3(BDelta23 27)R/I5 chimeric peptide, a selective antagonist for GPCR135 and GPCR142 over relaxin receptor LGR7: in vitro and in vivo characterization.

scientific article published on 2 July 2007

RXFP1 couples to the Galpha-Gbetagamma-PI3K-PKCzeta pathway via the final 10 amino acids of the receptor C-terminal tail.

scientific article published on April 2009

Real-time examination of cAMP activity at relaxin family peptide receptors using a BRET-based biosensor

scientific article published on 24 September 2018

Receptors for relaxin family peptides

scientific article

Recombinant RXFP1-LDL-A module does not form dimers

Recombinant expression of an insulin-like peptide 3 (INSL3) precursor and its enzymatic conversion to mature human INSL3.

scientific article published on 10 August 2009

Regulation of neurohypophysial hormone secretion in an Australian marsupial

scientific article published on 01 May 1995

Relaxin Therapy Reverses Large Artery Remodeling and Improves Arterial Compliance in Senescent Spontaneously Hypertensive Rats

scientific article published on 29 March 2010

Relaxin antagonizes hypertrophy and apoptosis in neonatal rat cardiomyocytes

scientific article published on 4 January 2007

Relaxin deficiency in mice is associated with an age-related progression of pulmonary fibrosis

scientific article published on 01 November 2002

Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro

scientific article published on 01 March 2004

Relaxin family peptide receptor (RXFP1) coupling to G(alpha)i3 involves the C-terminal Arg752 and localization within membrane Raft Microdomains.

scientific article

Relaxin family peptide receptors RXFP1 and RXFP2 modulate cAMP signaling by distinct mechanisms

scientific article

Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways

scientific article

Relaxin family peptide receptors--from orphans to therapeutic targets.

scientific article published on 06 June 2008

Relaxin family peptide systems and the central nervous system.

scientific article published on 07 March 2010

Relaxin family peptides and receptors in mammalian brain.

scientific article published on April 2009

Relaxin family peptides and their receptors

scientific article published on January 2013

Relaxin family peptides: structure-activity relationship studies.

scientific article published on 6 December 2016

Relaxin inhibits renal myofibroblast differentiation via RXFP1, the nitric oxide pathway, and Smad2

scientific journal article

Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo

scientific article published on 20 May 2004

Relaxin receptors--new drug targets for multiple disease states

scientific article

Relaxin remodels fibrotic healing following myocardial infarction

scientific article published on 10 January 2011

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

scientific article published on 15 January 2014

Relaxin research in the postgenomic era.

scientific article

Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats

scientific article published on 20 June 2005

Relaxin signaling in reproductive tissues.

scientific article published on April 2003

Relaxin signals through a RXFP1-pERK-nNOS-NO-cGMP-dependent pathway to up-regulate matrix metalloproteinases: the additional involvement of iNOS.

scientific article

Relaxin-2 does not ameliorate nephropathy in an experimental model of type-1 diabetes

scientific article published in January 2015

Relaxin-3 in GABA projection neurons of nucleus incertus suggests widespread influence on forebrain circuits via G-protein-coupled receptor-135 in the rat.

scientific article published on 30 October 2006

Relaxin-3 inputs target hippocampal interneurons and deletion of hilar relaxin-3 receptors in "floxed-RXFP3" mice impairs spatial memory.

scientific article published on 18 January 2017

Relaxin-3: Improved Synthesis Strategy and Demonstration of Its High-Affinity Interaction with the Relaxin Receptor LGR7 BothIn VitroandIn Vivo†

article

Relaxin-like bioactivity of ovine Insulin 3 (INSL3) analogues

scientific article published on December 2002

Relaxins enhance growth of spontaneous murine breast cancers as well as metastatic colonization of the brain

scientific article published on 21 August 2013

Reproductive biology of the relaxin-like factor (RLF/INSL3).

scientific article

Resolving the unconventional mechanisms underlying RXFP1 and RXFP2 receptor function.

scientific article

Responses of GPCR135 to human gene 3 (H3) relaxin in CHO-K1 cells determined by microphysiometry

scientific article

Restricted expression of LGR8 in intralaminar thalamic nuclei of rat brain suggests a role in sensorimotor systems

scientific article published in May 2005

Restricted, but abundant, expression of the novel rat gene-3 (R3) relaxin in the dorsal tegmental region of brain

scientific article published in September 2002

Reversal of cardiac fibrosis and related dysfunction by relaxin.

scientific article

Role of the intra-A-chain disulfide bond of insulin-like peptide 3 in binding and activation of its receptor, RXFP2.

scientific article published on 4 June 2010

Roles of the receptor, the ligand, and the cell in the signal transduction pathways utilized by the relaxin family peptide receptors 1-3.

scientific article published on April 2009

Serelaxin-mediated signal transduction in human vascular cells: bell-shaped concentration-response curves reflect differential coupling to G proteins

scientific article

Signal switching after stimulation of LGR7 receptors by human relaxin 2

scientific article

Signal transduction pathways activated by insulin-like peptide 5 at the relaxin family peptide RXFP4 receptor.

scientific article published on 31 May 2016

Signaling pathways of the LGR7 and LGR8 receptors determined by reporter genes

scientific article published on May 2005

Silencing relaxin-3 in nucleus incertus of adult rodents: a viral vector-based approach to investigate neuropeptide function

scientific article

Single chain peptide agonists of relaxin receptors

scientific article published on 11 January 2019

Site-specific conjugation of a lanthanide chelator and its effects on the chemical synthesis and receptor binding affinity of human relaxin-2 hormone

scientific article published on 07 March 2012

Solid-phase synthesis of europium-labeled human INSL3 as a novel probe for the study of ligand-receptor interactions

scientific article

Solution structure and characterization of the LGR8 receptor binding surface of insulin-like peptide 3.

scientific article

Solution structure and novel insights into the determinants of the receptor specificity of human relaxin-3.

scientific article

Solution structure, aggregation behavior, and flexibility of human relaxin-2

scientific article

Spatial Learning Requires mGlu5 Signalling in the Dorsal Hippocampus

scientific article published on 10 May 2015

Splice variants of the relaxin and INSL3 receptors reveal unanticipated molecular complexity

scientific article

Structural insights into the function of relaxins

scientific article

Structural properties of relaxin chimeras.

scientific article

Structure and activity in the relaxin family of peptides

scientific article published in April 2009

Structure and expression of the bovine oxytocin receptor gene.

scientific article published on December 1995

Structure and function relationship of murine insulin-like peptide 5 (INSL5): free C-terminus is essential for RXFP4 receptor binding and activation

scientific article published on 08 September 2011

Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist

scientific article

Studies on soluble ectodomain proteins of relaxin (LGR7) and insulin 3 (LGR8) receptors.

scientific article published on May 2005

Swim stress excitation of nucleus incertus and rapid induction of relaxin-3 expression via CRF1 activation.

scientific article published on 26 June 2009

Synthesis and pharmacological characterization of a europium-labelled single-chain antagonist for binding studies of the relaxin-3 receptor RXFP3.

scientific article published on 20 March 2015

Synthesis of fluorescent analogs of relaxin family peptides and their preliminary in vitro and in vivo characterization

scientific article

Synthesis, conformation, and activity of human insulin-like peptide 5 (INSL5).

scientific article

Synthesis, conformation, receptor binding and biological activities of monobiotinylated human insulin-like peptide 3.

scientific article published in February 2004

Synthetic covalently linked dimeric form of H2 relaxin retains native RXFP1 activity and has improved in vitro serum stability.

scientific article

Synthetic human insulin 4 does not activate the G-protein-coupled receptors LGR7 or LGR8.

scientific article published on May 2004

Targeted viral vector transduction of relaxin-3 neurons in the rat nucleus incertus using a novel cell-type specific promoter

scientific article published on 13 December 2019

The A-chain of human relaxin family peptides has distinct roles in the binding and activation of the different relaxin family peptide receptors

scientific article published on 22 April 2008

The NMR solution structure of the relaxin (RXFP1) receptor lipoprotein receptor class A module and identification of key residues in the N-terminal region of the module that mediate receptor activation

scientific article

The actions of relaxin family peptides on signal transduction pathways activated by the relaxin family peptide receptor RXFP4.

scientific article published on 26 November 2016

The chemistry and biology of human relaxin-3.

scientific article

The complex binding mode of the peptide hormone H2 relaxin to its receptor RXFP1

scientific article published on 18 April 2016

The different ligand-binding modes of relaxin family peptide receptors RXFP1 and RXFP2

scientific article

The effects of relaxin and estrogen deficiency on collagen deposition and hypertrophy of nonreproductive organs.

scientific article published on 24 August 2006

The evolution of the relaxin peptide family and their receptors.

scientific article published on January 2007

The human LGR7 low-density lipoprotein class A module requires calcium for structure

scientific article

The minimal active structure of human relaxin-2

scientific article

The molecular basis of oxytocin and oxytocin receptor gene expression in reproductive tissues.

scientific article

The relaxin gene-knockout mouse: a model of progressive fibrosis

scientific article published on 01 May 2005

The relaxin receptor (RXFP1) utilizes hydrophobic moieties on a signaling surface of its N-terminal low density lipoprotein class A module to mediate receptor activation.

scientific article

The relaxin receptor as a therapeutic target - perspectives from evolution and drug targeting

scientific article published on 16 February 2018

The role of N-terminal glycosylation in the human oxytocin receptor

scientific article published on 01 November 1997

The structural and functional role of the B-chain C-terminal arginine in the relaxin-3 peptide antagonist, R3(BDelta23-27)R/I5.

scientific article published in January 2009

The structural determinants of insulin-like Peptide 3 activity

scientific article

Transcriptional regulation of the bovine oxytocin receptor gene

scientific article published in March 2003

Understanding relaxin signalling at the cellular level

scientific article published on 25 December 2018

Up-regulation of mesotocin receptors in the tammar wallaby myometrium is pregnancy-specific and independent of estrogen.

scientific article published in May 2002

Using the novel HiBiT tag to label cell surface relaxin receptors for BRET proximity analysis

scientific article published on 30 July 2019

Viral-mediated delivery of an RXFP3 agonist into brain promotes arousal in mice

scientific article published in January 2013

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