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List of works by Myles H. Akabas

5-HT3 receptor ion size selectivity is a property of the transmembrane channel, not the cytoplasmic vestibule portals.

scientific article

A bitter substance induces a rise in intracellular calcium in a subpopulation of rat taste cells

scientific article published in November 1988

A closer look at attrition in MD-PhD programs

scientific article published on 01 July 2014

A role for the beta 1-beta 2 loop in the gating of 5-HT3 receptors.

scientific article published on October 2005

Accessibility of substituted cysteines in TM2 and TM10 transmembrane segments in the Plasmodium falciparum equilibrative nucleoside transporter PfENT1

scientific article published on 12 December 2018

Acetylcholine receptor channel structure probed in cysteine-substitution mutants.

scientific article

Are MD-PhD programs meeting their goals? An analysis of career choices made by graduates of 24 MD-PhD programs.

scientific article published on April 2010

Arg352 is a major determinant of charge selectivity in the cystic fibrosis transmembrane conductance regulator chloride channel

scientific article published on 01 April 1999

Balance of activity between LN(v)s and glutamatergic dorsal clock neurons promotes robust circadian rhythms in Drosophila

scientific article

Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment

scientific article

Channel-Lining Residues in the M3 Membrane-Spanning Segment of the Cystic Fibrosis Transmembrane Conductance Regulator ⬇️

scientific article published on September 1, 1998

Chloroquine-resistant isoforms of the Plasmodium falciparum chloroquine resistance transporter acidify lysosomal pH in HEK293 cells more than chloroquine-sensitive isoforms.

scientific article published on 25 September 2006

Cysteine Modification: Probing Channel Structure, Function and Conformational Change.

scientific article published on January 2015

Defining the propofol binding site location on the GABAA receptor

scientific article

Differential protein mobility of the gamma-aminobutyric acid, type A, receptor alpha and beta subunit channel-lining segments

scientific article published on 2 November 2004

Drosophila Pacemaker Neurons Require G Protein Signaling and GABAergic Inputs to Generate Twenty-Four Hour Behavioral Rhythms ⬇️

scientific article published on December 9, 2010

Emerging molecular mechanisms of general anesthetic action.

scientific article

Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum.

scientific article published on 17 September 2008

Evidence for distinct conformations of the two alpha 1 subunits in diazepam-bound GABA(A) receptors

scientific article

Functional and structural analysis of the GABAA receptor alpha 1 subunit during channel gating and alcohol modulation

scientific article published on 2 November 2004

GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.

scientific article published on 10 September 2002

GABAA receptor structure-function studies: a reexamination in light of new acetylcholine receptor structures

scientific article

Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptors

scientific article

Gating-induced conformational rearrangement of the γ-aminobutyric acid type A receptor β-α subunit interface in the membrane-spanning domain

scientific article

Identification of acetylcholine receptor channel-lining residues in the M1 segment of the alpha-subunit

scientific article published in October 1995

Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit

scientific article published in October 1994

Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption

scientific article

Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment.

scientific article

Identification of electrophysiologically distinct subpopulations of rat taste cells

scientific article published on 01 March 1990

Identification via a Parallel Hit Progression Strategy of Improved Small Molecule Inhibitors of the Malaria Purine Uptake Transporter that Inhibit Plasmodium falciparum Parasite Proliferation

scientific article published on 14 August 2019

Impact of Field Isolate Identified Nonsynonymous Single Nucleotide Polymorphisms on Plasmodium falciparum Equilibrative Nucleoside Transporter 1 Inhibitor Efficacy

scientific article published on 13 January 2020

Interaction of picrotoxin with GABAA receptor channel-lining residues probed in cysteine mutants.

scientific article

Length and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitization

scientific article

Locating the anion-selectivity filter of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel.

scientific article

MD-PhD graduates remain underrepresented in orthopaedic surgery: National MD-PhD Program Outcome Survey update

scientific article published on 21 March 2020

Malaria parasite type 4 equilibrative nucleoside transporters (ENT4) are purine transporters with distinct substrate specificity

scientific article (publication date: September 2012)

Na+/Ca2+ exchange inhibitors: potential drugs to mitigate the severity of ischemic injury

scientific article

Osmotic swelling of phospholipid vesicles causes them to fuse with a planar phospholipid bilayer membrane

scientific article published on 01 July 1982

Probing the multifactorial basis of Plasmodium falciparum quinine resistance: Evidence for a strain-specific contribution of the sodium-proton exchanger PfNHE

scientific article (publication date: June 2009)

Probing the structural and functional domains of the CFTR chloride channel.

scientific article published on October 1997

Purification and reconstitution of chloride channels from kidney and trachea

scientific article published on 01 June 1989

Purification and reconstitution of epithelial chloride channels

scientific article published on 01 January 1990

Purification of the Epithelial Cl Channel ⬇️

scientific article published on January 1, 1991

Purine import into malaria parasites as a target for antimalarial drug development

scientific article published on 25 November 2014

Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, and response to dietary folate restriction.

scientific article

Spontaneous thermal motion of the GABA(A) receptor M2 channel-lining segments.

scientific article published on 9 August 2005

State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments.

scientific article published on April 2006

Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis.

scientific article published on 13 September 2001

Structure of the M2 transmembrane segment of GLIC, a prokaryotic Cys loop receptor homologue from Gloeobacter violaceus, probed by substituted cysteine accessibility.

scientific article

Substituted-cysteine accessibility method

scientific article published on 01 January 1998

Substrate and Inhibitor Specificity of the Plasmodium berghei Equilibrative Nucleoside Transporter Type 1

scientific article published on 05 April 2016

Taking Charge: Feeding Malaria via Anion Channels

scientific article

Targeting the Plasmodium vivax equilibrative nucleoside transporter 1 (PvENT1) for antimalarial drug development

scientific article

The location of a closed channel gate in the GABAA receptor channel.

scientific article

The national MD-PhD program outcomes study: Outcomes variation by sex, race, and ethnicity

scientific article published on 03 October 2019

The national MD-PhD program outcomes study: Relationships between medical specialty, training duration, research effort, and career paths

scientific article published on 03 October 2019

Toward a structural basis for the function of nicotinic acetylcholine receptors and their cousins.

scientific article published on December 1995

Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1.

scientific article published on 08 October 2009

UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells

scientific article published on 10 June 2013

Using molecular dynamics to elucidate the structural basis for function in pLGICs

scientific article published on 04 October 2013

Watching single protons bind

scientific article published on 01 March 2006

Yeast-based high-throughput screen identifies Plasmodium falciparum equilibrative nucleoside transporter 1 inhibitors that kill malaria parasites

scientific article published on 30 January 2015

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