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List of works by Gary J Sharples

A bacteriophage mimic of the bacterial nucleoid-associated protein Fis

scientific article published on 24 March 2020

A model for dsDNA translocation revealed by a structural motif common to RecG and Mfd proteins

scientific article

A novel repeated DNA sequence located in the intergenic regions of bacterial chromosomes.

scientific article published on November 1990

An E. coli RuvC mutant defective in cleavage of synthetic Holliday junctions.

scientific article published on July 1993

Analysis of conserved basic residues associated with DNA binding (Arg69) and catalysis (Lys76) by the RusA holliday junction resolvase.

scientific article published on November 2000

Characterization of a thermosensitive Escherichia coli aspartyl-tRNA synthetase mutant.

scientific article published on June 1997

Cloning, overexpression, purification, and characterization of the Escherichia coli RuvC Holliday junction resolvase.

scientific article

Conservation of RecG activity from pathogens to hyperthermophiles

scientific article published on 01 January 2005

Crystal structure of DNA recombination protein RuvA and a model for its binding to the Holliday junction

scientific article

DNA binding by the meningococcal RdgC protein, associated with pilin antigenic variation.

scientific article published on February 2004

Dissociation of synthetic Holliday junctions by E. coli RecG protein.

scientific article published on January 1993

Evolution of a phage RuvC endonuclease for resolution of both Holliday and branched DNA junctions

scientific article

Exploring the links between peptoid antibacterial activity and toxicity

scientific article published on 01 February 2017

For absent friends: life without recombination in mutualistic gamma-proteobacteria

scientific article published on 21 May 2009

Formation and resolution of recombination intermediates by E. coli RecA and RuvC proteins.

scientific article

Functional similarities between phage lambda Orf and Escherichia coli RecFOR in initiation of genetic exchange

scientific article

Genetic analysis of an archaeal Holliday junction resolvase in Escherichia coli

scientific article published in July 2001

Genetic analysis of recombination in prokaryotes

scientific article published on October 1992

Glycosylated Nanoparticles as Efficient Antimicrobial Delivery Agents

scientific article published on 19 July 2016

Haemophilus virulence.

scientific article

Helicobacter pylori mutants defective in RuvC Holliday junction resolvase display reduced macrophage survival and spontaneous clearance from the murine gastric mucosa

scientific article

Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae.

scientific article

Holliday junction binding and resolution by the Rap structure-specific endonuclease of phage lambda

scientific article published in July 2004

Holliday junction processing in bacteria: insights from the evolutionary conservation of RuvABC, RecG, and RusA

scientific article

Holliday junction resolvases encoded by homologous rusA genes in Escherichia coli K-12 and phage 82.

scientific article published on April 1996

Identification of three aspartic acid residues essential for catalysis by the RusA holliday junction resolvase

scientific article published in February 1999

Location of a mutation in the aspartyl-tRNA synthetase gene of Escherichia coli K12.

scientific article published in November 1991

Medicinal Mascarene Aloes: An audit of their phytotherapeutic potential.

scientific article published on 21 October 2017

Molecular and functional analysis of the ruv region of Escherichia coli K-12 reveals three genes involved in DNA repair and recombination

scientific article published on April 1990

Mycobacterium tuberculosis RuvX is a Holliday junction resolvase formed by dimerisation of the monomeric YqgF nuclease domain

scientific article published on 28 January 2016

Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC

scientific article published on 11 April 2006

On the Antibacterial Activity of Azacarboxylate Ligands: Lowered Metal Ion Affinities for Bis-amide Derivatives of EDTA do not mean Reduced Activity.

scientific article published on 23 March 2018

Phage ORF family recombinases: conservation of activities and involvement of the central channel in DNA binding

scientific article

Preparation of an Antibacterial Poly(ionic liquid) Graft Copolymer of Hydroxyethyl Cellulose

scientific article published on 6 November 2015

Processing of intermediates in recombination and DNA repair: identification of a new endonuclease that specifically cleaves Holliday junctions

scientific article

Resolution of Holliday intermediates in recombination and DNA repair: indirect suppression of ruvA, ruvB, and ruvC mutations.

scientific article published on July 1993

Resolution of Holliday junctions in Escherichia coli: identification of the ruvC gene product as a 19-kilodalton protein

scientific article

Resolution of Holliday junctions in vitro requires the Escherichia coli ruvC gene product ⬇️

scientific article published on July 15, 1991

RusA proteins from the extreme thermophile Aquifex aeolicus and lactococcal phage r1t resolve Holliday junctions

scientific article published in April 2002

Sequence-specificity of Holliday junction resolution: identification of RuvC mutants defective in metal binding and target site recognition.

scientific article published on August 1998

Structural and functional characterization of the Redβ recombinase from bacteriophage λ.

scientific article published on 11 November 2013

Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast.

scientific article

Structural similarities between Escherichia coli RuvA protein and other DNA-binding proteins and a mutational analysis of its binding to the holliday junction

scientific article published on 01 April 1998

The C-terminus of the phage λ Orf recombinase is involved in DNA binding.

scientific article published on 13 December 2010

The N-terminal region of the RecU holliday junction resolvase is essential for homologous recombination.

scientific article published on 5 May 2009

The Potato Nucleotide-binding Leucine-rich Repeat (NLR) Immune Receptor Rx1 Is a Pathogen-dependent DNA-deforming Protein

scientific article published on 25 August 2015

The RdgC protein of Escherichia coli binds DNA and counters a toxic effect of RecFOR in strains lacking the replication restart protein PriA.

scientific article

The RuvAB branch migration translocase and RecU Holliday junction resolvase are required for double-stranded DNA break repair in Bacillus subtilis

scientific article published on 14 July 2005

The Tomato Nucleotide-binding Leucine-rich Repeat Immune Receptor I-2 Couples DNA-binding to Nucleotide-binding Domain Nucleotide Exchange

scientific article published on 24 November 2015

The acidic pin of RuvA modulates Holliday junction binding and processing by the RuvABC resolvasome.

scientific article

The intracellular immune receptor Rx1 regulates the DNA-binding activity of a Golden2-like transcription factor.

scientific article published on 7 December 2017

The mmsA locus of Streptococcus pneumoniae encodes a RecG-like protein involved in DNA repair and in three-strand recombination

scientific article published in March 1996

VceR regulates the vceCAB drug efflux pump operon of Vibrio cholerae by alternating between mutually exclusive conformations that bind either drugs or promoter DNA.

scientific article published on 2 April 2005

lambda Rap protein is a structure-specific endonuclease involved in phage recombination

scientific article published on November 1998

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