List of works - Mickael Audrain

Adeno-Associated Virus-Based Gene Therapy for CNS Diseases.

scientific article

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

scientific article

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.

scientific article

Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

scientific article published on 01 March 2019

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.

scientific article published on 13 June 2017

Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

scientific article published on 18 March 2019

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

article

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

scientific article

Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice.

scientific article published on 20 December 2016

Is it time to rethink the Alzheimer's disease drug development strategy by targeting its silent phase?

scientific article

Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease

scientific article published on 07 August 2020

Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice

scientific article published on 12 December 2020

Transient increase in sAPPα secretion in response to Aβ1-42 oligomers: an attempt of neuronal self-defense?

scientific article published on 19 September 2017

VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice

scientific article published on 10 January 2020

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.

scientific article published on 4 November 2015

miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease

scientific article published on 14 July 2020

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.

scientific article

List of works by Mickael Audrain

Adeno-Associated Virus-Based Gene Therapy for CNS Diseases.

Alzheimer's disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology.

Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.

Inhibition of DYRK1A proteolysis modifies its kinase specificity and rescues Alzheimer phenotype in APP/PS1 mice

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer's disease mice.

Is it time to rethink the Alzheimer's disease drug development strategy by targeting its silent phase?

Multiscale causal networks identify VGF as a key regulator of Alzheimer's disease

Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer's-related mice

Transient increase in sAPPα secretion in response to Aβ1-42 oligomers: an attempt of neuronal self-defense?

VGF-derived peptide TLQP-21 modulates microglial function through C3aR1 signaling pathways and reduces neuropathology in 5xFAD mice

Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model.

miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease

βAPP Processing Drives Gradual Tau Pathology in an Age-Dependent Amyloid Rat Model of Alzheimer's Disease.