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List of works by Phillip K. Darcy

A Multifunctional Role for Adjuvant Anti-4-1BB Therapy in Augmenting Antitumor Response by Chimeric Antigen Receptor T Cells

scientific article published on 12 January 2017

A Network of PDZ-Containing Proteins Regulates T Cell Polarity and Morphology during Migration and Immunological Synapse Formation

scientific article published on 01 June 2005

A Novel Target Antigen for the Treatment of Acute Myeloid Leukemia by CAR T Cells

scientific article published on 13 July 2017

A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells

scientific article published on May 2004

A novel combination strategy for effectively targeting cancer stem-like cells

scientific article published on 22 May 2017

A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer

scientific article published on 02 May 2016

A2A blockade enhances anti-metastatic immune responses

scientific article published on 22 October 2013

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

scientific article published on 27 March 2008

Activating and inhibitory receptors of natural killer cells

scientific article published on 22 June 2010

Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses

scientific article

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

scientific article published on 18 May 2020

Adoptive immunotherapy combined with intratumoral TLR agonist delivery eradicates established melanoma in mice

scientific article

Adoptive immunotherapy for cancer: the next generation of gene-engineered immune cells.

scientific article published on October 2009

Adoptive immunotherapy: a new era for the treatment of cancer

scientific article published on 01 January 2015

Adoptive transfer of T cells modified with a humanized chimeric receptor gene inhibits growth of Lewis-Y-expressing tumors in mice

scholarly article

Adoptive transfer of chimeric FcepsilonRI gene-modified human T cells for cancer immunotherapy

scientific article published on November 2006

Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection

scientific article published on 19 July 2005

Agonist immunotherapy restores T cell function following MEK inhibition improving efficacy in breast cancer

scientific article published on 19 September 2017

Alloreactive natural killer cells in hematopoietic stem cell transplantation

scientific article published on 16 August 2010

Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells

scientific article published on 19 July 2013

Antitumor activity of dual-specific T cells and influenza virus

scientific article published on 2 March 2007

Autoimmunity associated with immunotherapy of cancer ⬇️

scientific article published on April 29, 2011

BET-Bromodomain Inhibitors Engage the Host Immune System and Regulate Expression of the Immune Checkpoint Ligand PD-L1

scientific article

Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2.

scientific article

Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors

scientific article published on 20 August 2013

Blockade of PD-1 immunosuppression boosts CAR T-cell therapy

scientific article published on 10 October 2013

CAR T-cell therapy of solid tumors.

scientific article published on 22 December 2016

CAR-T Cells Inflict Sequential Killing of Multiple Tumor Target Cells

scientific article

CAR-T cells are serial killers

scientific article

CD11c+ dendritic cells and B cells contribute to the tumoricidal activity of anti-DR5 antibody therapy in established tumors

scientific article

CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer

scientific article published on 17 June 2013

CD73-deficient mice are resistant to carcinogenesis

scientific article

CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis

scientific article published on 3 February 2011

CD73: A potential biomarker for anti-PD-1 therapy

scientific article

CD73: a potent suppressor of antitumor immune responses

scientific article published on 07 April 2012

CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

scientific article published on 16 August 2017

Cancer immunotherapy utilizing gene-modified T cells: From the bench to the clinic.

scientific article

Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape.

scientific article

Characterizing the anti-tumor function of adoptively transferred NK cells in vivo

scientific article published on 8 April 2010

Chimeric antigen receptor-redirected T cells display multifunctional capacity and enhanced tumor-specific cytokine secretion upon secondary ligation of chimeric receptor

scientific article published in June 2013

Clinical relevance of host immunity in breast cancer: from TILs to the clinic

scientific article published on 15 December 2015

Colon epithelial cell differentiation is inhibited by constitutive c-myb expression or mutant APC plus activated RAS.

scientific article

Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers.

scientific article published on 2 June 2014

Combined CDK4/6 and PI3Kα Inhibition Is Synergistic and Immunogenic in Triple-Negative Breast Cancer

scientific article

Combined immune checkpoint blockade as a therapeutic strategy for BRCA1-mutated breast cancer

scientific article

Combined natural killer T-cell based immunotherapy eradicates established tumors in mice

scientific article published on August 2007

Cross-talk between tumors can affect responses to therapy

scientific article published on 17 June 2015

Differential potency of regulatory T cell-mediated immunosuppression in kidney tumors compared to subcutaneous tumors

scientific article

Dual-specific Chimeric Antigen Receptor T Cells and an Indirect Vaccine Eradicate a Variety of Large Solid Tumors in an Immunocompetent, Self-antigen Setting.

scientific article published on 13 December 2016

Editorial overview: Tumour immunology: New frontiers in cancer immunotherapy

scientific article published on 11 March 2014

Embryonic Lethality in Homozygous Human Her-2 Transgenic Mice Due to Disruption of the Pds5b Gene

scientific article

Engineering T cell function using chimeric antigen receptors identified using a DNA library approach

scientific article

Enhancing adoptive immunotherapy of cancer.

scientific article published on April 2010

Enhancing chimeric antigen receptor T-cell immunotherapy against cancer using a nanoemulsion-based vaccine targeting cross-presenting dendritic cells

scientific article published on 22 July 2020

Enhancing immunotherapy using chemotherapy and radiation to modify the tumor microenvironment

scientific article published on 2 August 2013

Enhancing the efficacy of adoptive cellular therapy by targeting tumor-induced immunosuppression

scientific article published on June 2015

Environmental enrichment does not impact on tumor growth in mice.

scientific article published on 12 June 2013

Ex vivo culture of chimeric antigen receptor T cells generates functional CD8+ T cells with effector and central memory-like phenotype.

scientific article published on 29 April 2010

Expression of a Chimeric Antigen Receptor in Multiple Leukocyte Lineages in Transgenic Mice

scientific article

Foxp3 expression in T regulatory cells and other cell lineages

scientific article

Foxp3 expression in macrophages associated with RENCA tumors in mice.

scientific article

Frizzled-7 dictates three-dimensional organization of colorectal cancer cell carcinoids

scientific article

Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth

scientific article

Gene modification strategies to induce tumor immunity.

scientific article

Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer

scientific article

Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen.

scientific article published on 4 March 2010

Generation of chimeric T-cell receptor transgenes and their efficient transfer in primary mouse T lymphocytes

scientific article published on January 2010

Genetic modification of mouse effector and helper T lymphocytes expressing a chimeric antigen receptor.

scientific article published on January 2014

Genetic modification of natural killer cells for adoptive cellular immunotherapy.

scientific article published on July 2009

HDAC Inhibitor Panobinostat Engages Host Innate Immune Defenses to Promote the Tumoricidal Effects of Trastuzumab in HER2+ Tumors

scientific article

IL-21 priming enhances T-cell immunotherapy

scientific article published on 01 June 2008

Identification and characterization of a novel family of mammalian ependymin-related proteins (MERPs) in hematopoietic, nonhematopoietic, and malignant tissues

scientific article published in October 2001

Immune modulation of the tumor microenvironment for enhancing cancer immunotherapy

scientific article

Immunomodulation by MYB is associated with tumor relapse in patients with early stage colorectal cancer.

scientific article published on 29 June 2016

Immunosuppressive activities of adenosine in cancer.

scientific article published on 19 May 2016

Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes

scientific article published in July 2004

Induction of tumor-specific T cell memory by NK cell–mediated tumor rejection

scientific article published on 17 December 2001

Loss of DNAM-1 ligand expression by acute myeloid leukemia cells renders them resistant to NK cell killing.

scientific article published on 27 June 2016

MAIT cells regulate NK cell-mediated tumor immunity

scientific article published on 06 August 2021

Manipulating immune cells for adoptive immunotherapy of cancer

scientific article published on 15 February 2014

Multiple antitumor mechanisms downstream of prophylactic regulatory T-cell depletion

scientific article published on 23 March 2010

Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux.

scientific article published on September 2004

Oncolytic virus and anti-4-1BB combination therapy elicits strong antitumor immunity against established cancer

scientific article published on 7 February 2012

P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation.

scientific article published in November 2002

Persistence and efficacy of second generation CAR T cell against the LeY antigen in acute myeloid leukemia

scientific article published on 08 July 2013

RAS/MAPK Activation Is Associated with Reduced Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancer: Therapeutic Cooperation Between MEK and PD-1/PD-L1 Immune Checkpoint Inhibitors

scientific article published on 29 October 2015

Redirected cytotoxic effector function. Requirements for expression of chimeric single chain high affinity immunoglobulin e receptors.

scientific article

Releasing the Brake on Oncolytic Viral Therapy.

scientific article published on 16 September 2015

Relevance of tumor-infiltrating lymphocytes in breast cancer

scientific article (publication date: 2015)

Reprogramming the tumor microenvironment to enhance adoptive cellular therapy

scientific article

Routes of delivery for CpG and anti-CD137 for the treatment of orthotopic kidney tumors in mice

scientific article

Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumors

scientific article published on November 2002

Stable IL-10: A New Therapeutic that Promotes Tumor Immunity

scientific article published on 01 December 2011

Supercharging adoptive T cell therapy to overcome solid tumor-induced immunosuppression

scientific article published on 01 June 2019

Supernatural T cells: genetic modification of T cells for cancer therapy

scientific article

Sustained antigen-specific antitumor recall response mediated by gene-modified CD4+ T helper-1 and CD8+ T cells

scientific article published in December 2007

T cells gene-engineered with DAP12 mediate effector function in an NKG2D-dependent and major histocompatibility complex-independent manner

scientific article published on 16 September 2005

Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy

scientific article

The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum

scientific article

The double-edged sword of IFN-γ-dependent immune-based therapies.

scientific article

The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited missense mutations in the perforin (PFN1) gene

scientific article

The potential impact of mouse model selection in preclinical evaluation of cancer immunotherapy

scientific article published on 3 July 2014

Therapeutic DNA vaccination against colorectal cancer by targeting the MYB oncoprotein.

scientific article

Three agonist antibodies in combination with high-dose IL-2 eradicate orthotopic kidney cancer in mice

scientific article

Tissues in different anatomical sites can sculpt and vary the tumor microenvironment to affect responses to therapy

scientific article published on 19 September 2013

Toll-Like Receptor Triggering and T-Cell Costimulation Induce Potent Antitumor Immunity in Mice

scientific article published in December 2009

Trafficking of T cells into tumors

scientific article

Tumor ablation by gene-modified T cells in the absence of autoimmunity.

scientific article published on 23 November 2010

Tumor immune evasion arises through loss of TNF sensitivity

scientific article published on 01 May 2018

Virotherapy, gene transfer and immunostimulatory monoclonal antibodies.

scientific article

XENOSPECIFIC CD8+ CYTOTOXIC T LYMPHOCYTE GENERATION

scientific article published on 01 May 1998

cAMP response element binding protein is required for mouse neural progenitor cell survival and expansion

scientific article

cDNA cloning of granzyme J.

scientific article published in January 1997

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