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List of works by Harold Smith

A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures

scientific article published on 31 December 2020

A hydrodynamic analysis of APOBEC3G reveals a monomer-dimer-tetramer self-association that has implications for anti-HIV function.

scientific article

A quantitative assay for assessing allelic proportions by iterative gap ligation.

scientific article published on February 1998

APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic

scientific article published on 18 September 2006

APOBEC-1 complementation factor (ACF) forms RNA-dependent multimers.

scientific article

APOBEC3G levels predict rates of progression to AIDS

scientific article published on 20 March 2007

APOBEC3G subunits self-associate via the C-terminal deaminase domain

scientific article published on 08 October 2008

APOBEC3G/CEM15 (hA3G) mRNA levels associate inversely with human immunodeficiency virus viremia

scientific article published on September 2005

APOBEC3G: a double agent in defense ⬇️

scientific article published on January 14, 2011

Activation induced deaminase: the importance of being specific.

scientific article published on June 2004

Alterations in chromatin conformation are accompanied by reorganization of nonchromatin domains that contain U-snRNP protein p28 and nuclear protein p107

scientific article

An analog of camptothecin inactive against Topoisomerase I is broadly neutralizing of HIV-1 through inhibition of Vif-dependent APOBEC3G degradation.

scientific article published on 4 November 2016

An auxiliary factor containing a 240-kDa protein complex is involved in apolipoprotein B RNA editing

scientific article

Analysis of U1snRNP-specific A protein cross-linked complexes

scientific article published on 01 October 1990

Analysis of protein complexes assembled on apolipoprotein B mRNA for mooring sequence-dependent RNA editing.

scientific article published on May 1998

Apolipoprotein B RNA sequence 3' of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing

scientific article

Apolipoprotein B mRNA and lipoprotein secretion are increased in McArdle RH-7777 cells by expression of betaine-homocysteine S-methyltransferase.

scientific article published on August 1999

Apolipoprotein B mRNA editing and the reduction in synthesis and secretion of the atherogenic risk factor, apolipoprotein B100 can be effectively targeted through TAT-mediated protein transduction

scientific article (publication date: February 2002)

Apolipoprotein B mRNA editing in vitro is a zinc-dependent process

scientific article published on 01 December 1993

Base-modification mRNA editing through deamination--the good, the bad and the unregulated.

scientific article published on October 1996

Chemical cross-linking of Sm and RNP antigenic proteins

scientific article published in June 1988

DNA mutagenic activity and capacity for HIV-1 restriction of the cytidine deaminase APOBEC3G depend on whether DNA or RNA binds to tyrosine 315.

scientific article

DNA polymerase alpha is tightly bound to the nuclear matrix of actively replicating liver

scientific article published on 01 December 1980

Deaminase activity on single-stranded DNA (ssDNA) occurs in vitro when APOBEC3G cytidine deaminase forms homotetramers and higher-order complexes

scientific article

Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity

scientific article

Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity

scientific article published on 01 October 1999

Dynamic domains of DNA polymerase alpha in regenerating rat liver

scientific article published on 01 June 1983

Effects of fatty acids on apolipoprotein B secretion by McArdle RH-7777 rat hepatoma cells

scientific article published on 01 July 1997

Ethanol increases apolipoprotein B mRNA editing in rat primary hepatocytes and McArdle cells

scientific journal article

Ethanol stimulates apolipoprotein B mRNA editing in the absence of de novo RNA or protein synthesis.

scientific article

Evidence that a nuclear matrix protein participates in premessenger RNA splicing

article

Functions and regulation of the APOBEC family of proteins

scientific article

HIV-1 Frameshift RNA-Targeted Triazoles Inhibit Propagation of Replication-Competent and Multi-Drug-Resistant HIV in Human Cells

scientific article published on 27 April 2017

High-affinity recognition of HIV-1 frameshift-stimulating RNA alters frameshifting in vitro and interferes with HIV-1 infectivity

scientific article

Immunological evidence for the role of phosphoprotein p68/pI = 7.3 in premessenger RNA splicing

scientific article published on 01 May 1989

In vitro apolipoprotein B mRNA editing activity can be modulated by fasting and refeeding rats with a high carbohydrate diet

scientific article published in March 1992

Induction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1

scientific article (publication date: 28 July 2000)

Integrating molecular medicine into the medical school curriculum

scientific article published on 01 March 1999

Intracellular trafficking determinants in APOBEC-1, the catalytic subunit for cytidine to uridine editing of apolipoprotein B mRNA

scientific article (publication date: 15 July 2001)

Macromolecular domains containing nuclear protein p107 and U-snRNP protein p28: further evidence for an in situ nuclear matrix.

scientific article

Measuring editing activity and identifying cytidine-to-uridine mRNA editing factors in cells and biochemical isolates

scientific article published in January 2007

Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business

scientific article (publication date: April 2003)

Metabolic regulation of APOBEC-1 complementation factor trafficking in mouse models of obesity and its positive correlation with the expression of ApoB protein in hepatocytes

scientific journal article

Metabolic regulation of apoB mRNA editing is associated with phosphorylation of APOBEC-1 complementation factor

scientific article

Multiple protein domains determine the cell type-specific nuclear distribution of the catalytic subunit required for apolipoprotein B mRNA editing

scientific journal article

N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA.

scientific article

Nanostructures of APOBEC3G support a hierarchical assembly model of high molecular mass ribonucleoprotein particles from dimeric subunits.

scientific article published on 31 October 2006

Nuclear Exclusion of the HIV-1 host defense factor APOBEC3G requires a novel cytoplasmic retention signal and is not dependent on RNA binding.

scientific article published on 28 December 2007

Nuclear matrix-bound deoxyribonucleic acid synthesis: an in vitro system

scientific article published on 01 December 1982

Only cytidines 5' of the apolipoprotein B mRNA mooring sequence are edited.

scientific article published on September 1994

Overexpression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing.

scientific article published on February 1996

Oxygen regulated 80 kDa protein and glucose regulated 78kDa protein are identical.

scientific article published on May 1991

Partial characterization of the auxiliary factors involved in apolipoprotein B mRNA editing through APOBEC-1 affinity chromatography.

scientific article published on October 1997

Properties of adenoviral DNA bound to the nuclear matrix.

scientific article

Quantitation of endogenous liver apolipoprotein B mRNA editing

scientific article published on 01 July 1990

RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing

scientific article published on 21 November 2016

RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates.

scientific article

Redistribution of U-snRNPs during mitosis

scientific article published on 01 March 1986

Regulation of hepatic apolipoprotein B RNA editing in the genetically obese Zucker rat

scientific article published on 01 September 1996

Reversible chemical cross-linking and ribonuclease digestion analysis of the organization of proteins in ribonucleoprotein particles

scientific article published on 01 November 1988

Ribosomal DNA sequences attached to the nuclear matrix

scientific article published on 01 December 1987

SnRNP core protein enrichment in the nuclear matrix.

scientific article

Structural and functional assessment of APOBEC3G macromolecular complexes.

scientific article published on 14 March 2016

Structural insights for HIV-1 therapeutic strategies targeting Vif.

scientific article

The APOBEC Protein Family: United by Structure, Divergent in Function

scientific article

The dimerization domain of HIV-1 viral infectivity factor Vif is required to block virion incorporation of APOBEC3G

scientific article

The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells

scientific article

The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions

scientific article published on 24 March 2014

The nuclear matrix continues DNA synthesis at in vivo replicational forks

scientific article published in July 1985

The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1

scientific article

Three distinct RNA sequence elements are required for efficient apolipoprotein B (apoB) RNA editing in vitro

scientific article

Tissue-specific differences in the role of RNA 3' of the apolipoprotein B mRNA mooring sequence in editosome assembly

scientific article published on 01 September 1999

Ultrastructural and biochemical comparisons of nuclear matrices prepared by high salt or LIS extraction.

scientific article

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